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Cancer Advances,  Health Advances,  Immunotherapy

Novel Hyperthermic Treatment Offers Hope for Stage 4 Metastatic Cancer

Brian Blum via Israel21c – It’s one of the most heart wrenching moments in medicine and in life. The doctor informs a patient that his or her stage 4 cancer has metastasized all over the body and nothing more can be done except to write a referral for hospice care.

But what if there was a way to shrink those stage 4 tumors by half? It wouldn’t make the cancer go away, but would transform it from a likely death sentence to a “chronic illness” with treatments required every few months.

That’s what Petah Tikva-based New Phase hopes to do by applying electromagnetic hyperthermia to treat inoperable tumors. Hyperthermia is when the body is heated up.

It’s been known for some time that cancerous cells don’t like heat. They die when the temperature hits about 45 degrees Celsius (114 Fahrenheit). Non-cancerous cells on the other hand, can survive temperatures up to 55C/131F.

That’s because tumor cells have a disorganized vascular structure which, unlike normal cells, has difficulty dissipating heat.

New Phase injects specially created iron oxide nanoparticles by IV. The nanoparticles are embedded within a phase change material (which releases or absorbs energy to provide heat or cooling) and coated with polyethylene glycol (a compound derived from petroleum).

They locate the tumors through a process known as EPR – “enhanced permeability and retention,” explains Ofer Shalev, who cofounded New Phase with Dr. Rafi Hof.

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