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Melatonin Could Be a Potential Therapy for Long-COVID Symptoms

AHA Publisher — Thu, 17 Nov 2022 08:00:30 +0000

Dr. Chinta Sidharthan via News-Medical – A recent review published in the journal Biomolecules discussed the potential uses of melatonin in treating brain fog and chronic fatigue syndrome or myalgic encephalomyelitis symptoms associated with long coronavirus disease (COVID). Background An emerging concern associated with the coronavirus disease 2019 (COVID-19) pandemic is long COVID or clinical sequelae consisting of chronic fatigue, memory loss, muscle weakness, reduced pulmonary capacity during exertion, persistent fever, myalgia, epileptic seizures, stroke, and other cardiovascular complications. Patients who have recovered from severe COVID-19 experience these debilitating symptoms for months after recovery. Furthermore, studies that examined vaccinated individuals who experienced breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections found a high incidence of long COVID symptoms such as deteriorated musculoskeletal, neurological, and mental health among these individuals after recovery. This indicates that vaccination provides only limited protection against long COVID. Melatonin is a cryoprotective hormone and chemical that exhibits anti-inflammatory, antioxidant, and immunoregulatory activity and has been seen to impair viral infections, play a role in circadian rhythm maintenance, and be effective against diabetes mellitus and cardiovascular diseases. It is also involved in the activation of glutathione-synthesizing enzymes. Melatonin could potentially be a therapeutic agent in treating long COVID symptoms. Long COVID Symptoms Brain fog is a general term used to defineimpaired cognitive function, such as difficulty concentrating, loss of working and short-term memory, and difficulty with verbal and non-verbal methods of learning and mathematical problem-solving. While brain fog can be a consequence of various factors such as sleep deprivation, malnutrition, pregnancy or menopause-related hormonal changes, or even chemotherapy, it was the most reported symptom among COVID-19-recovering patients with no history of other diseases or hypoxia. An intelligence test in the United Kingdom detected cognitive impairments in a significant number of individuals with COVID-19. Symptoms included memory loss, disorientation, and reduced mental energy. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by excessive and persistent fatigue, inability to perform physical exercise, and autonomic dysregulation. ME/CFS is also associated with disruption of circadian rhythms and the gut/mucosal barrier, mitochondrial dysfunction, and a pro-inflammatory state. Studies indicated that 45% of COVID-19 patients who were hospitalized and required intensive care unit admission exhibited ME/CFS symptoms up to six months after recovery. Melatonin as a Potential Long COVID Treatment Melatonin is a hormone naturally produced in all aerobically respiring life forms, and it performs antioxidant, anti-inflammatory, immunostimulant, and neuroprotective functions in the body. It reduces the pro-inflammatory response of macrophages, activates nuclear erythroid 2-related factor 2, and suppresses the activation of nuclear factor (NF)-κB. Melatonin is also known to balance inflammatory responses by decreasing the levels of pro-inflammatory cytokines such as interleukins (IL) 1β, 6, and 8, and tumor necrosis factor (TNF)-α, and increasing anti-inflammatory cytokine IL-10. Warburg’s effect during viral infections causes a shift from mitochondrial oxidative phosphorylation to glycolysis which occurs in the cytoplasm. This is accompanied by inflammation-promoting mechanisms such as an increase in NF-κB and hypoxia-inducible factor-1α. Consequently, the anti-inflammatory M2 macrophages are converted to pro-inflammatory M1 macrophages, causing a cytokine storm known to cause endothelial tissue and organ damage in severe COVID-19 patients. The anti-inflammatory effects of melatonin in preventing pro-inflammatory profiles or macrophages and suppressing NF-κB activation can help reverse Warburg’s effect in long COVID patients. Melatonin also regulates the amyloid β (Aβ) metabolism associated with Alzheimer’s disease. Studies with transgenic Alzheimer’s disease models have shown that melatonin can control neuroinflammation by interacting with Aβ40 and Aβ42 and increasing protein degradation. Furthermore, the ability of melatonin to regulate circadian rhythms and sleep patterns has been shown to improve cognitive function and sleep in patients in the early stages of cognitive decline. Melatonin is also known to exhibit therapeutic activity against the various symptoms of ME/CFS, such as oxidative stress, pro-inflammatory state, mitochondrial and bioenergetic dysregulation, and disruption of the gut/mucosal barrier. Conclusions Overall, the review reported the significant potential for the use of melatonin in long-COVID and COVID-19 therapy. Studies have shown melatonin is more effective in reducing COVID-19 inflammatory markers than commonly used SARS-CoV-2 antivirals. The authors believe that although melatonin exhibits anti-inflammatory and immunostimulant properties that many studies have reported being effective against COVID-19, it has not been promoted as a therapeutic option, possibly due to its easy availability and non-patentability, which makes it an unattractive target for pharmaceutical industries. They recommend clinical trials to explore the use of melatonin as a treatment for long COVID symptoms. To read the original article click here.

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Frontline Doctors Develop Protocol to Help Those Injured by COVID Jab

AHA Publisher — Fri, 01 Jul 2022 07:00:16 +0000

Sara Middleton via NaturalHealth365 – Since the late 1980s, the number of petitions filed with the United States National Injury Compensation Program (VICP) seeking compensation for injury or death caused by vaxxes has increased considerably. Last year’s total (2,057) neared the historical peak of 2003 (2,592). It’s yet to be seen how the trend will play out over the next few years. Incredibly, more than half of these petitions have been dismissed, and not all cases that received actual compensation were necessarily able to “prove” that a vax caused the purported injury or illness (although one could safely surmise that the entire VICP process is bogged down with bureaucratic red tape and other behind-closed-doors decisions that protect the best interests of anyone but the vax-injured). Regardless, the point is clear: people have and will continue to be injured by the COVID shots currently authorized for use by the Food and Drug Administration (FDA). Thankfully, while many public health officials, Big Pharma folks, and conventional healthcare providers are sticking their heads in the sand, some frontline doctors are taking a stand – and possibly risking their medical licenses by doing so – to help those who are harmed. No Conspiracy Here: Children and Adults Are Getting Hurt by COVID-19 Shots… But Are They Being Listened to? It’s hard to claim that we’re still in an “emergency” state when it comes to the pandemic (although that certainly isn’t stopping the FDA from authorizing the “emergency” use of the gene-based COVID shots for virtually everyone in the United States older than 6 months old). Meanwhile, data continues to emerge that muddies the water for anyone trying to make informed decisions about these injections. For instance, getting vaxxed seems to increase your risk of getting COVID-19 (a painfully ironic phenomenon known as “negative efficacy,”) which we can infer from the observation that highly vaxxed countries suffer from soaring infection and death rates compared to low vaxxed countries. Additionally, as summarized by Dr. Joseph Mercola in a recent newsletter, official vax safety surveillance data confirm that the mRNA jabs have “caused more harm in 18 months than all other vaxxes on the market, combined, over the past three decades.” And that’s even leaving alone the likelihood that VAERS is not capturing the true incidence of adverse effects from the COVID jabs due to the frustrating reality of adverse event underreporting. Of course, acknowledging that people are suffering serious and sometimes fatal issues because of these heavily propagandized drugs in no way ignores the fact that people have also been suffering because of COVID-19. But bringing to light this issue hopefully will encourage more providers to at least put vax injury on their radar when seeing people suffering from problems such as strokes, fall-related injuries after fainting episodes, heart inflammation, worsening chronic illness, “sudden unexplained deaths,” and more. Because truthfully, if doctors aren’t even considering the possibility that their patients’ suffering could be related to recent jabs due to ignorance or fear of professional repercussions, how would a potential link ever be uncovered? If patients aren’t listened to when they show up to urgent care clinics and emergency rooms, if their concerns are downplayed or ignored, or if their symptoms aren’t reported to VAERS, then how exactly will ongoing safety monitoring of these shots ever be appropriately carried out? Here Are Some Things You Can Do If You Develop Post-Vax Syndrome Following a COVID Shot, According to Frontline Experts The Frontline COVID-19 Critical Care Alliance (FLCCC) is a group of healthcare providers – led by esteemed Pulmonary and Critical Care Specialists Dr. Pierre Kory, M.D., M.P.A., and Dr. Paul E. Marik, M.D., FCCM, FCCP – who have created and shared life-saving, evidence-based protocols for patients throughout the pandemic (protocols that often go against mainstream messaging and are therefore frequently censored). Now, they’ve developed a protocol specifically for people who have suffered illness or injury following a COVID jab. The FLCCC endorses the importance of such a protocol given that “a temporal correlation between a patient receiving a COVID-19 vaccine and beginning or worsening of clinical manifestations is sufficient to diagnose as a COVID-19 vaccine-induced injury when the symptoms are unexplained by other concurrent causes.” If you’re curious, here are some “first-line” treatments from the FLCCC Alliance’s “I-RECOVER POST-VACCINE TREATMENT PROTOCOL” (the protocol includes many more treatments as well, including several non-pharmacological options): Intermittent daily fasting Vitamin C, D, and K2 Magnesium Melatonin Quercetin Nigella Sava Omega-3 fatty acids Ivermectin Aspirin Readers note: the FLCCC encourages patients to consult with a healthcare provider before starting any new treatment protocol, and that any treatment protocol should be individualized based on each patient’s needs. Keep this in mind as you search for a healthcare provider you can trust with your family’s health and wellbeing. Sources for this article include: Statista.com Rumble.com COVID19criticalcare.com Mercola.com Mercola.com To read the original article click here.

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Nature’s Tranquilizer for Better Sleep

AHA Publisher — Thu, 10 Feb 2022 08:00:24 +0000

Al Sears, MD, CNS – Not being able to get a good night’s sleep is one of the biggest complaints I hear from my patients… and it seems to increase as they age. It’s difficult enough for many of them to fall asleep, but once they do get to sleep it’s even more frustrating to suddenly wake up from a deep sleep. These brief periods of unconscious wakefulness are known as “cortical arousal,” and they’re perfectly normal. It’s how your body evolved to protect itself from potential danger. But when they happen too often, they can put your physical health at risk by disrupting the natural circadian rhythm of your body’s cardiovascular system. And that can lead to higher blood pressure, insulin resistance, heart disease – and in some cases, even higher risk of death. Fortunately, there are ways you can naturally overcome this increasingly common disorder – nicknamed “sleep arousal burden” (SAB). You don’t have to rely on Big Pharma’s addictive sleeping pills, either. More on how you can protect your sleep and your heart in a moment. In a new study published in European Heart Journal, researchers from Australia, the Netherlands, Denmark, and the United States examined the sleep patterns of 8,001 older men and women.1 The research came from three separate long-term studies. After analyzing over a decade’s worth of data, the scientists determined that waking up frequently increased the risk of heart disease and death.2 In other words, they found that when it comes to your heart health, it isn’t the quantity of sleep that counts… it’s the quality. Men who experienced SAB more than 8.5% of the time had a 13.4% higher risk of dying from heart disease and 34% increased risk of dying from any cause. The risk to the general population of men at a similar age was 9.6% and 28%, respectively.3 And if you’re a woman, you are particularly at risk… Women who suffered from SAB most often had nearly double the risk of dying from cardiovascular disease compared to women in general.4 The study authors recommend treating SAB by practicing “good sleep hygiene.” That includes losing weight if needed, not eating before bed, and minimizing noise and light pollution. These are all good suggestions. But they don’t get to the root of the problem… Get More of this Mineral for Better Sleep and Robust Heart Health Many people diagnosed with various sleeping disorders — including unconscious wakefulness — are deficient in the mineral magnesium. I call magnesium nature’s all-natural, non-addictive stress reliever and tranquilizer. You see, magnesium enhances the effect of the amino acid tryptophan, which your body needs to make melatonin. Without melatonin you can’t sleep. And without tryptophan, your body also can’t make the neurotransmitter serotonin, which stabilizes your mood balance and calms your brain. Studies have shown that magnesium is a powerful weapon against insomnia and waking up from restless leg syndrome.5,6 But this mineral is also vital for a healthy heart rhythm. Magnesium helps transport the electrolytes like calcium and potassium into cells. Electrolytes are important for the muscle contractions of a normal heartbeat. A magnesium deficiency increases irregular heartbeats known as arrhythmias. In a review published in 2019, researchers found that a low blood level of magnesium increases your risk of developing cardiovascular disease as well as atrial fibrillation, the most common heart rate disorder.7 Magnesium levels in our modern diet have plummeted. A hundred years ago, most Americans consumed more than 400 mg of magnesium per day, thanks to vegetables grown in nutrient-rich soil. Today, the average intake of magnesium is less than 200 mg a day.8 You can get magnesium by eating nuts, seeds, dairy, and dark green, leafy vegetables. But I also recommend supplementing with 1,000 mg a day. The most absorbable forms are magnesium citrate, glycinate taurate, or aspartate. Take it with vitamin B6 to increase the amount of magnesium that accumulates in your cells. 3 More Sleep-Inducing Supplements In addition to taking magnesium, I also recommend you: Take a tiny amount of melatonin. An MIT study shows you only need 0.3 mg for restful sleep. And taking too much causes receptors in the brain to become unresponsive.9 I suggest using a liquid or spray because they hit your bloodstream more quickly. Boost serotonin levels. This “feel good” brain chemical has a naturally calming effect on your body. I’ve had great success treating sleepless patients by recommending the serotonin precursor 5-HTP. I usually start patients on 20 mcg a day, and then gradually increase it to between 50-100 mcg. Don’t forget your CBD. The Center for Applied Health Sciences reported that adults who took CBD experienced a 22% improvement in sleep quality and a 21% improvement in sleep quantity.10In another study, researchers found that patients who took CBD for one month had 67% improved sleep.11 To Your Good Health, Al Sears, MD, CNS References: 1. Shahrbabaki SS, et al. “Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.” Eur Heart J. Published online April 19, 2021. doi:10.1093/eurheartj/ehab151 2. Shahrbabaki SS, et al. “Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.” Eur Heart J. Published online April 19, 2021. doi:10.1093/eurheartj/ehab151 3. Shahrbabaki SS, et al. “Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.” Eur Heart J. Published online April 19, 2021. doi:10.1093/eurheartj/ehab151 4. Shahrbabaki SS, et al. “Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.” Eur Heart J. Published online April 19, 2021. doi:10.1093/eurheartj/ehab151 5. Abbasi B, et al. “The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.” J Res Med Sci. 2012 Dec;17(12):1161-9. 6. Hornyak M , et al. “Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998;21(5):501-505 7. Liu M, Dudley S. “Magnesium, oxidative stress, inflammation, and cardiovascular disease.” Antioxidants (Basel). 2020 Oct; 9(10): 907. 8. Rosanoff A, et al. “Suboptimal magnesium status in the United States: are the health consequences underestimated?” Nutr Rev. 2012 Mar;70(3):153-64. 9. Brzeszinski A, et al. “Effects of exogenous melatonin on sleep: A meta-analysis.” Sleep Med Rev. 2005;9(1):41-50. 10. CV Sciences, Inc. (2019, June 17). “Effects of a CBD-containing supercritical fluid extract of hemp on markers of optimal wellness, stress resilience, and recovery in healthy subjects [Press release]. 11. Shannon S, et al. “Cannabidiol in anxiety and sleep: A large case series.” Perm J. 2019;23:18-041. To read the original article click here.

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Exciting Potential: How to IMPROVE Your Brain Function with Melatonin

AHA Publisher — Mon, 06 Dec 2021 08:00:01 +0000

Lori Alton via Naturalhealth365 – According to a recent report published in Alzheimer’s and Dementia Journal, Alzheimer’s disease – the sixth leading cause of death in the United States – claimed over 121,000 lives in 2019 alone, before the pandemic had swept the nation. Alzheimer’s disease claimed over 121,000 lives in 2019 alone, before the pandemic had swept the nation Meanwhile, the Alzheimer’s Association has released a sobering new statistic – deaths from Alzheimer’s disease and other forms of dementia have increased by a significant 16 percent since the onset of COVID-19. However, a natural intervention for the condition is casting a ray of hope. In a recent review article in the peer-reviewed journal Revue Neurologique, researchers report that the natural hormone melatonin shows exciting potential to prevent and even alleviate neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. In fact, the impressed scientists even concluded that “melatonin may be the solution we have been looking for.” Why are they so hopeful about the neuroprotective effects of melatonin? Let’s find out. Melatonin Sharpens Memory and Increases Formation of New Brain Cells Melatonin, commonly known as the “sleep hormone,” is produced in the pineal gland in the brain. This critical hormone regulates the circadian rhythms and the sleep-wake cycle while improving the overall quality of sleep. Researchers have long believed that melatonin may improve memory and cognition. And, the “proof is in the pudding.” In an older – but still influential – placebo-controlled study published in Psychopharmacology, 50 young men were given a one-time, 3-mg dose of melatonin. The effects were rapid, unequivocal, and clear-cut, with participants in the melatonin group able to recall more objects from a memorized list than those in the placebo group! The researchers concluded that melatonin could suppress the stress-induced hormones that affect memory processing. But does melatonin work for older individuals? Neuroprotective Effects of Melatonin May Improve Alzheimer’s Disease While melatonin exists in generous amounts in young people, it appears that supplies decrease with age. The review authors noted that patients with Alzheimer’s disease have lower melatonin levels than healthy people of the same age – and that melatonin deficiency may play a vital role in the development of Alzheimer’s disease and dementia. Raising melatonin levels in the body may not only combat age-related memory decline and cognitive impairment – but, the neuroprotective effects of melatonin may help slow the progression of neurodegenerative diseases. Scientists point out that almost half of all Alzheimer’s patients have problems with sleep. Lack of sleep is associated with increased plaque deposits of beta-amyloid, a protein strongly implicated in the development of the disease. Melatonin promotes the type of refreshing sleep needed for efficient brain function and accurate memory, with clinical studies supporting the ability of the hormone to slow the progression of cognitive disorders. Melatonin Improves Brain Function Through Multiple Mechanisms The neuroprotective effects of melatonin can be attributed to many factors. Melatonin appears to cushion the brain from the effects of “stress” hormones – such as epinephrine, cortisol, and norepinephrine – which can impair memory. It also increases levels of a protein known as a brain-derived neurotrophic factor (BDNF), which increases the formation of neurons. In addition, cell studies have shown that melatonin improves plasticity, the ability of the brain to change and adapt to new experiences. Finally, melatonin is a potent antioxidant that scavenges harmful free radicals (reactive oxygen species) that would otherwise cause oxidative stress and damage to cells and tissues, thereby triggering disease. Impressively, studies have shown that melatonin can even help to counter damage from memory-impairing drugs, including the chemotherapy drug fluorouracil and the anti-nausea medication scopolamine. Researchers theorize that melatonin achieved this by promoting cell division in the hippocampus, the brain’s “memory center.” Improve Sleep and Cognition with Melatonin Natural health experts advise using a high-quality melatonin formulation from a reputable vendor, with typical amounts ranging between 0.5 mg and 10 mg a day. To promote restful sleep, melatonin should be taken about 30 minutes before bedtime. However, if you take melatonin to correct out-of-sync circadian rhythms over the long term, it should be taken two to three hours before bedtime. Naturally, check with your integrative doctor before supplementing with melatonin. As a “pro” tip: The amino acid tryptophan is needed for the body to produce melatonin. You can raise your dietary intake of tryptophan with raw cheese, pasture-raised organic chicken, pumpkin seeds, and wild caught fish. In addition to the devastating human toll of Alzheimer’s disease – such as loss of precious memories and the ability to function independently – the financial burden of this illness is staggering. In fact, the national cost for Alzheimer’s and other dementias in 2021 is expected to clock in at $355 billion. No doubt, the relatively inexpensive, non-toxic, convenient, and safe choice of consuming melatonin may well emerge as an effective natural intervention for this cruel health issue. Sources for this article include: Alzheimers.org NIH.gov Healthline.com NIH.gov To read the original article click here.

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New Research Shows That Brighter Days Make for Better Nights

AHA Publisher — Thu, 23 Sep 2021 07:00:11 +0000

Mount Sinai Health System via Newswise – New York, NY(September 23, 2021) – A new study finds that more access to daylight at home improves circadian alignment, sleep and mental health in healthy adults. The REVOLV study was conducted by the Light and Health Research Center at the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) to explore how increasing daylight access at home affects circadian rhythm, sleep, vitality and mental health. The peer-reviewed paper was published on Sept. 23 in the International Journal of Environmental Research and Public Health. “The REVOLV study demonstrates the impact of daylight on the physiological, behavioral and subjective measures of circadian health in a real-world environment,” said senior author Mariana G. Figueiro, Ph.D., professor and director, Light and Health Research Center, Icahn Mount Sinai. “The findings highlight the importance of ensuring people are exposed to circadian-effective electric light or daylight indoors as well as outside for human health and well-being.” As the primary environmental cue for the body’s master biological clock, light-dark patterns are key for circadian alignment and are fundamental to multiple dimensions of health, including sleep and mental health. Although daylight provides the proper timing, quantity and color of light for promoting circadian alignment, modern indoor lifestyles typically offer fewer opportunities for adequate daylight exposure. In 2020, people spent 65% of their waking hours at home, compared to 50% in 2019, according to the Bureau of Labor Statistics. Leveraging this natural experiment during the COVID-19 pandemic, researchers tracked residents living in the Exo apartments in Reston, Virginia. During the crossover study, 20 residents spent one week in their apartments with electrochromic glass windows, also known as smart windows, which tint dynamically based on the location of the sun, and another week with standard windows with blinds. The participants wore sleep tracking devices, completed surveys on their health and well-being and provided saliva samples every 30 minutes over the course of five evening hours to measure their melatonin levels, a hormone that rises in the evening and triggers sleepiness. Researchers found that, in just one week, melatonin production in the body was delayed by 15 minutes when residents used their blinds, resulting in them falling asleep 22 minutes later and sleeping 16 minutes less each night. In contrast, consistent and quality sleep in the smart window condition resulted in increased vitality during the day, an 11% reduction in anxiety and a 9% reduction in stress. “When it comes to choosing a place to live, access to daylight and quality views are key features for prospective tenants,” said study author Piers MacNaughton, Sc.D., vice president of health strategy, View Inc. “This study shows that daylight and views are not just desirable amenities but also have fundamental impacts on our health and even our hormones.” In a previous study, the Urban Green Council looked at the prevalence of window coverings, which block daylight from entering residences when closed. They found that regardless of time of day, direction the window faced or whether a building was commercial or residential, 59% of the window area was covered by blinds or shades. More than 75% of the buildings they surveyed in New York City had more than half of their window area covered. The REVOLV study demonstrates that smart windows are one method of optimizing indoor daylight access in the built environment to improve occupant health without the drawbacks of visual and thermal discomfort, energy consumption and reliance on occupant behaviors that come with traditional solutions such as blinds. “In technology-driven markets like the Dulles Corridor in Northern Virginia, smart home technology, wellness-focused amenities and health-promoting activities are becoming increasingly higher priorities in making a final decision on where to call home,” said Jessica Murphy-Work, senior regional manager at Greystar. “In addition to improving access to daylight, design choices like incorporating smart windows can have implications on tenant attraction, retention and asset value.” The new REVOLV study reveals new insights about how daylight impacts our sleep, critical knowledge due to the ramifications these biological changes can have on our long-term health. Previous research has demonstrated that daytime light, especially natural daylight, can impact nighttime sleep quality. It has also been shown that electric lighting indoors tends to be dim and constant, which may not be beneficial for the circadian system’s needs. Lack of a robust light-dark pattern can lead to circadian disruption and poor sleep and health. A 2020 study, EVOLV, found that office workers in an office using smart glass to optimize daylight and views slept longer at night than those working in an office with traditional glass and blinds. Participants also scored 42% higher on cognitive assessments when exposed to optimized daylight and views. The benefits to sleep and cognitive performance were immediate, substantial and sustained. To read the original article click here.

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Study Reveals Nighttime Exposure to Blue Light Causes UNEXPECTED Harm to Your Health

AHA Publisher — Fri, 13 Aug 2021 07:00:45 +0000

Stephanie Woods via NaturalHealth365 – The fact that using your digital devices at bedtime can interfere with your sleep due to blue light emitted by light-emitting diodes (LED) screens is something we’ve known for years. As devices become more prevalent and become a part of everyday life for many, there has been an increase in certain health issues that are often caused by device over-usage. At the core of these problems is the LED screen due to the blue light that they emit. Researchers are now discovering that the health ramifications associated with blue light reach far beyond sleep disturbance. Exposure to blue light can disrupt the secretion pattern of specific hormones, upset the body’s thermoregulation, and disturb circadian rhythm. New evidence, however, shows that it decreases fat oxidation levels during sleep. One study found strong evidence that the type of light exposed to may influence certain physiological changes, including unwanted weight gain. Why Is Blue Light Emitted by Screens So Dangerous? Blue light is a light wave that is part of the light spectrum that the human eye can see – the visible light spectrum. It has the highest energy and shortest wavelength, vibrating in the 380 to the 500-nanometer range. It is most often associated with LED-lit screens for computers, smartphones, and digital devices. However, around a third of all visible light is actually blue light. In fact, the sun is the primary source of blue light. The problem with blue light emissions from device screens is that the eyes are directly exposed for lengthy periods and from close proximity. Exposure to sunlight typically does not have these issues. Most people wear sunglasses, shield their eyes, and limit exposure. But, of course, having the source too close to the eyes is not a problem with the sun. Blue light does have its place, providing some health benefits – but originating from natural sources such as the sun is preferable. However, when it comes from a screen that is mere inches from a person’s face, that can be a problem. From eye strain to weight gain and depression, studies link blue light overexposure to MULTIPLE health conditions The eye is not very efficient when it comes to blocking blue light. As blue light enters the eye, it passes through the lens and cornea to the retina. Retinal cells convert the light and send impulses to the brain that turns light waves into images. Essentially, the eye is wide open to receiving blue light, so it can be too much of a good thing when it is exposed via a device screen that is inches away. Health problems related to continued exposure to blue light (especially via LED screens) include: Eyestrain Damaged retinal cells Eye conditions like macular degeneration Myopia and nearsightedness Disrupted sleep patterns Sleep deprivation Inhibited production of melatonin Blurred vision Headaches Weight gain Decreased fat oxidation Depression (nighttime exposure) Changes in skin cells that speed the aging process Decrease in the hormones leptin and cortisol (stress hormone) Increased blood sugar levels (due to disrupted circadian rhythm) Decreased metabolism Scientists are only now beginning to connect the dots regarding the far reach of overexposure to blue light. It has traditionally been believed that it disrupted sleep patterns, which is true, but researchers now understand that it is only the tip of the iceberg. So how can you protect against the harmful effects of blue light exposure? Here are 5 simple solutions for you to try Anyone who uses a computer, tablet, smartphone, or other digital devices on a regular basis can benefit from decreasing their exposure to blue light. Fortunately, there are several things you can do to give your eyes a break and your health a boost. Shut down devices well before bedtime – Exposure to blue light before going to bed tricks the brain into believing it is daylight. In response, it does not produce melatonin which induces sleep. This can lead to insomnia and disrupted sleep patterns. By shutting down all devices at least two hours before bed, the body has a chance to make adjustments and transition from daytime to bedtime by producing the melatonin the body needs. Blue light glasses – More studies are shedding light on the effectiveness of blue light glasses. In response, more doctors and researchers agree that the glasses do indeed help people reduce their exposure to blue light and get better sleep. 20-20-20 Rule – Every 20 minutes, look at something at least 20 feet away for at least 20 seconds. Place interesting objects and pictures at different points around the room, 20 feet or more from you, to have something interesting to look at, and you will be more motivated to look longer. Blue light reduction apps – An app like f.lux adjusts a computer’s display color to reduce blue light. It can be set to change automatically at dusk or at a specific time, such as a few hours before bed. Control exposure to screens – Most people have some control over the lighting and glare on their screens. Move the device further away, so it isn’t as close, bring the device to a more posture-friendly height and level, and adjust the light in the room to reduce glare. Blue light filters for devices – Blue light filters for computer screens, tablets, smartphones, and other devices. These filters act as a barrier between the screen and the eye, so the exposure is greatly reduced. Opt for OLED lit screens – Organic light-emitting diodes (OLEDs) are a kinder, gentler light source that quietly overtakes LED-lit screens. More televisions, computers, phones, and other devices are beginning to use OLED because it does not produce as much blue light as LED screens. In fact, OLED exposure actually shows better physiological function, including higher metabolism and higher production of melatonin when compared to LED exposure. We all love our devices, but there can come the point where we no longer have our devices, but they have us. Your device is not more important than your health. You can replace a screen or smartphone. You can buy a new computer. Your body and mind are much more precious — and irreplaceable. There are so many options out there to make your screen time safer and more enjoyable. Take some time to find the right one for you. Sources for this article include: Nature.com UCDavis.edu Stanford.edu NIH.gov AAO.org JustGetFlux.com To read the original article click here.

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Can Melatonin Help Prevent Severe COVID-19?

AHA Publisher — Thu, 10 Dec 2020 08:00:12 +0000

Angela Betsaida B. Laguipo, BSN via News-Medical Net – The coronavirus disease (COVID-19) pandemic has rapidly spread worldwide, infecting over 64.50 million people across 191 territories. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the infection has already claimed more than 1.49 million lives. The coronavirus pandemic is by far the worst global health crisis in the past century. The magnitude of the disease’s spread stemmed from the number of people who traveled early in 2020 when there were still only a few cases of COVID-19. Of all the victims of the virus, older adults and those with underlying health issues are the most vulnerable and are more likely to develop severe symptoms. Currently, there is no approved drug that is safe and effective in mitigating severe or critical COVID-19. Many health experts have recommended repurposing old antivirals – like remdesivir and dexamethasone – to reduce the risk of developing severe illness. More recently, some have recommended melatonin as a potential therapeutic that can inhibit SARS-CoV-2 infection. A team of researchers at the University of Toronto in Canada has found that melatonin can be an adjuvant to augment the efficacy of anti-SARS-CoV-2 vaccines. They believe that the drug is a potential “silver bullet” to combat the COVID-19 pandemic. Melatonin and COVID-19 In the study, which was published in the journal Diseases, the scientists discussed the potential benefit of melatonin for COVID-19 patients. They discussed evidence implying that melatonin prevents SARS-CoV-2 infection, has anti-inflammatory, immunoregulatory, and antioxidant properties, counteracts chronodisruption, and combats many comorbidities, including metabolic syndrome, diabetes, and cardiovascular diseases. The SARS-CoV-2 pathogen enters the cells via the angiotensin-converting enzyme 2 (ACE2) receptor in the lungs and other organs in the body. The virus’s spike glycoprotein on its surface docks onto the ACE2 dimer to infiltrate the host cell and commence viral replication. Previous studies suggest that melatonin may be an effective antiviral agent amid the coronavirus pandemic. In one study, the researchers found that a drug combination of melatonin and mercaptopurine effectively hits the HCoV-host subnetwork and was recommended as a possible drug combination for SARS-CoV-2 infection. Another possible way melatonin may regulate viral infection is related to its effective binding and inhibition of calmodulin, which regulates the surface expression and retention of ACE2 in the plasma membrane. Anti-Inflammatory and Antioxidant Properties Apart from preventing infection with SARS-CoV-2, melatonin has also been noted for its anti-inflammatory, immunoregulatory, and antioxidant properties. Melatonin applies anti-inflammatory effects through sirtuin-1, which inhibits the polarization of macrophages towards the proinflammatory type. Further, the drug decreases the proinflammatory cytokines, which have been tied to severe COVID-19 disease. The drug has antioxidant properties as it acts as a free radical searcher; it is metabolized to compounds with high antioxidant activity, and triggers the synthesis of antioxidant enzymes. Chronobiotic and Cytoprotective Agent Apart from reducing inflammation and cytokine levels, melatonin is also a chronobiotic and cytoprotective agent. A chronobiotic agent is a drug that affects the physiological regulation of the body clock, which can correct a desynchronized circadian rhythm. Regulating and maintaining a stable body clock is important to boost energy levels and the immune system. Melatonin is also a cytoprotective agent, which can help combat the common comorbidities that can heighten the risk of severe COVID-19. These include diabetes, metabolic syndrome and ischemic cardiovascular disease. Lastly, melatonin also provides neuroprotection for COVID-19 patients. Some of the common symptoms of COVID-19 patients experience include loss of smell, paralysis, stroke, cranial nerve deficits, delirium, meningitis, seizures, and encephalopathy. “Melatonin as a potential “silver bullet” in the COVID 19 pandemic, as exemplified in the brain. Melatonin has possible antiviral activity by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association,” the researchers explained. In a nutshell, melatonin is a potent drug that can be used in treating COVID-19 patients. It is an antioxidant, anti-inflammatory, and immunomodulatory compound that impairs the complications of COVID-19. Also, melatonin is an effective chronobiotic agent that reverses disruptions in the circadian rhythm. As a neuroprotective agent, it helps prevent the neurological effects of COVID-19, including cognitive decay and brain fog. Older people have lower levels of circulating melatonin in the body, explaining why some may be more likely to suffer from severe symptoms. Viruses can induce an increase in inflammatory cytokines, and since older adults have low levels of melatonin, they will have impaired immunity. “Therefore, the use of the very safe drug melatonin in adequate doses can prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over,” the researchers explained. Further, the team noted that melatonin could be used as an adjuvant for future vaccines since it helps prevents reinfection. To read the original article click here.

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6 Ways to Naturally Eliminate Migraines

AHA Publisher — Wed, 28 Oct 2020 07:00:45 +0000

Dr. Matthew Roe via NaturalHealth365 – Migraine headaches are the second most common type of primary headache after tension headaches. And, just to be clear, a “primary” headache is a headache that is not caused by another disease or condition. Along with debilitating pain, migraines can generate blurred vision, dizziness, nausea, and sensitivity to light and sound. Often without much warning, migraines can happen once a year, monthly, or several times a week. And, unfortunately, migraines can either occur with an aura – which is known as the classic migraine – or without an aura, which is called a common migraine. What can trigger a migraine? The possible migraine triggers not only vary from one individual to another, but encompass a whole range of common substances. This can include hormonal imbalances, synthetic fragrances, processed cereals (or other junk foods) and skipping meals. A simple drop in blood sugar can cause all kinds of health issues including head pain. The list of possible triggers is so long – it often appears impossible to eliminate the so-called causes. In the food category alone the list is extensive and includes ripened and aged cheese, poor-quality chocolate, citrus fruits, conventionally-raised (processed) meat with nitrites such as hot dogs, MSG, caffeinated beverages and alcohol. Food additive such as nitrites, sulfites, and aspartame can be the culprit behind a migraine. In fact, studies show a large percentage of migraine sufferers point to specific foods as the trigger. Non-food triggers include changes in the atmosphere such as drops in barometric pressure, high temperatures and bright, fluorescent lights. Many women get migraines monthly due to hormone fluctuations or the use of birth control pills. However, one of the most common migraine triggers seems to be chronic stress. It is a known fact that anxiety, worry, depression and moods changes can all release specific brain chemicals – which can trigger a migraine. Sadly, Western medicine promotes the use of analgesic migraine medications – including both prescription pain relievers and over-the-counter drugs – which produce “rebound” headaches. The point here is simple: no pill will ever solve the (underlying) problem associated with chronic head pain. A better way to achieve freedom from chronic headache pain Even with many drugs, lifestyle techniques, and surgical options available to treat and prevent the onset of a migraine – finding the right combination of therapies to manage migraines can be difficult. Fortunately, there is growing scientific evidence to suggest that natural means are just as effective as prescription medication and, many times, even more effective. #1 – Biofeedback: Most studies on biofeedback show that it can reduce the frequency and duration of headaches. The effects of biofeedback appear to be comparable to many drugs used for chronic headaches, and can be recommended as early treatment for recurrent migraines. #2 – Acupuncture: Albrecht Molsberger, MD, a medical acupuncture said it is at least as effective as blood pressure medication such as, beta-blockers – most often used for migraine prevention. The American Headache Society has recommended acupuncture for migraines. Acupuncture helps the natural energy flow and is thought to correct an energy disruption which leads to a migraine. #3 – Melatonin: Two-thirds of study participants who took melatonin before going to bed every night for 3 months said the number of migraines they experienced dropped by 50%. #4 – Magnesium: Studies have shown that migraine sufferers have low brain magnesium during migraine attacks and may also suffer from a magnesium deficiency. It is thought magnesium deficiency may play a particularly important role in menstrual migraine. #5 – Diet: It pays to avoid headache-inducing substances, including nitrites in processed meats, sugar, processed foods, chocolate, nuts aged cheese, aspartame and monosodium glutamate (MSG) used in foods as a flavor enhancer. It’s also worth mentioning that dehydration is a major cause of headaches. Even though food may not be the underlying cause of a migraine, a poor diet does contribute to the problem by depleting vitamins and minerals – which are meant to help ward off an attack. #6 – Upper cervical chiropractic treatment: The most recent research is showing that the most plausible cause of migraine headaches resides in the autonomic nervous system. The swelling of the blood vessels in the brain and the drop in neurotransmitters are secondary and mainly occur in response to the changes in the autonomic nervous system. Emotional stress is a well known trigger for migraine. Japanese researchers have found that people living in fast-paced business centers in Tokyo tend to have an imbalance in the autonomic nervous system – specifically, an inhibition of the parasympathetic system that is active during relaxation, and an excitation of the sympathetic nervous system, which governs our response to stress. The major finding of a recent study is that migraine is a disorder of chronic sympathetic dysfunction. Many times the top vertebra in the spine known as the atlas can be jarred from its normal position. The atlas is the only vertebra in the entire spine not connected by discs to the vertebra below it and the atlas is the only vertebra that can induce increased pressure on the spinal cord. Right above the atlas sits the brain stem and a misalignment in the upper cervical spine can affect the functionality of the brain stem, which in turn can cause migraine headaches. The goal of the upper cervical treatment is to correct the misalignment consequently addressing the real cause of the migraine instead of just the symptoms. There are many case studies, which show a positive response using upper cervical chiropractic adjustments to treat migraines. About the author: Dr. Matthew Roe is a practicing upper cervical chiropractor and has a Bachelor of Science Degree in Exercise Science. He has a Doctor of Chiropractic degree graduating Cum Laude from Life University College of Chiropractic. Having studied with the best Upper Cervical specific doctors in the world he understands true healing. His practice focus is to help people fine true health naturally. For more information about Dr. Roe – visit: WinterGardenChiropractors.com Sources for this article include: Healthline.com, Medscape.com, Holistichelp.net, Health.com To read the original article click here. For more articles from NaturalHealth365 click here.

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Defeat Depression With These 10 Natural Interventions

AHA Publisher — Mon, 31 Aug 2020 07:00:15 +0000

Lori Alton via NaturalHealth365 – If you struggle with depression, you have plenty of company. According to the Anxiety and Depression Association of America, over 40 million Americans currently suffer from the condition. In fact, depression is so widespread that experts predict that about half of the population will experience at least one episode of depression in their lives. Clearly, there is a need for effective natural interventions for depression. Fortunately, recent research supports the ability of simple lifestyle changes and natural nutrients and supplements to complement conventional antidepressant therapy. For ten of the most effective natural techniques against depression, keep reading. Health ALERT: Discover the Complex Web of Interwoven Factors That Contribute to Depression No doubt, the causes of depression are complex. Experts say that genetics, hormonal imbalances, oxidative stress, chronic inflammation, poor nutrition, alcohol abuse and drug addiction can all be factors. In addition, underlying health conditions – such as diabetes, heart disease and cancer – can exacerbate depression. Depression is characterized by persistent feelings of sadness or emptiness, coupled with a loss of interest in everyday activities. Other symptoms can include anxiety, fatigue, difficulty concentrating, memory problems, changes in weight and trouble sleeping. Although doctors may prescribe pharmaceutical drugs (such as selective serotonin reuptake inhibitors like Zoloft and Prozac) to treat depression, SSRIs can feature toxic side effects and lead to suicidal thoughts. Finally, SSRIs are not effective for everybody. In fact, some experts estimate their success rate at a mediocre 50 percent or less! So, with no further ado, let’s get to the 10 best natural interventions for depression. Anti-Inflammatory Omega-3 Fatty Acids Are Effective Natural Interventions for Depression Omega-3 fatty acids have shown the ability to help reduce chronic inflammation, which contributes to with depression. In one study involving children with depression and published in American Journal of Psychiatry, impressed researchers concluded that supplementation with omega-3 fatty acids caused “highly significant” effects on symptom scores. Keep in mind, scientific language of trained researchers, deeming results “highly significant” amounts to an enthusiastic endorsement! And, a recent scientific review of studies concluded that omega-3’s were effective in treating depressed adults as well. While you can boost dietary intake with flax seeds, nuts, and cold-water fatty fish like salmon and sardines, supplementation may be needed for maximum mood-lifting benefit. Natural health experts typically suggest taking about 1,000 mg a day of omega-3-rich fish oil. Boost Mood with B-Complex Vitamins Essential B vitamins are important cofactors for the production of “chemical messengers” known as neurotransmitters. One of these, serotonin, is essential for stable mood and restful sleep. Deficiencies in these vitamins can disrupt the process, leading to mood disorders and impaired cognition. Specifically, low levels of folate (also known as vitamin B9) are closely linked with depression – so it’s no surprise that supplementation with folic acid, a synthetic form of folate, can promote the therapeutic effect of antidepressants. In a study published in Journal of Affective Disorders, patients receiving a combination of 500 micrograms of folic acid a day and the antidepressant Prozac experienced more relief of depressive symptoms – when compared with those who received the medication alone. Other B vitamins play an important role in psychological health as well. Deficiencies in Vitamin B12 can cause serious psychiatric disorders – which can be reversed with supplementation. And, supplementation with vitamin B6 – essential for serotonin synthesis – has been shown to markedly improve mood. You Can “Mellow Out” with Melatonin Melatonin, also known as the “sleep hormone,” is essential for regulating circadian rhythms. It also seems to play a role in lifting mood. Research has highlighted melatonin as one of the most effective natural interventions for depression. A controlled study of perimenopausal and postmenopausal women showed that taking melatonin nightly for six months led to significant improvement in depressive symptoms. In a separate study published in Clinical Psychopharmacology, 33 participants suffering from both major depression and sleep disorders took melatonin for four weeks – and also experienced improvement. Studies have used melatonin amounts between 3 and 6 mg, taken at bedtime. “Charge Up” Your Coenzyme Q10 Levels to Help Protect Against Depression Deficiencies in CoQ10, a vitamin-like nutrient produced in the body, have been linked with depression. A powerful antioxidant, CoQ10 helps to neutralize the harmful reactive oxygen species that cause oxidative stress. As oxidative stress is believed to trigger depression and neurodegenerative conditions, having sufficient levels of CoQ10 may help protect against them. CoQ10 is found in grass-fed beef, poultry, sardines and nuts. A natural health practitioner might recommend between 100 to 200 mg. per day. Vitamin D: The “Sunshine Vitamin” May Brighten Up Your Mood Vitamin D, which is produced in the skin in response to sunlight, plays an important role in mood. Unfortunately, shortfalls of this anti-inflammatory, antioxidant nutrient are quite common in the United States. And, deficiencies are linked with seasonal depression. In a Norwegian study published in Journal of Internal Medicine, high-amount supplementation with vitamin D3 was shown to improve symptoms of depression in obese and overweight participants. While individual needs vary according to age, weight, state of health and even local climate conditions, integrative doctors may suggest 1,000 to 8,000 IU of vitamin D3 per day, along with zinc, boron and magnesium. Guard Against Depression with DHEA DHEA, a hormone with the tongue-twisting name of dehydroepiandrosterone, regulates serotonin levels in the brain. In one controlled double-blind study published in Archives of General Psychiatry, researchers evaluated the effects of DHEA as a stand-alone therapy for both mild and severe depression. Participants were divided into three groups, with one group receiving dosages of 90 mg a day, a second group being given 450 mg, and the third given a placebo. The results were impressive. After three weeks, the team found that both DHEA groups experienced significant improvement in symptoms of depression when compared to the placebo group. Curcumin Helps Pharmaceutical Antidepressants Relieve Depression More Quickly Curcumin, the active ingredient in the medicinal spice turmeric, has been studied extensively for its potent antioxidant, analgesic and anti-inflammatory effects –and for its ability to lift mood and enhance cognitive function. Scientific research suggests that curcumin can protect levels of BDNF – a protein important for healthy brain function – while modulating serotonin signaling. In one clinical study involving individuals with new-onset depression, a 500-mg daily amount of curcumin was combined with an antidepressant. The researchers found that combining curcumin with medication brought about improvement more quickly than the medication alone. Remarkable Findings: Study Shows that Saffron Extracts Equal the Effects of Prozac Saffron, a common flavoring and coloring ingredient in Indian cuisine, contains a pair of powerful antioxidant carotenoids, crocin and safranal. Research has shown that saffron extracts work against depression in various ways, from fighting inflammation to neutralizing oxidative stress and protecting serotonin in the brain synapses. In one intriguing study, 30 mg per day of saffron extract a day was as effective for mild-to-moderate depression as Prozac (fluoxetine). Drug-Free Cognitive Behavioral Therapy Grows in Popularity Cognitive behavioral therapy centers on helping depressed individuals recognize negative thinking and replace it with more positive thoughts. Extensive clinical studies have shown cognitive behavioral therapy to be effective – both when used as a standalone treatment or in conjunction with other conventional treatments. A 2010 clinical trial showed that the technique effectively relieved depression in patients with COPD. In another study, CBT was found to be superior to drug therapy in several aspects. For a Natural Mood Lift: Get Physical Research suggests that exercise – particularly weight training and aerobic activities such as dancing, swimming, running and walking – can be highly beneficial when used in conjunction with medication to treat depression. In one recent study involving adults with major depression, physical exercise went head-to-head with Zoloft, one of the primary “go-to” SSRIs in mainstream medicine. The researchers concluded: four months of exercise worked about as well to relieve depression as the antidepressant. In addition, evidence supports the ability of exercise to prevent recurrent of depressive episodes. The truth is: the appropriate techniques, nutrients and supplements can go a long way towards brightening mood and easing depression and anxiety. As always, however, consult your trusted integrative doctor before trying any of these natural interventions for depression. Sources for this article include: LifeExtension.com, ADAA.org, NIH.gov, Gwern.net, NIH.gov, NIH.gov To read the original article click here. For more articles by NaturalHealth365 click here.

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