anticancer Archives - Amazing Health Advances

Forest Bathing to Boost Anticancer Immunity

The AHA! Team — Wed, 30 Jul 2025 06:38:14 +0000

Michael Greger M.D. FACLM via Nutrition Facts – Spending time in a forest, or even anticipating it, significantly lowers levels of cortisol (a stress hormone), more so than being in an urban area. Natural killer cells are one of the ways our body fights off cancer, and visiting a forest can induce a significant increase in both their numbers and their activity. I’ve previously shown how exposure to nature can have self-reported psychological benefits, but there was a dearth of data on changes in objective measurements, so I was excited to see this paper on the effects of forest bathing, “a traditional practice characterized by visiting a forest and breathing its air,” on levels of the stress hormone cortisol in the participants’ saliva. The level of cortisol in our saliva is considered an indicator of our stress level, and study participants’ salivary cortisol levels were significantly lower after walking in a forest or even just hanging out in one (“forest watching”), compared to walking or just being in a city, as you can see at 0:49 in my video Boosting Anticancer Immunity with Forest Bathing. However, the same effect was found before they went to the forest, too. Indeed, “forest bathing, in particular forest watching, was associated with significantly lower cortisol levels both before and after this practice if compared with visiting an urban area.” Therefore, it appears that just the thought of spending time in a forest relieves stress. So, “when comparing the effects of forest bathing versus urban visiting, the anticipated placebo effect…may play a more important role in influencing cortisol [stress] levels than the actual experience” of being in the forest. I was ready to dismiss this as just another nebulous psychological effect until I read this: “Studies on the effects of ‘Shinrin-yoku’ [forest bathing] on the immune function showed that visiting a forest can induce a significant increase in the number and activity of natural killer (NK) cells,” one of the ways our body fights off cancer. That got my attention. It all started with this study: Twelve men were taken on a long weekend trip to walk in the forest, and nearly all of them (11 out of 12) showed higher natural killer cell activity afterward. It wasn’t just a little increase either; they had about a 50 percent increase in NK cell activity after the trip compared to before they went to the forest, as you can see at 2:00 in my video. Now, exercise alone can affect immune function, but “there were no significant differences in walking steps before and during the trip.” The study participants were just walking in a forest instead. However, they were taken on a trip somewhere, which introduced other variables, so what about randomizing them to go on a city trip versus a forest trip? If there were some special forest effect, how long would it last? Do you have to walk in the forest every day? Before jumping into all that, let’s first see if it works in women, too. This study had the same kind of set-up, and the same kind of results: a significant boost in natural killer cell activity from walking in the woods. What’s more, this time, the participants were retested a week later, and their natural killer cell activity was still up. When they were retested a month after the trip their levels were back to baseline, as you can see at 2:45 in my video. So, walking in the woods once a week should do it, but the study involved a multi-day trip. Who can go to the forest all weekend, every weekend? How about just a day trip? The title gives it all away: “A Day Trip to a Forest Park Increases Human Natural Killer Activity and the Expression of Anti-Cancer Proteins in Male Subjects.” The same results and the same big jump measured the day after the trip compared to before and with the same staying power, as you can see at 3:08 in my video. And, natural killer cell activity was still boosted a week later. “This suggests that if people visit a suburban forest park once a week on a day trip, they may be able to maintain increased NK activity” and a boost in anticancer immune function. I’m still not convinced, though. How can you attribute the benefit to the forest itself, when all you have are before and after data? To make the case that nature had anything to do with it, you’d need a control group of study participants who took the same kind of trip but went somewhere else instead. And here we go. Again, the study title says it all: “Visiting a Forest, but Not a City, Increases Human Natural Killer Activity and Expression of Anti-Cancer Proteins.” By the end of the forest trip, the participants experienced a boost of 80 percent in NK activity after forest bathing, compared to only a 10 percent bump for the city walkers, as shown below and at 3:58 in my video. Both trips were matched for physical activity, alcohol, and sleep, too— other factors and behaviors that can affect immune function. So, we’ve got confirmation of boosted immunity, but only on the forest trip, “indicating that forest bathing does indeed enhance human NK activity.” Moreover, the researchers found that “the increased NK activity and numbers of NK cells induced by a forest bathing trip lasted more than 7 days, even 30 days, after the trip.” As you can see below and at 4:26 in my video, NK activity was still up a week later and even a bit up a month later. “This suggests that if people visit a forest once a month, they may be able to maintain increased NK activity. This may be important in health promotion and preventive medicine.” Now that we know that forest bathing induces a real effect, the next question is, Why? What is it about forests that give us the boost? (You can imagine Big Pharma wondering if it can be made into a pill.) We’ll find out next. The video I mentioned at the start is Are There Health Benefits of Spending Time in Nature?. Stay tuned for the follow-up post: Why Does Forest Bathing Boost Natural Killer Cell Function?. For other ways to improve immune function, check out related posts below. Key Takeaways Spending time in a forest, or even anticipating it, significantly lowers levels of cortisol (a stress hormone), more so than being in an urban area. Forest exposure is associated with a notable increase (around 50 percent) in NK cell activity, which plays a role in fighting off cancer. After a single forest trip, NK cell activity remains elevated for up to a week, and, in some cases, positive effects last up to a month. A day trip to the forest can be enough to maintain elevated NK cell activity if done weekly or monthly. Studies comparing forest versus city exposure confirm that forest environments uniquely boost immune function, independent of other factors like exercise and sleep. To read the original article click here.

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How Milk Thistle Extract can Support Liver Health and Healing

The AHA! Team — Fri, 27 Jun 2025 05:29:03 +0000

Lori Alton via NaturalHealth365 – With its spiky purple flowers and dull green leaves, milk thistle may appear to be nothing more than an ordinary weed growing wild in vacant lots and fields. Yet, this unimpressive-looking plant is truly a shining star when it comes to avoiding disease and promoting healing. Milk thistle, scientifically known as Silybum marianum, is prized by natural healers for its ability to eliminate liver ailments, including nonalcoholic fatty liver disease, which is currently reaching epidemic proportions in the United States. But supporting liver health is not milk thistle’s only gift. Discover how this extraordinary herb can help you. Milk thistle protects against toxic effects from cancer treatment, arrests tumors The active ingredient in milk thistle, an antioxidant flavonoid called silymarin, reduces the inflammation and oxidative damage that can trigger cancer. It also helps preserve glutathione, the body’s premier inflammation-fighting antioxidant. Scientists have known for some time that milk thistle may act against cancer. In a review conducted at the University of Minnesota, researchers cited “strong evidence” for silymarin’s liver-protective and anti-cancer effects. Significantly, they credited silymarin with combating cancer by inhibiting the binding of toxins to cell membrane receptors. In a new study published in The International Journal of Oncology, researchers found that silibinin, a form of silymarin, suppressed chemoresistance, the condition in which cancer fails to respond to the effects of drugs. The team noted that silibinin also prevented further malignancy, protected against potentially cancer-causing DNA mutations, and inhibited tumor growth. In other research, researchers found that silymarin also helps prevent liver damage from chemotherapy and protects the skin and mucosal lining from damage from radiation therapy. Milk thistle is a potent antifungal agent Overgrowth of Candida albicans, a common fungus, can cause symptoms of fatigue, “brain fog,” digestive problems, and skin rashes. And, a growing problem of drug resistance in pharmaceutical antifungals – which parallels the current epidemic of antibiotic resistance – can make Candida difficult to treat. Researchers have found that silymarin can penetrate the cell membrane of the Candida microbe, stopping the pathogen’s growth and spread and helping to clear the overgrowth. Silymarin is also effective in blocking and inhibiting biofilms, layered communities of pathogenic microorganisms that are stubbornly resistant to treatment. Silymarin helps to regulate glucose levels For the past thousand years, herbalists and Ayurvedic healers have advised milk thistle to support healthy blood sugar levels, and modern research confirms the value of this ancient remedy. In one recent study, a 90-day course of a combination of milk thistle, boswellia, and nettles slashed hemoglobin A1c levels – a measure of blood sugar over several months – by a substantial 19 percent. The herbal combination also drastically reduced blood sugar levels – from an average of 150 to 180 mg/dL to an average of 124 mg/dL – and triglyceride levels. In addition, a recently published cell study shows that silymarin protects the retina from diabetic damage, a common consequence of the disease. The Big NEWS: Milk thistle supports a healthy liver Milk thistle’s main claim to fame is its ability to improve liver enzymes, rebuild liver cells, and alleviate liver ailments. In addition to easing hepatitis and cirrhosis, milk thistle shows promise in dealing with nonalcoholic fatty liver disease and halting the progression to steatohepatitis, a more serious form of the condition. Research has supported milk thistle’s beneficial effects on liver disease, with one study showing that hepatitis patients treated with silymarin returned to work sooner and experienced less depression and anxiety than those in the control group. In addition, milk thistle helps detoxify the liver and protect against injury from heavy metals and drugs. In a review published in Phytotherapy Research, the team credited silymarin with reducing liver injury caused by a variety of toxins, drugs, and heavy metals, including acetaminophen, carbon tetrachloride, radiation, alcohol, iron overload, and Amanita phalloides, a type of poisonous mushroom. As an added bonus: milk thistle’s protective effects also extend to the stomach. The herb has been shown to suppress gastric inflammation and protect against ulcers caused by non-steroidal anti-inflammatory drugs. Surprising fact: Milk thistle has antidepressant properties Yet another surprising benefit of milk thistle is its ability to function as a natural mood elevator. Animal studies support its ability to reduce anxiety and depression caused by traumatic brain injury, which it appears to do by reducing the activity of microglial cells caused by a disturbance in the neural circuits between the limbic system and the cortex of the brain. In one study, silymarin performed as well as the pharmaceutical drugs fluoxetine (Prozac) and diazepam (Valium) in supporting mood. Researchers noted that silymarin reversed stress-induced changes to the hippocampus and cerebral cortex while boosting levels of the neurotransmitters serotonin and dopamine. Because of silymarin’s ability to reduce inflammation and neurodegeneration, researchers are even exploring its potential to prevent and treat Alzheimer’s disease. How should I take milk thistle? Experts recommend temporary short-term amounts of 150 mg, taken one to three times a day, for detoxification. A holistic healthcare provider may recommend 50 to 150 mg a day for liver support, maintenance, and longer-term use. Use a formulation standardized to 70 to 80 percent silymarin for best results. As always, consult your holistic doctor to determine if milk thistle is right for you and to determine the proper amount. Although it is generally considered safe and well tolerated, high amounts can cause mild digestive upset. Note: if you are allergic to any member of the aster family – such as daisies, ragweed, marigolds, or chrysanthemums – don’t take milk thistle. Milk thistle has long been revered for its ability to cleanse and detoxify the liver. However, recent research confirming its ability to ward off other diseases demonstrates that this herb is valuable and versatile. Editor’s note: To support healthy liver function, I highly recommend LuvByNature LiverLuv – which is gluten free, non-GMO and delicious. Sources for this article include: NIH.gov NIH.gov To read the original article click here.

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New Research Warns Tattoos May Increase Cancer Risk as Ink Migrates to Lymph Nodes

The AHA! Team — Fri, 27 Jun 2025 05:03:06 +0000

Cassie B. via Natural News – New research links tattoos to a higher risk of cancer, as ink migrates to lymph nodes, potentially causing chronic inflammation and abnormal cell growth. Swedish and Danish studies found tattooed individuals had increased lymphoma and skin cancer risks, with early tattoos and large designs showing the strongest associations. Black and colored inks contain harmful chemicals, including carcinogens and toxic metals, with red ink posing additional risks when exposed to sunlight or laser removal. Laser tattoo removal may worsen the danger by breaking down ink into more toxic byproducts, tripling lymphoma risk in some cases. Experts urge vigilance for skin changes in tattooed areas and call for stricter ink regulations while emphasizing healthy lifestyle choices to mitigate risks. Self-expression through body art In an era where self-expression through body art has become mainstream, shocking new research suggests that tattoos may carry a hidden danger: a significantly increased risk of cancer. Recent studies from Sweden and Denmark reveal that tattoo ink doesn’t just stay in the skin; it migrates through the body, accumulating in lymph nodes and potentially triggering chronic inflammation that could lead to lymphoma and skin cancer. With millions of inked individuals worldwide, these findings raise urgent questions about the long-term safety of what many consider harmless self-expression. The science behind the risk When tattoo needles deposit ink into the dermis—the skin’s deeper layer—the body’s immune system perceives the foreign particles as a threat. According to Christel Nielsen, lead author of a 2024 Swedish study, “a significant portion of the injected ink is transported away from the skin by the immune system.” This process sends pigment particles to lymph nodes, where they may linger for years, disrupting immune function and potentially fueling abnormal cell growth. The Swedish study found that 21% of malignant lymphoma patients had tattoos, compared to just 17% of controls. Most alarmingly, those who got their first tattoo within two years of diagnosis faced an 81% higher lymphoma risk. Meanwhile, Danish researchers analyzing twin data discovered that individuals with large tattoos (bigger than palm-sized) had nearly three times the risk of lymphoma and 2.37 times the risk of skin cancer. Size and color matter While the Swedish study found no clear link between tattoo size and cancer risk, Danish researchers observed a dose-response relationship. “The bigger the tattoo and the longer it has been there, the more ink accumulates in the lymph nodes,” explained Signe Bedsted Clemmensen, assistant professor at the University of Southern Denmark. Black ink, often containing carcinogenic polycyclic aromatic hydrocarbons, was particularly concerning, with black or grey tattoos associated with a 23-32% higher lymphoma risk. Colored inks pose their own dangers, as they may contain toxic metals like arsenic, lead, and chromium. Red ink, notorious for allergic reactions, can release harmful compounds when exposed to sunlight or laser removal. “Current regulations on tattoo ink ingredients are not sufficient,” warned dermatologist Dr. Trisha Khanna. Laser removal may worsen the problem For those considering tattoo removal, the risks might not end there. The Swedish study found that laser-treated tattoos were associated with triple the lymphoma risk. Laser breakdown of ink chemicals, particularly azo compounds, can release even more toxic byproducts into the body. How to protect yourself For already-tattooed individuals, experts emphasize vigilance. Persistent redness, itching, or unusual skin changes within inked areas should prompt immediate dermatological evaluation. “The best thing we can do for our health, tattoos or not, is to maintain a healthy lifestyle,” Nielsen advised, endorsing plant-rich diets linked to lower cancer rates. As tattoo culture thrives, these studies underscore the need for greater transparency about ink ingredients and long-term health impacts. While personal choice remains paramount, informed consent requires acknowledging emerging risks—something the body art industry and regulators can no longer ignore. For now, people considering getting a tattoo need to know that permanent ink may come with permanent consequences. As researchers continue investigating, consumers deserve full disclosure about what’s really under their skin. Sources for this article include: TheEpochTimes.com StudyFinds.org SciTechDaily.com New.Sky.com To read the original article, click here

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Black Cumin Seed Oil: Powerful Ally Against Breast Cancer & Chronic Inflammation

The AHA! Team — Wed, 07 May 2025 05:28:18 +0000

Lance D Johnson via Natural News – Long before Big Pharma dominated healthcare, ancient Egyptian, Greek, and Ayurvedic physicians prescribed black cumin seeds for ailments ranging from digestive disorders to infections. • Black cumin seed oil contains thymoquinone, a potent bioactive compound with anticancer, anti-inflammatory, and antioxidant properties. • Research shows thymoquinone induces apoptosis (programmed cell death) in breast cancer cells while protecting healthy cells. • Combining black cumin seed oil with conventional chemotherapy may enhance treatment efficacy and reduce drug resistance. • Historical use of Nigella sativa dates back thousands of years, but modern science is now validating its medicinal power. • Systemic inflammation drives chronic disease, and black cumin seed oil helps restore immune balance naturally. The science behind black cumin’s healing power For centuries, traditional healers have revered black cumin seed (Nigella sativa) as a cure-all, dubbing it “the remedy for everything but death.” Today, cutting-edge research confirms its extraordinary potential—particularly in combating breast cancer and taming the destructive inflammation underlying chronic disease. Unlike toxic chemotherapy drugs that ravage the body, black cumin seed oil offers a natural, scientifically backed alternative that targets cancer cells while fortifying overall health. Black cumin seeds are a treasure trove of bioactive compounds, with thymoquinone standing out as the most potent. Constituting 30–48% of the seed’s essential oil, thymoquinone has been shown in numerous studies to: • Trigger apoptosis in breast cancer cells (MCF-7, MDA-MB-231, T-47D) by up-regulating tumor suppressor genes like p53 and Bax while suppressing survival signals like Bcl-2. • Inhibit metastasis by blocking CXCR4, a protein that aids cancer spread, and reducing the activity of TWIST1, a gene linked to tumor progression. • Enhance chemotherapy by reversing drug resistance in doxorubicin- and tamoxifen-resistant cancer cells. A historical remedy validated by modern medicine Long before Big Pharma dominated healthcare, ancient Egyptian, Greek, and Ayurvedic physicians prescribed black cumin seeds for ailments ranging from digestive disorders to infections. The Prophet Muhammad reportedly called it “a cure for every disease except death.” Today, science is catching up: • A 2020 study found that Nigella sativa reduced tumor volume in mice by 67% and blocked liver metastasis. • When combined with paclitaxel (a common chemo drug), thymoquinone boosted apoptosis rates in triple-negative breast cancer cells. • Human trials show black cumin gel reduces radiation dermatitis in breast cancer patients, proving its protective effects. Yet, despite these breakthroughs, mainstream medicine continues to ignore natural solutions in favor of expensive, patentable drugs. Why inflammation is the silent killer — and how black cumin stops it Chronic inflammation is the root of nearly all modern diseases—cancer, heart disease, diabetes, and autoimmune disorders. As we age, the immune system loses its ability to regulate inflammation, leading to a dangerous imbalance. Black cumin seed oil restores equilibrium by: • Suppressing pro-inflammatory cytokines like IL-6 and TNF-?. • Boosting antioxidant defenses to neutralize free radicals. • Enhancing immune surveillance against cancerous cells. Chronic inflammation is the silent engine driving many degenerative diseases, from cancer to heart failure. While acute inflammation helps the body heal, unchecked systemic inflammation ravages tissues, accelerates aging, and primes the body for illness. Black cumin seed oil, rich in the bioactive compound thymoquinone, acts as a natural regulator, suppressing destructive inflammation while enhancing the immune system’s ability to fight infections and malignancies. Landmark study A landmark study published in Phytotherapy Research found that rheumatoid arthritis patients taking black cumin seed oil experienced dramatic relief—42.5% reported reduced joint swelling and stiffness. Another study in Experimental Biology and Medicine revealed thymoquinone’s ability to slow osteoarthritis progression by blocking enzymes that destroy joint tissue. Even more striking, research in the Egyptian Journal of Immunology showed the oil matched the anti-inflammatory effects of dexamethasone, a powerful steroid, without the harmful side effects. A natural cancer fighter hiding in plain sight Conventional oncology relies on toxic chemotherapy, but black cumin seed oil offers a gentler, yet equally aggressive, alternative. Studies demonstrate its ability to mobilize the immune system’s front line defenses: • Macrophages—cells that engulf and destroy cancerous invaders—become more active. • CD-8 T-cells, the body’s assassins of malignant cells, survive longer and attack more efficiently. • Natural killer cell function increases by 30%, while helper T-cells surge by 55%, orchestrating a stronger immune response. Beyond cancer, black cumin seed oil shows promise in cardiovascular care. By lowering LDL cholesterol and raising HDL, it may prevent artery-clogging plaque. It also appears to protect against ischemia-reperfusion injury—the tissue damage following heart attacks or strokes—offering hope for recovery where conventional medicine falls short. Allergy and asthma sufferers For allergy and asthma sufferers, the oil’s immune-modulating effects bring relief without the drowsiness or dependency of antihistamines. Patients report fewer nasal symptoms and easier breathing, thanks to its ability to calm hyperactive immune responses. With breast cancer rates climbing and conventional treatments often failing, the question isn’t whether natural therapies like black cumin seed oil work—it’s why they aren’t being embraced. If a drug demonstrated thymoquinone’s safety and efficacy, it would be fast-tracked by the FDA. Instead, patients are left to navigate the murky waters of Big Pharma’s profit-driven system. Sources include: NaturalHealth365.com MDPI.com Pubmed.gov Pubmed.gov To read the original article, click here

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Reviving the Ancient Healing Wisdom of Frankincense (Boswellia)

The AHA! Team — Mon, 30 Dec 2024 06:11:06 +0000

News Editors via Natural News – Frankincense oil may receive most of the fame and glory, but the humble Boswellia tree from which it is derived, can also create another powerful natural medicine. Oil and extracts of Boswellia have been used for thousands of years to treat numerous health conditions. (Article republished from GreenMedInfo.com) While many of us are familiar with the meditative, cleansing, and enchanting aromas of incense, the very word itself contains the powerful natural medicine from which it is derived. Frankincense, meaning “true incense” is a resin that comes from any tree species that belongs to the genus Boswellia. Spreading their branches through the Middle East, Africa, and India, this tree’s roots run deep in ancient usage and text. While all Boswellia species can produce frankincense, Boswellia serrata is the supernal species that is adorned in traditional medicinal systems like Ayurveda and Unani for producing exceptional extracts. Boswellia has a documented history of usage that dates back thousands of years Boswellia has a documented history of usage that dates back thousands of years, but it is quite possible this radical resin shared an evolutionary history with humans that greatly precludes our current estimates and archived paleoanthropological data. Just as fashion follows a circular cycle, with skinny jeans now the “newest rage”, so too is it time for a Boswellia revival and resurgence. Currently, there are 30 clinical studies on pubmed.gov, and 28 of those studies used B. serrata (the other 2 studies did not list a specific Boswellia species in their abstract). With a strong modern-day scientific backing, coupled with traditional use, Boswellia is a bright beacon pushing contemporary usage of natural medicines onward and upward. A few of its best-known therapeutic roles today include treating chronic health conditions like asthma, arthritis, cancer, and gastrointestinal issues. It has also been shown to reduce edema (swelling) from brain tumors after patients underwent radiotherapy [Kirste, 2011]. “RESULTS: Compared with baseline and if measured immediately after the end of radiotherapy and BS/placebo treatment, a reduction of cerebral edema of >75% was found in 60% of patients receiving BS and in 26% of patients receiving placebo (P = .023). These findings may be based on an additional antitumor effect. There were no severe adverse events in either group.” [Kirste, 2011] According to the American Academy of Allergy, Asthma, and Immunology in just 8 years (from 2001-2009), the prevalence of asthma jumped from 20 million people to 25 million people. That trend only seems to be increasing and if we extrapolate the data to 2017 there will be 30 million people with asthma, which is almost 10% of the population. Commonly used drugs, like inhaled corticosteroids or oral steroids may be effective, but at what cost? Serious long-term health consequences such as osteoporosis, cataracts, behavioral and mood changes, plus immunosuppression, are just to name a few [Dahl, 2006]. One of the reasons asthma is difficult to treat is because it involves an inflammatory enzyme pathway called the 5-LOX (arachidonate 5-lipoxygenase). Through a series of biochemical reactions, this enzyme produces substances called leukotrienes from the oxidation of lipid substrates, predominantly from arachidonic acid, a polyunsaturated omega-6 fatty acid [Safayhi, 2000]]. When leukotrienes are overly expressed, our immune system is excessively activated, and we enter a state of chronic inflammation, which can manifest as chronic diseases like asthma. One of the beautiful mechanisms by which Boswellia exhibits its benefits is through the prevention of degradation and oxidation to these fatty acids, thus reducing the inflammatory changes in the first place. Boswellia has also proven to be efficacious in other chronic illnesses like inflammatory bowel diseases. Collagenous colitis, which falls under the IBD umbrella, is characterized by chronic diarrhea and is typically treated with a polypharmacy approach. In a placebo-controlled, randomized, double-blind clinical study, B. serrata extract (BSE) was found to be superior in remission rates (63.6%) versus placebo (26.7%) after a six-week treatment [Madisch, 2007]. In a clinical study on chronic colitis, the remission rates were thirty percent higher in the Boswellia group (14 out of 20 patients) versus the anti-inflammatory pharmaceutical drug sulfasalazine (4 out of 10 patients) [Gupta, 2001]. In a clinical study on breast cancer patients undergoing radiotherapy, a Boswellia cream was found to significantly reduce the skin-damaging side effects [Togni, 2015]. Radiotherapy can cause extreme irritation, inflammation, itching, pain, and redness, which can severely alter a patient’s quality of life [Shaitelman, 2015]. Managing these disruptive side effects is typically done with steroids to reduce the immune response, but why risk the consequences when Boswellia is a much safer alternative? While Boswellia extract may be a formidable force, so too are the volatile oils (essential oils) derived from the gummy resin. There are four main species of Boswellia There are four main species of Boswellia from which high-quality frankincense oils are extracted: B. sacra, B. carteri, B. frereana, and B. serrata. While the chemical constituents may vary by species, in general, frankincense oil contains beneficial terpene compounds (limonene, alpha-pinene, beta-pinene, camphene, myrcene) [Woolley, 2012]. Human data may currently be limited on essential oil applications, but animal and cellular studies have elucidated some of the mechanisms responsible for these anti-cancer properties. Frankincense oil has demonstrated cytotoxic, apoptotic, and anti-proliferative properties against various cancer cell lines, including pancreatic cancer (which generally has an overall survival rate in humans of less than five years) [Ni, 2012]. Without applying reductionist principles to the innate wisdom of this plant, Boswellia probably has countless ways by which it improves health and restore balance. Whether you prefer a Boswellia extract or frankincense essential oil – caveat emptor (buyer beware) – as the purity and efficacy of products can vary greatly. Make sure to do your research and work with a company you know and trust. Read more at: GreenMedInfo.com To read the original article, click here

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Natural Plant Compound in Grapes Protects Brain Health, Research Reveals

AHA Publisher — Wed, 24 Aug 2022 07:00:14 +0000

Lori Alton via NaturalHealth365 – Over the past few decades, resveratrol, a polyphenol found in grapes and berries, has generated a lot of “buzz,” with numerous – and well-publicized – studies attesting to the cardiovascular benefits of resveratrol-rich red wine. (Non-drinkers can get resveratrol through foods and supplements). But what else can this natural plant compound do? Claims for the health-promoting benefits of resveratrol have been coming thick and fast, with researchers crediting it with antioxidant, anti-inflammatory, anti-aging, and anticancer effects. In fact, in a study published in the Journal of Neuroinflammation, scientists noted that resveratrol could protect brain cells in an unexpected way – by stimulating the destruction of specific proteins. Let’s explore the scientific research on this intriguing polyphenol. Benefits of Resveratrol May Include Hope for Treating Alzheimer’s Disease Resveratrol is classified as a phytoalexin, a sort of natural antibiotic that protects plants from fungal infection, blight, and ultraviolet radiation. Not unreasonably, scientists hope that resveratrol can extend its same protective benefits to human health. What is known is that resveratrol has powerful anti-inflammatory and antioxidant activity that can cause it to reduce oxidative stress. But, this is not the only gift to health in resveratrol’s “bag of tricks.” According to David Sinclair, AO, PhD, a professor of genetics at Harvard Medical School, resveratrol induces autophagy – a type of cellular defense that targets old, damaged proteins for destruction and recycling. The study referenced by Dr. Sinclair, revealingly titled “Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease,” also shows that resveratrol supplementation reduced cognitive and functional decline in Alzheimer’s patients. Earlier research supports these encouraging findings. In a 2018 study published in Biomedicine, researchers credited resveratrol with neuroprotective effects that could cause it to potentially act against Alzheimer’s, Huntingdon’s, and Parkinson’s diseases. The team reported that resveratrol promotes the clearance of beta-amyloid peptides – meaning that it may help reduce the deposit of harmful beta-amyloid plaques in the brain. It also reduces neuronal apoptosis – in other words, it prevents the death of brain cells. Resveratrol also offers neuroprotection to healthy individuals, so “topping up” on this beneficial compound may help protect cognitive function into old age. Resveratrol Supports Joint Health and Reduces Arthritic Inflammation Scientists have long been intrigued by the potential of resveratrol to ease inflammatory conditions such as rheumatoid arthritis (RA). While preliminary animal studies showed that resveratrol could suppress arthritic inflammation, human trials were clearly needed. In 2018, one took place. In a controlled study published in Clinical Rheumatology, researchers set out to study the therapeutic benefits of resveratrol for patients suffering from varying degrees of RA. One group received one gram of supplemental resveratrol – along with conventional treatment – a day for three months, while another group received only conventional treatment. The investigators found that the resveratrol group experienced less swelling and tenderness in joints and also had lowered levels of pro-inflammatory substances, including the “usual suspects” such as C-reactive protein, matrix metalloproteinase-3, necrosis factor-alpha, and interleukin-6. Boost Dietary Resveratrol With Tasty, Succulent Grapes and Berries You can ramp up your levels of dietary resveratrol by eating healthy amounts of grapes, blueberries, and pomegranates. Of course, opt for organic produce whenever possible. While red grapes are commonly believed to contain more resveratrol than green grapes, the American Institute for Cancer Research reports that the amount of resveratrol in grapes (which, by the way, is found mainly in the skins) is more dependent on growing conditions than on the color or type of grape. (When it comes to wine made from grapes, however, red wine contains more than white wine – as grape skins are used in making it). While red wine is an excellent source of resveratrol, health experts point out that alcohol can increase the risk of several common cancers – so its consumption should be sharply limited. Grapes and berries, on the other hand, are a safe non-alcoholic source of resveratrol. Rich in beneficial dietary fiber, these fruits also contain anthocyanins, natural plant pigments with the ability to promote overall health. By the way, other benefits of resveratrol include protecting the heart and supporting pulmonary function. It has also been shown in cell studies to target cancer cells and act against tumors – without harming healthy cells. How Much Resveratrol Is Right for Me? Multiple clinical trials have used resveratrol up to 5 grams a day with no toxic side effects. However, in some studies, amounts of over 2.5 grams a day caused side effects such as nausea, vomiting, and diarrhea. There has also been a paradoxical finding concerning resveratrol, with some studies suggesting that resveratrol can sometimes behave more like a pro-oxidant than an antioxidant – even causing DNA damage and oxidative stress. Researchers speculated that this phenomenon seems related to the amount consumed – and perhaps to the individual’s age – with more research clearly needed. Before supplementing with resveratrol, consult your integrative doctor to find the safest and most beneficial amount for you. Resveratrol has the potential to reduce inflammation and act against neurodegenerative conditions. The exciting possibilities of this natural plant compound have just begun to be explored. Sources for this article include: link.springer.com FoundMyFitness.com NIH.gov MedicalNewsToday.com NIH.gov AICR.org To read the original article click here.

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Amazing! New Research Links Chili Peppers to a LOWER Risk of Disease

AHA Publisher — Mon, 13 Dec 2021 08:00:15 +0000

Lori Alton via NaturalHealth365 – [A] report from the Journal of Clinical Pharmacy and Therapeutics contained exciting findings about the ability of capsaicin in chili peppers to fight deadly diseases and reduce the odds of premature death. One would think that the reveal of a potentially lifesaving dietary intervention would have made more of a “splash” in the mainstream scientific community … According to the U.S. Centers for Disease Control and Prevention, cancer – second only to heart disease as a cause of death – claimed close to 600,000 lives in 2019 alone, leading researchers to search for new and effective treatments. Recent studies have raised hopes that capsaicin could be among them. Let’s see what the research reveals. Capsaicin in Chili Peppers Linked to Lower Risk of Heart Disease, Cancer, and Death From All Causes The scientific review, which involved 570,000 people in four different countries and three different continents, was conducted by researchers at the renowned Cleveland Clinic. The team found that people who regularly ate capsaicin-rich chili peppers enjoyed a significant 23 percent lower risk of dying from cancer. Dietary intake of chili peppers also lowered the risk of heart disease by an eye-opening 26 percent – and was associated with a 25 percent reduction in risk of dying from any cause. The findings appeared to startle the scientists. “We were surprised to find that … regular consumption of chili pepper was associated with an overall risk reduction of all-cause, cardiovascular disease, and cancer mortality,” reported lead author Bo Xu, M.D., a cardiologist at Cleveland Clinic’s Heart, Vascular and Thoracic Institute. Dr. Xu called for further research to confirm these promising preliminary findings. Researchers already credit chili peppers with anti-inflammatory, antioxidant, anticancer, antiobesity, antimicrobial, and antidiabetic effects. Natural healers have long endorsed these spicy delicacies for their impressive list of benefits, which may include easing migraines, inhibiting fungal infections, fighting viruses, improving cognitive function, reducingjoint pain, improving vision, and alleviating ulcers. While other valuable micronutrients and antioxidants in spicy chili peppers may contribute to their therapeutic benefits, most scientists believe that capsaicin holds the key. Cause for Hope: Capsaicin in Chili Peppers Suppresses the Spread and Survival of Cancer Cells and Tumors In a 2019 review, “Application of capsaicin as a potential new therapeutic drug in human cancers,” published in the Journal of Clinical Pharmacy and Therapeutics, researchers examined the anticancer effects of capsaicin. They reported that it acts against the proliferation of cancer cells, while also limiting angiogenesis, the growth of new blood vessels to nourish tumors. In addition, capsaicin fights chronic inflammation, which has been closely linked to the development of cancer. Studies have also supported capsaicin’s ability to promote the effects of chemotherapy drugs, reduce chemotherapy side effects and enhance the tolerance of patients to cancer treatment – spurring hopes that it could be developed into a new auxiliary treatment for cancer. Because capsaicin has a short half-life in the body, scientists are currently working with capsaicin-laden nanoparticles to deliver the compound to cells more safely and effectively. Lung Cancer Cell Study: Capsaicin Stopped Cancer Cells in Their Tracks Other preliminary research has been encouraging as well. A new test-tube study shows that capsaicin interferes with lung cancer metastasis (the ability of cancer to spread). This is welcome news to oncological researchers – as one of the reasons lung cancer is so difficult to treat is that it moves to secondary locations such as the brain, liver, and bones. When scientists tested capsaicin in human non-small cell lung cancer cells, they discovered that the compound stopped cancer cell invasion, the first stage of metastasis. The team reported that capsaicin blocks a specific protein needed to regulate the proliferation survival and mobility of cancer cells. In addition, the scientists found that mice fed a capsaicin-enriched diet displayed far lower amounts of metastatic cancer cells in their lungs (after being fed a cancer-promoting diet) than mice that had not received capsaicin. From “Nippy” to “Nuclear” – Spicy Capsaicin in Chili Peppers Varies Wildly With Type Of course, capsaicin content – and the associated “heat”- varies from pepper to pepper. In fact, the spiciness of peppers is measured on the Scoville scale, with sweet red peppers scoring 0 units, pepperoncini clocking in at a modest 100 units, and poblano peppers at 1,000 units. Compare that to serrano peppers – at a zippy 10,000 units – or habaneros, which ring in at a scorching 100,000! Meanwhile, the notorious “ghost peppers” contain a blistering one million Scoville units. The hazards of excessive red chili pepper consumption can include painful irritation of the mouth, esophagus, stomach, and intestines – along with vomiting and diarrhea. If you want to partake of hot chili peppers, natural health experts advise proceeding cautiously and incorporating them slowly into the diet. In addition to capsaicin, spicy chili peppers contain high levels of antioxidant vitamin C – along with B complex vitamins, vitamin K, and vitamin A. So – if you are not sensitive to chili peppers – go ahead and make them a part of your healthy diet. That “heat” you feel when eating chili peppers just might be the “glow” of improved heart health, less cancer risk, and longer life Sources for this article include: MedicalNewsToday.com AmericanHeartAssociation.org Healthline.com ConserveEnergyFuture.com CDC.gov To read the original article click here.

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Curcumin Nanosystems Could Be Powerful COVID-19 Therapeutics

AHA Publisher — Tue, 20 Apr 2021 07:00:10 +0000

Dr. Liji Thomas, MD via News-Medical – With new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging, the coronavirus disease 2019 (COVID-19) pandemic is far from over. While the global vaccine rollout has moved at an impressive speed, the search for new safe, effective, and targeted therapies is still on. Now, a new study in Biomedicine and Pharmacotherapy reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanosystems to treat COVID-19. The Need for Therapeutics Though vaccines have been approved for emergency use, their efficacy against some of the new variants has been questioned. Moreover, vaccination coverage of at least 70% of the population in all the countries of the world is likely to take a long time, considering the current pace of vaccination, the shortfall in vaccine production, and logistical challenges. The world will still need effective and safe drugs, therefore, to intervene in serious illness caused by this virus. The current review focuses on the individual and synergistic activity of curcumin and nanostructures against the virus. Curcumin Curcumin is a polyphenolic compound isolated from the rhizome of the turmeric plant, Curcuma longa. It makes up the major curcuminoid in this plant, at 77% of the total, while the minor compound curcumin II makes up 17%, and curcumin III comprises 3%. Curcumin has been characterized and studied thoroughly, as a natural molecule with medicinal properties. Its tolerability and safety have been well documented, with a maximum dose of 12 g/day. Its uses have been described as anti-inflammatory, anticancer, and antioxidant, as well as antiviral. Curcumin has been suggested as a molecule with the potential to heal pulmonary edema and other injurious processes that lead to lung fibrosis following COVID-19. Curcumin Inhibits Viral Enzymes This is thought to be due to its ability to inhibit the virus itself, as well as to modulate inflammatory pathways. It regulates viral transcription and regulation, binds with high potency to the viral main protease (Mpro) enzyme that is key to replication and inhibits viral attachment and entry into the host cell. It may also disrupt viral structures. Its range of antiviral targets includes the hepatitis C virus, the human immunodeficiency virus (HIV), the Epstein-Barr virus and the influenza A virus. It has been reported to inhibit the 3C-like protease (3CLpro) more effectively than other natural products, including quercetin, or drugs like chloroquine and hydroxychloroquine. This could allow the reduction of viral loads within the human cell much more rapidly than other less inhibitory drugs, and thus prevent disease progression to acute respiratory distress syndrome (ARDS). It also inhibits papain-like protease (PLpro) with a 50% inhibitory concentration (IC50) of 5.7 µM that surpasses quercetin and other natural products. Curcumin Inhibits Host Cell Receptor The virus attaches to the human host target cell receptor, the angiotensin-converting enzyme 2 (ACE2). Modeling studies have shown that curcumin inhibits this virus-receptor interaction in two ways, by inhibiting both the spike protein and the ACE2 receptor. However, curcumin has low bioavailability, because it does not dissolve well in water and is unstable in aqueous media, especially at higher pH. When orally administered, it undergoes rapid metabolism by the gut and the liver. This obstacle may be overcome by using nanosystems. Many different nanostructured carriers may be used for this purpose, such as nanoemulsions, microemulsions, nanogels, micelles, nanoparticles and liposomes. Such carriers prevent the metabolic breakdown of the curcumin, increases its solubility and help it move through biological membranes. Three or more nanostructure-based curcumin products are already commercially available, but few studies have examined their efficacy against COVID-19 in vivo. These showed the ability of the formulations to modulate immune responses and to reduce the symptoms of the disease, and perhaps hasten recovery. Nanoparticle Advantages Nanoparticles (NPs) are one category of nanostructures that can be functionalized with ease, and have a wide potential range of materials and structures. This could allow them to be designed for specific viral targets within and outside the host cell. The addition of functional groups on the surface of the nanoparticles, such as antibodies, heparin and sugars, can enlarge the range of activity of the nanoparticle. Independent NP Mechanisms of Antiviral Activity NPs act in many ways, such as inactivation of the viral particle, inhibition of viral attachment and entry, and preventing viral replication. Depending on the functional group and the type of NP used, they can alter the viral capsid structure and thus reduce the viral load. By interacting with the SARS-CoV-2 spike, they can inactivate the virus, as shown earlier with metallic NPs, both preventing spike-ACE2 binding, and viral internalization. The occurrence of electrostatic interactions between charged NPs and the virus abolishes the effective charge on the latter, causing viral aggregation. With viral particles within the cell, the NPs can engage the viral RNA and prevent replication, followed by viral propagation to neighboring cells. Combined Formulations Thus, curcumin may inhibit viral targets, while the NPs may enhance the blockade on virus entry or use other inactivation mechanisms, depending on the functional group. Earlier studies show that silver NPs loaded with curcumin led to increased antiviral activity compared to either curcumin or silver NPs in isolation, with reduction of cell-cell fusion and syncytium formation. Curcumin-carbon dots are another option found to be effective in inhibiting entry by the porcine epidemic diarrhea virus, again a coronavirus. Implications and Future Directions These findings indicate the potential for the investigation of both curcumin and nanosystems for the treatment of SARS-CoV-2. Further studies are needed to validate the anti-SARS-CoV-2 activity of both these molecules, and their efficiency and synergism in vitro and in vivo, followed by clinical trials. Curcumin-NP formulations may be at the forefront of such investigations since they are already approved for therapeutic use. This article has been modified. To read the original article click here.

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