Immunotherapy Archives - Amazing Health Advances

Adding Immunotherapy to Chemotherapy After Surgery Improves Survival in Colon Cancer

The AHA! Team — Mon, 04 Aug 2025 05:43:16 +0000

Mayo Clinic via News-Medical – Colon cancer is the third most prevalent form of cancer in the U.S., and while screening has helped detect and prevent colon cancer from spreading, major advancements in treating colon cancer have lagged. Now, new research led by Mayo Clinic Comprehensive Cancer Center found that adding immunotherapy to chemotherapy after surgery for patients with stage 3 (node-positive) colon cancer – and with a specific genetic makeup called deficient DNA mismatch repair (dMMR) – was associated with a 50% reduction in cancer recurrence and death compared to chemotherapy alone. Approximately 15% of people diagnosed with colon cancer exhibit dMMR and, to date, these tumors appear less sensitive to chemotherapy. The results of the multi-center study were presented during a plenary session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago. “The findings from our study represent a major advance in the adjuvant treatment of dMMR stage 3 colon cancer and will now change the treatment for this type of cancer,” says oncologist Frank Sinicrope, M.D., who led the study. “It’s extremely rewarding to be able to offer our patients a new treatment regimen that can reduce the risk of recurrence and improve their chances of survival.” Until now, the standard treatment after surgery for any stage 3 colon cancer has been chemotherapy. However, the researchers note that approximately 30% of patients experience cancer recurrence despite this treatment. The clinical trial enrolled 712 patients with dMMR stage 3 colon cancer that had been surgically removed and who had cancer cells in their lymph nodes. The immunotherapy given in this study was an immune checkpoint inhibitor, known as atezolizumab, which activates one’s immune system to attack and kill cancer cells, which are responsible for cancer recurrence and spread. The patients – who lived in the U.S. and Germany – received chemotherapy for six months along with immunotherapy and then continued with immunotherapy alone for another six months. Dr. Sinicrope and others previously studied patients with colon cancer whose cells are unable to repair errors during DNA replication that create a nucleotide mismatch, a condition called dMMR. They noted that these patients’ tumors showed a striking increase in inflammatory cells within the tumor, including those that express the target of immune checkpoint inhibitors. This sparked the idea of using immune checkpoint inhibitors to make the immune cells more effective in attacking and killing the cancer cells. Based on the data from this study, Dr. Sinicrope recommends this combination of immunotherapy and chemotherapy treatment to be the new standard treatment for stage 3 deficient mismatch repair colon cancer. The research team plans to approach the National Comprehensive Cancer Network, a nonprofit organization consisting of 33 leading cancer centers, including Mayo Clinic, with this recommendation. The study included patients with Lynch syndrome, the most common form of hereditary colon cancer, as these patients can have tumors that show deficient mismatch repair (dMMR). We’re changing the paradigm in colon cancer treatment. By using immunotherapy at earlier stages of disease, we are achieving meaningful benefits for our patients.” -Frank Sinicrope, M.D., Mayo Clinic Comprehensive Cancer Center Source: Mayo Clinic To read the original article click here.

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How Milk Thistle Extract can Support Liver Health and Healing

The AHA! Team — Fri, 27 Jun 2025 05:29:03 +0000

Lori Alton via NaturalHealth365 – With its spiky purple flowers and dull green leaves, milk thistle may appear to be nothing more than an ordinary weed growing wild in vacant lots and fields. Yet, this unimpressive-looking plant is truly a shining star when it comes to avoiding disease and promoting healing. Milk thistle, scientifically known as Silybum marianum, is prized by natural healers for its ability to eliminate liver ailments, including nonalcoholic fatty liver disease, which is currently reaching epidemic proportions in the United States. But supporting liver health is not milk thistle’s only gift. Discover how this extraordinary herb can help you. Milk thistle protects against toxic effects from cancer treatment, arrests tumors The active ingredient in milk thistle, an antioxidant flavonoid called silymarin, reduces the inflammation and oxidative damage that can trigger cancer. It also helps preserve glutathione, the body’s premier inflammation-fighting antioxidant. Scientists have known for some time that milk thistle may act against cancer. In a review conducted at the University of Minnesota, researchers cited “strong evidence” for silymarin’s liver-protective and anti-cancer effects. Significantly, they credited silymarin with combating cancer by inhibiting the binding of toxins to cell membrane receptors. In a new study published in The International Journal of Oncology, researchers found that silibinin, a form of silymarin, suppressed chemoresistance, the condition in which cancer fails to respond to the effects of drugs. The team noted that silibinin also prevented further malignancy, protected against potentially cancer-causing DNA mutations, and inhibited tumor growth. In other research, researchers found that silymarin also helps prevent liver damage from chemotherapy and protects the skin and mucosal lining from damage from radiation therapy. Milk thistle is a potent antifungal agent Overgrowth of Candida albicans, a common fungus, can cause symptoms of fatigue, “brain fog,” digestive problems, and skin rashes. And, a growing problem of drug resistance in pharmaceutical antifungals – which parallels the current epidemic of antibiotic resistance – can make Candida difficult to treat. Researchers have found that silymarin can penetrate the cell membrane of the Candida microbe, stopping the pathogen’s growth and spread and helping to clear the overgrowth. Silymarin is also effective in blocking and inhibiting biofilms, layered communities of pathogenic microorganisms that are stubbornly resistant to treatment. Silymarin helps to regulate glucose levels For the past thousand years, herbalists and Ayurvedic healers have advised milk thistle to support healthy blood sugar levels, and modern research confirms the value of this ancient remedy. In one recent study, a 90-day course of a combination of milk thistle, boswellia, and nettles slashed hemoglobin A1c levels – a measure of blood sugar over several months – by a substantial 19 percent. The herbal combination also drastically reduced blood sugar levels – from an average of 150 to 180 mg/dL to an average of 124 mg/dL – and triglyceride levels. In addition, a recently published cell study shows that silymarin protects the retina from diabetic damage, a common consequence of the disease. The Big NEWS: Milk thistle supports a healthy liver Milk thistle’s main claim to fame is its ability to improve liver enzymes, rebuild liver cells, and alleviate liver ailments. In addition to easing hepatitis and cirrhosis, milk thistle shows promise in dealing with nonalcoholic fatty liver disease and halting the progression to steatohepatitis, a more serious form of the condition. Research has supported milk thistle’s beneficial effects on liver disease, with one study showing that hepatitis patients treated with silymarin returned to work sooner and experienced less depression and anxiety than those in the control group. In addition, milk thistle helps detoxify the liver and protect against injury from heavy metals and drugs. In a review published in Phytotherapy Research, the team credited silymarin with reducing liver injury caused by a variety of toxins, drugs, and heavy metals, including acetaminophen, carbon tetrachloride, radiation, alcohol, iron overload, and Amanita phalloides, a type of poisonous mushroom. As an added bonus: milk thistle’s protective effects also extend to the stomach. The herb has been shown to suppress gastric inflammation and protect against ulcers caused by non-steroidal anti-inflammatory drugs. Surprising fact: Milk thistle has antidepressant properties Yet another surprising benefit of milk thistle is its ability to function as a natural mood elevator. Animal studies support its ability to reduce anxiety and depression caused by traumatic brain injury, which it appears to do by reducing the activity of microglial cells caused by a disturbance in the neural circuits between the limbic system and the cortex of the brain. In one study, silymarin performed as well as the pharmaceutical drugs fluoxetine (Prozac) and diazepam (Valium) in supporting mood. Researchers noted that silymarin reversed stress-induced changes to the hippocampus and cerebral cortex while boosting levels of the neurotransmitters serotonin and dopamine. Because of silymarin’s ability to reduce inflammation and neurodegeneration, researchers are even exploring its potential to prevent and treat Alzheimer’s disease. How should I take milk thistle? Experts recommend temporary short-term amounts of 150 mg, taken one to three times a day, for detoxification. A holistic healthcare provider may recommend 50 to 150 mg a day for liver support, maintenance, and longer-term use. Use a formulation standardized to 70 to 80 percent silymarin for best results. As always, consult your holistic doctor to determine if milk thistle is right for you and to determine the proper amount. Although it is generally considered safe and well tolerated, high amounts can cause mild digestive upset. Note: if you are allergic to any member of the aster family – such as daisies, ragweed, marigolds, or chrysanthemums – don’t take milk thistle. Milk thistle has long been revered for its ability to cleanse and detoxify the liver. However, recent research confirming its ability to ward off other diseases demonstrates that this herb is valuable and versatile. Editor’s note: To support healthy liver function, I highly recommend LuvByNature LiverLuv – which is gluten free, non-GMO and delicious. Sources for this article include: NIH.gov NIH.gov To read the original article click here.

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7 Natural Ways to Enhance Immune Function

The AHA! Team — Wed, 12 Mar 2025 05:22:36 +0000

Dr. Don Colbert – When it comes to enhancing immune function naturally, the role of diet cannot be overstated. A balanced diet rich in immune-boosting foods is fundamental to maintaining a robust and resilient immune system. By incorporating a variety of nutrient-dense foods into your daily meals, you can provide your body with the essential vitamins, minerals, and antioxidants it needs to ward off illnesses and infections. Let’s delve deeper into how different foods contribute to immune health and why they should be a staple in your diet. While Vitamin C often gets the spotlight for its role in immune support, there is a vast array of other foods rich in antioxidants, vitamins, and minerals that provide significant immune-boosting benefits. To maintain a strong immune system, it’s crucial to incorporate a variety of these nutrient-rich foods into your daily diet. Let’s explore some of these powerful foods and understand how their unique components contribute to enhancing immune function. Pomegranate: A Powerful Antioxidant Source Pomegranates are a rich source of antioxidants, particularly polyphenols like punicalagins and anthocyanins. These compounds have been shown to have potent anti-inflammatory and immune-modulating effects. Antioxidants help protect the body from oxidative stress, which can damage cells and weaken the immune system. Research indicates that pomegranate extract can enhance the immune system by increasing the activity of natural killer (NK) cells, which play a crucial role in the body’s defense against infections and cancerous cells naturally. Pomegranates are known to promote gut health, which is closely linked to immune function, by fostering a healthy gut microbiome. Apples: Rich in Quercetin Apples are a great source of quercetin, a flavonoid with strong antioxidant and anti-inflammatory properties. Quercetin has been studied for its ability to modulate the immune system and reduce inflammation, which can help protect the body from various infections and diseases. Study published in the American Journal of Clinical Nutrition found that quercetin supplementation enhanced immune response in participants and reduced the incidence of respiratory infections. Incorporate apples into your diet can provide a natural source of quercetin, supporting overall immune health and helping the body to fight off pathogens more effectively. Sweet Potatoes: High in Vitamin A Sweet potatoes are rich in beta-carotene, which the body converts into Vitamin A. This essential vitamin is crucial for maintaining the integrity of the skin and mucous membranes, the body’s first line of defense against pathogens. Vitamin A also plays a role in the development and regulation of the immune system, particularly in maintaining the function of T-cells, which are critical for immune response. Studies have shown that a diet high in Vitamin A can enhance the body’s ability to fight off infections and reduce the severity of illnesses. Consuming foods like potatoes, carrots, and other beta-carotene-rich vegetables can provide your body with the necessary nutrients to maintain a robust immune system. Garlic: Nature’s Antibiotic Garlic has been used for centuries for its medicinal properties, particularly its ability to boost the immune system. Garlic contains allicin, a sulfur-containing compound known for its antimicrobial and immune-boosting properties. Allicin has been shown to enhance the immune response by stimulating the activity of various types of immune cells, including macrophages and natural killer cells. A study published in Advances in Therapy found that participants who took a garlic supplement experienced fewer colds and recovered faster compared to those who took a placebo. Including garlic in your diet whether raw or cooked, can provide these powerful immune-enhancing benefits. Cruciferous Vegetables: Full of Immune-Enhancing Compounds Cruciferous vegetables like broccoli, cauliflower, kale, and Brussels sprouts are not only rich in vitamins and minerals but also contain unique compounds such as sulforaphane. Sulforaphane has been shown to activate antioxidant pathways and enhance the immune system’s ability to fight off toxins and pathogens. A study published in the Journal of Nutritional Biochemistry highlighted sulforaphane’s ability to boost the immune system’s response to bacterial infections by activating immune cells. Consuming a variety of cruciferous vegetables provides a range of nutrients that support overall immune health and protect against disease. Nuts and Seeds: Packed with Immune-Supportive Nutrients Nuts and seeds, such as almonds, sunflower seeds, and flaxseeds, are rich in essential nutrients, including Vitamin E, zinc, and healthy fats. Vitamin E is a powerful antioxidant that helps protect cell membranes from oxidative damage, while zinc is vital for immune cell development and function. Researching has shown that Vitamin E can enhance immune function, particularly in older adults, by boosting the activity of T-cells. Including a handful of nuts and seeds in your daily diet can provide these critical nutrients, supporting both innate and adaptive immunity. 1. Fermented Foods: Probiotics for Immune Health Fermented foods like yogurt, kefir, sauerkraut, kimchi, and kombucha are rich in probiotics—live beneficial bacteria that support gut health. A healthy gut microbiome is essential for a well-functioning immune system, as it helps prevent harmful pathogens from colonizing the gut and entering the bloodstream. Research has demonstrated that regular consumption of probiotic-rich foods can enhance the immune system’s response to infections and improve overall digestive health. Including these foods in your diet can promote a ba environment, supporting immune function and protecting against illness. 2. Take Immune-Supporting Supplements Certain supplements can help strengthen your immune system by providing nutrients that may be lacking in your diet. Some of the most effective immune-boosting supplements include: Vitamin D: This vitamin is crucial for immune function, and deficiency is linked to increased susceptibility to infection. Studies suggest that Vitamin D supplementation can enhance the pathogen-fighting effects of monocytes and macrophages—white blood cells that are critical parts of immune defense. Zinc: Zinc is another vital nutrient for immune health, playing a key role in the development and function of immune cells. A meta-analysis found that zinc supplementation reduces the incidence of infections, particularly in the elderly and children. 3. Stay Hydrated Proper hydration is essential for overall health and immune function. Water helps carry oxygen to your body cells, which results in properly functioning systems. It also aids in the removal of toxins from the body, which can help prevent infections. Aim to drink at least 8 glasses of water a day, and more if you’re active or live in a hot climate. 4. Prioritize Sleep Quality sleep is one of the most effective natural ways to boost your immune system. During sleep, the body releases cytokines, a type of protein that targets infection and inflammation, effectively creating an immune response. Lack of sleep can decrease the production of these protective cytokines, weakening the immune response. Research shows that individuals who do not get adequate sleep are more likely to get sick after being exposed to a virus, such as the common cold virus. For optimal immune function, aim for 7-9 hours of uninterrupted sleep per night. 5. Engage in Regular Exercise Physical activity is not only great for overall health but also boosts the immune system. Regular moderate exercise can help reduce inflammation and promote the healthy turnover of immune cells. A study published in the journal Frontiers in Immunology found that regular moderate exercise can reduce the risk of illness by enhancing immune function. Exercise helps flush bacteria out of the lungs and airways, reduce stress hormones, and increase circulation of white blood cells. 6. Manage Stress Levels Chronic stress can negatively impact immune function, making you more susceptible to infections. Stress induces the production of cortisol, which can suppress the immune system’s effectiveness. Managing stress through techniques such as mindfulness, meditation, deep breathing, and yoga can help maintain a strong immune system. Studies have shown that people who meditate regularly have higher levels of antibodies and a stronger immune response. Incorporating stress-reducing practices into your daily routine can greatly support your overall immune health. 7. Maintain a Healthy Gut A large part of the immune system is located in the gut, where beneficial bacteria play a key role in defending against pathogens. Consuming probiotics and prebiotics can help maintain a healthy gut microbiome, which in turn supports immune function. Probiotics, such as those found in yogurt, kefir, and fermented foods, help populate the gut with beneficial bacteria. Prebiotics, found in foods like garlic, onions, and bananas, feed these beneficial bacteria, promoting a balanced gut environment. A healthy gut can prevent harmful pathogens from entering the bloodstream, thus enhancing overall immune function. Research has shown that probiotics can help reduce the duration of respiratory infections and support the immune system’s response to illness. By incorporating these seven natural strategies into your daily routine, you can effectively enhance your immune function and support overall health. Remember, a healthy immune system is your best defense against illness. Whether it’s through diet, supplements, or lifestyle changes, taking proactive steps to boost your immunity will help you live your best, healthiest life. References: Hemilä, H. (2017). Vitamin C and Infections. Nutrients, 9(4), 339. Aranow, C. (2011). Vitamin D and the Immune System. Journal of Investigative Medicine, 59(6), 881-886. Prasad, A. S. (2008). Zinc in Human Health: Effect of Zinc on Immune Cells. Molecular Medicine, 14(5-6), 353-357. Cohen, S., Doyle, W. J., Alper, C. M., Janicki-Deverts, D., & Turner, R. B. (2009). Sleep Habits and Susceptibility to the Common Cold. Archives of Internal Medicine, 169(1), 62-67. Nieman, D. C., & Wentz, L. M. (2019). The Compelling Link Between Physical Activity and the Body’s Defense System. Frontiers in Immunology, 9, 2299. Black, D. S., & Slavich, G. M. (2016). Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials. Annals of the New York Academy of Sciences, 1373(1), 13-24. Hao, Q., Dong, B. R., & Wu, T. (2015). Probiotics for Preventing Acute Upper Respiratory Tract Infections. Cochrane Database of Systematic Reviews, (2). To read the original article click here.

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Green Warriors: 14 Overlooked Plants Revolutionizing Cancer Treatment & Prevention

The AHA! Team — Wed, 30 Oct 2024 05:36:04 +0000

Patrick Tims via NaturalHealth365 – The plants around us are more than mere greenery. Traditional healers have recognized the powerful medicinal properties of various herbs and botanicals for centuries. Now, modern science is catching up, revealing the profound potential of these natural remedies in combating one of our most difficult health challenges: cancer. A new study published in Pharmaceuticals in April 2024 sheds light on how specific medicinal plants may help prevent and even treat various types of cancer. From familiar herbs to exotic species, researchers have identified plant-based compounds with promising anti-tumorigenic properties. Cultivating health: Medicinal plants with cancer-fighting potential While not all these plants can be easily grown at home, understanding their benefits can inform your choices in herbal supplements and traditional remedies. Here are some of the medicinal plants highlighted in the study for their potential to combat abnormal cell growth: 1. Hibiscus Hibiscus, a flowering plant, contains chemical components, including phenolic compounds. The dried extract of hibiscus is packed with phenols and saponins that inhibit the growth of prostate cancer cells. Hibiscus also contains anthocyanin, which helps decrease the growth of cervical cancer cells. Aside from treating cancer, the plant also helps treat severe illness, neurological problems, and diabetes. 2. Moringa oleifera This plant’s leaves, flowers, and pods are consumed raw or cooked. Moringa oleifera leaves contain minerals, vitamins, and essential amino acids. The plant’s chlorogenic acid, quinic acid, niacin, and other components help prevent the formation and spread of cancerous tumors. 3. Kalanchoe blossfeldiana Kalanchoes are colorful houseplants that make stunning additions to dinner tables while also playing an important role in improving human health. Kalanchoe extract has cytotoxic potential that prevents the spread of ovarian cancer. The flower’s extract stops the cancer cell cycle with an exceptionally potent ability to treat metastatic lung cancer. 4. Silybum marianum L. This tree plant is commonly used as an herbal remedy in other parts of the world. Derived from milk thistle, Silybum marianum L. is loaded with polyphenolic compounds and more that prevent the formation of cancerous tumors. The plant’s components are potent against prostate cancer. 5. Curcuma longa This perennial plant hails from the same family as ginger. Curcuma longa is chock-full of several hundreds of active components you’ve undoubtedly tasted in curcumin. Curcumin triggers apoptosis, meaning the death of cancer cells. Moreover, curcumin decreases the growth of tumor cells. 6. Withania somnifera This immunological superstar, also called Indian ginseng, hails from the rugged mountainous terrain of Punjab. The plant’s derivative, Withaferin-A, helps defeat breast cancer. This economical plant is also effective in the fight against a wide variety of oral cancers. 7. Glycyrrhiza glabra Also known as licorice, glycyrrhiza glabra is commonly used by those who practice Ayurvedic medicine. This herbaceous plant contains hundreds of compounds, some of which prevent the expansion of carcinogenesis through cell cycle stimulation and additional processes. Glycyrrhiza glabra is especially effective in the battle against breast cancer. 8. Nerium oleander As a member of the Apocynaceae family, Nerium oleander is an ornamental plant with surprising medicinal utility. The plant has anticancer, anti-diabetes, and anti-inflammatory capabilities. The plant’s extract is particularly potent in preventing the expansion of cancer cells, thwarting the growth of nearly all tested forms of carcinomas. 9. Catharanthus roseus Also known as Madagascar periwinkle, Catharanthus roseus contains chemical constituents ranging from alkaloids to flavonoids. The plant also contains many other compounds that make it quite the potent cancer-prevention powerhouse. To be more specific, the plant helps inhibit the spread of an inflammatory enzyme dubbed “sPLA2,” which is a common biomarker for breast cancer. 10. Arum palaestinum This lovely flowering plant is laden with flavonols, C-glycosides, alkaloids, and more. Though often used for ornamental purposes in home gardens, the plant also provides utility for treating chronic illness, diabetes, stomach issues, and cancer. The use of Arum palaestenium to treat hepatocellular carcinoma reveals the plant prevents cancerous cells from proliferating. 11. Soursop This tropical plant is used to treat cancer and other illnesses. Soursop has bioactive substances, including phenolic compounds, alkaloids, and acetogenins, with inherent antioxidant properties that help in the battle against cancer. 12. Burdock Burdock, a nearly ubiquitous plant, has medicinal components within its leaves, roots, and seeds. The plant contains B vitamins, minerals, amino acids, lignans, sterols, and phenols. Burdock’s natural lignan lappaol F is a formidable cancer-fighting agent that thwarts the growth of cancerous tumor cells through the cessation of cell cycles. In particular, burdock is valuable for its inherent ability to inhibit the advancement of tumors including cancerous pancreatic tumors. Moreover, burdock has excelled in the battle against cancer cells that have resisted multiple drugs. 13. Stinging Nettle Nettle is a medicinal plant that tastes surprisingly good. Add some homegrown nettles to your salad or soup, and you’ll receive an infusion of vitamins C, B, and A, along with beta-carotene, protein, magnesium, potassium, and iron that help fight cancer. This medicinal plant’s anticancer qualities have proven effective against three cancer cell lines, including breast cancer. 14. Dandelion Commonly used for medicinal purposes by various cultures, dandelion is loaded with vitamins D, A, B, and C. Moreover, dandelion’s zinc, manganese, magnesium and iron are also beneficial. Data from Korean researchers reveals dandelion flavonoids and phenols help thwart the growth of cancer. Dandelion extract has proven especially helpful in combating the spread of breast cancer. Tap into nature’s medicine cabinet by including these plants in your diet The medicinal plants highlighted in this study offer intriguing possibilities for enhancing health and reducing cancer risk. While not all of these plants are common garden varieties or suitable for home cultivation, there are ways to incorporate their benefits into your life: Explore traditional herbal remedies: Many plants studied, such as Curcuma longa (turmeric) and Moringa oleifera, have long histories in traditional medicine. Consider incorporating these into your diet or exploring herbal supplements under the guidance of a healthcare professional. Embrace culinary herbs: Some cancer-fighting plants, like Curcuma longa (turmeric), can be easily included in your cooking. These add both flavor and potential health benefits to your meals. Seek out specialized products: For plants like Annona muricata (soursop) or Catharanthus roseus (Madagascar periwinkle), look for teas, extracts, or supplements from reputable sources. Grow what you can: While not all medicinal plants are suitable for home gardens, some, like Hibiscus, can be grown in pots or gardens, adding beauty and potential health benefits to your space. Remember, while these plants show promise in cancer research, they’re not a substitute for professional medical care. Always consult with a holistic healthcare provider before making significant changes to your diet or starting new supplements, especially if you have existing health conditions or are undergoing cancer treatment. Sources for this article include: MDPI.com Planet-today.com To read the original article click here.

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Do Allergy Medications Increase Your Alzheimer’s Risk?

The AHA! Team — Mon, 10 Jun 2024 09:04:04 +0000

Al Sears, MD, CNS – I love this time of year. But many of my patients dread springtime… They come to my clinic sneezing and sniffling. They have runny noses, and watery, itchy eyes. They can’t sleep or work. You may have the same problems. You need relief fast to get back to your life. So you might be tempted to pop some OTC remedies or ask your doctor for a prescription. But you may be getting more than you bargained for with those allergy drugs. They may make you lose your mind. Let me explain… Many doctors treat allergies with a class of drugs called anticholinergics (ACs). You know them by names like Benadryl and Dimetapp. In a new study, scientists linked ACs to an increased risk of dementia.1 Researchers at the Indiana University School of Medicine looked at 451 people, with an average age of 73. Sixty of the patients were taking at least one AC drug. They gave the whole group memory and cognitive tests. They did PET scans to measure brain activity. They did MRI scans to measure changes in brain structure. The results were worrying… The people taking AC drugs did worse on short-term memory tests. They had worse verbal reasoning, planning skills, and problem-solving. They also had lower levels of brain activity, especially in the hippocampus — the region of the brain linked with memory. And they had reduced brain volume and larger cavities or holes inside their brains. In other words, people taking the drugs had more brain atrophy. And AC drugs cause damage quickly. In fact, using these drugs for as few as 60 or 90 days can cause cognitive problems.2 Allergies are your immune system overreacting to normal dust, pollen, and animal fur. Special cells in the blood vessel linings of the inner eyelids, nasal membranes, and lungs release substances called histamine and inflammatory prostaglandins. These are the real culprits behind all the misery. They release fluids to flush out what your body thinks is a viral or bacterial infection. I don’t prescribe those dangerous AC drugs for allergies. Instead, I help my patients relieve the symptoms naturally. 5 Safe, Natural Allergy Busters You Can Use Today Nasal irrigation. This therapy is a safe and easy way to rinse your sinuses. It flushes allergens and irritants out your nasal passages. You can find nasal rinse applicators, including neti pots and sinus-rinse kits, in most drug stores. Just follow the directions on the box. But one caution… Make sure the water is distilled and as sterile as possible. Tap water isn’t safe because it’s not adequately filtered or treated. And it can increase your risk of infection. Pineapple. This tropical fruit contains an enzyme called bromelain. It counteracts the effects of inflammatory prostaglandins. To help lessen inflammation, you’ll need to eat about a cup of fresh pineapple every day. You can also take a supplement. Look for a capsule that is at or near 2,400 GDU (gelatin dissolving units), the highest standardized potency you can get. I recommend you take 500 mg twice a day. Quercetin. This bioflavonoid targets the special cells that make histamine. Studies show it prevents allergies before they start. It can even stop allergic reactions in progress. And it works instantly.3 Quercetin is found naturally in many fruits and vegetables. Try eating more apples, broccoli, cherries, citrus fruit, cranberries, green tea, leafy greens, raspberries, red grapes, onions, shallots, and tomatoes. If you’re prone to allergies, start eating more of these foods a few weeks before spring arrives. Or you can supplement. I recommend taking 500 mg twice a day. Stinging nettle (urtica dioica). This prickly herb is a natural anti-inflammatory. It can prevent hay fever symptoms if taken as soon as they appear.4 It works by balancing histamine levels and preventing the production of prostaglandins. I recommend drinking nettle tea. You can find dried leaves or tea bags in your local health food store or online. Drink one or two cups a day with a meal. Vitamin C. You already know vitamin C boosts the immune system. But it also halts the production of histamine. And it speeds up the breakdown of histamine already in the blood. One study showed that taking 2,000 mg of vitamin C per day lowered histamine levels by 38% in healthy adults — after just one week.5 To Your Good Health, Al Sears, MD, CNS References: 1. Risacher S, et al. “Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults.” JAMA Neurol. 2016;73(6):721-32. 2. Xueya C, et al. “Long-term anticholinergic use and the aging brain.” Alzheimers Dement. 2013;9: 377–385. 3. Middleton, E. et al ” Quercetin: an inhibitor of antigen-induced human basophil histamine release.” J Immunol. 1991;127:546-50. 4. Roschek B Jr, et al. “Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis.” Phytother Res. 2009;23(7):920-6. 5. Johnston, C. et al ” Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis.” J Am Coll Nutr. 1992. II(2):172-76 To read the original article click here.

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Cancer Immunotherapy Pill Could Be On the Horizon

AHA Publisher — Wed, 17 Aug 2022 07:00:04 +0000

Brian Blum via Israel21c – Immunotherapy — activating the immune system to fight cancer — has been one of the most significant developments in the world of cancer treatment. But it still isn’t a cure-all, and scientists have been working to improve its delivery and efficacy. A recent breakthrough by Israeli and Portuguese scientists could result in cancer immunotherapy in a pill form that wouldn’t require a hospital stay or intravenous injection, would be less expensive, and may offer other benefits as well. Researchers at Tel Aviv University and the University of Lisbon, led in Israel by Prof. Ronit Satchi-Fainaro, head of the center for cancer biology research and the laboratory for cancer research and nanomedicine at TAU’s medical school, developed a synthetic molecule that is many magnitudes smaller than even the most advanced immunotherapy antibodies. The small size allows the molecule to penetrate and reach less accessible and less exposed areas of solid tumors. Moreover, unlike traditional immunotherapy antibodies, which have a hard time surviving the harsh acidity of the intestinal tract, the new molecules “have been designed especially to be resilient and not degrade in the gut, which opens up the exciting possibility of giving them orally,” explains Satchi-Fainaro. Most immunotherapy medications must travel through blood vessels to reach the tumor. The new tiny molecules can find their way to the target by diffusion without needing the “road” of blood vessels. The small synthetic molecules also would be much less expensive to produce at large scale than are today’s biological-based immunotherapy drugs, potentially enabling many more people to access immunotherapy. “We have already synthesized the small molecule with simple equipment, in a short time and at a fraction of the cost,” Satchi-Fainaro notes. Allowing patients to take the drug orally at home will also bring down the price by eliminating hospital costs. As described in the Journal for ImmunoTherapy of Cancer, the team has tested the molecule in vitro as well as on a human tumor in a special lab model, but not yet with actual patients. A commercial product is still years away, as further development and human testing is needed. ISRAEL21c has written about Satchi-Fainaro’s research on numerous occasions. She was featured in our article on bio-convergence. More recently, she has identified ways to treat melanoma and glioblastoma, an aggressive brain cancer. The current research was supported by Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES), the Israeli Ministry of Health, La Caixa Foundation, Liga Portuguesa Contra o Cancro, the ERC, the Israel Science Foundation, the Melanoma Research Alliance, the Israel Cancer Research Fund Professorship Award and the Morris Kahn Foundation. To read the original article click here.

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New Cancer Treatment Fools the Immune System to Attack

AHA Publisher — Wed, 06 Jul 2022 07:00:48 +0000

Brian Blum via Israel21c – Immunotherapy holds perhaps the greatest promise for fighting cancer in the 21st century. Rather than bombarding the body with toxic chemicals, as in chemotherapy, immunotherapy utilizes the immune system to neutralize malignant tumors. The only problem: It only works in about 20 percent of patients with solid tumors. The reason is straightforward, but still represents a vexing roadblock for cancer researchers: Tumors are not an infection coming from outside but an internal malfunction of the body’s own cells, which begin to replicate out of control. “Cancer looks like us. It’s hard for the immune system to identify,” explains Dr. Asher Nathan, CEO of NeoTX, a Rehovot-based startup developing a novel way of knocking out tumors – by coating them in bacteria. “Unlike with cancer, our bodies are finely tuned to attack bacteria,” Nathan says. “Bacteria is a billion years old. Our immune systems have had a long time to figure out how to effectively neutralize bacterial infections. That’s why you don’t wake up in the morning with a cold and think, ‘I’m going to die.’” Cancer, of course, is a very different story. Compared with bacteria, “cancerous tumors are like the new kid on the block,” Nathan notes. NeoTX is not Nathan’s first foray into medical technology; after immigrating to Israel 40 years ago from Chicago, he founded IntelliGene and EvoRX, two biotech companies formed around technologies he invented. For NeoTX, Nathan identified and licensed a drug developed by the Swedish company Active Biotech called naptumomab estafenatox (NAP). NAP is composed of two proteins: a genetically modified “superantigen” and an antibody that latches onto a tumor via a molecule called 5T4 found primarily on tumors. A superantigen is a bacterial derivative that elicits a strong antibacterial immune response. NeoTX calls its technology “Tumor-Targeted Superantigen” or TTS. Once NAP’s 5T4 antibody has attached itself to a tumor, the superantigen “reprograms” the immune system to mount an antibacterial response against the bacteria as well as the tumor. “The concept behind this drug is, let’s coat the tumor with a bacterial molecule so that the immune system will go into ‘Defcon 1’ and attack the tumor as if it’s bacteria,” Nathan says. The Secret Weapon Once the immune system knows what to look for, it sends in the body’s secret weapon: killer T-cells. The T-cells identify the bacteria-coated tumors, then start to create an army of cells primed to attack any superantigens they find. Nathan recommends the video below to see how T-cells work; they “grope around like a blind robot” and after hitting a superantigen, punch a hole in the cell … then insert a molecule that causes the cell to explode.” It’s a fine balance. When fighting a bacterial infection, “the body can go crazy,” Nathan notes. “You can get a high fever that exhausts the immune system. That’s how the bacteria continue to fight. We genetically engineered our superantigen to be safer. It doesn’t generate as strong a response, but it still creates a very powerful immune reaction.” Targeting bacteria is smart for another reason: Part of how tumors succeed in evading the body’s defenses is by releasing chemicals that weaken the immune response. “Anything we do nearby the tumor becomes problematic,” Nathan says. But with NAP, “the tumor-killing T-cells are created far from the immune-suppressed tumor site.” Only then do they begin their journey to seek out and destroy the tumors. Moreover, when the immune system encounters a superantigen bound to a tumor, it modifies the suppressive micro-environment around the tumor so that the body’s natural defenses are better able to kill it. “This creates a natural, holistic and profound immune response,” Nathan says. Reboots the Immune System But the best may be yet to come. “When we’ve tested this drug in animals, we find that even when you try to reintroduce cancers into, say, a mouse that’s been cured by the technology, it doesn’t stick,” Nathan says. “None of the mice that were ‘rechallenged’ got cancer again. The drug ‘wakes up’ the immune system – at least in mice – and we don’t need any more drug.” Nathan likens it to the reboot function on a computer. “The drug reboots the immune system so it can do what it natively needs to do – remove the suppressive environment and kill as many tumor cells as possible. Then, the T-cells can go after more targets.” NeoTX’s bacterial coating approach is currently in a Phase I trial in Israel and, based on encouraging results, has begun a Phase 2 trial in the United States with 30 patients. One patient has non-small cell lung cancer that had metastasized to the liver. “That’s a death sentence, usually within four months,” Nathan says. The patient received NeoTX’s drug over a decade ago (prior to it being licensed from Active Biotech). “She lived for 11 years and died of something else, not her cancer.” NAP plays particularly well with checkpoint inhibitors, another type of cancer treatment that aims to tamp down “checkpoints” created by the cancer that essentially trick the T-cells into thinking the tumor is a friend. “It’s like a secret handshake in a college fraternity,” Nathan quips. If the handshake were inhibited, so to speak, the T-cells would see the tumor for what it is – very much not a friend – and could attack. Combining NAP with a checkpoint inhibitor “allows our drug to kill more tumor cells,” Nathan says. AstraZeneca Collaboration Pharma giant AstraZeneca is collaborating with NeoTX on the former’s own checkpoint inhibitor technology. The hope is that patients who don’t normally respond will have greater success in beating back their cancers. Developing and commercializing any new drug can take up to 15 years and many millions of dollars. NeoTX has raised around $80 million so far. Nathan is optimistic that if NAP passes Phase 2 and 3 trials, it could hit the market as early as 2027. While the technology has so far been tested on solid lung, esophageal and urethral cancer tumors, patients with blood cancer such as lymphoma and leukemia could benefit, too – in particular those who are candidates for CAR-T, a promising treatment that involves removing T-cells from a patient, engineering them for maximum killing ability in a lab, then reinjecting them. CAR-T, a form of immunotherapy, tends to work well for blood cancers but poorly for solid tumors. That’s another aim for NeoTX – to provide a pharmaceutical complement that will allow CAR-T to be effective outside the blood cancer domain. Immunotherapy has become a crowded field. “If you look at all the companies that are trying to elicit an immune system response, there are probably 1,000 out there. But for the specific mechanism we’re trying, it’s zero,” Nathan notes. “One of our investors said to us, ‘You’re either geniuses or you’re crazy.’ I replied, ‘What makes you think it’s one or the other?’” NeoTX has no shortage of geniuses. Roger Kornberg, the 2006 winner of the Nobel Prize in chemistry, is the company’s chief scientist (as well as a long-time collaborator with Nathan in his previous endeavors). Michael Levitt and Arieh Warshel, who shared a Nobel in chemistry in 2013, are advisers. Dr. Marcel Rozencweig, a medical oncologist and 18-year veteran of pharma company Bristol Myers Squibb, where he was head of global oncology, is NeoTX’s president. Recently, the head of global clinical oncology at Bayer pharmaceuticals, Dr. Scott Fields, joined NeoTX as chief medical officer. “It is extremely rare that someone as high up as Scott Fields would leave pharma to work in such a small company,” Nathan tells ISRAEL21c. “It is even more rare that he would come to a company based in Israel.” Cancer, sadly, isn’t going away anytime soon. “The average person develops around five cancerous or pre-cancerous cells a day,” Nathan notes. “Our bodies are very efficient at killing, such that most people don’t get a new cancer every day. Our drug could level the playing field so the body can do what it’s meant to.” For more information, click here To read the original article click here.

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Leukemia Cure? Patient Still Cancer-Free 11 Years After Innovative Treatment

AHA Publisher — Wed, 15 Jun 2022 08:22:07 +0000

Lorie Johnson via CBN News – Doug Olson may be 75 years old, but he feels great. He’s still cancer-free 11 years after he potentially faced death from a blood cancer called chronic lymphocytic leukemia. At that time, his doctors informed him that the treatments he had been trying we not working. “Terrified is probably the best word to describe it,” Olson told CBNNews. Feeling he had nothing to lose, Doug agreed to an experimental treatment developed at the University of Pennsylvania called CAR-T therapy. It uses the patient’s own immune system, specifically the T-cells. Olson said the process of gathering those cells took about three hours. “Your blood comes out of one arm, goes into a machine that takes out your white cells and then the rest of your blood goes back in the other arm,” he said. Scientists then take the cells they removed and add receptors to them that allow the cells to bind to invading cancer cells and kill them. These modified T-cells are then multiplied in a lab and then infused into the patient. “We used my own white cells to kill the cancer cells, but it was brand new, they’d never done it before in humans,” Olson explained. “I’m sort of an eternal optimist. I figured what the heck, it worked in mice, maybe it’ll work in me.” Indeed it did. Just five weeks after receiving the treatment, Doug’s doctor announced good news. “He said, ‘Doug, we can’t find a single cancer cell on your body,'” Olson recalled. His success paved the way for thousands to be treated with CAR-T therapy. Now, more than a decade after being one of the first patients to try the therapy, Olson is still cancer-free, a remission so remarkable it was highlighted in the medical journal Nature. “We feel pretty good about using the word, ‘cure’ now,” Olson said. The U.S. Food and Drug Administration has approved CAR-T therapies to treat blood cancers like lymphomas and leukemias as well as multiple myeloma. Ahmed Galal, MD, FRACP, MSc, is a cellular therapy specialist, hematologic oncologist, and hematologist at Duke Blood Cancer Center in Durham, North Carolina, who treats patients with CAR-T therapy. “Basically it’s a game-changer,” he told CBN News. Dr. Galal said CAR-T therapy is usually administered at academic medical centers, like Duke, after other treatments failed. He said patient results are pleasing. “Their outcome is about 45-percent for five years. Now, these are the latest studies showing the duration of response is actually extending and is not coming down,” he said. “So I think eventually this will be a cure.” While CAR-T therapy has proven successful for certain types of blood cancers, it has not shown to be effective against other more common cancers, but that could change. Cancer researchers are currently conducting trials to treat some of the deadliest forms of the disease including pancreatic and lung cancers as well as brain tumors. “This is only the start,” said Dr. Galal. “CAR-T will expand more and more to different indications including more leukemias including actually other types of cancer in the solid tumor.” So while cancer is America’s second leading cause of death behind heart disease, cancer deaths have actually fallen by more than 30 percent since 1991. Health experts say the decreased death rate is due to better prevention, such as not smoking, increased screenings, like mammograms, and treatments, such as CAR-T therapy. To read the original article click here.

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Israeli Covid Drug Also Aids Cancer Immunotherapy Patients

AHA Publisher — Wed, 18 May 2022 07:00:15 +0000

Diana Bletter via Israel21c – Israeli biotechnology company Bonus BioGroup announced that its Covid drug, MesenCure, can also reduce life-threatening inflammatory overreaction in cancer patients treated with immunotherapy. A trial conducted by Bonus BioGroup at the Jackson Laboratory in California showed that MesenCure significantly lowered the inflammatory overreaction in cancer patients that could have caused multisystem failure. Studies show that up to 27 percent of patients undergoing biological cancer treatment who suffer from inflammatory overreaction may develop this potentially fatal complication. Inflammatory overreaction develops in up to 78% of oncology patients treated with biological immunotherapies, which stimulate the immune system to fight cancer, as well as in patients transplanted with blood-forming stem cells. Experts estimate that by 2027, in the United States alone, more than 18,000 patients will suffer from an inflammatory overreaction following biological treatments for cancer that could subsequently develop into a fatal condition. Shai Meretzki, CEO of Bonus BioGroup, said the company’s focus from the start has been cell therapy and tissue engineering to achieve bone tissue regeneration and reconstruction. The main building block is mesenchymal cells extracted from the patient’s adipose tissue. With the outbreak of the global coronavirus epidemic, Bonus BioGroup started experimenting with the very same mesenchymal cells, isolated from adipose tissue of healthy donors, to enhance ability to reduce inflammatory processes, including respiratory infections and other diseases. These efforts led to MesenCure, which Bonus BioGroup will continue to develop to treat severely ill Covid patients. “Demonstrating the success of the drug product MesenCure to integrate with cancer therapies is an important milestone for the company in realizing its vision to become a world leader in cellular therapy for the treatment of various diseases and medical conditions. These indications will present further financial opportunities … and will position Bonus BioGroup as an essential player in the field of oncology, in addition to regenerative medicine and tissue engineering,” Meretzki said. To read the original article click here.

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