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Curcumin Stops Cancer Cell Growth, New Research Confirms

The AHA! Team — Mon, 30 Jun 2025 05:24:05 +0000

Lori Alton via NaturalHealth365 – With its spiky purple flowers and dull green leaves, milk thistle may appear to be nothing more than an ordinary weed growing wild in vacant lots and fields. Turmeric, a kitchen spice from India and Southeast Asia, has long been treasured by natural healers for its ability to fight inflammation, regulate blood sugar, and combat infections. But turmeric benefits extend even beyond these traditional uses. Ongoing research suggests that its active ingredient – a plant pigment known as curcumin – could be a valuable weapon in the fight against cancer. Many studies have supported turmeric’s anticancer effects, including its ability to reduce the number and size of tumors. However, studies also revealed a dramatic and encouraging “twist:” turmeric can potentially target several particularly aggressive and lethal forms of cancer while leaving noncancerous cells unharmed. For instance, recent research has shown that curcumin may help fight colorectal cancer by influencing how cancer cells clean out damaged parts (autophagy) and self-destruct when unhealthy (apoptosis), offering new hope in combating this common and deadly disease. An international team of scientists concludes that curcumin inhibits an enzyme involved in carcinogenesis Researchers at the University of California, San Diego School of Medicine, Peking University, and Zhejiang University collaborated on a study published in the Proceedings of the National Academy of Sciences. The researchers used multiple models to show that turmeric can powerfully inhibit a specific enzyme called DYRK2 (or dual-specificity tyrosine-regulated kinase 2). The team used cutting-edge X-ray crystallography to obtain 3D images – in which curcumin could be seen binding to the enzyme at the atomic level. This is significant because binding to and inhibiting DYRK2 impairs the activity of proteasomes – protein complexes involved in cancer development. The team noted that inhibiting proteasome activity in cancer cells interfered with proliferation, reducing tumors, slower cancer growth, and an overall lessening of the cancer burden. Curcumin targets the “Achilles heel” of lethal cancers Some cancers – including triple-negative breast cancer and multiple myeloma – are classified by scientists as “proteasome-addicted,” meaning they are dependent on proteasome complexes. Impairing the activity of the proteasome inhibits tumor development, leading scientists to theorize that this dependency may well be the “Achilles’ heel” of these aggressive, hard-to-treat cancers. Pharmaceutical proteasome inhibitors have already been developed and approved, but there is a catch: these medications damage noncancerous cells. In response, resourceful researchers have been focusing on inhibiting proteasome activity by identifying and manipulating proteasome regulators. This is where the power of turmeric comes into play. By depleting DYRK2, curcumin suppresses proteasome activity – with very little damage to healthy cells in the area. Curcumin strengthens the cancer-fighting effects of pharmaceutical proteasome inhibitors – meaning that smaller dosages – and fewer side effects – may be possible. When used with carfilzomib – an FDA-approved proteasome inhibitor used to treat multiple myeloma – curcumin increased apoptosis (cancer cell death) – while causing minimal harm to healthy cells. Curcumin uses multiple pathways to target cancer If curcumin’s only cancer-fighting abilities were impairing the DYRK2 enzyme and inhibiting proteasome activity, it would still be a promising area for study in cancer prevention and treatment. However, curcumin has an impressive variety of cancer-fighting pathways. Curcumin helps inhibit angiogenesis, the growth and development of new blood vessels to nourish and support tumors. It also “switches off” genes that promote tumor development while helping the immune system identify and destroy malignant cells. In addition, curcumin can help to protect your DNA from potentially cancer-causing mutations caused by radiation and environmental toxins. It also suppresses the production of MMPs or matrix metalloproteinases. These enzymes attack the extracellular matrix and facilitate the invasion of cancer cells. Finally, by reducing the production of adhesion molecules that cling to cell walls, curcumin stops cancer cells from settling in place – effectively “throwing a monkey wrench” into the ability of cancer cells to metastasize. Additional research supports curcumin’s effectiveness. In one study, curcumin supplementation caused a 36 percent reduction in the size of lung tumors. In another, it caused a 40 percent decrease in the development of colon tumors. And – in one particularly promising clinical study – curcumin cut the growth rate of prostate-specific androgen (a marker of tumor progression) in half. How can I take curcumin? Study co-author Sourav Banerjee, Ph.D., a postdoctoral scholar at UCSD School of Medicine, remarked on curcumin’s “chemical drawbacks,” noting that orally administered curcumin is broken down and eliminated by the human body very quickly. Dr. Banerjee says, “It (curcumin) needs to be modified to enter the bloodstream and stay in the body long enough to target the cancer.” This is why experts say that adding turmeric to food may not provide enough bioavailable curcumin to obtain therapeutic results. The best option currently is to seek a high-quality, high-potency organic curcumin extract standardized to contain at least 95 percent curcuminoids. Note: Do not attempt to treat cancer or any other serious medical condition with turmeric or curcumin without the guidance of a qualified doctor. Before supplementing with curcumin, get the go-ahead from your trusted holistic healthcare provider. Simply put, as scientists continue to discover curcumin’s multiple effects against cancer, this amazing flavonoid seems destined to play a major role in natural cancer therapies and cancer prevention. Sources for this article include: NIH.gov To read the original article click here.

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Curried Chickpea Wraps Recipe

The AHA! Team — Wed, 09 Oct 2024 08:46:49 +0000

Recipe by: Dr. Michael Greger & Robin Robertson from The How Not to Die Cookbook – Curried Chickpea Wraps Recipe One of the ingredients of curry powder, which is one of my favorite spice mixes, is turmeric. Besides being so good for you, turmeric gives the blend its beautiful yellow color. The curried chickpea filling in this recipe also great on top of roasted sweet potatoes, in lettuce wraps, or served as a dip. COURSE: Main Course DIFFICULTY: Moderate SERVINGS: 4 INGREDIENTS ▢1½ cups cooked or 1 15.5-ounce BPA-free can or Tetra Pak salt-free chickpeas, drained and rinsed ▢1 ½ teaspoons curry powder, or to taste ▢1 teaspoon lemon juice ▢1 teaspoon date sugar ▢¼ teaspoon white miso paste ▢Savory Spice Blend to taste ▢½ cup chopped celery ▢⅓ cup shredded carrot ▢⅓ cup chopped cashews ▢⅓ cup raisins ▢1 firm sweet apple, cored and chopped ▢1 tablespoon chopped scallion ▢2 cups shredded lettuce or dark leafy greens of choice ▢4 100% whole-grain tortillas INSTRUCTIONS In a food processor, combine 1 cup of the chickpeas with the curry powder, lemon, date sugar, miso, and Savory Spice Blend to taste with 3 to 4 tablespoons of water. Process until smooth. Add the remaining ½ cup of chickpeas and the celery, carrot, cashews, raisins, apple, and scallion, and pulse just to combine and break up the chickpeas a bit. Taste and adjust the seasonings, if needed. To assemble, divide the chickpea mixture evenly onto the tortillas and top each with the lettuce. Tightly roll up each of the tortillas to make a wrap. Cut each wrap in half and serve immediately. To read the original article click here.

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Indian Spice Cuts Dementia Risk by 40%

The AHA! Team — Mon, 13 May 2024 08:01:26 +0000

Al Sears, MD, CNS – By age 60, you have a 50/50 chance of having a clinically enlarged prostate. And it only gets worse every year. When your prostate isn’t functioning properly, it’s hard to enjoy life. There is a new study from Harvard University that demonstrates the power of special plant compounds called flavonoids. It reinforces the advice I’ve been giving my patients for more than 30 years… Increasing your intake of specific nutrients can head off – and even reverse – early signs of memory loss. The Harvard researchers came to this conclusion after tracking the dietary habits and cognitive outcomes of 78,000 study participants for 20 years. They found that those with a high intake of certain flavonoids were almost 40% less likely to experience cognitive decline.1 While it’s not entirely clear how flavonoids protect your memories, researchers believe the antioxidant and anti-inflammatory properties of these plant metabolites are in play. But what is clear is that dementia and other forms of cognitive decline are not due to the “Alzheimer’s gene” (APOE-e4) or any other aspect of your DNA. It’s another strong indication genes aren’t to blame for the 110% increase in Alzheimer’s that’s projected to happen by 2050. As a regular reader, you know Big Agra’s endless production of processed carbs is the key cause of Alzheimer’s. Our bodies simply weren’t designed for the industrial, grain-based foods modern humans eat. This starchy diet touches off an inevitable cascade of insulin resistance, inflammation, weight gain, and cellular damage. And it’s one reason a growing number of researchers are beginning to refer to Alzheimer’s as “type 3 diabetes.”2 But I see a bright side to the Harvard study. It supports the message I’ve been sharing with my patients for years now… With the right nutrients, you CAN protect yourself from this terrible disease. Why Your Brain Wants You to “Eat the Rainbow” I encourage my patients to “eat the rainbow.” Flavonoids give fruits and vegetables their bright, rainbow-like colors. Think of red and green peppers, purple grapes, blackberries, strawberries, blueberries, carrots, oranges, grapefruit, and so forth. Other food sources of flavonoids include onions, celery, artichokes, and broccoli – as well as spices like parsley and oregano. But given the increasingly alien environment we live in, there’s one brain-protective flavonoid that stands above the rest. And I recommend all my patients include it in their diet. I’m talking about curcumin. Curcumin is the bright compound that gives turmeric it’s unique golden color. Studies show it contributes to significant memory improvement and stronger cognitive function. Turmeric is the ingredient that gives curry its savory, earthy taste. It’s a member of the ginger family. Some researchers believe the heavy curry consumption in rural India explains the low incidence of dementia there. It’s only about a third of the rate seen in Europe and the United States.3 Protect Your Brain with Indian Curry My family loves to make curry. Here’s one of our favorite recipes: Ingredients: 1 teaspoon coconut oil 4 boneless chicken thighs, cut into small pieces 2 cups diced yellow onion 2 cloves garlic, minced 2 tablespoons fresh ginger 6 two-inches pieces of fresh turmeric root, peeled and grated 1 1/2 teaspoons ground cumin 1 teaspoon ground coriander 1/2 teaspoon ground cardamom 1 can (13.6) ounces of coconut milk 1 cup chicken stock 1/2 teaspoon garam masala 4 cups cubed butternut squash 1 tablespoon lime juice Instructions: Sauté chicken in coconut oil until cooked, then remove and set aside. Sauté the onion until it begins to soften. Then add ginger and garlic. Add remaining spices and cook for about 30 seconds. Add the butternut squash, coconut milk, and broth. Simmer for 15 minutes. Add salt to taste along with freshly squeezed lime juice. Add chicken and serve. To Your Good Health, Al Sears, MD, CNS References: 1. Yeh, Tian-Shin, et al. “Long-term dietary flavonoid intake and subjective cognitive decline in US men and women.” Neurology. 2021 Sept;97(10):e1041 – e1056. 2. de la Monte S, and Wands R. “Alzheimer’s disease is type 3 diabetes: Evidence reviewed.” J Diabetes Sci Technol. 2008 Nov; 2(6): 1101–1113. 3. Chandra V, et al. “Incidence of Alzheimer’s disease in a rural community in India: The Indo-US Study.” Neurology. 2001 Sep 25;57(6):985-9. To read the original article click here.

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How to Treat Canker Sores

AHA Publisher — Wed, 02 Nov 2022 07:00:22 +0000

Michael Greger M.D. FACLM via Nutritionfacts – Vitamin C, turmeric, beta-glucan fiber, and vitamin B12 are put to the test for recurring canker sores (aphthous ulcers). Canker sores can be “a painful and often recurrent inflammatory process of the oral mucosa,” the lining of our mouths. Similar to other chronic inflammatory conditions, DNA damage due to oxidative stress caused by free radicals is thought to play a role. Normally, free radical production is balanced with antioxidants, but if the concentration of free radicals gets too high and our antioxidant enzymes and the antioxidants we get in our diet “cannot compensate for these radicals, the balance changes in favor of the oxidants”—that is, in a pro-oxidant direction. This can lead to oxidative damage within our body. Does that mean that people who experience recurring canker sores—also known as recurrent aphthous stomatitis (RAS)—have fewer antioxidants, more oxidation, and more DNA damage? Yes, yes, and yes. As you can see in the graph below and at 0:51 in my video Best Supplement for Canker Sores, they exhibit more pro-oxidants and more oxidative stress in their bloodstream, lower antioxidant status, and more DNA damage. This suggests it might be possible for antioxidants to help improve the DNA damage caused by recurring canker sores, but you don’t know until you put it to the test. Sixteen boys and girls around age 12 with recurring canker sores were given a whopping 2,000 mg (2 g) of vitamin C a day. That’s considered the tolerable upper daily limit for adults before you start getting diarrhea, and 1,200 mg may have that effect on a 12-year-old, but it’s all about risks versus benefits. How did they do? As you can see in the graph below and at 1:33 in my video, 15 out of the 16 kids cut the number of canker sores they were getting at least in half. In the three months before they started the vitamin C, they had averaged four canker sores each, but in the three months they were on it, they each had less than one on average. When they stopped the vitamin C for another three months, the ulcers started coming back. Then, when they once again added the vitamin C, the canker sore rate dropped again. What about directly applying antioxidants, like a turmeric gel? Let’s find out. A turmeric gel containing 2 percent curcumin, the yellow pigment in the spice turmeric, was swabbed directly onto canker sores twice a day and “significantly reduced pain intensity and size of the aphthous ulcer [canker sore] compared to placebo,” which was a gel containing no active ingredient. Okay, but wouldn’t it be nice to see a comparison to an active treatment from an independent research group, rather than this study without an active treatment that was funded by the curcumin gel manufacturer? Yes, and here we go. This randomized clinical trial compared a generic 2 percent curcumin gel to a prescription steroid gel and found that the curcumin worked just as well. This provides “strong evidence that [topical] curcumin gel can be used as an effective and safer alternative to steroids in treatment of RAS.” You may remember I’ve previously discussed that topical honey beat out the same steroid for both ulcer healing and pain reduction, as you can see in the graph and at 2:46 in my video. So, if you’re going to use something topically, honey seems better, but what if, instead of a topical application, you just want to swallow something like vitamin C but want something that doesn’t give you diarrhea? Thirty-one patients with recurring canker sores were split into two groups and received either 20 mg a day of placebo or yeast beta-glucan fiber, which is the amount found in just an eighth of a teaspoon of brewer’s yeast or nutritional yeast. As you can see below and at 3:17 in my video, the placebo group experienced no significant change, whereas ulcer severity in the yeast group was cut nearly in half. So, now you have another useful alternative. If it’s all about antioxidants, can’t you just treat recurring canker sores by eating a plant-based diet high in fruits and vegetables? That hasn’t been put to the test, but keep in mind a plant-based diet could also make things worse if one is not ensuring a regular reliable source of vitamin B12 through supplements or fortified foods. For example, a 30-year-old women had recurring canker sores for four years. She ate few animal products and didn’t supplement with vitamin B12, so she became B12-deficient and began experiencing weakness, tiredness, numbness, and tingling. She was immediately started on vitamin B12, and her deficiency symptoms got better. Her canker sores also improved and she experienced “a rapid and complete recovery” within weeks of starting vitamin B12 after years of suffering. We’ve known since the 1970s that vitamin B12 deficiency can lead to canker sores—so much so that it’s recommended to consider B12 deficiency any time a patient has with recurring canker sores. In fact, a number of nutrient deficiencies may contribute. A study compared the lab tests of those with recurrent canker sores to those without and found that more than half of the canker sore group showed evidence of hematinic deficiencies—that is, blood-forming nutrient deficiencies. In contrast, less than one in ten in the non-canker sore group exhibited these deficiencies. In this case, we’re talking about iron and folate deficiency in addition to vitamin B12 deficiency. When the study participants were given supplements, their canker sores improved and this was more pronounced among those who had no family history of canker sore problems. You can see how vitamin and mineral supplements might help people who are deficient, but might a supplement like vitamin B12 help people who are not vitamin B12 deficient? Apparently so. As the title of the study states, “cyanocobalamin”—the most common form of supplemental B12—“may be beneficial in the treatment of recurrent aphthous ulcers [canker sores] even when vitamin B12 levels are normal.” The researchers took a group of 72 patients with frequent canker sores and gave them vitamin B12, regardless of what their levels were. Ninety-six percent of the participants got better regardless of whether they started out vitamin B12–deficient or with normal vitamin B12 levels in their blood, as you can see below and at 5:37 in my video. In this case, there was no control group, though, so we don’t know how many would have gotten better without the vitamin B12 supplement. In addition, the researchers injected the vitamin B12, and injections can have an even greater placebo effect than pills—especially with something like a syringe of vitamin B12, which has a striking mad-scientist-looking ruby red color, as you can see below and at 5:57 in my video. If only there were a randomized, double-blind, placebo-controlled trial of oral vitamin B12 for canker sores. And, here we go. In this case, 1,000 micrograms of sublingual vitamin B12 were taken every day for six months. It took five months, but, eventually, the duration of canker outbreaks, the number of ulcers, and the level of pain were significantly reduced, “regardless of initial vitamin B12 levels in the blood.” So, whether you are vitamin B12–deficient or not, B12 supplements seem to help. By the end of the study, twice as many in the vitamin B12 group appeared to have been cured. The researchers concluded that “vitamin B12 treatment, which is simple, inexpensive, and low-risk, seems to be effective,” but don’t forget that it appeared to take months before it started working. In another randomized, double-blind, placebo-controlled trial of a vitamin B12 ointment applied directly to the canker sores, a significant reduction in pain was demonstrated within only two days compared to placebo, regardless of whether the participant was vitamin B12–deficient or not. Here’s a link to the video on the remarkable honey results I mentioned: Flashback Friday: Topical Honey for Canker Sores. Key Takeaways A canker sore can be a painful and recurring inflammation of the lining of the mouth, and DNA damage from oxidative stress caused by free radicals may play a role. Antioxidants typically balance free radical production, but oxidative damage within the body can result from changes in a pro-oxidant direction if free radical concentration gets too high and our antioxidant enzymes and the antioxidants we get from food consumed cannot compensate. People with recurrent aphthous stomatitis (recurring canker sores) exhibit more pro-oxidants and more oxidative stress in their bloodstream, lower antioxidant status, and more DNA damage. A daily 2,000 mg of vitamin C resulted in 15 out of 16 kids with recurring canker sores cutting the number of ulcers at least in half. After stopping the vitamin C, the canker sores began reappearing and then dropped back down after the C was re-added. A generic 2 percent curcumin gel worked just as well as a prescription steroid gel, and a topical honey also beat out the same steroid for both ulcer healing and pain reduction. Taking a daily dose of the amount of yeast beta-glucan fiber found in an eighth of a teaspoon of nutritional or brewer’s yeast also nearly halved ulcer severity, while those in the placebo group experienced no significant change. Vitamin B12 deficiency can lead to canker sores, as can hematinic (blood-forming nutrient) deficiencies. The most common form of supplemental vitamin B12, cyanocobalamin, may benefit individuals with recurring canker sores—even with normal B12 levels. When taken sublingually, though, it may take months before it starts significantly reducing the duration of canker outbreaks, the number of ulcers, and the level of pain. Directly applying vitamin B12 ointment to canker sores, however, was found to reduce pain significantly in only two days, compared to placebo, regardless of previous B12 status. To read the original article click here.

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Daily Whipped Frappe for Healthy Joints

AHA Publisher — Wed, 25 May 2022 07:00:17 +0000

Dr. Don Colbert – Looking for an easy, once-daily, effective drink for joint health? We’ve got a delicious one for you! Our Whipped Frappe for healthy joints promotes less pain, less inflammation, and less consumption of medications. What’s more, it’s easy to make and delicious. Just 6 ingredients: try this daily health shot today! Daily Whipped Frappe for Healthy Joints Ingredients 4 ounces low-carb non-dairy milk (coconut milk or almond milk) 1 scoop Keto Zone Hydrolyzed Collagen (Chocolate or Vanilla) 1/2 teaspoon ground turmeric 1 /2 teaspoon ground ginger 1/2 teaspoon ground cinnamon 1/8 teaspoon fresh ground pepper Instructions Place all ingredients in a mug (if using a hand-blender) or blender. Blend until whipped and frothy. Add crushed ice. Enjoy! Nutrition info: 549 calories, 49 grams fat, 6 grams net carbs (8 grams carbs, 2 grams fiber), 22 grams protein 5 Amazing Ingredients for Healthy Joints This amazing frappe is overflowing with effective ingredients for healthy joints. Here’s how each supports joints, reduced inflammation, reduced pain, and overall wellness. 1. TURMERIC FOR INFLAMMATION AND HEALTHY JOINTS Turmeric contains an amazingly strong compound called curcumins. While it’s still unknown exactly how they work to decrease joint pain, turmeric’s effects are well documented. In fact, a recent meta-analysis of curcumin studies concluded that the curcumins in turmeric extract were effective in treating arthritic pain (1). What’s more, animal studies show that curcumins protect cartilage. (2). Additionally, a study of 50 people who suffer from arthritis found a 58% decrease in stiffness and pain after 90 days with curcumin treatment. In fact, the participants’ C-reactive protein, a marker for inflammation, decreased by 16-fold! 2. GINGER FOR PAIN AND JOINT HEALTH The active medicinal ingredients in ginger are phytochemicals, known as gingerols and shogaols. Ginger has long been used as an herbal remedy to relieve many ailments from stomach issues like nausea and motion sickness to bacterial infections (3). But when it comes to pain, gingerols’ anti-inflammatory action comes to the forefront to help. In fact, studies, case studies, and anecdotal reports show that ginger is an effective pain reducer. In one case study from 2014, ginger effectively relieved osteoarthritis within 24 weeks, without any negative side effects (4). Another study from 2014 showed the effectiveness of topical ginger creams for joints (5). And, more studies conclude that gingerols possess anti-inflammatory and analgesic results (6) . 3. CINNAMON’S ANTI-INFLAMMATORY PROPERTIES Chronic inflammation in the body can lead to disease and illness over time, so consuming anti-inflammatory foods can help fight harmful inflammation. A study from 2018 found that cinnamon supplementation resulted in a significant decrease of serum levels of CRP (an inflammation marker), improvements in blood pressure, and improvements in joint health (less tender or swollen joints) (7). 4. REDUCED JOINT PAIN AND INFLAMMATION WITH BLACK PEPPER Piperine, the primary component in black pepper, is a strong anti-arthritis nutrient. In fact, study after study has shown reduced pain, increased healing, and decreased pathology in arthritic animals and humans (8). What’s more, piperine increases the absorption of another pain-fighting food, turmeric, by up to 10x. It does this by stimulating “transporters” in our intestines that are responsible for absorbing nutrients. 5. COLLAGEN FOR HEALTHY JOINTS Hydrolyzed collagen is now well-accepted as an effective food that supports healthy joints and skin. One study from Pennsylvania State University, athletes who took a hydrolyzed collagen supplement for 6 months had less joint pain when they were active and at rest (9). A 2016 study found type II collagen helped support knee health in those with osteoarthritis (10). Furthermore, a 6-month double-blind, randomized, placebo-controlled 2012 study suggested collagen hydrolysate could help improve lower back joint pain (11). Why Not Just Take Ibuprofen Instead? While ibuprofen is routinely consumed by pain sufferers, over-consumption of NSAIDS is associated with altered gut flora, potential ulcers, and other digestive issues. In fact, many experts consider it dangerous when routinely consumed. On the other hand, our whipped frappe contains ingredients that effectively support joint health while promoting full body wellness. Bottom Line No need to reach for the medicine cabinet. Try our Daily Whipped Frappe for Joint Health today. Fill your body with compounds from turmeric, ginger, cinnamon, black pepper, and collagen with one delicious daily drink! To read the original article click here.

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Study Finds Curcumin Is a Potential Therapeutic Agent Against the Omicron Variant of SARS-CoV-2

AHA Publisher — Wed, 04 May 2022 07:00:59 +0000

Shanet Susan Alex via News-Medical – A recent study published in the journal Computers in Biology and Medicine demonstrated that the phytochemical curcumin is a potent therapeutic prospect against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant. Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused over 508 million SARS-CoV-2 cases and six million deaths to date globally. As of now, the SARS-CoV-2 Omicron (B.1.1.529) variant is the dominant strain worldwide. Omicron was designated a variant of concern (VOC) since it can evade vaccine- and infection-induced immunity due to several mutations in its spike (S) protein, including 15 amino acid substitutions across the receptor-binding domain (RBD). Recent studies indicate that many of the most widely used COVID-19 vaccinations offer little or no immunity against Omicron infection. To date, no specific therapeutic regimen for this VOC has been recommended. As a result, Omicron might jeopardize worldwide attempts to contain the COVID-19 pandemic by posing a public health risk. About the Study The present paper aimed to profile seven phytochemicals (capsaicin, gingerol, allicin, curcumin, piperine, zingeberene, and cinnamaldehyde) and discover possible therapeutic options against the Omicron variant. The researchers built a three-dimensional layout of Omicron S RBD by integrating 15 amino acid alterations to the Native S structure. The team contrasted the structural changes of the Omicron S with the Native S. The authors docked the seven phytochemicals with the Omicron S-human angiotensin-converting enzyme 2 (hACE2) complex and the Omicron S protein… Conclusions The study findings illustrated that curcumin harbored the most significant inhibitory capability with Omicron S protein out of the seven phytochemicals tested. The authors also found that curcumin could disturb the Omicron S-hACE2 aggregate. Further, the MD simulation showed that curcumin might establish a stable complex with Omicron S in the physiological milieu. To summarize, the present data depicted that curcumin has the potential to be used as a medicinal agent against the highly infectious SARS-CoV-2 Omicron variant. This article has been modified. To read the original article click here.

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Turmeric with Black Pepper: What It’s Good for and How to Take It

AHA Publisher — Fri, 29 Apr 2022 07:00:48 +0000

Michael Greger M.D. FACLM via Nutrition Facts – Historians have gathered evidence showing that people—from long ago and from around the world—have used herbs, often in a sophisticated way. Quinine from Cinchona bark, for instance, was used to treat the symptoms of malaria long before the disease had even been identified, and the raw ingredients of a common aspirin tablet have been a popular painkiller for far longer than we have had access to tablet-making machinery. In fact, many pharmacological classes of drugs today include a natural product prototype that we had originally discovered through the study of traditional cures and folk knowledge of indigenous peoples. A plant in South Asia called adhatoda—from adu meaning “goat” and thoda meaning “not touch” because it’s so bitter even goats won’t eat it—has compounds that help open our airways. Adhatoda tea, with its leaves steeped with black peppercorns, has been used traditionally to treat asthma. I can see why tea would be made from that plant, but why incorporate black peppercorns? In 1928, scientists discovered what the South Asians evidently had already known: Adding pepper increases the anti-asthmatic properties of the adhatoda plant’s leaves. Why Black Pepper with Turmeric? The Indian spice turmeric, which gives curry powder its characteristic golden color, is so beneficial that my Daily Dozen recommends we get at least a quarter teaspoon every day. Why should we pair it with black pepper? Key Active Ingredients Curcumin in Turmeric Approximately 5 percent of the spice turmeric is composed of an active compound called curcumin, which is responsible for turmeric’s bright yellow color. Piperine in Black Pepper About 5 percent of black pepper by weight is comprised of piperine, a compound that gives the spice its pungent flavor. Piperine is a potent inhibitor of drug metabolism. One of the ways our liver gets rid of foreign substances is by making them water soluble so they can be more easily excreted. But, this black pepper molecule inhibits that process. How Do Turmeric and Black Pepper Work Together? Within an hour of consuming turmeric, we get a little bump in the level of curcumin in our bloodstream. We don’t see a large increase because our liver is actively trying to get rid of it. Would taking just a quarter teaspoon’s worth of black pepper suppress that process? Indeed. By adding just a little black pepper, the bioavailability of curcumin shoots up by 2,000 percent, as I discuss in more detail in my video Boosting the Bioavailability of Curcumin. Even just a little pinch of pepper—1/20th of a teaspoon—can significantly boost curcumin levels. And guess what a common ingredient in curry powder is besides turmeric? Black pepper. Other Ways to Boost Turmeric’s Benefits When we consume curcumin in its whole food form of turmeric root, whether fresh or dried as a powder, absorption of the pigment is also boosted. Natural oils found in turmeric root and turmeric powder can enhance the bioavailability of curcumin seven- to eight-fold. What’s more, when eaten with fat, curcumin can be absorbed directly into the bloodstream through the lymphatic system, thereby in part bypassing the liver. In India, this is exactly how turmeric is commonly used culinarily—with fat and black pepper. Amazing! Unfortunately, their traditional knowledge certainly failed them with ghee, which is practically pure butter fat. That may explain India’s relatively high rates of heart disease despite all the turmeric in their diet. What Is Turmeric Good For? What makes turmeric so healthful that it has a spot on my Daily Dozen? Treating Ulcerative Colitis: Curcumin seems to be a promising and safe medication—no side effects at all reported—for maintaining remission in patients with quiescent ulcerative colitis. Treating Lupus: A quarter teaspoon of turmeric has shown to be effective for the treatment of uncontrollable lupus (SLE) nephritis. Treating Osteoarthritis: Turmeric may work as well as, or better than, anti-inflammatory drugs and painkillers for the treatment of knee osteoarthritis. Speeding Recovery from Surgery: In the weeks following surgery, curucmin has been demonstated to lead to a dramatic drop in pain and fatigue. Treating Alzheimer’s: A teaspoon per day of turmeric may be effective and safe for the treatment of the behavioral and psychological symptoms of dementia in Alzheimer’s disease patients. Fighting Cancer: Curcumin has the ability to kill tumor cells and not normal cells. Furthermore, because it can affect numerous mechanisms of cell death at the same time, it’s possible that cancer cells may not easily develop resistance to curcumin-induced cell death like they do to most chemotherapy. Improving Endothelial Function: The efficacy of curcumin for boosting endothelial functionis comparable to that obtained with exercise. Therefore, regular ingestion of curcumin could be a preventive measure against cardiovascular disease in postmenopausal women. Preventing Diabetes in Prediabetics: In a randomized, double-blinded, placebo-controlled trial of folks diagnosed with prediabetes, in the group that were given curcumin supplements, none went on to get full-blown diabetes after nine months. They group saw a significant improvement in fasting blood sugars, glucose tolerance, hemoglobin A1C, insulin sensitivity, pancreatic insulin-producing beta cell function (measured two different ways), and insulin sensitivity. What if you already have diabetes? Same beneficial effects, and at a fraction of the dose. Treating Inflammation Eye Conditions: From conjunctivitis (pink eye) to uveitis, to a low-grade form of non-Hodgkin’s lymphoma, turmeric displays dramatic anti-inflammatory effects. What Are the Side Effects of Turmeric? I love cooking with turmeric and recommend including it into our daily routine that way rather than taking curcumin supplements, especially during pregnancy. Gallstones It takes about 40 milligrams to get a 50 percent gallbladder contraction, which keeps bile from stagnating. If you have a stone blocking your bile duct and eat something that causes your gallbladder to squeeze down hard, you may be seeing stars from the pain! Patients with biliary tract obstruction should be careful about consuming curcumin, but, for everyone else, these results suggest that curcumin can effectively induce the gallbladder to empty and thereby reduce the risk of gallstone formation in the first place and, ultimately, perhaps even gallbladder cancer. Kidney Stones Too much turmeric may increase the risk of kidney stones. The spice is high in soluble oxalates, which can bind to calcium and form insoluble calcium oxalate, which is responsible for approximately three-quarters of all kidney stones. Those with a tendency to form kidney stones should restrict turmeric intake to one teaspoon per day. How Much Turmeric and Black Pepper Should You Take Daily? With few downsides at culinary doses and myriad potential health benefits, I’d suggest trying to find ways to incorporate turmeric into your daily diet. I recommend consuming at least a quarter teaspoon of turmeric every day as part of my Daily Dozen checklist, and flavor your dishes with black pepper for added kick and added healthful benefits. How to Take Turmeric with Black Pepper Simply add these spices to your favorite soups and stews. They can also be blended with bananas and cashews to make a golden turmeric smoothie. Here are two of my favorite recipes that feature both turmeric and black pepper: Garden Veggie Tempeh Veggie Mac & Cheese Conclusion I’ve previously covered the topic of food synergy in videos such as Apples and Oranges: Dietary Diversity and Garden Variety Anti-Inflammation, emphasizing the importance of eating different plant foods to take advantage of some of these interactions. The black pepper mechanism reminds me of stories about grapefruit (Tell Your Doctor If You Eat Grapefruit) and broccoli (The Best Detox). A testament to the power of plants! I briefly mentioned the painkilling properties of aspirin. Did you know they’re found naturally throughout the plant kingdom? See Aspirin Levels in Plant Foods. In some circumstances, the wisdom of traditional medicine seems incredible, as I discuss in Tomato Effect. It can also be dangerous, as you can see in Get the Lead Out. Thank goodness for science! For all of our videos on the latest research on turmeric, visit our Turmeric topic page. In health, Michael Greger, M.D To read the original article click here.

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15 Simple Super Foods That Support Your Immune System

AHA Publisher — Tue, 31 Aug 2021 07:00:02 +0000

Dr. Don Colbert – If you’re looking to support your immune system and stick to a low-carb diet, you’re in luck. There are many low-carb Keto Zone® foods that support your immune system. In fact, while refined starches and sugar actually inhibit immune function, many healthy low-carbohydrate fats, proteins, and vegetables support it. Here is our Top 15 List! 15 Simple Superfoods That Support Your Immune System 1. Anti-Inflammatory Spices i.e. Ginger and Turmeric Looking for a strong anti-inflammatory, immune-supporting punch? Ginger and Turmeric are potent spices with anti-inflammatory components. In fact, the main compound in turmeric, curcumin, can normalize inflammation, joint pain, and provide a plethora of health benefits. What’s more, ginger does many of the same things. It promotes whole-body health, supports the immune system, reducing inflammatory and pain responses with its strong antioxidants. Why is reducing inflammatory responses important in supporting your immune system? Inflammation directly affects the immune system by changing the course of hormones and impacting the immune response (1). 2. Fish Oils and Omega-3 Sources Like anti-inflammatory spices, omega-3 fats from fish and seafood are foods that support your immune system. In fact, they are some of the most potent compounds to reduce inflammatory hormone production. It’s vital to have a good ratio of dietary omega-3 fats compared to omega-6 fats. Both are needed for human health, but modern diets are far too high in omega-6 foods (mostly due to processed foods), and too low in omega-3s from fish and seafood, seeds, nuts, and more. Great choices for omega3 fatsare salmon, halibut, and tuna. 3. MCT Oil Powder While it works differently than omega3 fats, the medium-chain triglycerides in MCT Oil Powder also reduce inflammatory reactions. In fact, studies have shown that MCT oil directly reduces the response of C-reactive protein (a marker for inflammation) (2). 4. High Antioxidants Fruits and Vegetables Antioxidants are also vital compounds in foods that support your immune system. Antioxidants fight free radicals that damage all cells and systems, including the immune system, reduce inflammation, and support cellular detoxification. For example, two high-antioxidant superfoods found in Divine Health Fermented Green Supremefood® and Organic Red Supremefood® that support the immune system in this way are beets, spirulina, and wheatgrass (3, 4, 5, 6). Great choices include berries, asparagus, greens, kale, broccoli, cauliflower, and more. 5. Oleocanthal Oleocanthal is a special compound isolated from high-quality Greek olive oils. While it’s not easy to find it in most commercial olive oils, it can be consumed in Dr. Colbert’s Oleocanthal (Powerful Antioxidant Concentrated from High-Phenolic Extra Virgin Olive Oil). In fact, it contains disease-fighting antioxidants, anti-inflammatories, and compounds that support heart health. Oleocanthal is so strong it reduces inflammation in similar strength to some medications, like ibuprofen (4). Additionally, it provides both antibacterial and antiviral action (5). Oleocanthal is a compound that absolutely supports your immune system. 6. Avocados Avocados are another anti-inflammatory food. It has fats called phytosterols. They are known to combat the inflammation associated with arthritis. Avocados also contain polyhydroxylated fatty alcohols (PFAs), which are also potent anti-inflammatories. Lastly, avocado’s oleic acid supports digestive tract health to directly boost the immune system. 7. Proteins from Eggs, Meats and More While many people consume more protein than they need, it is still a vital macronutrient for the immune system. In fact, when people suffer from protein malnutrition, they are typically unable to fight diseases from bacteria or viruses. The immune system, hormones, cellular growth and repair, and other systems all rely on adequate protein. 8. Collagen and Bone Broth If you’ve been told to eat chicken noodle soup when you’re sick, it’s mostly for the bone broth. The collagen in bone broth and Keto Zone Collagen Powder support the immune system by: Providing amino acids and proteins Fortifying the cells in the digestive tract Reducing inflammation 9. Natural and Supplemental Probiotics One very important step to support your immune system is to support your gut. The cells in the digestive tract and the healthy bacteria that live there are vital to the immune system and nourishment of the whole body. There are many ways to get probiotics, or healthy bacteria, in low-carbs foods. These include probiotics found in Keto Zone Collagen Powder, Organic Green and Red Supremefood®, Keto Zone Living Milled Chia with Probiotics, plain yogurt, kimchi, kombucha and more. By adding healthy bacteria to your diet, you can support your immune system (8). 10. Garlic and Onions Garlic is a wonderful food to support your immune system. Garlic’s compounds fight viruses and bacterias while supporting cellular detox. Studies show that garlic may be effective in supporting natural immune functions against antibiotic-resistant strains of bacteria (9) and strong viruses. Additionally, onions support your immune system with antioxidants, anti-bacterial and anti-cancer compounds. 11. Lemons and Lemon Juice Vitamin C is one of our most-studied and well-known antioxidants. Lemons contain vitamin C plus antibacterial components effective throughout the mouth and intestines. 12. Black Pepper, Cinnamon, and Cloves Setting in your spice cupboard are incredibly strong foods that support your immune system (in addition to turmeric and ginger). These include: Black peppercorns support your immune system with potent antioxidants like piperine and anti-inflammatory compounds (10. Cinnamon is not only known for being anti-inflammatory, but it’s cinnamaldehyde can also fight infections directly. It inhibits Salmonella, Staphylococcus aureus, and Helicobacter pylori. What’s more, it can fight tooth decay and supports the immune response to infection. Cloves, like cinnamon, are a spice that supports immune health, fights bacteria, and fights free radicals. 13. Cauliflower and Broccoli Cauliflower and broccoli are amazing vegetables. In addition to antioxidants that fight oxidative stress, their nutrients specifically support cellular detoxification to keep cells healthy and thriving. This includes both Phase 1 and Phase 2 of cellular detoxification. 14. Apple Cider Vinegar Organic apple cider vinegar is an ingredient in many folk medicine cures. It is known to fight both bacterial and viral infections, yeasts, and more. Importantly, you should never drink it straight. Always dilute to just 1-2 tablespoons per 8 ounces liquid to protect your esophagus. 15. Water, Green Tea, and Black Tea Green and black tea are packed full of antioxidants that fight free radicals, fight bacteria, and support your immune system. In fact, their specific nutrients fight microbes in the mouth. And water? Not only is it necessary for life, but it’s also necessary for the immune system. Especially during times of viral outbreak, it’s important to stay hydrated and keep your mouths and airways moist. Bonus: Introducing DR. COLBERT’S IMMUNE SUPPORT! In addition to consuming immune-supporting foods, now you can also support your immune system with Dr. Colbert’s Immune Support supplement. Dr. Colbert has designed this product specifically to promote healthy skin, gut health, connective tissue, and immune function. Get yours today! Bottom Line You don’t have to go shopping for extravagant foods to eat super foods that support your immune system. In fact, many on our list are likely already in your home. Support your immune system this year with healthy Keto Zone foods and supplements! To read the original article click here.

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Protect Yourself From Antibiotic Resistance by Using Natural Antibiotics

AHA Publisher — Wed, 18 Aug 2021 07:00:57 +0000

Michelle Marks via NaturalHealth365 – Most of us are aware that antibiotics are powerful drugs that fight bacteria-related infections with harmful side effects. Unfortunately, in today’s society of pill taking, we use too many antibiotics with the increasing danger of antibiotic resistance. The problem is further compounded with antibiotics found in factory foods like dairy and meat products. According to the CDDEP (The Center of Disease Dynamics, Economics, & Policy), the United States is one of the highest users of antibiotics – ranking fifth in the world. How the Wrong Diet Makes Antibiotics Useless Heavy prescription abuse and unintentional ingestion of antibiotic-based foods are the primary cause of resistance to antibiotics. Unfortunately, this is emerging as one of the most serious public health problems of our time. Although antibiotics can eliminate infectious conditions, their continuous use builds resistance to the antibiotic drug. The harmful bacteria in the body get accustomed to the therapeutic levels of antibiotic drugs and stop responding to the drug. In other words, an antibiotic drug, even at its highest potency, cannot stop bacterial growth and becomes incapable of treating an underlying infection. In fact, researchers suggest that almost every kind of bacterium has adapted itself to show resistance to antibiotic drug treatment. What Are the Potential Dangers of Antibiotic Resistance? Destroys healthy bacteria: The population of healthy bacteria in the gut is decreased to a smaller number creating an imbalance in the gut ecosystem resulting in frequent illness, indigestion, and poor nutrient absorption. Makes infections spread faster: Antibiotic-resistant bacteria can spread like wildfire to others in the family or neighborhood, threatening an entire community with a new strain of infection. Complicates treatment: Because the strain is more virulent, the patient does not respond to heavy doses of drugs. As a result, the treatment becomes more difficult and expensive. Death due to infection: The underlying infection remains untreated, posing a severe threat to other organs and, in some cases, leads to death. What Actions Can We Take to Avoid Antibiotic Resistance? 1. Avoid the spread of infection in the first place by washing your hands thoroughly. 2. Consume organically grown produce, avoid consuming animal and animal-based products that are fed antibiotics. 3. Choose natural antibiotics like garlic, herbs, and vitamin C that have bactericidal properties. What Are Natural Antibiotics? Nature has an effective yet safe answer to bacterial infections through various phytochemicals from different plant parts. These have been used for many centuries in traditional medicine systems to treat a variety of conditions. Natural antibiotics act in a unique mechanism – in addition to their bactericidal action. They stimulate the immune system, exhibit anti-inflammatory and anti-septic properties that inhibit the growth of bacteria, and scavenge them. What Are Some of My Options? Vitamin C: This water-soluble vitamin is a potent antioxidant and anti-infective agent. Abundant in all fresh fruits, especially the citrus variety, vitamin C can be consumed liberally in the diet in its natural state. If considering a vitamin C supplement, the recommended amount is 1-3 grams per day for healthy individuals. But, if you’re suffering from a troubling health issue – much more vitamin C may be required for a short period of time. Oregano oil: The oil of oregano leaves is a powerful anti-infective agent and natural antibiotic. It has been shown to be effective against harmful bacteria, yeast, and viruses. Most of the oregano oils in the market are usually a blend of other oils. The common recommendation is 2 – 3 drops 3 – 4 times daily. If consuming capsules, an amount of 100 – 150 mg per capsule per day is recommended. Olive leaves: Olive leaves are known for their anti-microbial properties and analgesic effects. The active ingredient oleuropein is responsible for its therapeutic effects. Olive leaves are low in toxicity, and the recommended safe amount for an adult is 25 mg per day twice daily for maintaining health. Ginger: The active components in ginger gingerols, zingerone, and shogaol are linked to its anti-bacterial effects. It is also a potent anti-inflammatory agent and is used in the Ayurvedic system of medicine as a pain reliever. Thus, ginger is a fantastic therapeutic food that can be included in the daily diet as part of a menu. As little as 2 – 3” of ginger added to a shredded, crushed, or cooked dish will take care of daily needs. Turmeric: This is a culinary staple in Indian cuisine and can be consumed safely at 1 to 2 teaspoons per day added to a recipe. Turmeric is known for its remarkable bactericidal, anti-inflammatory, anti-infective, and anti-carcinogenic effects. If considering a supplement, 500 grams consumed in a fat-soluble base facilitates its absorption. Garlic: There are plenty of studies that demonstrate the powerful antibacterial effect of garlic. One study showed that natural spices of garlic exhibited a potent antibacterial effect. According to the researchers of this study, garlic showed an effect on multi-drug pathogens and can be used for treating drug-resistant microbial diseases. Garlic needs to be crushed, exposed to air for a few minutes, and consumed raw for effective antibiotic effects. If using a supplement, consume garlic extract with at least 1.3% alliin at 600 – 1,200 mg per day. What’s the bottom line? With antibiotic resistance on the rise at an alarming rate, it seems wise to turn to natural and healthier alternatives to fight bacterial infections. It is also important to remember that we need to consume organic, natural, and antibiotic-free products for improving overall health and make a conscious effort to avoid unnecessary ingestion of antibiotics – which can damage our digestive system and immune function. Sources for this article include: NIH.gov NIH.gov NIH. gov To read the original article click here.

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