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Research Links Excessive Oxalates to Breast Cancer

The AHA! Team — Wed, 20 Aug 2025 05:46:57 +0000

Dr. Veronique Desaulniers via NaturalHealth365 – A study conducted by the National University of Cordova in Argentina compared the oxalate levels of breast cancer tumor tissue and regular breast tissue. They found that “all tested breast tumor tissues contain a higher concentration of oxalates than their counterpart non-pathological breast tissue.” Information about little-known compounds called oxalates can be confusing and conflicting. They are often equated with the “bad” substances in foods, but, in reality, oxalates are neither good nor bad. They can become problematic, however, when too many of them accumulate in the body. When there are too many oxalates – they can overwhelm the kidneys and lead to kidney stones and immune deficiency. Furthermore, research indicates that high levels of oxalate in the mammary area have been linked to breast cancer tumor growth as well. The body itself forms most oxalates Oxalates (COOH), or oxalic acid, are strongly acidic substances that help plants and animals metabolize. The body’s functions form about 60% to 80% of oxalates. The other 20 to 40% of oxalates come from food. Most fruits and vegetables contain a small amount of oxalic acid, and they are found in the leaves of plants as opposed to the roots, stalks, and stems. The following foods contain a high amount of oxalates overall: Rhubarb Chocolate Spinach Beet greens Swiss chard Some nuts, especially almonds, cashews, and peanuts Some berries, especially gooseberries Lemon and lime peel Some grains and pasta (except brown rice) Some legumes, especially navy beans, black beans, and soybeans Okra Parsley How are oxalates linked to breast cancer? Oxalates are oxidizing substances. As such, they are extremely volatile and can damage tissue in large amounts. Oxalate crystals cause the formation of kidney stones, which can block the flow of urine and lead to kidney infection and bladder cancer. These crystals are also razor sharp and can cause direct damage and long-lasting inflammation to whatever internal tissues they come into contact with. Oxalate-iron crystals can lead to iron depletion. When calcium-oxalate crystals form, they can lodge in internal organs and bone. As they grow, they crowd out bone marrow, leading to immune deficiency and anemia. Excess oxalates also can chelate heavy metals. However, oxalates trap metals like mercury and lead in tissues, unlike other chelators. Excess oxalate has been linked to fibromyalgia, vulvodynia (vulvar pain), digestive disorders, and autism. The most startling new connection between excess oxalates and disease has to do with breast cancer, however. A study conducted by the National University of Cordova in Argentina compared the oxalate levels of breast cancer tumor tissue and regular breast tissue. They found that “all tested breast tumor tissues contain a higher concentration of oxalates than their counterpart non-pathological breast tissue.” The researchers also discovered that oxalic acid caused tumor proliferation and stimulated the expression of pro-tumor genes. Surprisingly, proliferation did not happen when oxalate was injected into the backs of laboratory mice. This indicates that high oxalate levels do not induce cancer tumor growth in all types of tissue. Three ways to reduce your oxalate levels Obtain calcium from natural foods, not calcium supplements. Calcium has an interesting relationship with oxalates. Approximately 5-15% of the world population will develop some form of kidney stone. Of those, 80% will be calcium-oxalate stones. When calcium is combined with foods that are high in oxalates within the intestines, the two together form an oxalate-calcium crystal that the body cannot absorb. When this happens, a “stone” is formed that will make its way to the kidneys to eventually be eliminated in the urine. The presence of oxalate-calcium crystals, which can block urine flow and cause kidney infection, can also lead to a higher risk of renal, pelvis, and bladder cancers. These same kinds of crystals can also form in the lungs, nerves, brain, bones, blood vessels, and joints. Does this mean you should limit calcium intake if you are prone to kidney stones? Not necessarily. Research conducted on vegetarians found that they did not have higher-than-normal rates of calcium deficiency or osteoporosis caused by oxalate interference. In fact, according to a study published in the European Journal of Epidemiology, vegetarians had a lower rate of kidney stones than meat eaters did. Those who consumed calcium supplements regularly, however, have shown time and again to have higher rates of kidney stones. Calcium supplementation has also been linked to both prostate and breast cancer. Stick to natural and preferably vegetable and fruit-based calcium sources to avoid kidney stones and cancer. Be aware of your protein intake. Be cautious about protein, especially if it is derived from meat and dairy. Oxalates are produced from amino acids in the liver. Amino acids are the building blocks on which proteins are made so some researchers make the connection between total protein amounts and total oxalates formed. For meat-eating women, the general recommendation is around 5 ounces a day. This is equivalent to a small hamburger patty or four eggs. The USDA states that, on average, Americans eat 30% more meat protein than the recommended allowance. Maintain good intestinal flora. According to research, some individuals have a physiology prone to higher levels of oxalate uptake in the digestive tract (thus, a higher risk of kidney stones). Although there is evidence to suggest that hereditary disposition plays a role for some people, there is also a strong link between kidney stone formation and disorders of the digestive system, such as inflammatory bowel disease, leaky gut, and Crohn’s. Could oxalate hyper-absorption have more to do with extreme gut flora imbalance than genetics? The jury is still out on that one. What is known, however, is that it is the job of specific flora, in particular, certain species of Oxalobacter formigenes, Lactobacillus, and Bifidobacteria, to process oxalic acid and prepare it for absorption. Currently, there are several studies underway which focus on the role of oral probiotics in this process. Let food work for you to keep oxalate levels in balance Remember that problems only emerge when there is an excess of oxalates in the system. The standard American diet contributes to oxalate overload, but you can also keep it in check by being proactive with prevention. Eating antioxidant-rich food, consuming citrate-rich lemon and lime juice (which experts say can help prevent calcium-oxalate kidney stones), staying hydrated, and watching your salt intake are other ways to keep kidney stones in check. Also, don’t let the fear of kidney stones prevent you from getting adequate amounts of vitamin C and D. One of the ways that oxalates are formed is through conversion from vitamin C. However, studies thus far have been inclusive as to whether high vitamin C intake actually leads to increased oxalate production. In regards to vitamin D, deficiency of this vital substance has reached pandemic proportions in the developed world, including among those who have experienced kidney stones. Be sure to get your levels checked the next time you get blood work done. Maintaining a healthy balance of all substances in the body, including oxalates, is the only way to achieve and experience true health naturally. Editor’s note: For the finest quality vitamin C and D plus many other supplements, shop LuvByNature today. Sources for this article include: NIH.gov NIH.gov Oxfordjournals.org MDPI.com NIH.gov NIH.gov NIH.gov Sciencedaily.com Scientificamerican.com Nutrition.org To read the original article click here.

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Tricking the Body to Treat Breast Cancer

AHA Publisher — Fri, 18 Mar 2022 07:00:43 +0000

Sanford Burnham Prebys via Newswise – With the help of two new grants from the National Institutes of Health totaling more than $4.4 million, Sanford Burnham Prebys professor Charles Spruck, Ph.D., and his team are refining a cutting-edge breast cancer treatment. The new approach, known as viral mimicry, tricks the body into thinking that it has a viral infection, stimulating immune responses that can help the body fight cancer and improve the effects of other treatments. “Modern cancer treatment relies on using multiple treatment strategies to minimize the risk of resistance, so the beauty here is that while we’ve found that our approach has anti-tumor properties when used alone, it also has the potential to work synergistically with other treatments,” says Spruck. “Fortunately, it is cancer-specific, so unlike chemotherapy, this treatment won’t harm healthy cells, thus also limiting adverse side effects.” ER+ Breast Cancer Is Treatable, But Frequently Recurs Breast cancer is the most common cancer globally, and about 70% of all breast cancer cases are ER+, meaning that cancer cells use the hormone estrogen to grow. In the United States, there are about 3 million people living with ER+ breast cancer. Because ER+ tumors rely on hormones to grow, they can be inhibited with anti-hormone therapies, which are much less toxic than standard chemotherapy. Early-stage ER+ breast cancer is usually responsive to treatment, but a significant proportion of patients go on to have a relapse when the cancer returns, often traveling to other areas of the body. These relapses tend to be much more treatment resistant and often occur many years after the initial cancer is gone. “For survivors, there’s always the risk of a relapse that could resist treatment and eventually kill them,” says Spruck. “That’s a terrifying prospect to live with, especially if you’re otherwise healthy and cancer-free. That’s why we need to develop better, less toxic treatments.” Useful Viruses Are in Our Genome The new approach takes advantage of a bizarre evolutionary feature of our genome called endogenous retroviruses (ERVs). These are small, repeated sections in our genome that were left behind by viruses infecting our ancient ancestors. Unlike regular viruses, ERVs do not make us sick. Instead, they help control gene expression by moving around and inserting themselves into different locations in our genome. ERVs don’t make us sick because they are usually silent, meaning that the proteins they encode are not expressed in the body. However, researchers have found that it’s possible to reactivate these fragments in cancer cells and fool the body into mounting an immune response. “The body thinks there’s an infection, which kicks the immune system into high gear,” says Spruck. “This makes cancer cells more receptive to immunotherapy and can slow tumor growth, but without the harsh side effects of chemotherapy.” Bringing Viral Mimicry to the Clinic With the new grants, the team will more fully explore how viral mimicry can be used to fight ER+ breast cancer. The team is also working on converting its approach, which has only been studied in a lab setting, into a drug that can be administered in the clinic. “We’re still a few years out from using this in the clinic, but we’ve seen that it works in the lab, and once it does make it into the clinic, it’s going to be safer and less toxic than current treatment options,” adds Spruck. The researchers are also confident that the method will be applicable to other cancers beyond ER+ breast cancer. “We discovered the pathway in breast cancer, but the fact remains that with a few exceptions, the majority of tumors are cold for most cancers,” says Spruck. “We’re not just improving breast cancer treatment, we’re opening a door to a new way of approaching cancer.” To read the original article click here.

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Roswell Park Researchers Identify Key Link Between Stress and Cancer

AHA Publisher — Mon, 08 Nov 2021 08:00:50 +0000

Roswell Park Comprehensive Cancer Center via Newswise – BUFFALO, N.Y. — Stress can have a significant negative effect on health, but our understanding of how stress impacts the development and progression of cancer is just beginning. A team from Roswell Park Comprehensive Cancer Center has identified an important mechanism by which chronic stress weakens immunity and promotes tumor growth. Their findings, just published in Cell Reports, point to the beta-adrenergic receptor (β-AR) as a driver of immune suppression and cancer growth in response to stress, opening the possibility of targeting this receptor in cancer therapy and prevention. Using a preclinical model of triple-negative breast cancer, a research team led by Hemn Mohammadpour, PhD, DVM, a postdoctoral research affiliate in the lab of Elizabeth Repasky, PhD, and Dr. Repasky, who is Co-Leader of the Cell Stress and Biophysical Therapies Program and the Dr. William Huebsch Professor in Immunology at Roswell Park, found that as tumors grow, they become more sensitive to stress signals coming from the nervous system. Specifically, the researchers discovered that a population of immune cells known as myeloid derived suppressor cells (MDSCs) show an increase in the expression of β-AR, a molecule that controls the function of key immune cells. The findings will help researchers better understand why prolonged exposure to stress often makes our immune system less effective, and build on Roswell Park’s pioneering research into the relationship between stress and cancer. “This increase in β-AR expression on myeloid-derived suppressor cells allows these cells to be stimulated by the stress hormone norepinephrine, which fosters an immunosuppressed environment that promotes tumor growth by increasing MDSCs’ ability to generate and process energy and suppress anti-tumor immune response,” says Dr. Mohammadpour, the paper’s first author. “This study provides some very important clues that help explain the specific mechanisms by which prolonged stress stimulates tumor growth and decreases lifespan.” While there has been a longstanding recognition that long periods of stress, or chronic activation of nerves, are harmful to overall health, details about how this occurs are unclear, especially in the setting of cancer. A better understanding of the specific ways in which stress influences cancer, particularly in terms of lowering immunity against tumor cells, could be used to design new drugs or therapies that can help to minimize negative effects of chronic stress and boost cancer immunotherapy. Based on these findings, Dr. Repasky’s team is planning new clinical and laboratory studies to identify therapies — including existing therapies already approved for other applications — that can block these harmful stress signals and stop the negative cycle of cancer growth and metastasis. “This is especially important for cancer patients, who frequently endure greatly increased levels of stress after their diagnosis, including anxiety, depression and worry about factors like finances and family interactions,” adds Dr. Mohammadpour. Several clinical trials are planned or underway to investigate which interventions are most effective at mitigating the effects of stress in patients with cancer. Roswell Park is currently studying the effects of combining the β-AR blocker propranolol, which is traditionally used to treat migraine headache and various heart problems, with immunotherapy. The study, “β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME,” was supported by the National Institutes of Health and National Cancer Institute (grants R01CA205246, R01CA099326, R01CA172105, F32CA239356, K99 HL155792, T32CA085183 and F30CA265127 and P30CA016056, Roswell Park’s core grant from the NCI) and by the Roswell Park Alliance Foundation. Co-authors include Philip McCarthy, MD, Professor of Oncology and Internal Medicine and Director of Roswell Park’s Transplant & Cellular Therapy Center; Scott Abrams, PhD, Co-Leader of Roswell Park’s Tumor Immunology and Immunotherapy Program; and Cameron MacDonald, a predoctoral trainee in immunology. To read the original article click here.

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Eating THESE Seeds May Reduce Breast Cancer Mortality, Study Shows

AHA Publisher — Thu, 21 Oct 2021 07:00:47 +0000

Stephanie Woods via NaturalHealth365 – Breast cancer is the second most common cancer in women in the United States, coming just behind skin cancer. It also falls just behind lung cancer as the second leading cause of death in women. An estimated 1 in 8 women will be diagnosed with breast cancer in their lifetime. And, while – conventionally speaking – doctors promote mammograms as a “helpful” diagnostic tools to detect the presence of tumors, they do nothing to decrease the risk of developing breast cancer. Thankfully, nature provided various plants that contain compounds with cancer-fighting properties. One such example is flaxseed, which according to studies may reduce the mortality rate by as much as 70%. High Concentrations of Lignans Make Flaxseed a Cancer-Fighting Superfood Flaxseed is chock full of phytoestrogens called lignans. These plant estrogens act as antioxidants in the body. You can find lignans in many common foods: Beans Pumpkin seeds Broccoli Sesame seeds Grains like oats, wheat, barley, and rye Sunflower seeds While these are all great sources, flaxseed tops them all with amounts that are much, much higher. And it seems that a high concentration of lignans is precisely what is needed when fighting breast cancer. Impressive Research Shows Flaxseed Reduces Tumor Growth A review of research on flaxseed and breast cancer from the University of Toronto highlights some exciting discoveries that could mean very good news for cancer patients. Observational studies showed a reduced breast cancer risk (primarily among postmenopausal women) in connection with the intake of flaxseed, urinary excretion, or serum levels. A 33% to 70% reduction in breast cancer mortality was attributed to lignans. Most animal studies maintaining a diet that is 2.5% to 10% flaxseed, flaxseed oil, or the equivalent amount of lignans reduces the growth of tumors. Clinical trials found that tumor growth in breast cancer patients was reduced after patients were given 25 grams of flaxseed a day for 32 days. That’s not all! Flaxseed boosts brain health as well which helps with mental health issues like depression and anxiety. Flaxseed Protects Women From Breast Cancer in MULTIPLE Ways Science has identified several ways that flaxseed can help protect women from breast cancer: It decreases the proliferation of tumor cells Lignans block the blood supply to the tumor It lowers the risk of metastasis Lignans block estrogen receptors and lower excess estrogen production Study after study shows that flaxseed is not only a powerful cancer fighter, but it can also reduce your risk of cancer. Best of all, it is something you can start adding to your diet today. Here Is How to Incorporate Flaxseeds Into Your Diet Most of the studies found that 2.5 tablespoons of flaxseed, just 25 grams, is effective in fighting cancer. Postmenopausal women can safely have up to 40 grams a day. But how do you do it? Flaxseed isn’t that tasty on its own, but you can still get the benefits by adding it to foods you are already eating such as: Oatmeal Mashed sweet potato Smoothies Salad Yogurt Cereal Soups Muffins Bread Naturally, you should look for organic brown or golden flaxseeds to ensure purity and avoid varieties that may be polluted with agrochemicals. Grinding your flaxseed will make it easier to incorporate into your foods, but when it is ground it does go rancid fairly quickly. You want to grind about a week’s worth of flaxseed at a time and store it in the refrigerator or freezer in an airtight container. It is also recommended that you work up to at least 2 tablespoons but give your body time to get used to all the fiber by incremental increases. Making this small change to your diet could save your life. Sources for this article include: Cancer.org GreenMedInfo.com AICR.org To read the original article click here.

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White Blood Cells May Be Harnessed to Boost Cancer Immunotherapy

AHA Publisher — Tue, 12 Oct 2021 07:00:00 +0000

Jon Schiller via Israel21c – White blood cells called Eosinophils can be “summoned” in order to fight cancer by both destroying the cancer cells directly as well as recruiting the immune system’s cancer-fighting T-cells, according to a new study published in the journal of the American Association for Cancer Research. Eosinophils produce powerful destructive proteins intended for fighting parasites. However, in the modern Western world, where high levels of hygiene have significantly reduced the risk of many parasites, eosinophils can be harmful, inducing allergies and asthma. Considering the destructive power of eosinophils, the researchers decided to test the potential benefits of these white blood cells if turned against cancer cells. Examining tissue samples of lung metastases taken from breast cancer patients, the researchers found that eosinophils reach the lungs and penetrate cancerous tissues, where they often release their destructive proteins and summon T-cells for reinforcement. Ultimately, T-cells gather in the affected lungs, slowing the growth of tumors. In the absence of eosinophils, lung metastases were much larger than those exposed to the white blood cells. These findings led to the conclusion that eosinophils could serve as a basis for improved immunotherapeutic medications to fight cancer effectively. “We chose to focus on lung metastases for two main reasons. First, metastases, and not the primary tumors, are often the main problem in treating cancer, and the lungs are a major target for the metastasis of many types of cancer,” said lead researcher Prof. Ariel Munitz of Tel Aviv University’s department of microbiology and clinical immunology. “Second, in a preliminary study we demonstrated that eosinophils gather in tumors developing in mucous tissues like the lungs, and therefore assumed that they would be found in lung metastases as well,” he added. Compared to traditional techniques like chemotherapy, immunotherapy generally leads to longer protection from cancer and fewer side effects. This new discovery may contribute to the development of new methods of immunotherapy. “Enhancing the number and power of T-cells is one of the main targets of immunotherapy treatments administered to cancer patients today,” said Munitz. To read the original article click here.

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Protein in Prostate Cancer May Inhibit Tumor Growth

AHA Publisher — Wed, 16 Jun 2021 07:00:57 +0000

University of Georgia via EurekAlert – Prostate cancer is the second most common cancer among men, according to the American Cancer Society. It’s also one of the trickiest cancers to diagnose and treat. But new research from the University of Georgia has identified a protein that appears to prevent the cancer from spreading to and colonizing the bone, providing a new target for future therapeutics. “Unfortunately, prostate cancer that has spread to the bone is very aggressive, often lethal and very difficult to treat,” said Brian Cummings, corresponding author of the study and head of the College of Pharmacy’s pharmaceutical and biomedical sciences department. “Even in cases of successful treatment, the patient’s quality of life is severely lessened due to bone loss.” Prostate cancer that hasn’t spread beyond nearby organs has nearly a 100% survival rate, meaning almost all of these patients will live at least another five or more years after their initial diagnosis and treatment. But for men whose cancer has spread to other organs or the bone, that five-year survival rate plummets to 30%, according to the American Cancer Society. In the U.S., about one in every eight men will be diagnosed with prostate cancer and more than 34,000 men die each year from the disease. The new study, published by Scientific Reports, focused on cancer-associated fibroblasts, which are the most abundant type of cell in tumors and are responsible for cancer growth and spread. The researchers found that knocking out a specific protein, called glypican-1, could prevent tumor cells from spreading into nearby bone. The study supports a previous report from Cummings’ laboratory suggesting that this protein may prevent tumor growth. The researchers found that the protein doesn’t alter the cancer cells themselves. Instead it affects a group of neighboring cells called fibroblasts. Fibroblasts are cells that help make up connective tissues in people and animals. But fibroblasts can also be present in cancerous tumors, where they facilitate cancer growth and spread. To determine the glypican-1 protein’s role in helping cancer spread, the researchers combined human prostate cancer cells and human bone-derived cells to examine how the cancer cells transformed the fibroblast. Then they genetically modified the cancer cells and the fibroblast to knock out the protein. Without the protein, the prostate cancer cells had problems transforming the fibroblast. The study was the first to demonstrate such a role for glypican-1 and suggests that this protein may have the same effect on tumor growth in people. “Part of the significance of this study is that it demonstrates how cancer cells are able to change their environment in ways to facilitate their own growth,” Cummings said. “Prostate cancer cells alter their environment so that they can colonize bone. This study identifies a role for a protein that appears to inhibit the harmful changes that prostate cancer makes to the bone.” “This protein appears to stop the ability of cancer cells to change their environment, which decreases the cancer’s aggressiveness. The fact that this protein is found in the bone, where many aggressive prostate cancer cells reside, further increases the potential impact of this work.” To read the original article click here.

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Natural Dietary Treatments for Fibroids

AHA Publisher — Thu, 13 May 2021 07:00:09 +0000

Michael Greger M.D. FACLM via Nutrition Facts – The same diet that helps regulate hormones in women may also reduce exposure to endocrine-disrupting pollutants. Fibroids are the most common benign tumors in women. They can grow to a foot in diameter and affect the majority of women before they hit menopause. Although fibroids tend to be asymptomatic, when symptoms do occur, they tend to manifest as heavy menstrual bleeding—so much so that women may get anemic and experience a lot of pain. So, what can women do? I discuss this in my video The Best Diet for Fibroids. Up to half go into surgery and get their entire uterus removed. “Although hysterectomy is generally considered a safe operation, complications occur in a significant proportion of patients” and, obviously, you can’t have kids any more. The alternative is a variety of hormone-modulating drugs, which can shrink the fibroids and provide relief, but many of these drugs have significant side effects, like bone loss, so you really don’t want to be taking them for more than a few months. What’s the bottom line? “There is currently no evidence to support the routine use of medical treatment in women with uterine fibroids.” No wonder many women turn to “complementary and alternative treatments…including exercise, diet, herbs, and acupuncture.” Women who exercise seven or more hours a week do seem to have lower risk of having fibroids than women who exercise less than around 20 minutes a day, but exercise has never been put to the test for treating fibroids. Likewise, to date, there isn’t a single randomized controlled trial of acupuncture for the treatment of fibroids to help guide us. In terms of herbs, there are two Asian herbal preparations that show promise—a five-herb combo called Guizhi Fuling and a Malaysian ten-herb formula that contains “secret ingredients” that must not be that secret since they’re just listed in the study, as you can see at 1:50 in my video—and they seemed to work as well as a leading drug. The problem is that traditional Asian herbal remedies may contain a few extra ingredients, like arsenic, mercury, and lead, which have been detected in most of the samples tested from Asian market and health food store shelves, and not just a little. Some, apparently, had really toxic amounts. So, these two Asian herbal preparations “may reduce fibroid size, but there is insufficient evidence to support the efficacy or safety of these treatments.” And, certainly, don’t try to apply caustic herbs internally, as this can lead to scarring, stenosis, and ulceration. Well, what about diet? In one of the largest studies of diet and fibroids, fibroid tumors were “associated with beef and ham consumption, whereas high intake of green vegetables seems to have a protective effect.” The researchers figured that the “association between levels of estrogen, diet, and breast and endometrial [uterine lining] cancers also may help us understand” why. Indeed, “[f]or breast and endometrial cancers, a direct association with the frequency of consumption of meat and ham was observed…whereas protection was conferred by high intake of vegetables and fruits.” Thus, there may be these shared risk factors between estrogen-responsive malignant tumors, like breast cancer, and estrogen-responsive benign tumors, like fibroids. We know the presence of fibroids seems to correlate with an increase in the amount of estrogens flowing through your body, for example, and that women eating vegetarian diets have significantly lower levels of excess estrogen. Researchers are using this knowledge to try to explain why there are lower rates of endometrial cancer—that is, lining-of-the-uterus cancer—and possibly breast cancer among vegetarian women, but it could also help explain the fibroid findings. “The incidence of breast cancer among vegetarian American women (Seventh Day Adventists) is 60 to 80 per cent of the incidence among American women in general, and the incidence among women in Africa and Asia is even lower.” Why might vegetarian women have lower estrogen levels? A famous study in the New England Journal of Medicine concluded that it was their “increased fecal output, which leads to increased fecal excretion of estrogen,” resulting in lower blood levels. Double the fecal output, in fact, as you can see at 4:07 in my video. And, you can put it to the test. Maybe the same reason African-American women have more fibroids is the same reason they have worse breast cancer survival: too much estrogen in their bloodstream due to a less than optimal diet. So, researchers designed a study to see what would happen if they were switched to a more plant-based, higher fiber diet. Compared with the Caucasian women, the African-American women started out with much higher estrogen levels, again helping to explain their increased mortality from breast cancer. But, after they were put on a healthier diet, all of their levels came down, “suggest[ing] that a substantial reduction in breast cancer risk can be achieved” by adopting a diet centered around more whole plant foods. The same also appears to be true for fibroids, especially eating lots of cruciferous vegetables—broccoli, cabbage, and Chinese cabbage—as well as tomatoes and apples. Women who underwent premature puberty, starting their periods before age 11, may also be at increased risk of fibroids later in life, and we know that higher childhood red meat intake is associated with earlier age of starting one’s period, though total protein and animal protein in general may contribute. For example, girls who eat meat tend to start their periods about six months earlier than vegetarian girls. Those who eat meat analogues like veggie burgers and veggie dogs start their periods nine months later on average, and a similar puberty normalizing influence was found with consumption of whole plants foods, such as beans. It could also be the endocrine-disrupting pollutants that build up the food chain. Researchers tooksamples of internal abdominal fat from women and found there appeared to be a correlation between the presence of fibroids with the levels of a number of PCBs in their fat. So, does that mean fish-eaters have higher risk of fibroids? Researchers did find a small increase in risk associated with the intake of long-chain omega-3 fats, mostly from “dark-meat fish consumption,” by which they meant fish like sardines and salmon. This could be because of “the endocrine-disrupting chemicals commonly shown in fish,” or it could just be a statistical fluke. It would be consistent with the increased risk seen among “sport-fish consumers.” Recognizing that diet and endocrine-disrupting persistent organic pollutants have been associated with a variety of gynecologic conditions, including fibroids, researchers looked at consumers of fish fished out of the Great Lakes and found a 20 percent increased risk for every ten years they had been eating the fish. In the most comprehensive study to date, researchers compared pollutant levels in fat samples from women with fibroids to fat liposuctioned out of women without fibroids. They didn’t just find higher levels of PCBs in fibroid sufferers, but also long-banned pesticides, like DDT and hexachlorocyclohexane, PAHs, which are polycyclic aromatic hydrocarbons formed when coal is burned, tobacco is smoked, and meat is grilled, as well as heavy metals, arsenic, cadmium, lead, and mercury. These levels correlated not only to fibroids, but also to seafood consumption or excess body fat. So, the researchers determined that “shedding excess weight and limiting seafood consumption would confer a protective effect” on fibroid tumor development by minimizing exposure to environmental pollutants as much as possible. Okay, so a plant-based diet may be best, but is there a plant in particular that has been shown to be particularly powerful? Plant-based compounds with disease-preventive properties, dietary phytochemicals are found in whole grains, fruits, vegetables, beans, split peas, chickpeas, and lentils, herbs, spices, nuts, and certain beverages. As I discuss in my video The Best Food for Fibroids, we know they can help regulate the initiation, promotion, and spread of cancerous tumors, so what about benign tumors like fibroids? Most anti-cancer drugs on the market now were originally derived from plants or plant products, so why not try to use plants to target the inflammation or blood supply of fibroids? Might fibroids be a consequence of chronic inflammation within the body? We know that women with fibroids are more likely to eat more beef and ham, and fewer fruits and green vegetables, but whole plant foods don’t just have anti-inflammatory effects but antioxidant effects as well. “If the generation of free radicals exceeds the protective effects of antioxidants, oxidative damage will occur,” which has been implicated in a variety of disease states, including gynecological conditions such as fibroids. If you collect fresh fibroids, as well as normal uterine tissue from hysterectomy surgeries, the fibroid cells have significantly fewer antioxidant enzymes, as you can see at 1:20 in my video, so might antioxidant-rich foods help? Well, if you drip some strawberries onto cells in a petri dish, you can apparently kill of some fibroid tumor cells, while leaving normal uterus cells alone. But, what good does that do us? That’s only relevant if we can show those strawberry compounds get absorbed through our gut and achieve high enough concentrations in uterine tissue. The same with curcumin, the component of the spice turmeric. One of its so-called “miraculous” properties is suppressing the growth of uterine fibroid cells, but, again, that was just in vitro. Yes, an inhibitory effect was found and at concentrations that don’t compromise the growth of normal, regular uterine tissue, but my patients are people, not petri dishes. It’s pretty neat to find out what happens to human fibroid cells as you drip higher and higher concentrations of green tea compounds on them in a test tube, as you can see for yourself at 2:19 in my video, but I care less about what happens in vitro or in mice, whether or not they have any clothes on—one study looked at “a nude mice model”—but there were no randomized, controlled clinical studies until 2013. Subjects were randomized to green tea extract or placebo for four months. In the placebo group, fibroid volume increased by 24 percent. That’s what fibroids do; they continue to grow. However, those randomized to the green tea group showed a reduction in total fibroid volume—and not just by a little. There was a dramatic decrease, shrinking by almost a third, which is a highly significant difference, as you can see at 3:02 in my video. Okay, but did the women feel any better? Yes, they experienced a dramatic decrease in symptom severity, as well. Month after month, nothing much happened in the placebo group, but those taking the pills that looked the same but happened to contain green tea compounds had consistent improvement and felt lessening symptoms, each month better than the last, as well as an improved health-related quality of life, month after month, that was significantly better than control. What’s more, their blood counts got better too. With all that continued excess blood loss every month, the blood levels kept decreasing in the placebo group, but they reversed in the green tea group. So, anemia also significantly improved, because average blood flow significantly diminished. And, all this—the fibroid shrinkage, less pain, better periods—was achieved with “no adverse effects.” So, not only were the results comparable to those for the drugs that are commonly used—again, without the side effects—but the results were also comparable to uterine artery embolization, where they try to cut the blood supply to the fibroid, which is great—unless they accidentally cut the blood supply to the rest of the uterus and cause uterine necrosis, one of many reported major complications. Others include death, not only of the fibroid, but also of the patient, along with other potential complications that may arise from accidentally clogging off non-target arteries. In my book, a side-effect-free solution as good as a more invasive procedure is potentially better than. The researchers conclude that green tea compounds show “promise as a safe and effective therapeutic agent for women with symptomatic UFs [uterine fibroids]. Such a simple, inexpensive, and orally administered therapy...

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Study Opens the Way for a Potential New Cure for Children with Hard-to-Treat Neuroblastoma

AHA Publisher — Mon, 11 Jan 2021 08:00:58 +0000

University of Gothenburg via News-Medical Net – Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor’s growth. Neuroblastoma is the most common form of childhood cancer, derived from the peripheral nervous system, i.e., the part of the nervous system that is not the brain or spinal cord. The disease can occur in the chest, neck, abdomen and adrenal glands and can also spread to the spine. Symptoms include general aches, anemia and skeletal pain. The average age of children at diagnosis is 17 months, and it is rarely diagnosed over the age of five. The milder form of neuroblastoma can, in some cases, self-heal, while the more aggressive form is the deadliest form of childhood cancer. Treatment is successful in less than half of these cases. A Long Noncoding RNA Molecule Influences Tumor Suppressor Gene Expression Central molecule in the study is the p53 gene. The p53 gene is often mutated in other cancer forms but rarely in neuroblastoma. When it is not mutated, p53 codes for a protein that inhibit the growth of cancer. This study shows that how the expression levels of a long non-coding RNA molecule influences the function of p53 protein. Interestingly, this long non-coding RNA increases p53 function in the nucleus to make tumor cells more susceptible to cytostatic treatment.” (Chandrasekhar Kanduri, Professor, Medical genetics specialized in RNA epigenetics, University of Gothenburg) Two Small Molecule-Based Drug Combination for Neuroblastoma The RNA molecule NBAT1 changes the function of the protein CRM1, which transports p53 from nucleus to cytoplasm. NBAT1 also helps in keeping the p53 protein in the nucleus to increase p53 controlled gene expression. Based on these findings, the research group tested a new treatment that combines the drugs Selinexor and Nutlin-3a. Both drugs are currently undergoing clinical trials for cancer treatments but not for neuroblastoma. Selinexor restores p53’s ability to inhibit cancer growth and Nutlin-3a inhibits the breakdown of p53. “The combination treatment blocks the protein export function of CRM1, which leads to p53 accumulation in the cell nucleus. This treatment increases p53 dependent functions, such as DNA damage and cell death. We think that combining these two drugs with current treatment strategies may allow us to cure hard-to-treat neuroblastomas.” The results are promising, but they are based on preclinical studies of cancer cell lines and mouse models (xenografts) and more research is needed before the findings can be translated into treatment. These laboratory results have been partly validated with the neuroblastoma patient data, obtained in collaboration with the researchers at Karolinska Institutet. Thus, this study has clearly opened the way for a potential new treatment strategy for high-risk neuroblastoma patients. To read the original article click here.

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T-cells Could Be Made into Better Cancer Killers by Increasing Their Protein Production

AHA Publisher — Thu, 21 May 2020 07:00:53 +0000

Medical University of South Carolina via EurekAlert – Hollings Cancer Center researchers at the Medical University of South Carolina have developed a technique to monitor protein production in a type of immune cell known as a T cell & have shown that T cells with robust protein production are more effective. A team of scientists from Hollings Cancer Center at the Medical University of South Carolina (MUSC) has developed a novel flow cytometry technique that can, for the first-time, quantify protein production in T-cells. T cells are immune cells that surveil the body and can effectively target and kill cancer cells. However, when T cells are in the vicinity of a tumor, cancer cells sap their energy, leading to a decrease in their protein production. This change leads to T cells losing their tumor-killing ability. The new technique, developed by the MUSC team, can be used to monitor protein production in T cells and understand how it becomes depressed in the tumor microenvironment. Interventions could then be developed to restore T cells’ protein production and ability to control tumor growth. The team, led by Jessica E. Thaxton, Ph.D., recently reported its findings in a priority brief in Cancer Immunology Research. Thaxton is an assistant professor in the departments of Orthopaedics and Physical Medicine and Microbiology and Immunology at MUSC and a member of Hollings Cancer Center, a National Cancer Institute designated cancer center. “This study reveals our first attempt at trying to understand how T cells undergo the process of making proteins,” explained Thaxton. “Before this paper or before this technology, scientists had very little idea how much protein T cells make. It was a shot in the dark. But now we have quantitative data that shows how much protein T cells make, and we can begin to ask questions like, ‘Which proteins?’ and ‘How are they made?'” In the past four years, the team observed more than 50 human tumors, and in most tumors, they noticed the existence of T cells that made very little protein. This finding led them to surmise that there are T cells unable to make proteins residing in tumors. According to Thaxton, the new technology will help them to monitor these T cells and reawaken their protein production machinery and cancer-fighting ability. “This paper establishes that T cells that are able to make protein in tumors have phenomenal ability to control tumor growth,” explained Thaxton. “We ultimately want to remodel the existing T cell population in tumors, and that is really where our laboratory is headed.” To understand more fully protein production in T cells in tumors, the scientists used two different types of signaling molecules (cytokines) called IL-15 and IL-2. It has been established in other studies that T cells treated with IL-15 control tumor growth very well, but those conditioned with IL-2 do so poorly. The team found that T cells conditioned with IL-15 were able to make proteins in the tumor microenvironment and in tumors, whereas IL-2 conditioned T cells experienced diminished protein production in tumors. These results will help scientists to understand how they can reawaken tumor T-cells and increase their protein production, thereby enhancing their ability to control tumor growth. Thaxton believes that a simple strategy of combining a modulator that changes the way that T cells generate energy will allow T cells to experience sustained protein production in tumors and produce more effective immunotherapy treatments for patients. Unlike many current immunotherapies, which can be quite expensive, this approach would be cost-effective and thus a more realistic strategy for treating cancer patients from all walks of life. Thaxton believes that the current study is the very first set of experiments that begins to delineate the role of protein production in anti-tumor immunity. “There is a lot more in store that we are now uncovering from this basic first set of experiments,” explained Thaxton. “This paper is a model of our first insight into how protein production is regulated in T cells, and we are working on which parts of the regulation are the most important for tumor control.” To read the original article click here.

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