treating depression Archives - Amazing Health Advances

Debunking the Myth of the Chemical Imbalance with Dr. Joanna Moncrieff

AHA Publisher — Wed, 15 Jun 2022 08:01:21 +0000

Dr. Caroline Leaf – In this podcast (episode #383) and blog, I talk to psychiatrist, researcher, professor and best-selling author Dr. Joanna Moncrieff about critical psychiatry, the difference between a drug-centered and disease-centered approach in the field of mental health, the history of psychiatry, withdrawal from psychotropic drugs, the dangers of medicalizing misery, the myth of chemical imbalance, the potential downsides of using psychedelics to treat mental health, and so much more! Joanna calls herself a critical psychiatrist. This means that she doesn’t sign on to the mainstream view of psychiatry, which claims that all mental disorders are the same as brain diseases that need to be treated with drugs, ECT and other interventions that focus on physiological or biochemical symptoms. Human beings come in all shapes and sizes—we are all different. This means we have a huge range of assets, but also a huge range of problems and difficulties. It is not helpful to just call these issues a disease or think of them in solely medical terms, unless we are convinced, by a good body of evidence, that there are specific abnormal brain issues present. Everything we do is reflected in our brains. We need to distinguish brain activity that goes along with everything we do from a neurological disease like a brain tumor. But we are also more than just our biology; everyone’s mental health issue is unique to them on a social, spiritual, biological, psychological and spiritual level. We are also more than just our biology Of course, saying a mental health issue is not a neurological disease doesn’t mean that there is nothing happening in the brain. It also doesn’t mean that we do not influence what happens in the brain by both what we do and how we live and, sometimes, by taking certain drugs. Joanna discusses this difference in depth in her book The Myth of the Chemical Cure: A Critique of Psychiatric Drug Treatment. As Joanna points out, the current disease-centered approach claims that symptoms of depression are caused by a brain chemical abnormality, and psychotropics like anti-depressants help rectify this abnormality and improve mental health symptoms. This hypothesis currently dominates the field of mental health, yet we have no evidence that it is the best way to understand mental issues. First, there is no strong evidence that depression, for example, is associated with any particular biochemical abnormality. Moreover, we do not know if the drugs we use work in this way, i.e. correcting biochemical imbalances. This is due to the fact that the mental health drugs we use are psychoactive. They cross the blood-brain barrier and change the normal state of the brain, which means they can change our feelings, thoughts, perceptions and even behaviors, just in the same way a substance like alcohol can. Joanna takes a different approach—what she calls the “drug-centered” model. This centers around understanding what prescribed psychiatric medication is doing in the brain and body, and how it is changing the state of the brain like a substance such as alcohol does. We need to understand the kind of alterations these drugs make and factor them out of the equation—we cannot simply say that they are targeting and “correcting” a hypothetical biochemical imbalance. For example, benzodiazepines are currently used to treat anxiety. These drugs, when given to someone in a high state of arousal, can help calm down the brain and body. Yet they also do the same for someone who is not anxious—they alter the brain by reducing brain activity. There is no strong evidence that these psychoactive drugs are “curing” anxiety. To understand psychoactive drugs and their use in mental healthcare, we first need to understand their general effects in people, including individuals who do not have anxiety or symptoms of another mental issue. Yes, some people may see these mind-altering effects as an improvement, but not everyone. It is also important to consider the negative outcomes that often occur when a person comes off these drugs—withdrawal symptoms can be incredibly traumatic and last for a long period of time. Unfortunately, even though there is very little specific biological evidence that distinguishes the brains of people diagnosed with mental disorders and people that are not; much of current mental healthcare research and treatments are biased in the direction of the disease-centered approach. For instance, research done on brain abnormalities in people diagnosed with schizophrenia has often been used to “prove” that schizophrenia “shrinks” people’s brains. Yet it has been shown that the antipsychotic drugs individuals diagnosed with schizophrenia take to treat also affect brain volume and function. Based on this new research, we now think that this reduction in brain volume is significantly (if not wholly) due to the effects these drugs have as they cross the blood-brain barrier, not just the fact that these individuals have been diagnosed with schizophrenia. Additionally, it is important to point out that the trials that supposedly establish the “fact” that psychiatric drugs are effective acute treatments are placebo-controlled trials. This means that psychoactive drugs are compared to an inert placebo tablet that doesn’t have any noticeable mind or brain effects. Researchers are not distinguishing whether the drug hypothetically “cures” the purported underlying basis of the disorder or is having specific mind-altering and brain-altering effects (the drug-centered model mentioned above). These trials show the psychoactive drug does something different to the placebo, a feeling which can be enhanced when people in the trials realize they are taking a psychoactive drug. People’s expectations of what treatment they get can have a powerful effect on their outcomes, which is something we do not often consider when it comes to psychiatric medications. These placebo trials are not properly double-blinded, and as such we should not be placing so much trust in the interpretations of the results and any healthcare treatments based on these interpretations. In fact, even when these trials show a positive effect when the drug is taken, this is not significant in the long term. In a large 2018 meta analysis, for example, the difference between taking an anti-depressant and placebo was incredibly small, and of doubtful clinical value. There are also many issues surrounding the research on psychiatric drug withdrawal, as Joanna discusses in detail in her book A Straight Talking Introduction to Psychiatric Drugs: The truth about how they work and how to come off them. People usually don’t take these psychoactive drugs for a few days or weeks. They generally take them for months or years, often based on research done on the long-term effects of psychiatric drugs like anti-depressants, called “relapse prevention trials”. These trials look as if they are examining the benefits of long-term treatment, but what they are actually doing is enrolling people that have already been using these drugs for years, then randomizing them to either continue the treatment or be weaned off (usually very quickly) onto the placebo. The latter group often experience intense withdrawal effects, since these drugs alter brain function and chemistry. However, in the trials, these withdrawal effects are often assumed to be because of the “brain disease”. This can make someone feel terrible or believe that there is something intrinsically wrong with them, even though what these research studies are actually studying is not the benefit of long-term treatment but the adverse effects of withdrawing from these psychoactive medications quickly. Very few studies try to wean people off these drugs gradually, and even these still have a risk of significant withdrawal effects that bias the clinical data. The longer someone is on these drugs, the greater chance that their withdrawal effects will be more significant and last longer. In Joanna’s blogs, she points out that this is why it is so important to understand how these drugs affect the mind and brain, so that you are more empowered to know what choice will be best for you and your unique circumstances. Some people may find these drugs very beneficial in the short term; however, it is important to understand how these drugs can be dependence-forming in the long term. There are ways to withdraw from psychiatric drugs, although this is best done under the guidance of an appropriate medical professional. You can reduce higher doses a lot quicker than lower doses; for lower levels, people often use tapering strips or liquids to reduce the drug by very small amounts over time. It is important to take a flexible approach, and avoid switching between certain drugs, especially anti-depressants, as much as possible. (Anti-depressants are often quite different from each other.) Joanna uses these methods in her London clinic, which she is hoping to expand into other areas of the UK and perhaps the world. Joanna and her team also want to try to set up a peer-support group to help other people trying to withdraw and find hope. Thankfully, there are also great sites like Mad in America, Rxisk, ISEPP and other patient-run websites that seek to provide people with helpful information and address all parts of the human experience, not just our biology. To read the original article click here.

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Can CBD Actually Help with Anxiety?

AHA Publisher — Wed, 06 Apr 2022 07:00:05 +0000

Dr. Caroline Leaf – In this podcast (episode #367) and blog, I talk to NED founders Ret and Adriaan about CBD, treating mental health issues holistically, natural remedies for anxiety and stress, and more. CBD is just one part of the hemp plant that has multiple health benefits. This is why the team at NED focuses on using only oil extracted from USDA Certified Organic hemp plants, grown by an independent farmer named Jonathan in Paonia, CO. (If you have a minute, do an image search for Paonia, Colorado—it is gorgeous!) This is one of the main reasons they are able to produce full-spectrum hemp oil from high quality hemp flowers that contain both cannabidiol (CBD) and its accompanying phytocannabinoids. Why is this so important? Focusing on the whole plant helps us better digest and use all the health benefits that the hemp plant offers by allowing the cannabinoids to bind to our extra-cellular receptors—it’s not just about CBD! These receptors are found throughout the body and help absorb naturally-occurring endocannabinoids in the body, which are important when it comes to regulating pain, moods, brain function and more. As often happens in life, sometimes these endocannabinoids don’t get produced, and we need to supplement with natural products to put our systems back into balance. If the endocannabinoid system is functioning well, it helps create homeostasis (or balance) throughout the brain and body at a base level. Cumulatively, this helps to prevent inflammation in the brain, foggy thinking, emotional burnout, lack of cognitive fluency and other brain issues. This is also the case with mental distress and anxiety. Many people have found that CBD products help them calm down and think more clearly in stressful situations by harmonizing the mind and helping balance the many systems of the brain and body. It is important to note here that CBD is not the same as weed/marijuana. Weed contains the active ingredient THC, which is what makes people feel high when they ingest or smoke it. CBD, on the other hand, is one of the two major cannabinoids in the hemp plant, and only contains trace amounts of THC from the extraction process—it is the plant that gets you “well”, rather than high. I personally use Ned’s CBD products to de-stress and improve my sleeping habits because they are chock full of premium CBD and a full spectrum of active cannabinoids, terpenes, flavonoids, and trichomes. Ned’s full spectrum hemp oil helps nourish and enhance the body’s endocannabinoid system to offer functional support for stress, sleep, inflammation and balance. I especially love Ned’s De-Stress Blend, which has so much more than just CBD. Like all their products, they designed this blend to help people feel better using what is available in the natural world. The 1:1 formula of their sleep blend uses CBD and CBG made from the world’s purest full spectrum hemp and features a botanical infusion of ashwagandha, cardamom and cinnamon, which have the following properties: CBG is known as “the mother of all cannabinoids” because of how effective it is at combatting anxiety and stress by inhibiting the re-uptake of GABA, the neurotransmitter responsible for stress regulation. Ashwagandha is an amazing Ayurvedic adaptogen that enhances your body’s resilience to stress. Cardamom and cinnamon make the blend taste delicious! Cinnamon is also a powerful prebiotic that supports your gut health, a key player in your mental health, while cardamom combats stress by helping reduce your blood pressure and cortisol levels. Another NED product I love is their Mellö Magnesium supplement blend with 3 forms of chelated magnesium, GABA, L-theanine, and over 70 trace minerals. This blend is specifically designed to support memory, mood, brain function, the stress response, nerve and muscle health and sleep. I love that it is a full spectrum magnesium supplement that blends three of the most bioavailable and absorbable forms of chelated magnesium to ensure the widest range of whole body benefits, because there is no point in taking a supplement that passes straight through you before your cells can use it. This blend includes magtein® magnesium l-threonate as well. This was developed and patented by MIT scientists for its unique ability to cross the blood-brain barrier and increase intracellular magnesium levels in nerve cells, or neurons, which helps support brain health. Of course, healing and restoring balance in the brain and body is not a quick-fix, one-supplement thing. It takes some time for homeostasis to be achieved, which is why I constantly emphasize that true mental self-care is a lifestyle. This will also look different for everyone, so be careful of thinking that if you take CBD for a week you will feel great because you had a friend who said it helped them immediately. You should always start with the smallest recommended dose of CBD and increase it only if you feel you need more, preferably with the guidance of a professional. You should also make sure you are not allergic to any of the ingredients in the CBD product you want to take. Regular blood tests and consultations with a medical professional can also help you figure out how much CBD is best for your body type and lifestyle, making it most effective. We need to recognize that CBD is not a panacea. It is just one tool in our holistic mental self-care toolkit, alongside detoxing the brain, eating well, spending time in nature, exercising regularly, building the brain, self-regulating our thinking, and the many other mind-management lifestyle techniques I talk about in my books, podcast and blog. To read the original article click here.

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Oxygen Treatment Found Effective Against Depression

AHA Publisher — Wed, 22 Dec 2021 08:00:26 +0000

Abigail Klein Leichman via Israel21c – Depressed patients who received oxygen-enriched air treatment for a month found their symptoms improved, according to a new proof-of-concept study by Ben-Gurion University of the Negev researchers. Their findings were reported recently in Scientific Reports. Fifty-five patients were divided into two groups: The first was treated with 35 percent oxygen-enriched air and the other with regular air (21% oxygen) for seven to eight hours per night over the course of a month. After treatment, depressive symptoms in the enriched oxygen group were reduced on several measurement scales. “As a proof-of-concept, our results are promising. Increasing the fraction of oxygen in the inhaled air reduces symptoms of depression,” said lead researcher Abed N. Azab, a pharmacologist in the university’s department of nursing. He noted that the treatment was administered safely under normal atmospheric conditions – not in a hyperbaric chamber — and did not cause adverse effects. “Of course, there is much more to discover. Would longer treatments be even more beneficial? Would higher oxygen concentrations better improve symptoms or not?” added Azab. He called for further studies to answer those questions and to see whether the treatment would be effective also on in-hospital patients with severe depression. The study was funded by a National Alliance for Research on Schizophrenia & Depression Independent Investigator Award won by researcher Prof. Yuly Bersudesky. Additional researchers on the study were Yehudit Bloch, Prof. R. H. Belmaker, Prof. Pesach Shvartzman, the late Pnina Romem and Arkady Bolotin. To read the original article click here.

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