Scientists Uncover Cell Responsible for Repairing Liver Tissue

The AHA! Team — Mon, 06 May 2024 18:05:40 +0000

University College London via News-Medical – A type of cell responsible for repairing damaged liver tissue has been uncovered for the first time by a team of scientists, including Professor Rajiv Jalan (UCL Liver & Digestive Health). The study, published in Nature, showed how these new-found cells migrate to the site of damage, providing new insights into the way the liver heals itself. The authors say the findings could spur the development of new therapies that harness the liver’s unique capacity to regenerate. During acute liver failure, the organ’s ability to repair and regenerate is often overwhelmed, with patients requiring an emergency liver transplant to regain liver function. Scientists from the University of Edinburgh studied human liver tissue from patients with acute liver failure for signs of cell proliferation and regeneration following the rapid loss of liver function. They found that a significant proportion of cells retained the ability to multiply. There were, however, still substantial areas of damage in the patients’ livers, suggesting that processes other than cell proliferation are critical during regeneration. The research team profiled the genes within every liver cell in both healthy and regenerating human liver tissue to better understand the regeneration process, using a technique called single-cell RNA sequencing. The findings uncovered a previously undetected population of wound-healing liver cells that emerge during human liver regeneration to aid recovery. Working with University of Glasgow scientists at the Cancer Research UK Scotland Institute, the team used special imaging techniques in mice to view the wound-healing cells in action. Researchers from the UCL Institute for Liver & Digestive Health and the Royal Free Hospital then provided important clinical validation of the novel mechanism of liver repair in humans. “We investigated whether the ‘liver repair’ mechanisms that the team from Edinburgh and Glasgow discovered in animal models also occurred in humans, and found that the mechanisms were present in patients with severe acute indeterminate hepatitis. This provides evidence that the observations made in the study are likely to be clinically relevant for the treatment of liver diseases in humans.” -Professor Rajiv Jalan, UCL Liver & Digestive Health During liver regeneration, so-called leader cells appear at the edge of the healthy tissue, dragging the tissue together to close the wound – similarly to how skin heals after a cut. Imaging also revealed that the population of healing liver cells appears before cell proliferation begins. Widespread infection is a major concern following acute liver failure. Bacteria from the gut can escape into the liver when the liver is damaged. This can lead to sepsis if the liver is unable to clear the infection. The liver may prioritise the healing of wounds before cell proliferation to restore the gut-liver barrier and prevent the spread of bacteria, experts say. Professor Neil Henderson, principal investigator of the study from the University of Edinburgh’s Centre for Inflammation Research, said: “Cutting-edge technologies have allowed us to study human liver regeneration in high definition for the first time, facilitating the identification of a cell type that is critical for liver repair. “We hope that our findings will accelerate the discovery of much-needed new treatments for patients with liver disease.” The research team also included scientists from the Universities of Birmingham, Cambridge and Texas, and the United States Acute Liver Failure Study Group network. This work was funded by Wellcome. Journal reference: Matchett, K. P., et al. (2024). Multimodal decoding of human liver regeneration. Nature. doi.org/10.1038/s41586-024-07376-2. To read the original article click here.

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Study: Light Therapy Helps Burn Injuries Heal Faster by Triggering Growth Protein

AHA Publisher — Mon, 09 Aug 2021 07:00:40 +0000

University at Buffalo via Newswise – Light therapy may accelerate the healing of burns, according to a University at Buffalo-led study. The research, published in Scientific Reports, found that photobiomodulation therapy – a form of low-dose light therapy capable of relieving pain and promoting healing and tissue regeneration – sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein that controls cell growth and division. The findings may impact therapeutic treatments for burn injuries, which affect more than 6 million people worldwide each year, says lead investigator Praveen Arany, DDS, PhD, assistant professor of oral biology in the UB School of Dental Medicine. “Photobiomodulation therapy has been effectively used in supportive cancer care, age-related macular degeneration and Alzheimer’s disease,” says Arany. “A common feature among these ailments is the central role of inflammation. This work provides evidence for the ability of photobiomodulation-activated TGF-beta 1 in mitigating the inflammation, while promoting tissue regeneration utilizing an elegant, transgenic burn wound model.” The study measured the effect of photobiomodulation on the closure of third-degree burns over a period of nine days. The treatment triggered TGF‐beta 1, which stimulated various cell types involved in healing, including fibroblasts (the main connective tissue cells of the body that play an important role in tissue repair) and macrophages (immune cells that lower inflammation, clean cell debris and fight infection). The researchers also developed a precise burn healing protocol for photobiomodulation treatments to ensure additional thermal injuries are not inadvertently generated by laser use. The effectiveness of photobiomodulation in treating pain and stimulating healing has been documented in hundreds of clinical trials and thousands of academic papers. The therapy was recently recommended as a standard treatment for pain relief from cancer-associated oral mucositis (inflammation and lesions in the mouth) by the Multinational Association for Supportive Care in Cancer. To read the original article click here.

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Scientists Uncover Cell Responsible for Repairing Liver Tissue

Study: Light Therapy Helps Burn Injuries Heal Faster by Triggering Growth Protein