sulforaphane Archives - Amazing Health Advances

Sulforaphane Benefits: The Secret to Broccoli’s Superfood Status

AHA Publisher — Wed, 20 Jul 2022 07:00:08 +0000

Jillian Levy, CHHC via Dr. Axe – Cruciferous vegetables, such as broccoli and cauliflower, are well-known for their disease-preventive effects, but have you ever wondered why exactly that is? One reason is because of the compound called sulforaphane, which you’ll find in certain vegetables and other also in extract form. What does sulforaphane do for the body? Studies show it can help fight cancer, diabetes, arthritis and other inflammatory conditions, brain and liver damage, and more. What Is Sulforaphane? Sulforaphane (SFN) is a phytochemical compound that’s naturally found in some vegetables, specifically those in the Brassica (or cruciferous) plant family. This includes veggies like broccoli, cabbage, Brussel sprouts and cauliflower. You can obtain sulforaphane from eating these vegetables, plus from supplements (such as those made from broccoli sprouts) that contain concentrated extract forms of SFN. Technically, SFN is a type of aliphatic isothiocyanate. It’s thought to have high bioavailabilitycompared to other phytonutrients, making it very useful for potentially helping prevent and treat diseases, especially cancer. SFN is produced by the conversion of glucoraphanin through the enzyme called myrosinase. Benefits Is sulforaphane anti-inflammatory? Yes — it’s been shown to have anti-inflammatory and antioxidant-like effects and help fight oxidative stress. Here’s more about how SFN can benefit various aspects of your health: 1. Helps Reduce Inflammation A number of studies have found that sulforaphane can help reduce biomarkers of inflammation, including among both overweight and otherwise healthy adults. This suggests that SFN can help manage inflammation-related conditions, including arthritis, cardiovascular disease and others. One way in which SFN suppresses inflammation and oxidative stress is by impacting NF-κB, a key regulator of inflammatory responses. It can also down-regulate proinflammatory enzymes, such as cyclooxygenase (COX-2) and NO synthase (iNOS), giving SFN cancer-fighting and anti-carcinogenic effects. SFN also supports a strong immune system by enhancing natural killer cell activities and other markers of enhanced immune function. Therefore, it’s thought to have the ability help prevent both chronic and acute/infectious diseases. 2. Can Help Prevent Diabetes SFN works as an indirect antioxidant in a way that reduces the risk for type 2 diabetes and its complications, such as neuropathy (nerve damage). It can help prevent oxidative stress and lipid peroxidation, which are thought to be important factors in the pathogenesis of diabetes complications. It may also help reduce LDL “bad cholesterol” and generally support cardiovascular health. 3. May Help in Treatment of Some Cancers Because SFN can kill cancer cells and suppress tumor growth in their early stages, it’s used in extract form to treat certain types of cancer, such as prostate cancer and pancreatic cancer. Sulforaphane has been shown to induce apoptosis (death of cancer cells), suppress cancerous cell cycles so their progression is limited, inhibit angiogenesis (formation of new blood vessels that allow tumors to grow) and anti-inflammatory activities, and inhibit metastasis (spreading of cancer to other locations in the body). 4. Supports Liver Function and Detoxification Why is sulforaphane good for the liver? Due to its ability to boost antioxidant effects in the body and support phase 2 detoxification enzymes, it can help prevent the liver becoming damaged and dysfunctional. Some of the ways it supports detoxification and liver function include: Inhibiting detoxification enzymes that activate chemical carcinogens. Reducing the level of toxic intermediates with carcinogenic potential. Increasing activity of phase 2 detoxification enzymes. Sulforaphane is actually considered the most potent of the phase 2 inducing substances. According to the National Cancer Institute, this is “a process in which the liver uses one of two major enzyme pathways to change a toxic substance, such as an anticancer drug, into a less toxic substance that is easier for the body to excrete.” Limiting the effect of aflatoxin on liver cells. Providing significant protection against environmental and food-borne pollutants. 5. Increases Synthesis of Glutathione (a “Master Antioxidant”) Sulforaphane itself is not an actual antioxidant, but instead it exerts antioxidant effectsprimarily by induing glutathione and other antioxidant compounds. Therefore, it’s considered an “indirect antioxidant.” This means that SFN can decrease oxidative stress, which is a major contributor to many age-related diseases. SFN supports glutathione in promoting detoxification and protecting us against toxicity and disease. It can also provides DNA protection against harmful mutations. 6. Defends Against Lung Damage Sulforaphane limits pro-inflammatory effects and harmful effects of chemicals that can contribute to various lung diseases. It improves the body’s ability to remove toxins related to respiratory diseases, and it’s a potent inducer of HO-1 (haemoxygenase-1), which plays an important role in modulating the effects of oxidants in the lungs. 7. Supports Gastrointestinal Function By blocking growth of the harmful bacteria known as Helicobacter pyloris, SFN can help decrease the risk for gastric tumor and ulcer formation. It may also possibly protect against stomach cancer. Because it can promote healthy microflora in the colon, SFN also potentially offers protection against colorectal cancer. 8. Protects the Brain From Damage SFN is thought to have a positive impact on dopaminergic neurons in the brain, which are associated with Parkinson’s disease. Research shows that SFN helps prevent dopaminergic cells in the brain from experiencing cytotoxicity and neuronal death, which can contribute to Parkinson’s. It may also help defend against other neurodegenerative diseases, such as Alzheimer’s disease, in part by protecting mitochondria. Risks and Side Effects Sulforaphane from food sources is thought to be very safe overall. Of course, if someone has a sensitivity or allergy to cruciferous vegetables, that person should avoid consuming them. Sulforaphane is also available in broccoli extract products. These are generally safe when used in recommended amounts for up to six months. It’s important not to overuse sulforaphane supplements, which can potential cause side effects, such as stomach upset, gastrointestinal discomfort and weight gain. Who should not take sulforaphane? Are there any interactions with other drugs? Sulforaphane can affect how quickly the liver breaks down substances, including some medications. If you take medications, especially the types listed below, don’t start supplementing with this compound unless you speak with your health care provider first about possible interactions. This is particularly important if you have liver disease, heart disease or diabetes, or if you take anticonvulsant medications. Use caution if you take any of these medications (Note: other medications not listed here may also interact with SFN): clozapine (Clozaril) cyclobenzaprine (Flexeril) fluvoxamine (Luvox) haloperidol (Haldol) imipramine (Tofranil) mexiletine (Mexitil) olanzapine (Zyprexa) pentazocine (Talwin) propranolol (Inderal) tacrine (Cognex) theophylline zileuton (Zyflo) zolmitriptan (Zomig) and others Food Sources Broccoli, especially young broccoli sprouts, has been shown to be the most significant dietary source of sulforaphane. Other cruciferous vegetables also have a high sulforaphane content, including: kale cauliflower Brussels sprouts cabbage (red, white or green) watercress collard greens mustard greens bok choy It’s best to lightly cook cruciferous veggies or eat them raw if you can tolerate them to absorb the most SFN. Overheating and cooking these veggies can deplete some SFN, so try not to roast or grill them until they’re burnt. Supplements and Dosage Currently there is no daily recommended intake recommendations for sulforaphane. Dosage recommendations vary depending on someone’s overall health and goals. Supplement brands also vary widely in terms of how concentrated their products are — therefore always read the label carefully. When SFN has been studied, including in human and animal studies, dosages tend to range between 3–10 µmo per kilogram of body weight. SFN can be toxic when take in very dosages between 150–300 mg/kg body weight, so never take a higher amount than recommended. Look for sulforaphane supplements in capsule or extract form. (Always check the active ingredient name.) Sulforaphane is sometimes also called sulforafan, or 1-Isothiocyanato-4-(methylsulfinyl) butane. Conclusion Sulforaphane is a phytochemical found in cruciferous/Brassica vegetables that has many protective effects. It can potentially help prevent cancer, diabetes, and liver, lung and brain damage. You can obtain it from eating veggies, like broccoli, kale, cauliflower, cabbage and Brussel sprouts, or taking it in supplement form (capsule or extract). If you take medications, speak with your doctor before beginning to take this compound as a supplement. To read the original article click here.

The post Sulforaphane Benefits: The Secret to Broccoli’s Superfood Status appeared first on Amazing Health Advances.

New Scientific Review: Broccoli Compounds Act Against Cancer, but Western Medicine Ignores Its Benefits

AHA Publisher — Tue, 14 Dec 2021 08:00:18 +0000

Lori Alton via NaturalHealth365 – For almost three decades, forward-thinking scientists have been investigating the potential of sulforaphane – found in cruciferous vegetables such as broccoli and Brussels sprouts – to combat cancer. In a new review published in Frontiers in Nutrition, the authors evaluated sulforaphane research while shedding light on the multiple mechanisms through which this potent natural compound targets cancer cells. Yet, despite very promising results, the team noted there has been a delay in Western medicine’s acceptance of the therapeutic potential of sulforaphane. Why are conventional oncologists “dragging their feet” on this?! Let’s see what the research reveals. Preliminary Studies Showcase Anticancer Effects of Sulforaphane in Broccoli Cell and animal studies have shown that sulforaphane has anticancer effects, with the ability to cause apoptosis, or pre-programmed “suicide,” in cancer cells. Sulforaphane has also been shown to inhibit the ability of cancer to invade other cells and to slow the progression of lesions into malignant tumors. (As it turns out, sulforaphane has the capacity to inhibit angiogenesis, the formation of new blood vessels carrying oxygen and nutrients to tumors). Research has shown that a high dietary intake of cruciferous vegetables – such as broccoli, kale, cabbage, and Brussels sprouts – is associated with a lower risk of cancers. And, a recent (2020) review of clinical studies indicates that cruciferous vegetables rich in sulforaphane may reduce the risk of breast cancer. And, according to the U.S. Centers for Disease Control and Prevention, breast cancer currently claims the lives of over 42,000 women a year in the United States. No doubt, more women need to hear about the health benefits of cruciferous vegetables. Hope Against a Lethal Disease: Sulforaphane in Broccoli Inhibits Triple-Negative Breast Cancer Cells, While Potentially Setting the Stage for Treatment Triple-negative breast cancer is among the deadliest of all breast cancers – and there are currently no effective therapies. However, researchers say that sulforaphane works against the signaling pathways needed for the development and metastasis of this type of cancer. A 2019 study published in Cancer Prevention Research revealed that sulforaphane suppressed the growth and tumorsphere formation of triple-negative breast cancer stem cells, both in vitro (in test tubes) and in vivo (in living creatures). One of the reasons for the virulence of triple-negative breast cancers is that the cells don’t have the receptors that allow effective treatments to be given. But, a meta-analysis of studies found that sulforaphane – along with epigallocatechin gallate, a flavonoid found in green tea – restored estrogen receptors in triple-negative breast cancer cells, thereby potentially “opening the door” for treatment! And, the encouraging research is not limited to breast cancer. In a study published in Oncotarget – Peer-Reviewed Oncology and Cancer Research, scientists found that sulforaphane significantly inhibited thyroid cancer cell proliferation as well – leading them to label it a “potentially effective antitumor agent.“ Bureaucratic Obstacles and “Red Tape” Have Slowed Sulforaphane Research In the Frontiers of Nutrition review, the authors discussed the delay in sulforaphane’s acceptance as a cancer treatment – along with the delay in the acceptance of cruciferous vegetables as a preventive, and possibly therapeutic, intervention. Until the beginning of the 21st century, pure sulforaphane – which was used in many of the studies – was considered a drug by the Food and Drug Administration, meaning trials had to be strictly regulated. In addition, while sulforaphane had obvious anticancer effects, it was difficult for researchers to “tease out” exactly which other nutrients in cruciferous vegetables (such as flavonoids, anthocyanins, carotenoids, fiber, vitamins, and minerals) might be acting against cancer as well. As if that doesn’t make the research tricky enough, cruciferous vegetables contain varying amounts of glucoraphanin and other anticancer constituents – depending on the species, temperature, time of harvest, light, and soil. Calling the current therapeutic use of plant compounds “woefully inadequate,” the team suggested supporting health and preventing disease through the promotion and marketing of “healthy diets rich in fresh fruits and vegetables.” They also called for more research to explore the effects of sulforaphane. Good News: Sulforaphane Precursors Help Absorbability Three decades of research have illustrated the cancer-fighting abilities of sulforaphane. However, experts point out that you can’t just “pop a pill” of this compound – as stomach acids would quickly destroy it. So, how do we get this precious anticancer molecule into our bodies? Researchers say this requires the use of a “precursor” known as glucoraphanin, which is converted to sulforaphane in the digestive tract. And, one more “player”- an enzyme known as myrosinase – is needed. This natural plant chemical activates sulforaphane upon being ripped, cut, or chewed. While mature broccoli lack sulforaphane-boosting power, fresh, raw broccoli sprouts possess a much greater ability than mature florets to boost blood levels. (We’re talking 10 to 100 times more!) But: food-borne pathogens are sometimes found in broccoli sprouts, causing many natural health experts to warn that they require extensive decontamination before they can be eaten. Fortunately, supplementary glucoraphanin and myrosinase are available in enteric caplets, which are coated to avoid stomach acids. Before supplementing, however, consult your integrative doctor or health coach for guidance. Of course – despite their limitations in raising sulforaphane levels – cruciferous vegetables have consistently been linked with lower cancer rates, as well as with other health benefits. Eating generous amounts of these vegetables should be part of your daily health routine. Unfortunately, conventionally-trained nutrition “experts” barely acknowledges the existence of plant chemicals – and physician training includes almost no nutrition education. The reviewers would clearly like to see this situation change – and called for a complete “reinvention of the country’s healthcare,” with phytochemicals, such as sulforaphane, at the forefront. Let’s see if anyone is listening. Sources for this article include: LifeExtension.com NIH.gov NIH.gov CDC.gov To read the original article click here.

The post New Scientific Review: Broccoli Compounds Act Against Cancer, but Western Medicine Ignores Its Benefits appeared first on Amazing Health Advances.

Dr. Greger’s Daily Dozen Healthiest of Healthy Foods

AHA Publisher — Mon, 09 Aug 2021 07:00:29 +0000

Michael Greger M.D. FACLM via Nutrition Facts – In my book How Not to Die, I center my recommendations around a Daily Dozen checklist of everything I try to fit into my daily routine. In my book How Not to Die, I suggest we try to center our diets around whole plant foods. Some plants are healthier than others, though. Apparently, you can live for extended periods eating practically nothing but white potatoes, for example, and, by definition, that would be a whole food, plant-based diet—but not a very healthy one. All plant foods are not created equal. The more I’ve researched over the years, the more I’ve come to realize that healthy foods are not necessarily interchangeable. Some foods and food groups have special nutrients not found in abundance elsewhere. For example, sulforaphane, the amazing liver-enzyme detox-boosting compound, is derived nearly exclusively from cruciferous vegetables. You could eat tons of other kinds of greens and vegetables on a given day and get no appreciable sulforaphane if you didn’t eat something cruciferous. Same with flaxseeds and the anticancer lignan compounds: Flax may average a hundred times more lignans than other foods. And mushrooms? Well, mushrooms aren’t even plants. They belong to an entirely different biological classification and contain some nutrients like ergothioneine that may not be made anywhere in the plant kingdom. So, technically, maybe I should be referring to a whole food, plant- and fungus-based diet…but that sounds a little gross. It seems like every time I come home from the medical library buzzing with some exciting new data, my family rolls their eyes, sighs, and asks, What can’t we eat now? Or they’ll say, Wait a second. Why does everything seem to have parsley in it all of a sudden? They’re very tolerant! As the list of foods I tried to fit into my daily diet grew, I made a checklist and put it up on a little dry-erase board on the fridge, and we made a game out of ticking off the boxes. This evolved into my Daily Dozen, the checklist of everything I try to fit into my daily routine. In my video Dr. Greger’s Daily Dozen Checklist, you can see the list, the daily minimum servings I recommend, and examples of foods that go into each category. My Daily Dozen includes Beans, Berries, Other Fruits, Cruciferous Vegetables, Greens, Other Vegetables, Flaxseeds, Nuts and Seeds, Herbs and Spices, Whole Grains, Beverages, and Exercise. By Beans, I mean legumes, which also include split peas, chickpeas, and lentils. It may not seem like you’re eating beans when you have a bowl of pea soup, for example, or dip carrots into hummus, but you are. We should try to get at least three servings a day. A serving is defined as a quarter cup of hummus or bean dip; a half cup of cooked beans, split peas, lentils, tofu, or tempeh; or a full cup of fresh peas or sprouted lentils. Technically, peanuts are legumes, but, nutritionally, I put them in my Daily Dozen Nuts and Seeds category. Similarly, I put green beans, snap peas, and string beans into the Other Vegetables category. My Daily Dozen includes at least one serving of Berries a day, which is a half cup of fresh or frozen, or a quarter cup of dried. Biologically speaking, avocados, bananas, and even watermelons are technically berries, but to simplify things, I use the colloquial term for any small edible fruit. So, this category includes kumquats, grapes, raisins, and fruits that are typically thought of as berries even though they technically aren’t, like blackberries, cherries, mulberries, raspberries, and strawberries. For Other Fruits, a serving is a medium-sized fruit, a cup of cut-up fruit, or a quarter cup of dried fruit, and I recommend at least three daily servings. Again, I’m using the colloquial rather than the botanical definition, which is why I put tomatoes in the Other Vegetables group. Cruciferous Vegetables include broccoli, cabbage, cauliflower, Brussels sprouts, collards, and kale, and I recommend at least one half-cup serving a day. My Daily Dozen also calls for at least two additional daily servings of Greens, cruciferous or otherwise, and two serving of Other Vegetables, with a serving being a cup of raw leafy vegetables, a half cup for raw or cooked non-leafy vegetables, and a quarter cup of dried mushrooms. Everyone should try to incorporate one tablespoon of ground Flaxseeds into their daily diet, in addition to one serving of Nuts and Seeds. A quarter cup of nuts is considered a serving, or you can have two tablespoons of nut or seed butters, including peanut butter. Chestnuts and coconuts don’t count nutritionally as nuts. For my Herbs and Spices category, I recommend a quarter teaspoon a day of the spice turmeric, along with any other salt-free herbs and spices you may enjoy. To meet my Daily Dozen, you need at least three servings of Whole Grains, and a serving can be a half cup of hot cereal (like oatmeal), cooked whole grains or so-called pseudograins (like amaranth, buckwheat, and quinoa), cooked pasta, or corn kernels; a cup of ready-to-eat cold cereal; one tortilla or slice of bread; half a bagel or english muffin, or three cups of air-popped popcorn. The serving size in the Beverage category is one 12-ounce glass, and I recommend at least five servings a day in addition to the water you get naturally from the foods in your diet. If you’re curious, I explain my rationale in my How Many Glasses of Water Should We Drink a Day? video. Finally, my Daily Dozen calls for at least one daily “serving” of exercise, which can be split up over the day. I recommend 90 minutes of moderate-intensity activity, such as walking briskly (for instance, at a pace of four miles per hour), or 40 minutes of vigorous activity, like jogging or active sports. See my video How Much Should You Exercise? if you’d like more information. This may sound like a lot of boxes to check, but it’s easy to knock off a bunch at a time. One simple peanut butter and banana sandwich on whole-grain bread can check off four boxes, and imagine how many Daily Dozen boxes you could tick off when you sit down to a big salad of two cups of spinach, a handful of arugula, a handful of walnuts, a half cup of chickpeas, a half cup of red bell pepper, and a small tomato. That’s seven boxes in just one salad! Sprinkle on your flaxseeds, add a handful of goji berries, enjoy it with a glass of water, and end with some fruit for dessert, and you just met nearly half of the Daily Dozen in a single meal! And, if you just ate it on your treadmill…just kidding! Do I check off each glass of water I drink? No. In fact, I don’t even use the checklist anymore. I just used it initially as a tool to get me into a routine. Whenever I sat down to a meal, I challenged myself by asking, Could I add greens to this? Could I add beans to this? Can I sprinkle on some flax or pumpkin seeds? What about some dried fruit? The checklist just got me into the habit of wondering how I can make each meal even healthier. The checklist also helped with grocery shopping. Although I always keep bags of frozen berries and greens in the freezer, if I’m at the store and want to buy fresh produce for the week, it helps me figure out how much kale or blueberries I need. In fact, the checklist even helped me picture what a meal might look like. When you look over the Daily Dozen, as you can see at 6:44 in my video, you see that it includes three servings each of Beans, Other Fruits, and Whole Grains, and about twice as many vegetables in total than any other component, when you add up the Cruciferous Vegetables, Greens, and Other Vegetables. So, glancing at my plate, I can imagine one quarter of it filled with grains, one quarter with legumes, and vegetables taking up the other half, along with a side salad and fruit for dessert, for instance. I really like one-bowl meals where everything’s mixed together, and even then the checklist helps me visualize. Instead of a big bowl of spaghetti with some veggies and lentils on top, I think of a big bowl of vegetables with some pasta and lentils mixed in. Instead of a big plate of quinoa with some stir-fried vegetables, I picture a meal that’s mostly vegetables with some quinoa and beans added in there, too. There’s no need to be obsessive about the Daily Dozen. On hectic travel days, when I’ve burned through my snacks and find myself stuck in some airport food court, I’m lucky if I hit even a quarter of my goals. If you eat poorly one day, just try to eat better the next. To help track your progress, volunteers created Dr. Greger’s Daily Dozen apps for both iPhone and Android. You can download and use them both for free with no ads and no cost. My hope is that the checklist will serve as a helpful reminder to try to eat a variety of some the healthiest foods every day. KEY TAKEAWAYS All plant foods are not created equal, so although we should try to center our diets around whole plant foods, we should be sure to incorporate the most healthful ones. Some of the most special and important nutrients are sulforaphane, which is found almost exclusively in cruciferous vegetables, and flaxseeds with their anticancer lignan compounds. The Daily Dozen checklist is the synopsis of recommendations I make in my book How Not to Die, incorporating everything I try to fit into my daily routine and lists categories and minimum servings. My Daily Dozen includes Beans (and legumes, including split peas, chickpeas, and lentils), Berries, Other Fruits, Cruciferous Vegetables, Greens, Other Vegetables, Flaxseeds, Nuts and Seeds, Herbs and Spices, Whole Grains, Beverages, and Exercise. The Daily Dozen is intended to inspire you to eat more healthful options and look at each eating experience as an opportunity to maximize nutrition. To help you tick the Daily Dozen boxes, volunteers created Dr. Greger’s Daily Dozen app, completely free to download and use, and available for both iPhone and Android. This was quite the departure from our regular blogs! Normally, we just share the science from the primary sources in the peer-reviewed medical literature, but I want NutritionFacts.org to be more than just a reference site. I want it to be a practical guide on translating this mountain of data into day-to-day decisions, which is where my Daily Dozen app slips into the mix. It’s available for free on iTunes and as an Android app, thanks to an amazing group of volunteers through our Open Source Initiative. To read the original article click here. For more articles from Dr. Greger click here.

The post Dr. Greger’s Daily Dozen Healthiest of Healthy Foods appeared first on Amazing Health Advances.

Helpful Foods to Support People with Autism

AHA Publisher — Wed, 14 Apr 2021 07:00:59 +0000

Michael Greger M.D. FACLM via Nutrition Facts – The sulforaphane found in five cents’ worth of broccoli sprouts has been shown to benefit autism in a way no drug ever has in a randomized, double-blind, placebo-controlled study. You may remember my series of videos, which includes Prevent Cancer from Going on TOR, about target of rapamycin (TOR), the engine-of-aging enzyme. Kids with autism tend to have higher TOR activity in their bodies, and this hyperactive TOR signaling may play a role in causingautism, which makes TOR a potential target to treat autism or even theoretically reverse it if we could target downstream TOR signaling, like between TOR and S6K1, as you can see at 0:29 in my video Best Foods for Autism. In fact, that’s one of the ways sulforaphane, a compound in broccoli and other cruciferous vegetables, kills off prostate cancer cells—by inhibiting the signal transduction between TOR and S6K1. Sulforaphane is also “a potent inhibitor” of breast cancer cells because “it targets downstream elements of the [TOR] pathway.” So, if broccoli blocks TOR and if we give it to those with autism, maybe it would block some of the synaptic dysfunction that contributes to the features of autism—and that’s in addition to blocking autism pathways four other ways: oxidative stress, lower antioxidant capacity, mitochondrial dysfunction, and brain inflammation. What’s more, this doesn’t only occur in a petri dish. “Importantly, sulforaphane can cross the blood-brain-barrier,” so when you eat broccoli, sulforaphane quickly reaches your brain “to exert its protective effects”—at least it does in theory. You don’t know, of course, until you put it to the test. You can understand why such a study could attract researchers from such leading institutions as Harvard and Johns Hopkins, and get published in one of our most prestigious journals, the Proceedings of the National Academy of Sciences. What did they find? First, what did they do? “In a placebo-controlled, double-blind, randomized trial, young men (aged 13–27) with moderate to severe ASD [autism] received” sulforaphane from broccoli sprouts or an indistinguishable sugar pill. They were dosed according to body weight: Those under 100 pounds got about a tablespoon of broccoli sprouts’ worth of sulforaphane a day, which is about a cup’s worth of broccoli, those weighing between 100 and 200 pounds got about the equivalent of two cups of broccoli or two tablespoons of fresh broccoli sprouts, and those over 200 pounds got three cups’ worth a day or a little under a quarter cup of broccoli sprouts. Why didn’t the researchers use actual broccoli or actual sprouts? If they had, it wouldn’t have been a blinded study. The patients, doctors, and parents would know who was and who wasn’t getting the special treatment, which could introduce bias through the placebo effect. Instead, with this study set-up, no one knew until the end who got the sulforaphane and who got the placebo. The researchers chose dietary sulforaphane because of its capacity to reverse oxidation, dysfunction, and inflammation, but when put to the test, did it actually work? The placebo didn’t. Give people with autism nothing, and nothing much happens. But effectively secretly sneak them some broccoli, and substantial improvements in behavior, social interaction, and verbal communication occurred. However, it all disappeared once the broccoli was stopped. As you can see at 3:25 in my video, on the Aberrant Behavior Checklist, which includes things such as repetitive behaviors, there was no big change in the placebo group, which is what you’d expect, but the abnormal behaviors plunged in the sulforaphane group—the group who got the sulforaphane found in only about five cents’ worth of broccoli sprouts a day. The study ended in week 18, however, and a month later, things were heading back to where they started. There were similar findings on a Social Responsiveness Scale: significant improvements were seen until the treatment was stopped, and then the participants went right back to functioning as poorly as those in the placebo group had continued to function. And these weren’t just scores on a page. “The substantial improvements…were conspicuous”—the doctors, parents, and caregivers could see the improvements. No drug has ever been shown to have these kinds of effects. What’s more, these were young men, starting at age 13. One could imagine it working as well or even better with younger children because their brains are still developing. And, is there a downside? “Broccoli sprouts are widely consumed as a food item all over the world by a very large number of individuals, without any reports of adverse effects”—but remember we’re talking about whole foods, not sulforaphane supplements. Indeed, broccoli sprouts work, but commercial broccoli sprout supplements hardly work at all. As you can see at 4:55 in my video, broccoli has sulforaphane, with the florets more so than the stems, and broccoli sprouts have about ten times more sulforaphane. In comparison, broccoli pills, powders, and supplements have little or none. So, broccoli and other cruciferous vegetables arefor all kids, whether they have autism or not, and they may be for pregnant women as well for the potential prenatal prevention of autism in the first place. This article covers the big finale to my initial three-part video series on autism. For the background that led researchers down this path of clues, check out Fever Benefits for Autism in a Food and Fighting Autism Brain Inflammation with Food. You can also check: Flashback Friday: The Best Foods for Fighting Autism and Brain Inflammation. We understand there may be a variety of challenges pertaining to catering to picky palates, sensory and food texture sensitivities, or kids who are reluctant to try new foods, and we hope this evidence-based article can provide some helpful health information to parents and health practitioners. For more tips and tricks, check out How to Get Kids to Eat Their Vegetables. To read the original article click here. For more articles from Dr. Greger click here.

The post Helpful Foods to Support People with Autism appeared first on Amazing Health Advances.

Cooked or Raw? The Best Ways to Eat This Superfood to Reduce Your Risk of Cancer

AHA Publisher — Wed, 02 Dec 2020 08:00:36 +0000

Edit Lang via NaturalHealth365 – Our diet plays a vital role in preventing cancer. Members of the Brassica family of vegetables are particularly rich in a chemical compound, sulforaphane, renowned for its cancer-fighting abilities. Of all the cruciferous vegetables, broccoli is one of the best sources of sulforaphane. Studies confirmed that sulforaphane lowers your risk of cancer through several mechanisms. One such mechanism is that it upregulates detoxification enzymes. But whether you eat your broccoli raw or cooked makes a dramatic impact on its cancer-fighting power. Boost your liver’s detoxification to lower your risk of cancer Proper detoxification is central to maintaining optimum health and cutting your cancer risks. An overburdened, sluggish, or fatty liver is often at the root of chronic conditions, including several cancer types. Besides minimizing our exposure to the multitude of environmental toxins and pollutants, we can do even more by nourishing our liver with the right foods. The best way to ensure that our bodies effectively remove the vast number of toxins we are exposed to every day is by boosting our liver’s detoxifying enzymes. Sulforaphane, the most potent natural phase 2 enzyme inducer, is abundant in cruciferous vegetables. When broccoli, cauliflower, Brussel sprouts are a regular part of our diet, we can increase our liver’s ability to remove carcinogens and heavy metals from the blood. Cooking destroys enzyme needed for sulforaphane formation While broccoli is an excellent sulforaphane source, there is actually none in the plant until you begin to chew it. Instead, broccoli contains a sulforaphane precursor, called glucoraphanin. When you chew or chop the broccoli, the precursor begins mixing with an enzyme called myrosinase. Once activated, the myrosinase enzymes transform glucosinolates into sulforaphane. Although glucoraphanin is heat-resistant and can withstand cooking, the myrosinase enzyme cannot. Heat destroys it. Without the enzyme, there is no sulforaphane. The destruction of the enzyme may explain why we get significant suppression of cancer cell growth from raw broccoli, but hardly anything from when it is cooked. Hate raw broccoli? Here is how to cook it to preserve its sulforaphane content If you cannot find peace with the idea of munching on raw broccoli flowerets, there may be an effective way to cook broccoli and still benefit from its cancer-protective effects. In a 2018 study, a group of researchers set out to determine broccoli’s sulforaphane stability during the stir-frying process. First, they pulverized the broccoli, chopping it into tiny pieces to activate as much myrosinase enzyme as possible. Then they split their samples into three groups: One raw One stir-fried for four minutes immediately after chopping One chopped and then left alone for 90 minutes before being stir-fried for four minutes The results showed that the third sample group, where the chopped broccoli was left alone for 90 minutes, had 2.8 times higher sulforaphane content than the sample group stir-fried immediately after chopping. Add mustard seed to increase sulforaphane formation on cooked broccoli Although boiling broccoli deactivates the enzyme needed for sulforaphane formation, there is something you can do to preserve its cancer-protective compounds. Researchers found that when they added powdered mustard seeds to cooked broccoli, sulforaphane formation increased. Adding only half a teaspoon of powdered mustard seeds was enough to provide a natural source of the enzyme and boost the broccoli’s cancer-fighting compound. Broccoli does not get enough credit for all the goodness it offers to our health. Whether we choose to eat it raw, cooked, or stir-fried, we can preserve its sulforaphane content to help protect against free radicals, improve detoxification, and help prevent cancer. Sources for this article: Pubmed.gov, Pubs.acs.org, NutritionFacts.org, NaturalHealth365.com To read the original article click here. For more articles from NaturalHealth365 click here.

The post Cooked or Raw? The Best Ways to Eat This Superfood to Reduce Your Risk of Cancer appeared first on Amazing Health Advances.