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A Natural Supplement to Lower Cholesterol May Ease Anxiety

AHA Publisher — Wed, 16 Jun 2021 07:00:18 +0000

Abigail Klein Leichman via Israel21c – A natural food supplement ordinarily used to lower cholesterol was found to reduce anxiety in mice, according to a new Weizmann Institute of Science study. The plant-derived substance, beta-sitosterol, calmed the lab mice by itself and also worked synergistically with the antidepressant drug Prozac. Published May 18 in Cell Reports Medicine, the study results need to be confirmed in clinical trials to see if beta-sitosterol could help relieve anxiety in humans. Developing antianxiety drugs is challenging, because the brain circuits for anxiety are closely related to those responsible for memory, awareness and other functions vital for handling danger. Scientists try to find compounds that selectively suppress anxiety without causing unwanted side effects. Several years ago, Prof. Mike Fainzilber’s biomolecular sciences lab at Weizmann discovered that in stressful situations, mice lacking the protein importin alpha-five showed less anxiety than the control mice. The calmer mice were found to have about 120 genes with a characteristic pattern of expression in the hippocampus, one of the brain regions that regulate anxiety. In the new study, Fainzilber lab senior intern Nicolas Panayotis led a search of an international genomic database for existing drugs or other compounds that might mimic the same gene expression signature. He identified five candidates and tested their effects on behavior in mice. That was how the researchers zeroed in on beta-sitosterol, a plant substance now sold as a dietary supplement intended mainly to reduce cholesterol levels. No Side Effects In a series of behavioral experiments, mice given beta-sitosterol showed much less anxiety than the control group. They were, for example, less fearful than the controls when placed in an illuminated enclosure, daring to walk into its brightly lit center, whereas the control mice stayed on the darker periphery, avoiding the stress of the bright light. Moreover, the mice receiving beta-sitosterol did not exhibit any of the side effects that might be expected from antianxiety medications – their locomotion was not impaired, and they did not refrain from exploring novel stimuli. Then the researchers gave the mice beta-sitosterol in combination with fluoxetine, a selective serotonin reuptake inhibitor (SSRI) sold under the brand name Prozac. The combination had a synergistic effect: Both beta-sitosterol and fluoxetine reduced anxiety at lower doses when given together, compared with the doses needed to produce the same effect when they were administered separately. “One of the major problems with existing antianxiety medications is that they produce side effects, so if beta-sitosterol could help cut down the dosage of such medications, it might potentially also reduce the unwanted side effects,” Panayotis said. Plant-Derived A great advantage of beta-sitosterol is that it is naturally present in a variety of edible plants, and it is thought to be safe, as it has been marketed for years as a nutraceutical. The substance is found in particularly large concentrations in avocados, but also in pistachios, almonds and other nuts, as well as in canola oil and in various grains and cereals. However, this does not mean that simply eating avocado can induce a calming effect. “You’d need to eat avocado day and night to get the right dose – and you would be more likely to develop digestive problems than relieve your anxiety,” Panayotis said. The precise mechanism of beta-sitosterol’s effect on anxiety remains to be revealed, but the scientists did find that the expression of several genes known to be activated in stressful situations was reduced in mice given the supplement. They also found that these mice had changes in the levels of certain metabolites and neurotransmitters in brain areas involved in anxiety. Since the study focused on brain regions and neural pathways that are involved in regulating anxiety in both mice and humans, the researchers are optimistic that the findings will apply to humans as well. “There’s a need for a clinical trial to test the use of beta-sitosterol for reducing anxiety in humans. Until then, we recommend that people consult their physicians before taking the supplement for this purpose,” Fainzilber said. Researchers included Philip Freund and Letizia Marvaldi of the Biomolecular Sciences Department; Tali Shalit of the Nancy and Stephen Grand Israel National Center for Personalized Medicine; Alexander Brandis and Tevie Mehlman of the Life Sciences Core Facilities Department; and Michael Tsoory of the Veterinary Resources Department. To read the original article click here. For more articles from Israel21c click here.

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Exposure to Nature Promotes Psychological Well-Being in Children and Offsets Excessive Computer Use

AHA Publisher — Fri, 18 Sep 2020 07:00:58 +0000

Lori Alton via NaturalHealth365 – Virtually every Baby Boomer can probably recall this recurring parental suggestion: “Why don’t you kids go outside and play?!” Scientific research now agrees on the wisdom of this advice, with recent studies supporting the benefits of “green time” in lowering blood pressure, lifting mood and reducing levels of stress hormones in children and adults alike. Over the past two decades, however, the use of screen-based technology has soared, with restorative “green time” often sacrificed to “screen time” – a particularly troublesome scenario for children and teens. For the first time, a new systematic review explores the benefits of green time – and the effects of screen time – in children and teenagers. Review: American Preteens May Spend Only a Handful of Hours a Week Enjoying the Benefits of Green Time – with Troubling Consequences Shockingly, one study revealed that 12-year-old children in the United States report spending less than six hours a week outside – less than they report spending on screen time in a single day! Keep in mind, according to psychologist and screen technology expert Dr. Mike Brooks, PhD, many teens spend as much as nine hours (not including school or homework!) on screen-based media, while children may spend eight to 12. In addition, roughly 25 percent of all adolescents describe themselves as “constantly connected” to the Internet. Many researchers believe that excessive screen time is detrimental to young people, as it stimulates the hypothalamic-pituitary-adrenal axis and dopaminergic circuits at a time when those sensitive systems are developing and changing. On a practical note, excessive screen time can interfere with mental health necessities such as adequate sleep, in-person social activities, academic activities and regular exercise. Warning: High Screen Time with Low Green Time is Associated with Poorer Psychological and Cognitive Health In a systematic review published September 4 in PLOS One, the authors evaluated 186 studies to assess the effects of green time and screen time on mental health, cognitive function and academic achievement in children and teens in the United States, Canada, the UK, New Zealand and Australia. The researchers evaluated studies that explored the use of visual screen-based technologies such as TV, video games, smart phones, surfing the internet, social media and texting – as well as investigating exposure to green spaces and outdoor activities. In young people of all age groups, higher screen time was found to be associated with detrimental effects (although positive consequences from moderate exposures were found). The authors reported that in schoolchildren 5 to 11 years old, screen time exposures were generally associated with unfavorable psychological outcomes such as depressive symptoms, behavioral problems, sleeplessness and poorer cognitive function and attention. In a study published in Archives of Pediatrics and Adolescent Medicine, the researchers found that higher screen time was associated with reduced happiness and poorer academic outcomes. And, in older teens, high levels of screen time were associated with higher levels of depressive symptoms and anxiety. Green time, on the other hand, was associated with favorable outcomes such as reduced anger, healthier cortisol profiles, more energy and increased happiness. In addition, green time decreased long-term anxiety – and one study found that learning in a forest setting was associated with a steeper daily decrease in cortisol levels, when compared to traditional indoor classes. The authors pointed out that natural areas and green spaces tend to have better air quality and less noise pollution when compared to congested, high-traffic areas. And, direct sunlight promotes restful sleep by regulating circadian rhythms and spurring the production of vitamin D – a potent anti-inflammatory, immune system booster and natural antidepressant. Important Caveat: Researchers Credit “Moderate Screen Time” with Many Benefits The fact is: an estimated 47 percent of U.S. employment is classified as being at high risk of computerization in coming years. Stressing the need for young people to be “tech-literate,” the authors were careful to point out the upside of computer use. They noted that “moderate” screen time can aid academic achievement while allowing young people to forge new connections, enhance existing relationships and access the world beyond their immediate surroundings. And, some studies found that computer gaming was associated with increased reading and problem-solving scores. But, How Much Screen Time Is too Much? When it comes to recommending guidelines, Dr. Brooks points out that this is a highly individual matter, dependent on context, type of media, quality of content and the age of the child or teen. As a general rule, Dr. Brooks notes that one to two hours of recreational screen time on a school day is reasonable for teens, with three to four permissible on weekends and holidays. He adds that devices should be kept out of bedrooms when it’s time to sleep – and away from family meals. Boost Mental and Psychological Health with Nature-Centered Activities When it comes to getting quality green time, the options for both adults and young people are almost unlimited. Wilderness hiking, rock climbing, strolling in parks, swimming in oceans and lakes, jogging on outdoor paths, climbing trees or simply playing tag in a field – all qualify as green time. And, practices like “forest bathing” and “earthing” – in which contact with nature is used to lower blood pressure and reverse harmful electrical charges in the body – are steadily growing in popularity as well. Of course, common sense, safety guidelines and age-appropriate supervision must be observed – whatever the activity. Today’s technology offers a rich source of information, opportunity and inspiration for young people – but it also presents hazards. This new review shows that green time can act as a buffer for the toxic effects of too much screen time, while promoting physical and psychological health. So, unplug and log off for a while – and encourage your family to do the same. The rewards are tremendous! Sources for this article include: ScienceDaily.com, PsychologyToday.com To read the original article click here. For more articles from NaturalHealth365 click here.

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