restoring vision Archives - Amazing Health Advances

New Drug Shows Promise in Restoring Vision for People with Nerve Damage

The AHA! Team — Fri, 04 Apr 2025 05:24:11 +0000

University of Colorado Anschutz Medical Campus via EurekAlert! – Research from the University of Colorado Anschutz Medical Campus reveals drug could potentially help repair vision in those with multiple sclerosis (MS) and other neurological conditions. Researchers at the University of Colorado Anschutz Medical Campus have found a promising drug candidate that could help restore vision in individuals with multiple sclerosis (MS) and other neurological conditions that damage neurons. The study was published this week in the journal Nature Communications. The drug, LL-341070, enhances the brain’s ability to repair damaged myelin— the protective sheath around nerve fibers. Damage to myelin is a hallmark of diseases like MS, as well as a natural consequence of aging, often resulting in vision loss, loss of motor skills, and cognitive decline. The research, focused on vision, demonstrated that while the brain has some ability to repair itself when myelin is damaged, the process can be slow and inefficient. Researchers observed that LL-341070 significantly accelerated the repair process and improved brain function related to vision in mice, even after severe damage. “This research brings us closer to a world where the brain has the capacity to heal itself” “This research brings us closer to a world where the brain has the capacity to heal itself” said Ethan Hughes, PhD, co-lead author and associate professor in the Department of Cell and Developmental Biology at the CU School of Medicine. “By harnessing this potential, we hope to help people with diseases like MS by potentially reversing some of the damage, offering people the opportunity to regain their vision and cognitive function.” Researchers discovered that the treatment makes the repair process is much more effective following serious damage, highlighting the importance of intervention with severe injury. Even partial repair of myelin was found to significantly improve vision-related brain functions. “We’ve known for years that myelin plays a crucial role in brain function” “We’ve known for years that myelin plays a crucial role in brain function,” said Daniel Denman, PhD, co-lead author of the study and assistant professor in the Department of Physiology and Biophysics at the CU School of Medicine. “This study highlights the role of cortical myelin in visual function. The drug could be a game-changer because it accelerates the brain’s natural repair mechanisms.” The researchers plan to test the drug in other areas of the brain and refine the treatment, hoping to make it even more effective and eventually accessible to patients. “This discovery is just the beginning,” Hughes said. “We are optimistic that LL-341070 and similar therapies could one day provide real, tangible benefits to patients by improving overall brain function and quality of life.” About the University of Colorado Anschutz Medical Campus The University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education and patient care. The campus encompasses the University of Colorado health professional schools, more than 60 centers and institutes and two nationally ranked independent hospitals – UCHealth University of Colorado Hospital and Children’s Hospital Colorado – which see more than two million adult and pediatric patient visits yearly. Innovative, interconnected and highly collaborative, the CU Anschutz Medical Campus delivers life-changing treatments, patient care and professional training and conducts world-renowned research fueled by $910 million in annual research funding, including $757 million in sponsored awards and $153 million in philanthropic gifts. Journal Nature Communications To read the original article click here.

The post New Drug Shows Promise in Restoring Vision for People with Nerve Damage appeared first on Amazing Health Advances.

3D Printing Your Own Personalized Contact Lenses

The AHA! Team — Mon, 21 Oct 2024 08:26:35 +0000

John Jeffay via Israel21c – Lensy envisions that within a few years, the optometrist will check your vision, press a button and hand you a perfect pair of custom contact lenses. Instant 3D-printed contact lenses are the future. You’ll go for an eye exam, the optometrist will check your vision, press a button, and within minutes you’ll have a pair of contact lenses that are a perfect fit and provide perfect vision. Leonardo da Vinci came up with the theoretical idea of contact lenses in 1508. They didn’t become a practical reality until the 1930s. Yet even now they haven’t really taken off. Three billion people globally wear glasses, but only 150 million opt for contacts. The reason: Price and comfort. Contact lenses work out to be far more expensive than eyeglasses, especially now that 90 percent of users choose disposables. And many people find they simply can’t wear them – because their eyes are the wrong shape. Eyes are a bit like feet, Edan Kenig, CEO at Israeli startup Lensy, tells ISRAEL21c. They come in different shapes and sizes. Yet off-the-shelf contact lenses are “one-size-fits-all” aside from the optical part in the center. So they more or less fit 70% of the world’s population, but for the other 30%, it’s just tough. That’s because the big players in the optical market use the same molds to mass-manufacture millions of lenses. Some inevitably end up being too loose, some too tight, depending on tiny but significant differences in eye shape and size. Kenig says his technology will solve both the price and comfort problems, and his lenses could be available to buy four years from now. Resin 3D “I would really like to wear contact lens for the whole day,” says Kenig, who is extremely short-sighted (a minus-11 prescription). “But now I’m limited to use them only for sport [he does Brazilian Jiu-Jitsu] for a few hours because it’s not comfortable for me.” He’s a biophysicist by training and later became an engineer and an entrepreneur, learning how to develop ideas into products. He saw the potential of an emerging technology called resin 3D-printing, a more sophisticated form of standard 3D printing. It uses UV light to “cure” or harden a resin, rather than squirting material through a nozzle to build objects layer by layer. Kenig and his small team, based in Rehovot, central Israel, have adapted a form of contact lens material and developed a technique to resin 3D-print it. They’ve got as far as printing a contact lens — and say they’re the first to have done so — but still need to perfect it before they can try it out in a human eye. Custom solutions Lensy is an early-stage startup founded in early 2022 with help from the Israel Innovation Authority. The company currently has no external funding. Big companies are also researching and developing printed lenses, says Kenig, but they’re planning what he calls “large, cumbersome, expensive printers” rather than the desktop version he’s working on. For the 70% of people with “normal” eyes, mass-produced lenses will likely remain the best option, he says. For the other 30%, tailored lenses will be a gamechanger. “The further away you are away from the average fit, the more problems you’re going to have, such as people with a high astigmatism, people with high myopia and people with peculiar eye shapes that are not round and not spherical. “The optometrist will then have the opportunity to make a custom solution so the patient will have an affordable, comfortable fit that’s tailored to their needs.” The machine will be available on a lease basis, using capsules that will cost the optometrist $50 per eye. The lenses will be reusable, although it’s possible that the technology will evolve to produce disposables. Like shoes “Contact lenses aren’t a new solution, yet they have many disadvantages that haven’t been resolved by better materials or better designs,” Kenig says. Around a fifth of wearers give up on them every year, he says. So although new users are always starting, the market is effectively stagnant. That’s partly to do with the cost – around $4 a day, he says – but largely because of the one-size-fits-all restriction. “It’s like going into a shoe store,” says Kenig, “and all the shoes are size nine [42 in Europe]. So if you’re size nine, great. If you’re size eight, you will have some problems. But if you’re seven or 11, it’ll be impossible.” Kenig says getting contact lenses today is time-consuming, cumbersome and labor-intensive, and the patient has to be really committed. Even a minor miscalculation means the optician will have to have the lenses redone. “If you have problem with your off-the-shelf contact lens, the optician will tell you to take glasses instead. They don’t have the tools to tailor your lenses.” In the future, Kenig says Lensy could make contact lenses that incorporate existing technology for kids that actually slows the progress of myopia as their eyes grow. Kenig also says lenses could one day be impregnated with slow-release drugs to avoid the need for painful eye injections, and smart contact lenses could be embedded with sensors and cameras. For more information, click here. To read the original article click here.

The post 3D Printing Your Own Personalized Contact Lenses appeared first on Amazing Health Advances.

Improving Vision with At-Home Brain Exercises

The AHA! Team — Fri, 18 Oct 2024 08:08:57 +0000

John Jeffay via Israel21c – RevitalVision offers a unique intervention for people with eyesight challenges, treating the brain where images are processed. Doctors told Amit Azulay again and again that she’d never be able to drive because of medical conditions affecting her eyesight. She proved them wrong — using a unique piece of software developed by a startup in Israel that has been clinically proven to improve vision. Despite suffering nystagmus (involuntary eye movements) and albinism, her eyesight became good enough to apply for a license (see her delighted response to the news here). Amit, aged 25, is one of many patients who say the online training exercises have literally changed their lives. RevitalVision offers a unique intervention for people with eyesight challenges. It doesn’t treat the eye. It treats the brain. The eye is the hardware, providing the best optical signal it can. But in many cases, the brain struggles to process that signal. That could be because of medical conditions including diabetes, glaucoma or AMD (age-related macular degeneration). It could be a cataract patient whose hardware has been upgraded (cloudy lenses replaced with clear ones) but whose software (the brain) hasn’t caught up. Or somebody who’s had laser surgery but now has blurry vision resulting from reduced contrast sensitivity and still has to wear glasses. Or somebody with “lazy eye” (amblyopia) whose brain sidelines signals from the eye that doesn’t work as well as the other. Or somebody who’s borderline for wearing glasses and would prefer not to. RevitalVision addresses all these problems, and more, with a structured program that trains the brain to better make sense of the blurry signals it receives. Screams of joy RevitalVision’s program typically involves three half-hour, at-home computer sessions per week for two or three months. Patients are trained via a dedicated app. The result, says Yair Yahav, the company’s CEO, is a measurable improvement in vision of 20% to 25%, equivalent to an extra two or more lines on a standard eye chart or, in many cases, the difference between a driving license and no license. “Some patients come to our premises in Modi’in [central Israel], where we have a team of optometrists,” he tells ISRAEL21c. “About once a week I hear screams of joy from a patient in another room who now has good enough vision to qualify for a driving license. We have people who are literally crying. “They’ve been told their whole life that there’s no way, forget it, you’ll never be able to drive. “Then they come to us and if they’re missing just one or two lines [on the eye chart], that’s the average, we tell them they have an 85% to 90% chance of success.” One patient testimonial is from a woman who couldn’t read the label on her medicine, or see well enough to sign a check. She now can. Another, a graduate student with congenital nystagmus, always had to sit at the front of the class to read the board. Now she can sit anywhere. “It’s really lifechanging for many, many people,” says Yahav. Image processing He explains the science behind what they do. “The quality of the image we see depends both on image capturing and image processing,” he says. “We don’t treat the lens of the eye; we treat the brain by enhancing its ability to process visual information, which results in significant vision improvement.” The brain training is based on a “Gabor patch,” which looks like a grid of blurry black and white stripes on a gray background. It was invented by Dennis Gabor, who was born in Hungary, fled the Holocaust, invented holography, and was awarded the Nobel Prize for physics in 1971. His seemingly simple image perfectly matches the shape of the receptive fields of neurons, or nerve cells, in the part of the brain that processes visual information. Repeatedly stimulating those neurons improves their performance, just like physical exercise at the gym builds muscle, says Yahav. Shoring up weaknesses RevitalVision uses an algorithm to understand exactly where the weaknesses lie for each patient. In a typical on-screen exercise, the patient sees three images pop up, two of a Gabor patch and one of a blank. They have to click, using their computer’s mouse, to indicate which is which. The exercises get harder and harder, with the Gabor patch appearing less clear or further toward the edge of the patient’s field of vision. All the time, the algorithm is assessing responses and adjusting the images it displays accordingly. “Our software maps the patient’s cortical deficits, neurons that do not respond well. Then the algorithm tailors specific stimulation to match those deficits,” says Yahav. “Once the patient is consistently answering correctly, the software knows that’s the exact threshold, the maximum vision of the patient in this exercise, and moves on to the next one. “We are training the neurons to be more responsive and restoring the basic mechanism of visual processing in the brain,” he says. FDA approved Yahav says RevitalVision has “the only regulated product approved by the FDA with clinical claims to improve vision for a variety of eye diseases and impairments.” Some products approved to treat amblyopia, he says, are not for those over the age of nine. RevitalVision builds on pre-Internet technology developed in Israel, which it acquired from another company. This technology was launched commercially two years ago as a web-based product available by direct purchase or through an eyecare specialist. So far, the company’s product has treated 15,000 patients. “We’ve raised $7 million so far and we’re raising another $6 million. Now we are scaling up,” says Yahav. The company received a grant from the Israel Innovation Authority during its product development stage, and is conducting trials at Shamir Medical Center associated with Tel Aviv University. It currently employs six people in Israel, six in India and one in the UK. The potential market is so huge that the biggest challenge right now is to spread the word, says Yahav. For more information, click here. To read the original article click here.

The post Improving Vision with At-Home Brain Exercises appeared first on Amazing Health Advances.

Improving Vision with At-Home Brain Exercises

The AHA! Team — Fri, 09 Aug 2024 08:17:33 +0000

The post Improving Vision with At-Home Brain Exercises appeared first on Amazing Health Advances.

Retinal Implants Can Give Artificial Vision to the Blind

AHA Publisher — Wed, 10 Mar 2021 08:00:35 +0000

École Polytechnique Fédérale de Lausanne (EPFL) via Newswise – Newswise — Being able to make blind people see again sounds like the stuff of miracles or even science fiction. And it has always been one of the biggest challenges for scientists. Diego Ghezzi, who holds the Medtronic Chair in Neuroengineering (LNE) at EPFL’s School of Engineering, has made this issue a research focus. Since 2015, he and his team have been developing a retinal implant that works with camera-equipped smart glasses and a microcomputer. “Our system is designed to give blind people a form of artificial vision by using electrodes to stimulate their retinal cells,” says Ghezzi. Star-Spangled Sky The camera embedded in the smart glasses captures images in the wearer’s field of vision, and sends the data to a microcomputer placed in one of the eyeglasses’ end-pieces. The microcomputer turns the data into light signals which are transmitted to electrodes in the retinal implant. The electrodes then stimulate the retina in such a way that the wearer sees a simplified, black-and-white version of the image. This simplified version is made up of dots of light that appear when the retinal cells are stimulated. However, wearers must learn to interpret the many dots of light in order to make out shapes and objects. “It’s like when you look at stars in the night sky – you can learn to recognize specific constellations. Blind patients would see something similar with our system,” says Ghezzi. Running Simulations, For Now The only catch is that the system has not yet been tested on humans. The research team first needs to be certain of their results. “We aren’t yet authorized to implant our device in human patients, since obtaining the medical approval takes a long time. But we came up with a process for testing it virtually – a type of work-around,” says Ghezzi. More specifically, the engineers developed a virtual reality program that can simulate what patients would see with the implants. Their findings have just been published in Communication Materials. Field of Vision and Resolution Two parameters are used to measure vision: field of vision and resolution. The engineers therefore used these same two parameters to evaluate their system. The retinal implants they developed contain 10,500 electrodes, with each one serving to generate a dot of light. “We weren’t sure if this would be too many electrodes or not enough. We had to find just the right number so that the reproduced image doesn’t become too hard to make out. The dots have to be far enough apart that patients can distinguish two of them close to each other, but there has to be enough of them to provide sufficient image resolution,” says Ghezzi. The engineers also had to make sure that each electrode could reliably produce a dot of light. Ghezzi explains: “We wanted to make sure that two electrodes don’t stimulate the same part of the retina. So we carried out electrophysiological tests that involved recording the activity of retinal ganglion cells. And the results confirmed that each electrode does indeed activate a different part of the retina.” The next step was to check whether 10,500 light dots provide good enough resolution – and that’s where the virtual reality program came in. “Our simulations showed that the chosen number of dots, and therefore of electrodes, works well. Using any more wouldn’t deliver any real benefits to patients in terms of definition,” says Ghezzi. The engineers also performed tests at constant resolution but different field-of-vision angles. “We started at five degrees and opened up the field all the way to 45 degrees. We found that the saturation point is 35 degrees – the object remains stable beyond that point,” says Ghezzi. All these experiments demonstrated that the system’s capacity doesn’t need to be improved any further, and that it’s ready for clinical trials. But the team will have to wait a little longer before their technology can be implanted in actual patients. For now, restoring vision remains in the realm of science fiction. To read the original article click here.

The post Retinal Implants Can Give Artificial Vision to the Blind appeared first on Amazing Health Advances.