quercetin Archives - Amazing Health Advances

Unexpected Allergy RELIEF from a Common Plant Compound

AHA Publisher — Wed, 31 Aug 2022 07:00:38 +0000

Lori Alton via NaturalHealth365 – According to the Centers for Disease Control and Prevention, over 19 million adults in the United States have been diagnosed with allergic rhinitis in the past year alone. Also known as hay fever and seasonal allergies, allergic rhinitis causes a host of troublesome symptoms that can include congestion, sneezing, coughing, headache and itching, and watery eyes. While Western medicine attempts to treat hay fever with antihistamines, these drugs can cause unwanted side effects – including drowsiness, dizziness, and rapid heart rate. A recent University of Michigan study on quercetin benefits shows that this flavonoid, which is found in fruits and vegetables, can safely support lung function. Other research has showcased its allergy-easing effects. Let’s look at some of the most compelling benefits of quercetin. Benefits of Quercetin Include Potent Antioxidant and Anti-Inflammatory Effects The health-promoting benefits of flavonoids such as quercetin have long been known to scientists. Two decades ago, in groundbreaking research published in the American Journal of Clinical Nutrition, researchers identified flavonoids as effective antioxidants that could protect against chronic illnesses. In animal, cell, and clinical studies, quercetin has been shown to decrease inflammation and scavenge harmful free radicals, thereby reducing disease-causing oxidative damage. In addition, one study showed that quercetin supplementation decreased markers of oxidative stress and inflammation in patients with a chronic lung disease known as pulmonary sarcoidosis. In a 2020 clinical trial published in BMJ Open Respiratory Research, scientists evaluated the effects of supplementary quercetin on chronic obstructive pulmonary disease (COPD), a blanket term for a group of diseases that cause breathing problems. Participants with COPD were given supplementary quercetin for a week – with researchers concluding that the flavonoid was effective in reducing oxidative stress and lung inflammation. One of the primary goals of the study was to evaluate the safety of quercetin – and there was great news in that department. The team reported that the treatment was well-tolerated, with participants reporting no serious adverse events. Of course, it’s not only individuals with COPD that can benefit from quercetin. This non-toxic natural compound is proving its merits as a natural intervention to ease allergy discomfort. Quercetin Supports Healthy Lung Function, Studies Suggest One of quercetin’s “superpowers” is its ability to help stabilize cells that release histamine in the body. In other words, quercetin can function as a natural antihistamine. According to family medicine physician Jaclyn Tolentino, D.O., quercetin may help to reduce allergy symptoms such as runny nose, watery eyes, and swelling of the face and lips – minus the drying or sedating effects associated with pharmaceutical antihistamines. In addition, quercetin-rich diets are associated with a lower incidence of asthma, which currently affects 8.4 percent of American adults. In a review involving over 10,000 participants published in the American Journal of Clinical Nutrition, the investigators found that the risk of asthma was reduced by an eye-opening 24 percent with a high-quercetin diet. (The scientists also found health-sustaining benefits for the flavonoids naringenin, hesperidin, and kaempferol. This trio of antioxidant compounds tends to be found alongside quercetin in fruits and vegetables, so eating these healthy foods is a win/win for your health.) Incidentally, in a separate study, 12 weeks of quercetin supplementation reduced the risk of upper respiratory infections in healthy adults. (Not only does quercetin reduce the risk of developing certain diseases, but it appears to help healthy people stay that way!) Quercetin Benefits Heart Health Population studies show that people who eat diets high in flavonoids – such as quercetin, resveratrol, and catechin – have healthier levels of cholesterol. And preliminary studies have suggested that quercetin may reduce blood pressure and blood sugar in obese and overweight participants. Quercetin has also been found to improve cardiovascular health by inhibiting platelet aggregation – the tendency of blood to form dangerous clots. So, it’s really not surprising that the AJCN study showing asthma reduction from quercetin also showed that high-quercetin diets decreased the risk of death from ischemic heart disease. Clearly, supporting heart health is among the many benefits of quercetin. Boost Quercetin Intake with Organic Fruits and Vegetables Good dietary sources of quercetin include black and green tea, berries, cherries, tomatoes, onions, leafy green vegetables, cruciferous vegetables, peppers, beans, and apples. (Pro tip: Red apples are a better source than green apples, so – when it comes to quercetin content – a Red Delicious decisively beats a Granny Smith. And, don’t even think of peeling that apple. Most of its quercetin is found in the skin). When it comes to quercetin content, organic produce is the way to go. A recent study published in the Journal of Agricultural and Food Chemistry showed that organic tomatoes contained a stunning 79 percent more than those that were conventionally grown. Quercetin is available in supplementary form, sometimes packaged with bromelain (an anti-inflammatory enzyme found in pineapples) and vitamin C to increase bioavailability. Natural healers typically recommend quercetin amounts of 500 mg to 1,000 mg a day – but check first with your integrative doctor before supplementing. As a growing body of research shows, quercetin is emerging as a potent natural antioxidant that can support respiratory function and help to combat allergies. It’s just one more evidence-based reason to eat your (preferably organic) fruits and veggies! Sources for this article include: WomensHealthMag.com CDC.gov CDC.gov NIH.gov Healthline.com NIH.gov To read the original article click here.

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Frontline Doctors Develop Protocol to Help Those Injured by COVID Jab

AHA Publisher — Fri, 01 Jul 2022 07:00:16 +0000

Sara Middleton via NaturalHealth365 – Since the late 1980s, the number of petitions filed with the United States National Injury Compensation Program (VICP) seeking compensation for injury or death caused by vaxxes has increased considerably. Last year’s total (2,057) neared the historical peak of 2003 (2,592). It’s yet to be seen how the trend will play out over the next few years. Incredibly, more than half of these petitions have been dismissed, and not all cases that received actual compensation were necessarily able to “prove” that a vax caused the purported injury or illness (although one could safely surmise that the entire VICP process is bogged down with bureaucratic red tape and other behind-closed-doors decisions that protect the best interests of anyone but the vax-injured). Regardless, the point is clear: people have and will continue to be injured by the COVID shots currently authorized for use by the Food and Drug Administration (FDA). Thankfully, while many public health officials, Big Pharma folks, and conventional healthcare providers are sticking their heads in the sand, some frontline doctors are taking a stand – and possibly risking their medical licenses by doing so – to help those who are harmed. No Conspiracy Here: Children and Adults Are Getting Hurt by COVID-19 Shots… But Are They Being Listened to? It’s hard to claim that we’re still in an “emergency” state when it comes to the pandemic (although that certainly isn’t stopping the FDA from authorizing the “emergency” use of the gene-based COVID shots for virtually everyone in the United States older than 6 months old). Meanwhile, data continues to emerge that muddies the water for anyone trying to make informed decisions about these injections. For instance, getting vaxxed seems to increase your risk of getting COVID-19 (a painfully ironic phenomenon known as “negative efficacy,”) which we can infer from the observation that highly vaxxed countries suffer from soaring infection and death rates compared to low vaxxed countries. Additionally, as summarized by Dr. Joseph Mercola in a recent newsletter, official vax safety surveillance data confirm that the mRNA jabs have “caused more harm in 18 months than all other vaxxes on the market, combined, over the past three decades.” And that’s even leaving alone the likelihood that VAERS is not capturing the true incidence of adverse effects from the COVID jabs due to the frustrating reality of adverse event underreporting. Of course, acknowledging that people are suffering serious and sometimes fatal issues because of these heavily propagandized drugs in no way ignores the fact that people have also been suffering because of COVID-19. But bringing to light this issue hopefully will encourage more providers to at least put vax injury on their radar when seeing people suffering from problems such as strokes, fall-related injuries after fainting episodes, heart inflammation, worsening chronic illness, “sudden unexplained deaths,” and more. Because truthfully, if doctors aren’t even considering the possibility that their patients’ suffering could be related to recent jabs due to ignorance or fear of professional repercussions, how would a potential link ever be uncovered? If patients aren’t listened to when they show up to urgent care clinics and emergency rooms, if their concerns are downplayed or ignored, or if their symptoms aren’t reported to VAERS, then how exactly will ongoing safety monitoring of these shots ever be appropriately carried out? Here Are Some Things You Can Do If You Develop Post-Vax Syndrome Following a COVID Shot, According to Frontline Experts The Frontline COVID-19 Critical Care Alliance (FLCCC) is a group of healthcare providers – led by esteemed Pulmonary and Critical Care Specialists Dr. Pierre Kory, M.D., M.P.A., and Dr. Paul E. Marik, M.D., FCCM, FCCP – who have created and shared life-saving, evidence-based protocols for patients throughout the pandemic (protocols that often go against mainstream messaging and are therefore frequently censored). Now, they’ve developed a protocol specifically for people who have suffered illness or injury following a COVID jab. The FLCCC endorses the importance of such a protocol given that “a temporal correlation between a patient receiving a COVID-19 vaccine and beginning or worsening of clinical manifestations is sufficient to diagnose as a COVID-19 vaccine-induced injury when the symptoms are unexplained by other concurrent causes.” If you’re curious, here are some “first-line” treatments from the FLCCC Alliance’s “I-RECOVER POST-VACCINE TREATMENT PROTOCOL” (the protocol includes many more treatments as well, including several non-pharmacological options): Intermittent daily fasting Vitamin C, D, and K2 Magnesium Melatonin Quercetin Nigella Sava Omega-3 fatty acids Ivermectin Aspirin Readers note: the FLCCC encourages patients to consult with a healthcare provider before starting any new treatment protocol, and that any treatment protocol should be individualized based on each patient’s needs. Keep this in mind as you search for a healthcare provider you can trust with your family’s health and wellbeing. Sources for this article include: Statista.com Rumble.com COVID19criticalcare.com Mercola.com Mercola.com To read the original article click here.

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Improve Your Heart Health With These Tart Berries

AHA Publisher — Mon, 09 May 2022 06:55:25 +0000

Lori Alton via NaturalHealth365 – For many people, eating cranberries is a sort of “one-off.” A traditional, time-honored companion to turkey and stuffing, cranberries may be consumed at a holiday meal – often in the form of canned, processed cranberry jelly – then promptly forgotten until next year. But, if this is the extent of your experience with cranberries, you may be missing out on valuable nutrients and plant compounds that can make for a “happy heart.” In a new study conducted at King’s College, London, researchers discovered that polyphenols in cranberries could improve blood vessel function, thereby promoting cardiovascular health. So, let’s see what makes these tart little crimson berries so uniquely beneficial to the human heart. Well-Controlled Study on Cranberries Yields Impressive Findings The “gold-standard” trial – a type of research widely acknowledged as the most rigorous kind of study – involved a group of healthy young men given a cranberry extract every day for a month (with a control group receiving a placebo). The team found that the cranberry extract significantly improved cardiovascular function, resulting in better flow-mediated dilation – a marker of heart health that measures the widening of blood vessels. The researchers noted that the improvements began as soon as two hours after cranberry consumption and persisted throughout the month of the study. Significantly, the volunteers didn’t have to gobble large quantities of cranberries or consume high extract dosages. The amount used in the study – nine grams of freeze-dried powdered berries – was roughly equivalent to eating a daily 100-gram serving of fresh cranberries, an amount the scientists called “reasonable.” Researchers Find “Solid Evidence” of Vascular Benefits from Cranberries The study, published last month in the journal Food and Function, illustrated the impact of cranberries on heart health. Lead author Dr. Ana Rodriguez-Mateos, of the Department of Nutritional Sciences at King’s College London called cranberries an “important fruit” in the prevention of heart disease for the general public. “The increases in polyphenols … and related improvements in flow-mediated dilation after cranberry consumption emphasize the important role cranberries may play in cardiovascular disease prevention,” Dr. Rodriguez commented. Co-author Dr. Christian Heiss, Professor of Cardiovascular Medicine at the University of Surrey, agreed. “Our findings provide solid evidence that cranberries can significantly affect vascular health, even in people with low cardiovascular risk,” Dr. Heiss pointed out. In other words, eating cranberries can help keep an already-healthy heart in good shape. Proanthocyanidins Help Neutralize Harmful Free Radicals Botanically known as Vaccinium macrocarpon, cranberries are closely related to blueberries and bilberries and share many of their properties. Cranberries are rich in antioxidant compounds, including quercetin, myricetin (also found in parsley and celery), and ursolic acid, which have anti-inflammatory effects. These antioxidants can scavenge harmful free radicals that would otherwise cause oxidative stress and damage. As if that weren’t enough antioxidant “bang for the buck,” cranberries contain the antioxidant vitamins C and E and a substantial amount of heart-healthy fiber. But the real key to the cardiovascular benefits of cranberries could be their proanthocyanidins. Research has shown that these natural plant pigments may help keep arteries supple and flexible while helping to maintain desirable cholesterol readings. In addition, proanthocyanidins help to regulate the balance of “friendly” versus “unfriendly” bacteria in the all-important gut microbiome, the community of bacteria in the digestive tract. Finally, proanthocyanidins can also decrease levels of a pro-inflammatory substance known as homocysteine. Clearly, these berries have what it takes to support efficient heart function. Use in Salads, Sauces, and Salsa Cranberries are available fresh, dried, powdered, or juiced. Because the fresh, raw berries are so naturally tart and acidic, you probably won’t want to nibble them “straight” as a snack. However, you can incorporate these crimson delicacies into recipes with a little creativity and imagination. For example, you can pair dried berries with roasted, lightly salted nuts to create a satisfying homemade trail mix or stir them – along with raspberries and strawberries – into yogurt. This trio of colorful berries can also add flavor, fiber, and antioxidants to oatmeal. (For best results, add during the last minute of cooking). Make a refreshing salsa by combining chopped fresh cranberries with minced red onion, jalapeno peppers, cilantro, lime juice, and a bit of honey to taste. You can also add fresh or dried berries to salads, sauces, and marinades. Another option is to freeze cranberries and use them as you would ice cubes, adding them to fruit punches or spritzes for a festive touch. Natural health experts say that cranberry juice offers health benefits but lacks the fiber found in whole berries. It’s best to limit yourself to two cups of cranberry juice a day. Opt for 100 percent cranberry juice and avoid “cocktails” or “juice blends” that may contain large amounts of sugar. Dried cranberries may also be loaded with sugar to make the taste more palatable. ClevelandClinic.org reports that one serving of dried cranberries can contain a stunning 25 grams of added sugars! To avoid taking in excessive sugars, always check the labels). As large amounts of cranberries can cause stomach upset and diarrhea, they should be consumed in moderation. They can also increase the risk of kidney stones in susceptible people. Full of antioxidants, fiber, and beneficial micronutrients, cranberries make a great addition to your healthy diet. Maybe it’s time to put these tarts, tiny fruits on the menu year-round! Sources for this article include: ScienceDaily.com ClevelandClinic.org To read the original article click here.

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Flavonoids in Strawberries May Hold the Key to Slowing Aging and Preventing Degenerative Disease

AHA Publisher — Tue, 02 Nov 2021 07:00:48 +0000

Lori Alton via NaturalHealth365 – There is one point on which experts in both alternative and Western medicine wholeheartedly agree: brightly-colored fruits and vegetables – such as purple Concord grapes, brilliant orange pumpkins, and ruby-red raspberries – are rich in antioxidant plant pigments that can help ward off chronic degenerative diseases. And, research has just revealed yet another benefit of “eating the rainbow.” Two flavonoids in vibrant red strawberries, fisetin, and quercetin, have been recognized by scientists for their ability to destroy “senile” cells in the body. Senile cells, also known as senescent cells, accelerate the aging process while triggering deadly illnesses such as diabetes, heart disease, cancer, Alzheimer’s’ disease, and chronic kidney disease. So let’s take a closer look at the ability of fisetin and quercetin in strawberries to combat destructive senescent cells. Race Against Time: Scientists Scramble to Create Senolytics to Battle Chronic Disease Senescent cells are older, damaged cells that have stopped their normal growth cycle and begun to produce inflammatory (and possibly carcinogenic) chemicals. Researchers have found that aging in tissues is associated with increased cellular senescence – and that multiple chronic diseases, including obesity and chronic kidney disease – are accompanied by an ever-growing accumulation of senescent cells. While these senescent cells are obviously “bad news,” there is a reason for hope. Scientists at the Mayo Clinic are currently pioneering the use of senolytics, which are agents that can destroy senescent cells. While some senolytics – such as the cancer drug dasatinib – must be synthesized in laboratories, the exciting fact is that fisetin and quercetin are natural senolytics found in many fruits and vegetables, including strawberries. By the way, strawberries are the richest dietary source of fisetin on the planet! Early animal studies on senolytics have been encouraging. In a paper published by the esteemed medical journal The Lancet, the authors noted that senolytics could “delay, prevent or alleviate” an impressive menu of age- and senescence-related conditions, including frailty, cataracts, osteoporosis, cardiac dysfunction, pulmonary fibrosis, metabolic syndrome, diabetes, and dementia. Good News: Research on Senolytics, Including Fisetin and Quercetin, Hails Them as Potentially “Transformative” In a controlled clinical trial published in The Lancet, researchers explored the effects of senolytics on human patients with chronic diseases. The team reported that a combination of dasatinib and quercetin decreased senescent cells in patients with diabetes and chronic kidney disease – and improved walking endurance and gait speed in patients with pulmonary fibrosis. The scientists concluded that senolytics could improve physical function and extend health and lifespan – and said they could be “transformative” in treating older adults with multiple chronic degenerative diseases. It should be emphasized, with the U.S. Centers for Disease Control and Prevention reporting that six out of ten American adults currently have a chronic disease – and four out of ten suffer from multiple chronic conditions – this is truly encouraging news! Fisetin and Quercetin in Strawberries Combat Heart Disease and Cancer Fisetin and quercetin both have potent anti-inflammatory and antioxidant effects, allowing them to scavenge harmful free radicals, prevent disease-causing oxidative damage and reduce the inflammation that lies at the root of many chronic diseases. According to a recent review published in Frontiers in Chemistry, fisetin strongly inhibits the growth of cancer cells. The team reported that fisetin’s anticancer effects increased when paired with antioxidant vitamin C. And, conveniently, strawberries are rich in both. Powerful as they are, fisetin and quercetin are not the only disease-fighting antioxidants strawberries bring to the table. These sweet, juicy berries are also rich in procyanidins, anthocyanins, and ellagic acid – which has also been shown to stop the growth of cancer cells. In addition, multiple population studies have demonstrated a link between berry consumption and decreased risk of heart disease-related deaths. For example, in a controlled trial published in Nutrition Research, supplementation with freeze-dried strawberries lowered LDL cholesterol and improved various risk factors for atherosclerosis in patients with metabolic syndrome. And, it doesn’t’ hurt that strawberries are rich in folate – which can help prevent strokes – and potassium, which helps to lower blood pressure. Spectacular Strawberries Are Simple to Serve While strawberries are undeniably full of disease-fighting antioxidants, senolytics, and micronutrients, they are first and foremost a luscious treat that can be prepared and served with a minimum of fuss. Strawberries can be enjoyed “as is,” or you can balance their sweetness with a splash of balsamic vinegar, a dash of black pepper, a sprinkle of cinnamon, or a scattering of fresh basil or mint. Try stirring them into Greek yogurt, adding them to salads or blending them into your favorite smoothie. By the way, the leaves at the top of the berry are edible – as well as nutritious. Save them to toss into salads or smoothies, or dry them for use in herbal teas. With a modest 32 calories and a substantial 2 grams of fiber in each 3.5-ounce serving, strawberries are a wholesome, low-calorie food with a relatively low glycemic index. Of course, for maximum benefit, always opt for organic berries whenever possible. But, don’t eat strawberries if you are allergic to them. Experts point out that strawberry allergies are more likely to occur in people with allergies to birch pollen and/or apples. Bottom line: strawberries have a rich supply of anti-aging compounds and disease-fighting antioxidants – paired with their juiciness, beautiful scarlet coloration, and irresistible taste. So, no doubt, this fruit makes a spectacular addition to your healthy diet. Sources for this article include: NIH.gov Healthline.com NIH.gov CDC.gov To read the original article click here.

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Quercetin: 8 Proven Benefits of This Antioxidant (#1 Is Incredible)

AHA Publisher — Fri, 29 Oct 2021 07:00:31 +0000

Jillian Levy, CHHC via Dr. Axe – Have you ever wondered what makes a “superfood” super? Or what top superfoods like red wine, green tea, kale and blueberries all have in common? The answer is quercetin, a natural compound tied to what all of us seek: better longevity, heart health, endurance, immunity, and more. Quercetin is considered to be the most widely distributed and extensively studied flavonoid, according to a 2018 review. It’s been shown in dozens of studies to have anti-carcinogenic, anti-inflammatory and antiviral activities. In fact, there isn’t much this powerful antioxidant compound can’t do, especially when combined with the health benefits of bromelain, an anti-inflammatory enzyme. All this explains why many experts recommend consuming food sources that contain quercetin regularly. So what are those foods, and how much should you consume? Let’s explore. What Is Quercetin? Quercetin is a type of flavonoid antioxidant that’s found in plant foods, including leafy greens, tomatoes, berries and broccoli. It’s technically considered a “plant pigment,” which is exactly why it’s found in deeply colored, nutrient-packed fruits and vegetables. Considered one of the most abundant antioxidants in the human diet, quercetin plays an important part in fighting free radical damage, the effects of aging and inflammation, according to many studies. While you can get plenty of it from eating a healthy diet, some people also take this compound in concentrated supplement form for even stronger anti-inflammatory effects. What is quercetin used for? According to the Department of Pathology and Diagnostics at the University of Verona in Italy, quercetin glycosides and other flavonoids, (like kaempferol and myricetin) are “anti-viral, anti-microbial, anti-inflammatory and anti-allergic agents.” They have potential to be expressed positively in different cell types in both animals and humans. Flavonoid polyphenols are most beneficial for down-regulating or suppressing inflammatory pathways and functions. Quercetin is considered the most diffused and known nature-derived flavonol there is, showing strong effects on immunity and inflammation caused by leukocytes and other intracellular signals. How It Works Research shows that anti-inflammatory foods containing quercetin can help manage a number of inflammatory health problems, including heart disease and blood vessel problems, allergies, infections, chronic fatigue, and symptoms related to autoimmune disorders like arthritis. How exactly do flavonoids benefit us? It all comes down to high-antioxidant foods‘ ability to be “scavenge free radicals.” As a major bioflavonoid in our diets, quercetin (a type of “polyphenolic antioxidant”) helps slow the aging progress because it lessens the effects of oxidative stress on the body. Oxidative stress takes place in all of us but is increased by things like a poor diet, high levels of stress, a lack of sleep and exposure to chemical toxins. Quercetin plays a role in regulating the immune system’s response to outside stressors through cell signaling pathways called kinases and phosphatases, two types of enzyme and membrane proteins needed for proper cellular function. Benefits 1. Lowers Inflammation Flavonoids, (aka bioflavonoids or bioflavonoide) including quercetin, are important anti-inflammatories because they act as antioxidants, which mean they literally fight the natural process of “oxidation” that takes place over time as we age. Quercetin can help stop damaging particles in the body known as free radicals, which negatively impact how cells work — including damaging cell membranes, changing the way DNA works, increasing cell mutations and causing healthy cells to die. It can also reduce expression of inflammatory genes such as interleukin. Research now shows us that inflammation is the root of most diseases, including heart disease, cancer, cognitive decline, some mental disorders and autoimmune disorders. At this time, practitioners and patients report using quercetin to effectively fight conditions related to inflammation, including: “hardening of the arteries” (atherosclerosis) high cholesterol heart disease and circulation problems insulin resistance and diabetes eye-related disorders, including cataracts allergies, asthma and hay fever stomach ulcers cognitive impairment gout viral infections inflammation of the prostate, bladder and ovaries chronic fatigue syndrome cancer chronic infections of the prostate skin disorders, including dermatitis and hives 2. Fights Allergies Is quercetin an antihistamine? Some consider it to be a natural antihistamine and an anti-inflammatory, possibly making it effective for lowering the effects of seasonal and food allergies, plus asthma and skin reactions. However, most research to date has been conducted on animals and not humans. Histamines are chemicals that are released when the immune system detects an allergy or sensitivity, and they are what account for uncomfortable symptoms we face whenever the body has an allergic reaction. Quercetin can help stabilize the release of histamines from certain immune cells, which results in decreased symptoms like coughs, watery eyes, runny noses, hives, swollen lips or tongue, and indigestion. It’s long been used in ancient Chinese herbal formulas created to block allergies to certain foods (such as peanuts). Studies conducted on mice suggest that it may be equivalent at fighting allergies as some prescription medications, all with little to no side effects. 3. Supports Heart Health Because of its ability to lower inflammation and oxidative stress, quercetin seems to be beneficial for people with heart and blood vessel-related disorders, according to a number of studies. For example, eating lots of deeply colored fruits and veggies that contain flavonoids is linked to a lower risk of cardiovascular disease, and even death, in older adults, among reduced risk for vascular diseases. It’s also been connected to reduced risk for type 2 diabetes and obesity, which have many of the same risk factors as heart disease. Studies done in animal and some human populations show that various types of flavonoids (quercetin, resveratrol and catechins, for example) can help reduce the risk of atherosclerosis, which is a dangerous condition caused by plaque building up within the arteries. Cut-off blood flow in the arteries is one of the primary risk factors for experiencing a heart attack or stroke, which is why cardiac arrest is less likely among people who eat a nutrient-packed diet. Antioxidants also seem to protect the body from experiencing increases in LDL “bad” cholesterol and can help regulate blood pressure levels. Certain studies show that quercetin prevents damage to LDL cholesterol particles, and it seems that people who eat the most flavonoid-rich foods typically have healthier and lower cholesterol levels, plus fewer incidences of hypertension and high blood pressure. In fact, if you’ve ever heard that red wine is good for your heart, that’s because it’s a natural source of quercetin. It’s one of the main active ingredients in red wine extract, which is associated with healthier heart function. 4. Helps Fight Pain Taking quercetin supplements may help lower pain associated with autoimmune conditions such as arthritis, as well as infections, including those of the prostate and respiratory tract. That’s because studies suggest quercetin reduces inflammatory pain. For example, there’s some evidence from several small studies that people experiencing bladder pains from infections (causing an urgent need to urinate, swelling and burning) have fewer symptoms when taking quercetin supplements. Flavonoids are also linked to reduced symptoms of prostatitis (inflammation of the prostate) and rheumatoid arthritis (RA). There’s evidence that when patients with RA switch from eating a “typical Western diet” to one higher in antioxidant-rich foods (like uncooked berries, fruits, vegetables, nuts, roots, seeds and sprouts), they experience less pain and reoccurring symptoms. 5. Might Help Improve Energy and Endurance Quercetin is added to some athletic supplements because it’s believed to help increase athletic performance and endurance, likely because of its positive effects on blood flow. Researchers from the School of Applied Physiology at the Georgia Institute of Technology found that, on average, “quercetin provides a statistically significant benefit in human endurance exercise capacity (VO2 max) and endurance exercise performance).” While improvements were at times small, it makes sense that antioxidants could boost physical performance since they help increase the health of blood vessels, which carry oxygen and nutrients to muscle and joint tissue. Other studies also show that it helps increase immune function and prevents susceptibility to illnesses that can occur when someone trains intensely and experiences exhaustion. One study found evidence that taking 500 milligrams of quercetin twice daily helped protect cyclers from developing exercise-induced respiratory infections following periods of heavy exercise. Because it can boost your energy level, does quercetin affect sleep? For example, is there a link between quercetin and insomnia? One study found evidence that it may alter the sleep-wake cycle partly through activation of GABA receptors. However, insomnia is generally not believed to be a common side effect of taking it in dietary supplement form. 6. Might Help Fight Cancer A Boston University School of Medicine study published in the Journal of Biological Regulators and Homeostatic Agents shows a link between a nutrient-dense diet rich in quercetin plus other antioxidants and a lowered risk of cancer. Quercetin seems to have potential chemo-preventive activity and might have a unique antiproliferative effect on cancerous cells, making it an effective addition to any natural cancer treatment approach. Research shows that this may result from the modulation of either EGFR or estrogen-receptor pathways. Recent studies have found quercetin can help stop the processes involved in cell proliferation and mutation, the growth of tumors, and symptoms related to typical cancer treatments, such as radiation or chemotherapy. At this time, the majority of studies done on quercetin’s effects on cellular functioning have involved animals, so more research is still needed to reveal specific effects on human cancer cells. This is especially true when taken in high doses above the amount someone would get from a healthy diet. 7. Helps Protect Skin Health Capable of blocking “mast cells,” which are immune cells critical in triggering allergic reactions, inflammatory disease and autoimmune disease, researchshows that quercetin helps protect skin from the effects of disorders like dermatitis and photosensitivity. Flavonoids like quercetin block the release of many pro-inflammatory cytokines, such as IL-8 and TNF, which helps stop symptoms related to skin inflammation, even in people who don’t find relief from other conventional treatments or prescriptions. Studies have found that this compound has antioxidant and anti-inflammatory effects that help fight allergic and inflammatory diseases, as well as some prescriptions, when taken in oral supplement form. For example, some people take quercetin for eczema since it can inhibit the secretion of histamine and pro-inflammatory markers. 8. Protects Liver Health Recent research has shown that this antioxidant has protective effects when administered to rats with ethanol-induced acute liver injury. Researchers concluded that “quercetin, by multiple mechanisms interplay, demonstrates hepatoprotective effect on liver-injury induced by alcohol, by increasing ethanol metabolizing enzyme activities, increasing antioxidant system activities against oxidative stress, lowering the expressions of pro-inflammation cytokines.” A 2017 study found evidence indicating that quercetin attenuates liver inflammation and fibrosis in mice through inhibiting macrophages infiltration. Researchers believe it “holds promise as potential therapeutic agent for human fibrotic liver disease”, a condition triggered by liver injury and inflammation. 9. Protects Against Neurological Disorders There’s mounting evidence showing that quercetin offers neuroprotective benefits, due to its ability to defend the brain against oxidative stress and inflammation, leading to potentially less risk for cognitive conditions like Alzheimer’s disease and dementia. A 2018 study concluded that “findings suggest a possible new protective role for dietary flavonoids on alzheimer’s disease (AD).” The study found that administration of quercetin in early-middle stages of AD pathology ameliorates cognitive dysfunction and boosts protection mainly related to increased Aβ clearance and reduced astrogliosis, which is related to destruction of neurons. Food Sources What foods have the most quercetin? All types of tasty red, green and purple-pigmented plants come packed with quercetin — for example, red wine, blueberries, apples, red onion and even green tea are some of the best sources. Quercetin is actually believed to be the most abundant flavonoid in the human diet. But the amount found in plant foods can vary a lot depending on where they’re grown, how fresh they are, how they’re prepared and so on. Some of the top sources of quercetin to add to your diet include: Apples Peppers Red wine Dark cherries and berries (blueberries, bilberries, blackberries and others) Tomatoes Cruciferous veggies, including broccoli, cabbage and sprouts Leafy green veggies, including spinach, kale Citrus fruits Cocoa Cranberries Whole grains, including buckwheat Raw asparagus Capers Raw red onion Olive oil Black and green tea Beans/legumes Herbs,...

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Two New Studies Test Quercetin And COVID Outcomes

AHA Publisher — Mon, 18 Oct 2021 07:00:14 +0000

Dr. Joseph Mercola – In an August 21, 2021, newsletter,1 Dr. Michael Murray discussed the use of quercetin for respiratory infection symptoms. In November 2020, he’d suffered a “very mild and brief bout of COVID-19.” He also recounts an anecdotal story of a friend who developed suspicious respiratory symptoms. His friend had been taking a number of supplements said to offer protection, but was still feeling awful. As it turns out, the one thing he’d not taken was quercetin, and as soon as he did, that same day, his symptoms started to dissipate. This experience, Murray says, “is consistent with the results from two clinical trials” that were recently published. Quercetin seems to be a safe, far less expensive, and easier-to-obtain and it works by a similar mechanism, driving zinc into the cells to stop viral replication. Statistical Improvement in Clinical Outcomes In the first study,2 42 COVID-19 outpatients were divided into two groups. One group of 21 patients received standard medical therapy consisting of analgesics and an antibiotic (acetaminophen 500-milligram (mg) to 1,000-mg dose if body temperature was higher than 37.5 degrees C — 99.5 F — with a maximum daily dosage of 3 grams, and 500 mg azithromycin for three consecutive days). The other group of 21 patients received standard therapy plus the equivalent of 600 mg of quercetin per day (divided into three doses) for seven days, followed by another seven-day course of 400 mg of quercetin per day (divided into two doses). The quercetin was used with sunflower lecithin, which has been demonstrated to increase absorption in the gut by as much as 20 times, compared to pure quercetin formulations. The main outcomes being evaluated were virus clearance and symptoms. After one week of treatment, 16 of the 21 patients in the quercetin group tested negative for SARS-CoV-2 and 12 reported that all symptoms had diminished. In the standard care group, only two tested negative and four had partially improved symptoms. By the end of Week 2, the five remaining patients in the quercetin group tested negative. In the standard care group, 17 of the 19 remaining patients tested negative and one had died. “These results are impressive and hopefully additional studies will be conducted on hospitalized patients to see how quercetin might be helpful in more severe cases,” Murray wrote in his newsletter. Can Quercetin Reduce Hospitalizations and Deaths? The second study3 — a prospective, randomized, controlled and open-label trial — gave 152 COVID-19 outpatients a daily dose of 1,000 mg of quercetin for 30 days to evaluate its adjuvant effects in the treatment of early symptoms and the prevention of severe infection. According to the authors: “The results revealed a reduction in frequency and length of hospitalization, in need of non-invasive oxygen therapy, in progression to intensive care units and in number of deaths. The results also confirmed the very high safety profile of quercetin and suggested possible anti-fatigue and pro-appetite properties. QP (Quercetin Phytosome®) is a safe agent and in combination with standard care, when used in early stage of viral infection, could aid in improving the early symptoms and help in preventing the severity of COVID-19 disease. It is suggested that a double-blind, placebo-controlled study should be urgently carried out to confirm the results of our study.” Mechanisms of Action As noted in the first study4 above, quercetin was chosen based on the fact that it has antiviral, anti-blood clotting, anti-inflammatory and antioxidant properties, all of which are important in the treatment of SARS-CoV-2 infection. In the second study, more detailed mechanisms of action are reviewed. According to the authors:5 “SARS-CoV-2 proteases, like 3-chymotrypsin-like protease (3CLpro), papain-like pro-tease (PLpro), RNA-dependent RNA polymerase, spike (S)protein and human angiotensin-converting enzyme 2 (hACE2) are considered possible targets for developing effective anti-COVID-19 drugs. Recently, molecular docking studies have suggested the possible binding interaction of quercetin with the 3CLpro, PLpro, and S-hACE2 complex. Some recent results, obtained by biophysical techniques, appear to support the results of the molecular docking studies. Quercetin, a flavonol not naturally present in the human body, is the most abundant polyphenol in fruits and vegetable and is widely used as a dietary supplement to boost the immune system and promote a healthy lifestyle. Quercetin is characterized by three crucial properties: antioxidant, anti-inflammatory and immunomodulatory. The combination of these actions allows quercetin to be a potential candidate to support all unhealthy conditions where oxidative stress, inflammation and immunity are involved.” Initially, quercetin gained attention because it’s a zinc ionophore, meaning it shuttles zinc — which has well-known antiviral effects — into your cells just like the drug hydroxychloroquine. In particular, quercetin exerts significant inhibition on the binding of specific spike proteins to ACE-2 receptors, thereby blocking the ability of the virus to infect human cells. Quercetin has also been shown to directly neutralize viral proteins the are critical in the replication of SARS-CoV-2. ~ Dr. Michael Murray Some proposed the primary reason hydroxychloroquine and quercetin worked was because of this feature. Of course, you also had to take zinc along with either of them. To effectively act as a zinc ionophore, the quercetin also needs vitamin C. Since then, other studies, including the two reviewed here, have shown quercetin has other actions that makes it useful against SARS-CoV-2 as well. As reported by Murray in his newsletter: “In particular, quercetin exerts significant inhibition on the binding of specific spike proteins to ACE-2 receptors, thereby blocking the ability of the virus to infect human cells. Quercetin has also been shown to directly neutralize viral proteins the are critical in the replication of SARS-CoV-2.” In some studies, quercetin has also been shown to inhibit the release of inflammatory cytokines, which could help alleviate infection-related symptoms and suppress excessive inflammatory responses from occurring. Its antioxidant effects may also help prevent tissue damage caused by scavenging free radicals, thereby aiding in the recovery process of viral infections.6 Quercetin’s Antiviral Properties Quercetin’s antiviral properties have been attributed to three main mechanisms of action: Inhibiting the virus’ ability to infect cells Inhibiting replication of already infected cells Reducing infected cells’ resistance to treatment with antiviral medication For example, research7 funded by the U.S. Defense Advanced Research Projects Agency (DARPA), published in 2008, found it lowers your risk of viral illness such as influenza and boosts mental performance following extreme physical stress, which might otherwise undermine your immune function and render you more susceptible to infections. Here, cyclists who received a daily dose of 1,000 mg of quercetin in combination with vitamin C (which enhances plasma quercetin levels8,9) and niacin (to improve absorption) for five weeks were significantly less likely to contract a viral illness after bicycling three hours a day for three consecutive days, compared to untreated controls. While 45% of the placebo group got sick, only 5% of the treatment group did. Quercetin Works Against Many Common Viruses Before the COVID-19 pandemic struck, several studies had highlighted quercetin’s ability to prevent and treat the common cold and seasonal influenza.10,11,12,13,14,15,16,17,18 By attenuating oxidative damage, it also lowers your risk of secondary bacterial infections,19 which is actually the primary cause of influenza-related deaths. Importantly, quercetin increases mitochondrial biogenesis in skeletal muscle, which suggests part of its antiviral effects are due to enhanced mitochondrial antiviral signaling.20 Quercetin also works against other viruses, as demonstrated in the following studies: • A 1985 study found quercetin inhibits infectivity and replication of herpes simplex virus type 1, polio-virus type 1, parainfluenza virus type 3 and respiratory syncytial virus (RSV).21 • A 2016 animal study22 found quercetin inhibited mouse dengue virus and hepatitis virus. • Other studies have confirmed quercetin’s power to inhibit both hepatitis B23 and C24 infection. • A March 2020 study25 found quercetin provides “comprehensive protection” against Streptococcus pneumoniae infection, both in vitro and in vivo, primarily by neutralizing pneumolysin (PLY),26 one of the toxins released from pneumococci that encourages S. pneumoniae infection to blossom in the first place. Streptococcus pneumoniae is responsible not only for pneumonia, but can also be involved in some ear and sinus infections, meningitis and certain blood infections.27 As reported by the authors of this study:28 “The results indicated that quercetin significantly reduced PLY-induced hemolytic activity and cytotoxicity via repressing the formation of oligomers. In addition, treatment with quercetin can reduce PLY-mediated cell injury, improve the survival rate of mice infected with a lethal dose of S. pneumoniae, alleviate the pathological damage of lung tissue and inhibit the release of cytokines (IL-1β and TNF-α) in bronchoalveolar lavage fluid. Considering the importance of these events in antimicrobial resistant S. pneumoniae pathogenesis, our results indicated that quercetin may be a novel potential drug candidate for the treatment of clinical pneumococcal infections.” How Quercetin Combats Inflammation and Boosts Immunity Aside from its antiviral activity, quercetin is also known for boosting immunity and combating inflammation. As noted in a 2016 study29 in the journal Nutrients, mechanisms of action include (but is not limited to) the inhibition of:30 Lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components LPS-induced mRNA levels of TNF-α and interleukin (IL)-1α in glial cells, which results in “diminished apoptotic neuronal cell death” The production of inflammation-producing enzymes Calcium influx into the cell, which in turn inhibits pro-inflammatory cytokine release, as well as histamine and serotonin release from intestinal mast cells31 According to this paper, quercetin also stabilizes mast cells, has cytoprotective activity in the gastrointestinal tract, and “a direct regulatory effect on basic functional properties of immune cells,” which allows it to inhibit “a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions.”32 Bioavailability While quercetin does have potent antiviral effects, in order for it to work effectively you need sufficiently high dosages to raise the level of quercetin in your body’s tissues. The relatively low absorption rate of quercetin is why a sunflower lecithin formulation was used. Research33 published in the July-December 2021 issue of the Journal of Natural Health Products Research, found a quercertin matrix has the same total absorption rate as quercetin phytosome — and higher peak blood levels. “Since both of these forms of quercetin produce similar blood levels, they should produce the same effects at equal dosages based upon quercetin content,” Murray wrote in his newsletter, adding: “My dosage recommendation as part of a nutritional supplement program to support immune function is 250 mg twice daily. And in patients with active Infection, my recommendation is … six capsules twice a day providing a total of 3,000 mg of quercetin. This high dosage should be taken for at least 10 days and then reduced to a maintenance dosage of 250 mg twice daily … [This] high dosage may not be necessary. But my dosage calculations are based upon likely tissue concentrations needed to exert the strongest antiviral effects. And given the safety of quercetin, there is no harm at this level.” Protocol Using Quercetin One doctor who early brought quercetin into the limelight was Dr. Vladimir Zelenko. As hydroxychloroquine became difficult to obtain, Zelenko switched to recommending quercetin instead, as it’s readily available as an over-the-counter supplement. For a downloadable “cheat sheet” of Zelenko’s protocol for COVID-19, visit VladimirZelenkoMD.com. Other Health Benefits of Quercetin There are also other lesser known benefits and uses for quercetin, including the prevention and/or treatment of:34 High blood pressure35,36 Cardiovascular disease37 Obesity38 and metabolic syndrome39 (a cluster of conditions including high blood pressure, high blood sugar, high triglyceride levels and fat accumulation around the waist that raise your risk for Type 2 diabetes, heart disease and stroke) Certain kinds of cancer, in particular leukemia, and to a lesser degree breast cancer40 Nonalcoholic fatty liver disease (NAFLD)41 Gout42 Arthritis43 Mood disorders44 Aluminum-induced neurodegenerative changes, such as those seen in Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS).45 Longevity, thanks to its senolytic benefits (clearing out damaged and worn-out cells)46,47 Research has also highlighted...

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Quercetin: 8 Proven Benefits of This Antioxidant (#1 Is Incredible)

AHA Publisher — Fri, 10 Sep 2021 07:00:41 +0000

Jillian Levy, CHHC via Dr. Axe – Have you ever wondered what makes a “superfood” super? Or what top superfoods like red wine, green tea, kale and blueberries all have in common? The answer is quercetin, a natural compound tied to what all of us seek: better longevity, heart health, endurance, immunity, and more. Quercetin is considered to be the most widely distributed and extensively studied flavonoid, according to a 2018 review. It’s been shown in dozens of studies to have anti-carcinogenic, anti-inflammatory and antiviral activities. In fact, there isn’t much this powerful antioxidant compound can’t do, especially when combined with the health benefits of bromelain, an anti-inflammatory enzyme. All this explains why many experts recommend consuming food sources that contain quercetin regularly. So what are those foods, and how much should you consume? Let’s explore. What Is Quercetin? Quercetin is a type of flavonoid antioxidant that’s found in plant foods, including leafy greens, tomatoes, berries and broccoli. It’s technically considered a “plant pigment,” which is exactly why it’s found in deeply colored, nutrient-packed fruits and vegetables. Considered one of the most abundant antioxidants in the human diet, quercetin plays an important part in fighting free radical damage, the effects of aging and inflammation, according to many studies. While you can get plenty of it from eating a healthy diet, some people also take this compound in concentrated supplement form for even stronger anti-inflammatory effects. What is quercetin used for? According to the Department of Pathology and Diagnostics at the University of Verona in Italy, quercetin glycosides and other flavonoids, (like kaempferol and myricetin) are “anti-viral, anti-microbial, anti-inflammatory and anti-allergic agents.” They have potential to be expressed positively in different cell types in both animals and humans. Flavonoid polyphenols are most beneficial for down-regulating or suppressing inflammatory pathways and functions. Quercetin is considered the most diffused and known nature-derived flavonol there is, showing strong effects on immunity and inflammation caused by leukocytes and other intracellular signals. How It Works Research shows that anti-inflammatory foods containing quercetin can help manage a number of inflammatory health problems, including heart disease and blood vessel problems, allergies, infections, chronic fatigue, and symptoms related to autoimmune disorders like arthritis. How exactly do flavonoids benefit us? It all comes down to high-antioxidant foods‘ ability to be “scavenge free radicals.” As a major bioflavonoid in our diets, quercetin (a type of “polyphenolic antioxidant”) helps slow the aging progress because it lessens the effects of oxidative stress on the body. Oxidative stress takes place in all of us but is increased by things like a poor diet, high levels of stress, a lack of sleep and exposure to chemical toxins. Quercetin plays a role in regulating the immune system’s response to outside stressors through cell signaling pathways called kinases and phosphatases, two types of enzyme and membrane proteins needed for proper cellular function. Benefits 1. Lowers Inflammation Flavonoids, (aka bioflavonoids or bioflavonoide) including quercetin, are important anti-inflammatories because they act as antioxidants, which mean they literally fight the natural process of “oxidation” that takes place over time as we age. Quercetin can help stop damaging particles in the body known as free radicals, which negatively impact how cells work — including damaging cell membranes, changing the way DNA works, increasing cell mutations and causing healthy cells to die. It can also reduce expression of inflammatory genes such as interleukin. Research now shows us that inflammation is the root of most diseases, including heart disease, cancer, cognitive decline, some mental disorders and autoimmune disorders. At this time, practitioners and patients report using quercetin to effectively fight conditions related to inflammation, including: “hardening of the arteries” (atherosclerosis) high cholesterol heart disease and circulation problems insulin resistance and diabetes eye-related disorders, including cataracts allergies, asthma and hay fever stomach ulcers cognitive impairment gout viral infections inflammation of the prostate, bladder and ovaries chronic fatigue syndrome cancer chronic infections of the prostate skin disorders, including dermatitis and hives 2. Fights Allergies Is quercetin an antihistamine? Some consider it to be a natural antihistamine and an anti-inflammatory, possibly making it effective for lowering the effects of seasonal and food allergies, plus asthma and skin reactions. However, most research to date has been conducted on animals and not humans. Histamines are chemicals that are released when the immune system detects an allergy or sensitivity, and they are what account for uncomfortable symptoms we face whenever the body has an allergic reaction. Quercetin can help stabilize the release of histamines from certain immune cells, which results in decreased symptoms like coughs, watery eyes, runny noses, hives, swollen lips or tongue, and indigestion. It’s long been used in ancient Chinese herbal formulas created to block allergies to certain foods (such as peanuts). Studies conducted on mice suggest that it may be equivalent at fighting allergies as some prescription medications, all with little to no side effects. 3. Supports Heart Health Because of its ability to lower inflammation and oxidative stress, quercetin seems to be beneficial for people with heart and blood vessel-related disorders, according to a number of studies. For example, eating lots of deeply colored fruits and veggies that contain flavonoids is linked to a lower risk of cardiovascular disease, and even death, in older adults, among reduced risk for vascular diseases. It’s also been connected to reduced risk for type 2 diabetes and obesity, which have many of the same risk factors as heart disease. Studies done in animal and some human populations show that various types of flavonoids (quercetin, resveratrol and catechins, for example) can help reduce the risk of atherosclerosis, which is a dangerous condition caused by plaque building up within the arteries. Cut-off blood flow in the arteries is one of the primary risk factors for experiencing a heart attack or stroke, which is why cardiac arrest is less likely among people who eat a nutrient-packed diet. Antioxidants also seem to protect the body from experiencing increases in LDL “bad” cholesterol and can help regulate blood pressure levels. Certain studies show that quercetin prevents damage to LDL cholesterol particles, and it seems that people who eat the most flavonoid-rich foods typically have healthier and lower cholesterol levels, plus fewer incidences of hypertension and high blood pressure. In fact, if you’ve ever heard that red wine is good for your heart, that’s because it’s a natural source of quercetin. It’s one of the main active ingredients in red wine extract, which is associated with healthier heart function. 4. Helps Fight Pain Taking quercetin supplements may help lower pain associated with autoimmune conditions such as arthritis, as well as infections, including those of the prostate and respiratory tract. That’s because studies suggest quercetin reduces inflammatory pain. For example, there’s some evidence from several small studies that people experiencing bladder pains from infections (causing an urgent need to urinate, swelling and burning) have fewer symptoms when taking quercetin supplements. Flavonoids are also linked to reduced symptoms of prostatitis (inflammation of the prostate) and rheumatoid arthritis (RA). There’s evidence that when patients with RA switch from eating a “typical Western diet” to one higher in antioxidant-rich foods (like uncooked berries, fruits, vegetables, nuts, roots, seeds and sprouts), they experience less pain and reoccurring symptoms. 5. Might Help Improve Energy and Endurance Quercetin is added to some athletic supplements because it’s believed to help increase athletic performance and endurance, likely because of its positive effects on blood flow. Researchers from the School of Applied Physiology at the Georgia Institute of Technology found that, on average, “quercetin provides a statistically significant benefit in human endurance exercise capacity (VO2 max) and endurance exercise performance).” While improvements were at times small, it makes sense that antioxidants could boost physical performance since they help increase the health of blood vessels, which carry oxygen and nutrients to muscle and joint tissue. Other studies also show that it helps increase immune function and prevents susceptibility to illnesses that can occur when someone trains intensely and experiences exhaustion. One study found evidence that taking 500 milligrams of quercetin twice daily helped protect cyclers from developing exercise-induced respiratory infections following periods of heavy exercise. Because it can boost your energy level, does quercetin affect sleep? For example, is there a link between quercetin and insomnia? One study found evidence that it may alter the sleep-wake cycle partly through activation of GABA receptors. However, insomnia is generally not believed to be a common side effect of taking it in dietary supplement form. 6. Might Help Fight Cancer A Boston University School of Medicine study published in the Journal of Biological Regulators and Homeostatic Agents shows a link between a nutrient-dense diet rich in quercetin plus other antioxidants and a lowered risk of cancer. Quercetin seems to have potential chemo-preventive activity and might have a unique antiproliferative effect on cancerous cells, making it an effective addition to any natural cancer treatment approach. Research shows that this may result from the modulation of either EGFR or estrogen-receptor pathways. Recent studies have found quercetin can help stop the processes involved in cell proliferation and mutation, the growth of tumors, and symptoms related to typical cancer treatments, such as radiation or chemotherapy. At this time, the majority of studies done on quercetin’s effects on cellular functioning have involved animals, so more research is still needed to reveal specific effects on human cancer cells. This is especially true when taken in high doses above the amount someone would get from a healthy diet. 7. Helps Protect Skin Health Capable of blocking “mast cells,” which are immune cells critical in triggering allergic reactions, inflammatory disease and autoimmune disease, researchshows that quercetin helps protect skin from the effects of disorders like dermatitis and photosensitivity. Flavonoids like quercetin block the release of many pro-inflammatory cytokines, such as IL-8 and TNF, which helps stop symptoms related to skin inflammation, even in people who don’t find relief from other conventional treatments or prescriptions. Studies have found that this compound has antioxidant and anti-inflammatory effects that help fight allergic and inflammatory diseases, as well as some prescriptions, when taken in oral supplement form. For example, some people take quercetin for eczema since it can inhibit the secretion of histamine and pro-inflammatory markers. 8. Protects Liver Health Recent research has shown that this antioxidant has protective effects when administered to rats with ethanol-induced acute liver injury. Researchers concluded that “quercetin, by multiple mechanisms interplay, demonstrates hepatoprotective effect on liver-injury induced by alcohol, by increasing ethanol metabolizing enzyme activities, increasing antioxidant system activities against oxidative stress, lowering the expressions of pro-inflammation cytokines.” A 2017 study found evidence indicating that quercetin attenuates liver inflammation and fibrosis in mice through inhibiting macrophages infiltration. Researchers believe it “holds promise as potential therapeutic agent for human fibrotic liver disease”, a condition triggered by liver injury and inflammation. 9. Protects Against Neurological Disorders There’s mounting evidence showing that quercetin offers neuroprotective benefits, due to its ability to defend the brain against oxidative stress and inflammation, leading to potentially less risk for cognitive conditions like Alzheimer’s disease and dementia. A 2018 study concluded that “findings suggest a possible new protective role for dietary flavonoids on alzheimer’s disease (AD).” The study found that administration of quercetin in early-middle stages of AD pathology ameliorates cognitive dysfunction and boosts protection mainly related to increased Aβ clearance and reduced astrogliosis, which is related to destruction of neurons. Related: Berberine: The Plant Alkaloid that Helps Treat Diabetes & Digestive Problems Food Sources What foods have the most quercetin? All types of tasty red, green and purple-pigmented plants come packed with quercetin — for example, red wine, blueberries, apples, red onion and even green tea are some of the best sources. Quercetin is actually believed to be the most abundant flavonoid in the human diet. But the amount found in plant foods can vary a lot depending on where they’re grown, how fresh they are, how they’re prepared and so on. Some of the top sources of quercetin to add to your diet include: Apples Peppers Red wine Dark cherries and berries (blueberries, bilberries, blackberries and others) Tomatoes Cruciferous veggies, including broccoli, cabbage and sprouts Leafy green veggies, including spinach, kale Citrus fruits Cocoa Cranberries Whole grains, including buckwheat Raw...

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Allergy ALERT: Here Is How to Reduce Your Exposure to Allergens Plus 5 Natural Solutions

AHA Publisher — Fri, 14 May 2021 07:00:26 +0000

Sara Middleton via NaturalHealth365 – According to the Asthma and Allergy Foundation of America, more than 50 million Americans experience allergies of some sort every year. And with spring in full swing, millions of us are about to experience the hallmark sneezing, itchy throats, and watery eyes that signal hay fever in full effect. Want to find relief that doesn’t depend solely on the pharmacy? Let’s review some of the most effective natural allergy options we know about. HEPA Filters, Probiotics, and These Additional Allergy Solutions Might Give You Relief This Spring and Summer If you’re trying to stay away from prescription or over-the-counter antihistamines, consider adding a variety of natural allergy relief remedies into your daily routine. Some may work for you better than others, so experiment with a few. HEPA filters: It’s not clear if HEPA (high-efficiency particulate air) filters always or significantly improve allergy symptoms, but we do have some studies that support their use. For instance, one 2018 study from the Asian Pacific Journal of Allergy and Immunology found that the use of HEPA filters improved clinical symptoms of allergic rhinitis as well as reduced the amount of particulate matter in the air. Probiotics: In 2015, a systematic review of 23 studies concluded that “probiotics may be beneficial in improving symptoms and quality of life in patients with allergic rhinitis,” but note that further research is needed to clarify recommendations. Currently recommended amounts for probiotic supplements range widely, from 1 billion to 10 billion or more colony-forming units (CFUs). The scientific plausibility of probiotics alleviating allergy symptoms is considerable, given that probiotics support gut and immune health. Acupuncture: Ever tried acupuncture? A 2015 review of 13 papers, including 2,365 participants, published in the American Journal of Rhinology & Allergy, found that acupuncture appears to be a safe and valid natural remedy for allergy relief. Frankincense oil: Inhaling this fragrant essential oil (either by putting it in a diffuser or placing it in a carrier oil and dabbing it behind the ears) may reduce fatigue, ease symptoms, and improve quality of life in people who have seasonal allergies, according to a 2016 randomized controlled trial. Other essential oils touted for their allergy-relief benefits include peppermint oil and eucalyptus oil. Quercetin: Laboratory studies have found that this nutrient — found in foods like broccoli, cauliflower, onions, citrus fruits, grapes, and green tea — prevents the release of histamine, which is a key compound involved in the body’s allergic response. We don’t have strong human data to prove its effectiveness at reducing allergy symptoms, but anecdotal evidence suggests it offers benefits. Other nutrients and supplements said to promote allergy relief include vitamin C and the blue-green algae spirulina. Here Are 5 Ways to Reduce Your Exposure to Allergens Treating allergies, whether with medications or natural remedies, is important for improving your quality of life. But preventing an allergic response in the first place matters, too. Here are five simple ways to avoid your exposure to allergens in your home and community: Check the pollen forecast: Input your town and zip code at Pollen.com or a similar resource, so you’ll know how bad the pollen is in your area and will be prepared to take more preventive action. On high pollen count days, stay indoors and close the windows. When going outside, wear wraparound sunglasses to block allergens from your eyes, and try putting some Vaseline around your nose to trap pollen particles! Shower before going to bed to avoid bringing pollen and debris onto your pillowcase and bed linens. Vacuum and dust regularly. And, finally, as a “bonus tip,” many integrative healthcare providers will remind you to avoid conventionally-produced dairy products, sugar or flour-based food products because they tend to cause mucus buildup. Sources for this article include: Pollen.com AAFA.org NIH.gov APJAI-journal.org NHS.uk NIH.gov EPA.gov Harvard.edu Hindawi.com MountSinai.org NIH.gov To read the original article click here. For more articles from NaturalHealth365 click here.

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Compounds in Traditional Chinese Medicine Herbs May Inhibit SARS-CoV-2 Infection

AHA Publisher — Fri, 04 Dec 2020 08:00:05 +0000

Lakshmi Supriya, PhD. via News-Medical Net – Using computational methods, a team of researchers identified three compounds in traditional Chinese medicine that could be used against SARS-CoV-2: quercetin, puerarin and kaempferol. Of the three compounds, quercetin showed the highest binding affinity to both the ACE2 receptor and the receptor-binding domain of the SARS-CoV-2 spike protein, and could thus provide a dual synergistic effect. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of the ongoing coronavirus disease 2019 (COVID-19) pandemic, infects human hosts by binding with the human angiotensin-converting enzyme 2 (ACE2) receptor on their cells, notably the epithelium lining the respiratory tract. The receptor-binding domain (RBD) of the coronavirus spike protein binds to ACE2 followed by membrane fusion to the host cell, thus allowing the virus to infiltrate the cell and commence replication. Traditional Chinese medicine, widely used for many diseases, showed therapeutic effects during the 2003 SARS-CoV epidemic. The RBD of the SARS-CoV-2 has significant structural homology with SARS-CoV. Although the use of Chinese herbs with modern medicine has shown benefits in COVID-19 patients, several components are present in the herbs and have complex interactions, making it challenging to uncover the molecular mechanisms responsible for its therapeutic effects. Several computational studies have helped predict active compounds in the medicinal herbs with the potential to accelerate traditional medicine-based drug discovery. Finding Potential Compounds Against SARS-CoV-2 Researchers from various institutions in China used computational analysis to discover potential molecule candidates against SARS-CoV-2 infection. Using the Traditional Chinese Medicine Pharmacology database, they screened for molecules that could target ACE2. They identified the compound puerarin that could target ACE2. Then, they screened for Chinese herbs that have this compound in the database and found five. Furthermore, since it is thought that compounds in the same herbal medicine have synergistic properties, they expanded their search to include all the compounds in the five herbs to arrive at 41 compounds. Upon analyzing which compounds were present in the maximum number of herbs, they found puerarin was present in all the five herbs, and quercetin and kaempferol were present in three herbs. Next, they predicted potential drug targets of the selected compounds using the database, leading to 240 possible targets. Upon further analysis, they selected puerarin, quercetin, and kaempferol for further study. Next, the authors performed molecular docking analysis to determine potential binding sites and binding affinity to ACE2. All the three compounds could bind on the same region of ACE2, which is located some distance from the binding position of SARS-CoV-2. It is likely the compounds are causing changes in conformations rather than competing with the spike protein to bind to ACE2. Quercetin had the highest binding affinity, forming both strong and weak hydrogen bonds. They also experimentally determined the binding of the three compounds to ACE2 using surface plasmon resonance. Similar to the theoretical analysis, they found quercetin had higher binding affinity to ACE2 than puerarin. They also observed that puerarin affected the binding of spike protein to ACE2, and quercetin almost completely disrupted the spike protein binding to ACE2. Molecular docking analysis showed that quercetin has high binding affinity to the spike protein. Using pathway enrichment analysis for the COVID-19-related genes, they found quercetin affected the immune-modulation and viral infection activities. How the Compounds Affect SARS-CoV-2 All the three compounds tested were found in the herb Radix Bupleuri confirming that compounds in a single herb have synergistic pharmacological properties. The herb is popular in China and has been used to treat flu, inflammation, malaria, and hepatitis B. It is also one of 26 Chinese herbal medicines advised by traditional Chinese medicine practitioners to combat COVID-19. Puerarin has been approved for use in China for decades and could be an ideal drug repurposed for its antiviral properties. Although its binding affinity is lower than quercetin, it has a safe dose limit of about 0.5 gram, so it could be used at a high dose to achieve a suitable antiviral effect. It also has beneficial effects on fever, cardiovascular disease, and neurological dysfunction, so it can also be used as an adjuvant to help improve COVID-19 symptoms. Quercetin showed a higher binding affinity to both ACE2 and the RBD of the spike protein. The dual binding effect of quercetin could therefore be synergistic and provide a strong antiviral effect against SARS-CoV-2. Furthermore, since analysis suggested that quercetin could affect immunomodulation, and because studies have shown patients with severe COVID-19 disease tend to experience cytokine storms, quercetin could help alleviate symptoms in such cases. To read the original article click here.

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