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Study Reveals Higher Breast Cancer Mortality Risk for Black Women Across All Tumor Types

The AHA! Team — Fri, 25 Oct 2024 08:15:48 +0000

Mass General Brigham via News-Medical – Breast cancer is the most diagnosed cancer among U.S. women and the second leading cause of cancer death. Black women who develop breast cancer are around 40% more likely to die of the disease than white women, but it was unclear until now whether this disparity exists across all types of breast cancer. Now, a meta-analysis led by Mass General Brigham researchers shows that Black women have a higher risk of dying from breast cancer for all tumor subtypes, and the size of this disparity varies from 17-50% depending on the type of breast cancer. These findings, published in the Journal of Clinical Oncology, demonstrate that higher mortality rates among Black women with breast cancer are at least partially attributable to factors that are independent of tumor biology-;for example, socioeconomic inequality, delays in diagnosis, and inadequate access to timely quality cancer treatment resulting from systemic racism. “Our findings demonstrate that multiple, interacting factors contribute to disparities in breast cancer survival between Black and white women. To achieve equity, intervention is necessary at multiple levels-;from community to healthcare systems and individual healthcare providers, to patients themselves learning about their disease and what their expectations should be for their care.” Erica Warner, ScD, MPH, senior author, cancer epidemiologist at Massachusetts General Hospital, founding member of the Mass General Brigham healthcare system Though it is often discussed as a single disease, breast cancer has multiple subtypes that differ in risk factors, treatment, and prognosis. These subtypes are defined based on whether the cancer cells carry hormone receptors for estrogen or progesterone, which can be targeted for treatment, and whether they carry HER2 (human epidermal growth receptor 2), a protein associated with cancer aggressiveness and another potential treatment target. Breast cancer has multiple subtypes that differ in risk factors, treatment, and prognosis “There had been an anecdotal sense in the research community that differences in survival between Black and white women were greater for the most treatable forms of the disease-;tumors that carry hormone receptors-;and smaller for the historically less-treatable, hormone-negative tumors,” said Warner. To investigate whether these anecdotes were supported by the evidence, Warner’s team combined data from 18 studies that were published between 2009 and 2022. Altogether, these studies analyzed 228,885 breast cancer cases, 34,262 of which were in Black women. They found that survival was worse for Black women for all breast cancer subtypes, though the size of these disparities varied between breast cancer subtypes. There was a larger racial disparity for hormone-positive tumors, which were associated with a 34-50% higher risk of death for Black women, compared to hormone-negative tumors, which were associated with a 17-20% higher risk of death for Black women. “These findings underscore a stark reality in our healthcare system: Black women are facing higher risks of death from breast cancer compared to their white counterparts, across all types of the disease. This disparity isn’t just about biology,” said co-author Paulette Chandler, MD, MPH, associate epidemiologist in the Division of Preventive Medicine at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system. “It’s a call to action for healthcare providers, policymakers, and communities alike to confront these inequities head-on and strive for meaningful change in breast cancer outcomes.” Because hormone-negative tumors are less common, Warner says that racial disparities in breast cancer survival for hormone-negative subtypes were likely not observed previously because individual studies lacked statistical power due to the small number of cases. “There may also be differences in the biological characteristics of some tumor subtypes between racial groups that our therapies are not attuned to, potentially because of underrepresentation of Black women in clinical trials,” said Warner. The researchers point to several existing multilevel intervention programs However, these racial disparities are not inevitable, and the researchers point to several existing multilevel intervention programs that have successfully reduced disparities in cancer survival. These programs leverage multiple strategies, including helping patients navigate the healthcare system, proactively identifying social needs and connecting patients with resources to address those needs, and by implementing systems that alert healthcare workers of missed appointments or unmet care milestones. At the national level, interventions like ACCURE and Equal Hope aim to close gaps in mortality and survival between Black and white women. Locally, MGH is collaborating with Boston Medical Center on a virtual Equity Hub for Cancer Treatment with the goal of enhancing partnerships and improving cancer care for underserved patients at community-based mental health centers. Source: Mass General Brigham Journal reference: Torres, J. M., et al. (2024) Racial Differences in Breast Cancer Survival Between Black and White Women According to Tumor Subtype: A Systematic Review and Meta-Analysis. Journal of Clinical Oncology. doi.org/10.1200/JCO.23.02311. To read the original article click here.

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Dairy Milk Hormones’ Effects on Cancer

The AHA! Team — Fri, 07 Jun 2024 08:44:47 +0000

Michael Greger M.D. FACLM via Nutrition Facts – What are the effects of the female sex hormones in cow’s milk on men, women, and children? All foods of animal origin contain hormones, but most of our dietary exposure to hormones comes from dairy products. By quantity, as you can see below and at 0:16 in my video The Effects of Hormones in Dairy Milk on Cancer, it is mostly prolactin, corticosteroids, and progesterone, but there are also a bunch of estrogens, which concentrate even further when other dairy products are made. For instance, Hormones are five times more concentrated in cream and cheese, and ten times more in butter. When it comes to steroid hormones in the food supply, about three-quarters of our exposure to ingested female sex steroids come from dairy, and the rest is split evenly between eggs and meat (including fish). Indeed, eggs contribute about as much as all meat combined, which makes a certain amount of sense since an egg comes straight from a hen’s ovary. Among the various types of meat, you get as much from white meat (fish and poultry) as you do from pork and beef, and this is just from natural hormones—not added hormone injections, like bovine growth hormone. So, it doesn’t matter if the meat is organic. Animals produce hormones because they’re animals, and their hormones understandably end up in animal products. About half of the people surveyed “did not know that milk naturally contains hormones,” and many “lacked basic knowledge (22% did not know that cows only give milk after calving)”—that is, they didn’t realize what milk is for—feeding baby calves. Researchers suggested we ought to inform the public about dairy production practices. In response, one Journal of Dairy Science respondent wrote that telling the public about the industry’s new technologies, like transgenic animals (meaning genetically engineered farm animals), “or contentious husbandry practices” (such as taking away that newly born calf so we can have more of the milk or “zero-grazing for dairy cows”—i.e., not letting cows out on grass), “does not result in high rates of public approval,” so ixnay on the educationay. The public may not know the extent to which they are exposed to estrogen through the intake of commercial milk produced from pregnant cows, which has potential public health implications. Modern genetically improved dairy cows, can get reimpregnated after giving birth and lactate throughout almost their entire next pregnancy “Modern genetically improved dairy cows, such as the Holstein,” the stereotypical black and white cow, can get reimpregnated after giving birth and lactate throughout almost their entire next pregnancy, which means that, these days, commercial cow’s milk contains large amounts of pregnancy hormones, like estrogens and progesterone. As you can see in the graph below and at 2:42 in my video, during the first eight months of a pregnant cow’s nine-month gestation, hormone levels in her milk shoot up more than 20-fold. Even so, we’re only talking about a millionth of a gram per quart, easily 10 to 20 times less estrogen hormones than you’d find in a birth control pill. In that case, would drinking it really have an effect on human hormone levels? Researchers analyzed three different estrogens and one progesterone metabolite flowing through the bodies of seven men before and after they drank about a liter of milk. Within hours of drinking the milk, their hormone levels shot up, as you can see in the graph below and at 3:08 in my video. The researchers also looked at the average levels of female sex steroids flowing through the bodies of six schoolchildren (with an average age of eight) before and after they drank about two cups of milk. Within hours of drinking the milk, their levels shot up, tripling or quadrupling their baseline hormone levels, as you can see in the graph below and at 3:23 in my video. So, one can imagine the effects milk might have on men or prepubescent children, but what about women? Presumably, women would have high levels of estrogen in their body in the first place, wouldn’t they? Well, not all women. What about postmenopausal women and endometrial cancer, for example? Estrogens have “a central role” in the development of endometrial cancer, cancer of the lining of the uterus. “Milk and dairy products are a source of steroid hormones and growth factors that might have physiological effects in humans.” So, Harvard researchers followed tens of thousands of women and their dairy consumption for decades and found a significantly higher risk of endometrial cancer among postmenopausal women who consumed more dairy, as shown below and at 4:19 in my video. What about dietary exposure to hormones and breast cancer? Unfortunately, “understanding the role of dietary hormone exposure in the population burden of breast cancer is not possible at this time.” For more on the relationship between cancer and dairy, see related videos below. I talk about the effect of dairy estrogen on men in Dairy Estrogen and Male Fertility. What about the phytoestrogens in soy? See here. Key Takeaways Although hormones are in all animal products, the majority (about three-quarters) of our dietary exposure comes from milk and other dairy products. The hormones in milk concentrate even further when other dairy products are produced—e.g., five times more concentrated in cream and cheese, and ten times more in butter. The rest (about one-quarter) of our exposure to ingested female sex steroids is split evenly between eggs and meat (including fish), with eggs contributing about as much as all meats combined and white meat (fish and poultry) contributing about as much as pork and beef. About 50 percent of people surveyed didn’t know that hormones are naturally found in milk, and more than one in five didn’t know that cows only produce milk after calving (intended to feed their calves). In response to the suggestion that consumers should be informed of dairy production practices, a Journal of Dairy Science respondent disagreed, believing that telling the public about practices, such as genetically engineering animals, removing calves soon after birth, and keeping cows off grass or pasture, “does not result in high rates of public approval.” Today, dairy cows may be reimpregnated after giving birth and lactate throughout nearly their whole pregnancy. So, large amounts of pregnancy hormones, like estrogens and progesterone, can be found in commercial cow’s milk. Researchers found that hormone levels shot up in men and school-aged kids within hours of drinking about a liter of milk. Estrogens play “a central role” in the development of endometrial cancer, and researchers found a significantly greater risk of this type of cancer among postmenopausal women who consume more dairy, which is a source of steroid hormones and growth factors. Regarding breast cancer and dietary exposure to hormones, “understanding the role” isn’t currently possible. To read the original article click here.

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CANCER ALERT: 300+ Chemicals Found to Increase Risk of Breast Cancer

AHA Publisher — Thu, 05 Aug 2021 07:23:02 +0000

Sara Middleton via NaturalHealth365 – According to the American Cancer Society, the typical woman has a 1 in 8 chance of developing breast cancer at some point in her lifetime. Sadly, the rates of breast cancer have increased dramatically in recent decades. Today, breast cancer remains the most common type of cancer affecting women, other than skin cancer. Why are breast cancer rates skyrocketing – could the growing number of cancer-causing chemicals found in our environment be to blame? Data from one new study suggests yes. Hundreds of Chemicals Found in Common Everyday Products Shown to Promote the Synthesis of Hormones Linked to Breast Cancer, New Research Finds The study, published in the recent edition of Environmental Health Perspectives, used laboratory testing to identify chemicals that may cause breast cancer by elevating the synthesis of estradiol (estrogen) and progesterone, two hormones linked to an increased breast cancer risk. The researchers found that 296 chemicals demonstrated the ability to increase the activity of one or both of these hormones. Chemicals, including hexythiazox, oxyfluorfen, pirimiphos-methyl, and 3,3′-dimethylbenzidine, were found in various sources, including “pesticides, consumer product ingredients, food additives, and drinking water contaminants.” The researchers note that at least 53 of the chemicals tested are currently being used in consumer products, despite the fact that there is “inadequate information to assess carcinogenic potential.” Incredibly, as many as 13% of the nearly 300 chemicals were previously identified as “unlikely” carcinogens or reproductive/developmental toxicants, despite showing cancer-causing potential in the comprehensive laboratory study. How could such a misclassification occur? One explanation relates to a failure of conventional toxicology testing. Generally, toxicology testing of U.S. consumer products only looks at whether chemicals mimic estrogen or bind to hormone receptors. But what is rarely tested is whether chemicals can actually trigger estrogen production, which is exactly what these researchers discovered. “Because [estradiol and progesterone] are important risk factors for breast cancer, chemicals that increase their synthesis may also increase the risk for breast cancer and must be prioritized for further research and exposure reduction,” the authors conclude. Beyond Everyday Household Items, Common Pharmaceutical Products Have Been Associated With Breast Cancer, Too It’s not just food, pesticides, and household products that can expose you and your loved ones to chemicals that increase the risk of cancer. Unfortunately, many drugs and medical products have an elevated cancer risk, too. Remember hormone replacement therapy (HRT)? Once widely recommended by medical professionals, HRT has been strongly linked to breast cancer, as just one example. We see this especially among postmenopausal women, who are more likely to have breast cancer when they have higher blood levels of estradiol, according to the Susan G. Komen Foundation. According to BreastCancer.org, combination HRT increases a woman’s risk of breast cancer by as much as 75 percent. Another group of medications linked with breast cancer – oral contraceptives, according to the National Cancer Institute. Indeed, the International Agency for Research on Cancer and World Health Organization identified combination oral contraceptives (which contain estrogen and progestin) as a Group 1 carcinogen back 2005 – putting “the pill” in the same category as arsenic, asbestos, and tobacco smoke. Question: if you’re a female or the parent of a female, did your doctor ever explain to you the full range of risks associated with this medication? Were you ever informed that oral contraceptives might cause cancer? Sources for this article include: Childrenshealthdefense.org Grandviewresearch.com NIH.gov NIH.gov NIH.gov Komen.org Cancer.gov WHO.int To read the original article click here. For more articles from NaturalHealth365 click here.

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6 Steps to Balance Hormones Naturally

AHA Publisher — Wed, 07 Apr 2021 07:00:16 +0000

Dr. Josh Axe, DC, DMN, CNS – Hormones — such as estrogen, testosterone, adrenaline and insulin — are extremely important chemical messengers that affect many aspects of your overall health. Conventional treatments for hormonal imbalances typically include synthetic hormone replacement therapies, birth control pills, insulin injections, thyroid medications and more. Unfortunately, for the majority of people suffering from hormonal disorders, relying on these types of synthetic treatments often does three things: It makes people dependent on taking prescription drugs for the rest of their lives in order to keep symptoms under control. It simply masks the patient’s symptoms, but doesn’t solve them, which means that the patient can continue to develop abnormalities in other areas of the body while the disorder progresses. It potentially causes a higher risk for serious side effects, such as stroke, osteoporosis, anxiety, reproductive problems, cancer and more. Is it possible to balance hormones naturally? The good news is: yes, in many cases it is. Below you’ll learn about some root causes of hormonal problems, as well as about treatment options to help you balance your hormones naturally. What Is the Endocrine System? The endocrine system is in charge of coordinating the relationship between different organs and hormones, which are chemicals that are released into your bloodstream from cells within your endocrine glands. Hormones are secreted by various glands and organs, including your thyroid, adrenals, pituitary, ovaries, testicles and pancreas. The entire endocrine system works together to control the level of hormones circulating throughout your body, and if one or more is even slightly imbalanced, it can cause widespread health problems affecting growth, sexual development and function, sleep, metabolism and hunger. Once your hormones are in circulation, they target specific tissues or cells by binding to receptors that are located inside the cell or on its surface. These hormones work as chemical messengers and play a key role in your body’s daily functions. The endocrine system is made up of many glands, including the pituitary gland or “master gland” that’s responsible for sending information from your brain to other glands in your body. The pituitary gland also produces many hormones that travel throughout the body and have different important functions. The pituitary gland is made up of two different tissue types: the anterior pituitary that synthesizes and releases classic hormones, and the posterior pituitary gland that secretes neurohormones that are made in the hypothalamus. Two hormones that are secreted by the anterior pituitary gland are growth hormone, which is responsible for your proper growth and development, and prolactin, which is the hormone that stimulates milk production after childbirth. Tropic hormones are also produced and secreted by the anterior pituitary gland, which is an endocrine gland, and they also target other endocrine glands. These hormones include: thyroid-stimulating hormone (also called thyrotropin) follicle-stimulating hormone luteinizing hormone adrenocorticotropic hormone The posterior pituitary gland doesn’t produce hormones on its own, but stores and secretes two hormones made in the hypothalamic region, vasopressin and oxytocin, and then releases them into the bloodstream. Other important glands of the endocrine system include the pineal gland, thyroid gland, parathyroid glands, thymus gland and adrenal glands. There are two major groups of hormones that circulate the human body — those that derive from amino acids (protein hormones, peptides and amines) and those that derive from lipids (steroids). Here’s a quick breakdown of these hormone subgroups: Amine hormones: Hormones that are synthesized from the amino acids tryptophan (such as melatonin) and tyrosine (such as thyroid hormones and dopamine). Peptide hormones: Hormones that consist of short chain amino acids and include antidiuretic hormone (called vasopressin) and oxytocin. Protein hormones: Hormones that consist of longer polypeptides and include growth hormone and follicle-stimulating hormone. Steroid hormones: Hormones that are derived from cholesterol and include testosterone, estrogens and cortisol. When these hormones send messages, they are received by hormone receptors that process the message and signal specific event or cellular mechanisms that initiate the target cell’s response. Signs and Symptoms Before we talk about how to balance hormones naturally, it helps to know which signs and symptoms of hormone imbalances to look out for. These include: Infertility and irregular periods Weight gain or weight loss (that’s unexplained and not due to intentional changes in your diet) Depression and anxiety Fatigue Insomnia Low libido Changes in appetite Digestive issues Hair loss and hair thinning Symptoms of hormonal imbalances can range dramatically depending on what type of disorder or illness they are caused by. For example, high estrogen can contribute to problems that include endometriosis and reproductive issues, while symptoms of diabetes often include weight gain, changes in appetite, nerve damage and problems with eyesight. Some specific problems associated with some of the most common hormonal imbalances include: Estrogen dominance: changes in sleep patterns, changes in weight and appetite, higher perceived stress, slowed metabolism Polycystic Ovarian Syndrome (PCOS): infertility, weight gain, higher risk for diabetes, acne, abnormal hair growth Low estrogen: low sex drive, reproductive problems, menstrual irregularity, changes in mood Hypothyroidism: slowed metabolism, weight gain, fatigue, anxiety, irritability, digestive issues, irregular periods Low testosterone: erectile dysfunction, muscle loss, weight gain, fatigue, mood-related problems Hyperthyroidism & Grave’s disease: anxiety, thinning hair, weight loss, IBS, trouble sleeping, irregular heartbeats Diabetes: weight gain, nerve damage (neuropathy), higher risk for vision loss, fatigue, trouble breathing, dry mouth, skin problems Adrenal fatigue: fatigue, muscle aches and pains, anxiety and depression, trouble sleeping, brain fog, reproductive problems Risk Factors and Causes Hormonal imbalances are multi-factorial disorders, meaning they are caused by a combination of factors — such as your diet, medical history, genetics, stress levels and exposure to toxins from your environment. Some of the major contributors to hormonal imbalances include: Food allergies and gut issues: An expanding field of new research shows that your gut health plays a significant role in hormone regulation. If you have leaky gut syndrome or a lack of beneficial probiotic bacteria lining your intestinal wall, you’re more susceptible to hormonal problems, including diabetes and obesity. That’s because inflammation usually stems from your gut and then impacts nearly every aspect of your health. Being overweight or obese High levels of inflammation caused by a poor diet and a sedentary lifestyle Genetic susceptibility Toxicity (which is related to exposure to chemicals like pesticides, or viruses, cigarettes, excessive alcohol and some medications) High amounts of stress, and a lack of enough sleep and rest Adrenal dysfunction is the largest cause of the hormonal imbalance with the sex hormones — especially because of something called the “cortisol steal.” This occurs when cholesterol, which usually helps to make the sex hormones, combines with too much stress and the enzyme 17/20 lyase blocks the conversion; the production of cortisol ensues. Cortisol then causes the imbalance of progesterone, estrogen and testosterone, which then decreases the sex drive. How to Balance Hormones Naturally 1. Swap Carbs for Healthy Fats Foods that balance hormones include a variety of fat-containing foods that provide short, medium and long-chain fatty acids. Your body needs various types of fats to create hormones, including saturated fat and cholesterol. Not only are these essential fats fundamental building blocks for hormone production, but they keep inflammation levels low, boost your metabolism and promote weight loss. Healthy fats have the opposite effect of refined carbohydrates, which lead to inflammation and can mess with the balance of your hormones. My four favorite sources of anti-inflammatory, healthy fats include: coconut oil, avocados, grass-fed butter and wild-caught salmon. Coconut oil uses are plentiful — for example, coconut oil (or cream/milk) has natural anti-bacterial and fat-burning effects. Avocado benefits include improving heart health, lowering inflammation, controlling your appetite and contributing to your daily intake of fiber and nutrients such as potassium. Salmon nutrition is also impressive: it’s one of the best sources of omega-3 fatty acids, which are known to lower inflammation and help with cognitive functions. Omega-3 fatty acids are a large component of brain-cell membranes and are important for cell-to-cell communication in the brain. Research shows that omega-3 fatty acids help protect against hippocampal neuronal loss and reduce pro-inflammatory responses. What food causes hormonal imbalance? It’s best to limit or avoid added sugar, processed carbs and refined vegetable/seed oils. Here’s a rule of thumb: Steer clear from oils high in omega-6 fats (safflower oil, sunflower, corn, cottonseed, canola, soybean and peanut), and load up on rich sources of natural omega-3s instead (wild fish, flaxseed, chia seeds, walnuts and grass-fed animal products). There is a type of omega-6 fat that you want to get in your diet called GLA. GLA (gamma-linoleic acid) can be taken in supplement form by using evening primrose oil or borage oil, and it’s also found in hemp seeds. Studies show supplementing with GLA can support healthy progesterone levels. 2. Supplement to Fill Nutritional Voids While a healthy diet is key for all aspects of health, it’s sometimes necessary to supplement in order to fill nutritional voids that can be leading to a hormone imbalance. Here are the top supplements to focus on in order to balance hormones: Evening primrose oil: Evening primrose oil contains omega-6 fatty acids, such as LA and GLA, that support overall hormonal function. Supplementing with evening primrose oil can help to relieve premenstrual and PCOS symptoms. It also helps to create a healthy environment for conception. Vitamin D: What is the best vitamins to take for hormonal imbalance? Vitamin D is definitely one of them, since it almost acts like a hormone inside the body and has important implications for keeping inflammation levels low. This is why people who live in dark areas often suffer from seasonal depression and other health problems unless they supplement with vitamin D. Sunshine is really the best way to optimize vitamin D levels because your bare skin actually makes vitamin D on its own when exposed to even small amounts of direct sunlight. Most people should supplement with around 2,000–5,000 IU daily of vitamin D3 if they live in dark areas, during the winter, and on days when they’re not in the sun. Bone broth: Bone broth soothes the digestive system and supplies the body with nutrients that can be easily absorbed. Consuming bone broth or protein powder made from bone broth is especially beneficial to your health because it contains healing compounds like collagen, proline, glycine and glutamine, which have the powder to boost your overall health. Probiotics: Probiotics are healthy bacteria that can actually improve your production and regulation of key hormones like insulin, ghrelin and leptin. They can also aid in repairing your gut lining, which in turn can balance your hormones. When undigested food particles, like gluten for example, leak through your gut into your bloodstream, it causes disease-causing inflammation that impacts the entire body — especially glands like the thyroid that is very susceptible to heightened inflammation. Most people with leaky gut have an a deficiency of probiotics in their guts. To consume more probiotics, you can both add fermented foods to your diet (such as yogurt, kefir, sauerkraut, etc.) and take probiotic capsule supplements. Adaptogen Herbs: Adaptogen herbs are a unique class of healing plants that promote hormone balance and protect the body from a wide variety of diseases, including those caused by excess stress. In addition to boosting immune function and combating stress, research shows that various adapotogens — such as ashwagandha, medicinal mushrooms, rhodiola and holy basil — can: Improve thyroid function Lower cholesterol naturally Reduce anxiety and depression Fight brain cell degeneration Stabilize blood sugar and insulin levels Support adrenal functions Ashwagandha, in particular, can be extremely effective at balancing hormones. It benefits thyroid function because it promotes the scavenging of free radicals that cause cellular damage. Ashwagandha can be used to support a sluggish or overactive thyroid, and it can also help to overcome adrenal fatigue. Your adrenals can become overtaxed when you experience too much emotional, physical or mental stress, leading to the disruption of hormones like adrenaline, cortisol and progesterone. Holy basil, which is also known as tulsi, helps to regulate cortisol levels, thereby working as a natural remedy for anxiety and emotional stress. Studies show that holy basil can also protect your organs and tissuesagainst chemical stress from pollutants and heavy metals,...

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Sleep Disturbances May Contribute to Weight Gain in Menopause

AHA Publisher — Fri, 26 Mar 2021 07:00:24 +0000

Endocrine Society via Newswise – WASHINGTON—Addressing sleep symptoms during menopause may reduce susceptibility to weight gain, according to a small study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting. “Our findings suggest that not only estrogen withdrawal but also sleep disturbances during menopause may contribute to changes in a woman’s body that could predispose midlife women to weight gain,” said lead researcher Leilah Grant, Ph.D., of Brigham and Women’s Hospital in Boston, Mass. “Helping women sleep better during menopause may therefore reduce the chances a woman will gain weight, which in turn will lower her risk of diabetes and other related diseases.” Rates of obesity increase in women around the age of menopause. Menopause-related weight gain is often thought to be caused by the withdrawal of the female hormone estrogen. Estrogen is unlikely to be to be the only contributing factor, however, since all women stop producing estrogen in menopause while only about half of women gain weight, Grant said. Another common symptom, also affecting around half of women during menopause, is sleep disturbance, which has independently been linked to changes in metabolism that might increase the risk of weight gain. To better understand the role of sleep disturbances and hormonal changes in menopausal weight gain, the researchers studied 21 healthy pre-menopausal women. They used an experimental model simulating the sleep disturbance experienced in menopause to examine the effects of poor sleep on the body’s use of fat. Participants had two nights of uninterrupted sleep followed by three nights of interrupted sleep, where they were woken by an alarm every 15 minutes for 2 minutes each time. The researchers then restudied a subset of nine participants in the same sleep interruption protocol after they were given a drug called leuprolide, which temporarily suppressed estrogen to levels similar to menopause. Compared to a normal night of sleep, after three nights of disturbed sleep there was a significant reduction in the rate at which the women’s bodies used fat. A similar reduction in fat utilization was also seen when estrogen was suppressed, even during normal sleep. The combination of low estrogen and sleep disturbance also reduced fat utilization, but the effect was not larger than either exposure on their own. “In addition to estrogen withdrawal, sleep disturbances decrease fat utilization,” Grant said. “This may increase the likelihood of fat storage and subsequent weight gain during menopause.” To read the original article click here.

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7 Tips to Enjoy Your Best Health During Menopause

AHA Publisher — Thu, 17 Sep 2020 07:00:01 +0000

Dr. Don Colbert – Did you know menopause can begin in your 40s, 50s, or 60s? While the average age is 51-52 years, many women begin experiencing symptoms like emotional changes, skin changes, hot flashes, fatigue, difficulty sleeping and more much earlier. In addition, many women find that it becomes difficult to maintain healthy weight and overall good health during menopause. If this describes you or a loved one, there are many healthy steps you can take to achieve your weight and health goals during menopause. Here are our top 7 tips. What is Menopause? Menopause is defined as the point in time 12 months after a woman’s last period. In the months before this 12-month-transition and during it, women experience many changes. This time period is often referred to as peri-menopause, and it’s the body’s transition to no longer being able to bear children. The menopausal transition can last 7-14 years, from pre-menopause to peri-menopause to menopause. Pre-menopause often begins around age 45, with an average age of 51-52 years for menopause. But, it can also be triggered by a hysterectomy or surgical removal of the ovaries, since these organs have a big influence on hormone production. What’s more, women often go through a lot of emotional and social changes at this time as well. Their children may be leaving home or becoming adults, work responsibilities can change, or they may become caring for their own elderly parents. It’s important to consider the whole-body effects of menopause, including mental, physical, social, and emotional health. What Causes Negative Symptoms During Menopause? The challenging symptoms associated with menopause are mostly due to hormone changes. These changes include a decreased production of estrogen and progesterone (made in the ovaries), and an increased production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increase. The decrease in estrogen is thought to cause most of the symptoms of menopause. Estrogen, or more specifically estradiol (E2), is secreted from the follicles of a woman’s ovaries. Since eggs are no longer being released from the ovaries, follicles no longer develop, and E2 declines (1). This decline can be erratic and devastating to some. In fact, many women first experience a significant increase in E2 in their mid-40s and then an abrupt drop. Others have more of steady decline. The overall E2 decline can cause: Irregular periods Vaginal dryness Hot flashes Chills Night sweats Sleep problems Mood changes Weight gain and slowed metabolism Thinning hair and dry skin Loss of breast fullness Changes in labido In addition, many women experience insulin resistance (which can make fat loss difficult), increases in cortisol, and decreases in bone density during and after menopause. 7 Ways to Enjoy Your Best Health During Menopause While this may all sound quite dire, it doesn’t have to be. You can take steps to enjoy your best health during menopause. In fact, some women thrive and feel wonderful as they go through this life phase transition. It’s not without challenges, but they can be met with healthy strategies. Here are our 7 ways to enjoy your best health during menopause. 1. START WITH SPIRITUAL HEALTH DURING MENOPAUSE It all begins with your spirit. As you enter, go through, or even pass menopause, keep your focus on God and His promises. Change can be tough, but our God does not change. His love for you and steadfastness lasts from everlasting to everlasting. Even through menopause, if God is for you, who can be against you? Don’t let negative thoughts, self-doubt, self-criticism, or stress take control. God can help you conquer all of this. 2. AIM FOR A HEALTHY WEIGHT DURING MENOPAUSE Next, hit one of the toughest parts of menopause head-on. Since menopause can be associated with rises in cortisol and insulin resistance, it can be a very challenging time to obtain or maintain a healthy weight. These changes even affect how and where fat is deposited in the body (2). But, there is certainly a lot of hope for a healthy weight with the right eating lifestyle. To aim for a healthy weight during menopause, start by reducing carbohydrates. When you vastly reduce carbohydrates and enter ketosis, your body can improve insulin sensitivity, fat loss, and overall health during menopause. In fact, a study in over 88,000 women reported that a low-carb diet was associated with a decreased risk of postmenopausal weight gain, while a higher-carb low-fat diet increased risk of weight gain among participants (3). What’s more, intermittent fasting, fasting in general, healthy detox and cleanses can have a huge impact during menopause. To get started with your own ketogenic and fasting journey, try: Dr. Colbert’s Keto Zone Diet Book 21 Day Detox Challenge 3. CONSIDER HEALTHY HORMONE LEVELS DURING MENOPAUSE Again, the majority of symptoms during menopause come down to hormonal changes, and the biggest change occurs with estrogen. But, it’s not just about the level of estrogen, but estrogen’s metabolism and balance in relation to other hormones during menopause. Some women experience estrogen dominance (elevated estrogen relative to other hormones) and others experience loss of testosterone and progesterone. There is a natural way to help balance your estrogen changes, no matter it’s level. Diindolylmethane (DIM) is a natural compound, found in cruciferous vegetables, that alters the metabolism of estrogen in order to help the body balance hormones. DIM works specifically by converting “bad estrogens,” into good estrogen metabolites. Bad estrogens are those that cause most pre-menstrual and menopause symptoms including fat gain, cramping, acne, low energy, and more. They are also found in higher levels in those with breast cancer. Good estrogens promote leaner bodies with more muscle, high-quality collagen in connective tissues, healthy bone density, and good cholesterol levels. DIM encourages estrogens to metabolize to the beneficial forms while deterring negative forms. If you are interested in adding DIM to your supplement regimen, Hormone Zone is a balanced, natural supplement complex that contains DIM. 4. GUARD YOUR BONES DURING MENOPAUSE Due to changes in hormones, bone density also becomes a risk factor for women during menopause and after. Instead, of just hoping for better bone health, though, you can take steps to fortify your bones with bone-building foods and supplements. Great food choices include protein foods and meats, eggs, nuts, green beans, fish (including small bones), plain yogurt, and more. In addition, it’s important for menopausal women to get enough Vitamin K2, or menaquinone. This vitamin is found in animal foods and fermented foods. Unlike the more familiar vitamin K1, K2 is often deficient in adults. It’s often overlooked as an important nutrient, but it’s becoming clear that K2 has many specific, important functions in the body. Vitamin K2 is extremely important for bone health, especially in post-menopausal women. Supplementing vitamin K2 and vitamin D together may reduce spinal fractures, hip fractures, and osteoporosis. Further, vitamin K2 supports good dental health from infancy into advanced age. To get enough K2 every day, use Hormone Zone, a natural supplement that support women’s health. 5. BUILD MUSCLE DURING MENOPAUSE At the start of the menopause transition, a woman’s rate of fat gain doubles and her lean muscle mass declines. This is a double whammy, and it’s again related to hormone changes! It’s imperative for women to double-down on gaining muscle rather than losing it. To increase muscle gains, stay active, and use resistance training. You can do so by adding inclines (like hills) when you walk or hike, engaging in a weight-class at a local gym, or using at-home resistance bands and online workout options. More muscle will support healthy metabolism, bone health, healthy blood sugars, and insulin sensitivity. 6. MENTAL HEALTH & STRESS DURING MENOPAUSE Unfortunately, there is also a link between menopause and increased risk of depression (4). The physical and emotional changes associated with menopause can certainly take a toll on mental health. It’s crucial that women take time for themselves every day during this time (and throughout life) to engage in activities that support their mental health. These can include: Prayer Time with loved ones and friends Self-care Counseling, if needed Journaling and Gratitude Hobbies and fun activities Stress Relief through time outdoors, etc. In addition, we’ve posted many strategies to reduce stress and cortisol each day. Along with these tips, we also have a wonderful adaptogen supplement that supports healthy cortisol levels and balance: Divine Health’s Living Serene 3. It can make a world of difference! 7. GOALS & OPTIMISM DURING MENOPAUSE Lastly, menopause can be a time of new life! You can set goals and head into your future with optimism, if you so choose. In fact, optimism is literally a fountain of youth. It’s associated with longer and happier life! And best of all, it can be learned. In fact, while studies show that approximately 25% of optimism is genetic (5), we can learn and practice the other 75% through with prayer, meditation, journaling, and gratitude (6). In addition, the more you put the other 6 healthy habits into practice, the more optimistic you’ll likely feel, which completes a wonderful cycle for your best health during menopause (7). You can do it! Bottom Line Menopause if full of transition and chance, and much of it is tough. However, the power is in your hands. You can choose to care for yourself spiritually, physically, mentally, and emotionally. You can practice optimism and tap into one of the most powerful fountains of youth! In addition, we have products that can help you enjoy your best health during menopause. These include Dr. Colbert’s Keto Zone Diet Book 21 Day Detox Challenge Hormone Zone Divine Health’s Living Serene 3 You have the tools and the power. Look at each day, through menopause and after, with hope and joy! To read the original article click here. For more articles from Dr. Colbert click here.

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Studies Suggest a Fasting Diet Could Boost Breast Cancer Therapy

AHA Publisher — Fri, 24 Jul 2020 07:00:13 +0000

University of Southern California via EurekAlert – A USC-led team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans. In studies on mice and in two small breast cancer clinical trials, researchers at USC and the IFOM Cancer Institute in Milan — in collaboration with the University of Genova — found that the fasting-mimicking diet reduces blood insulin, insulin-like growth factor 1 (IGF1) and leptin. In mice, these effects appear to increase the power of the cancer hormone drugs tamoxifen and fulvestrant and delay any resistance to them. The results from 36 women treated with the hormone therapy and fasting-mimicking diet are promising, but researchers say it is still too early to determine whether the effects will be confirmed in large-scale clinical trials. The research was published in the journal Nature. “Our new study suggests that a fasting-mimicking diet together with endocrine therapy for breast cancer has the potential to not only shrink tumors but also reverse resistant tumors in mice,” said Valter Longo, the study’s co-senior author and the director of the Longevity Institute at the USC Leonard Davis School of Gerontology and professor of biological sciences at the USC Dornsife College of Letters, Arts and Sciences. “We have data that for the first time suggests that a fasting-mimicking diet works by changing at least three different factors: IGF1, leptin and insulin.” The researchers say the two small clinical trials are feasibility studies that showed promising results, but they are in no way conclusive. They believe the results support further clinical studies of a fasting-mimicking diet used in combination with endocrine therapy in hormone-receptor-positive breast cancer. The scientists also contributed to a recent clinical study of 129 breast cancer patients conducted with the University of Leiden. The results, published last month in Nature Communications, appeared to show increased efficacy of chemotherapy in patients receiving a combination of chemotherapy and a fasting-mimicking diet. In the two new small clinical trials — one of which was directed by the study co-corresponding author Alessio Nencioni — patients with hormone-receptor-positive breast cancer receiving estrogen therapy along with cycles of a fasting-mimicking diet seemed to experience metabolic changes similar to those observed in mice. These changes included a reduction in insulin, leptin and IGF1 levels, with the last two remaining low for extended periods. In mice, these long-lasting effects are associated with long-term anti-cancer activity, so further studies in humans is needed. “Some patients followed monthly cycles of the fasting-mimicking diet for almost two years without any problems, suggesting that it is a well-tolerated intervention,” Nencioni said. “We hope this means that this nutritional program that mimics fasting could one day represent a weapon to better fight cancer in patients receiving hormone therapy without serious side effects.” “The results in mice are very promising. And the early clinical results show potential as well, but now we need to see it work in a 300- to 400-patient trial,” Longo explained. The data also suggest that in mice, the fasting-mimicking diet appears to prevent tamoxifen-induced endometrial hyperplasia, a condition in which the endometrium (or the lining of the uterus) becomes abnormally thick. The study authors believe this potential use of the fasting diet should be explored further, given the prevalence of this side effect of tamoxifen and the limited options for preventing it. Approximately 80% of all breast cancers express estrogen and/or progesterone receptors. The most common forms of hormone therapy for these breast cancers work by blocking hormones from attaching to receptors on cancer cells or by decreasing the body’s hormone production. Endocrine therapy is frequently effective in these hormone-receptor-positive tumors, but the long-term benefits are often hindered by treatment resistance. Several clinical trials, including one at USC on breast cancer and prostate patients, are now investigating the effects of the fasting-mimicking diets in combination with different cancer-fighting drugs. “I like to call it the nontoxic wildcard for cancer treatment,” Longo said. “These clinical studies we have just published — together with the many animal studies published in the past 12 years — suggest that cycles of the fasting-mimicking diet has the potential to make standard therapy more effective against different cancers, each time by changing a different factor or nutrient important for cancer cell survival.” To read the original article click here.

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Depression Is Prevalent During Menopause, Confirms Study

AHA Publisher — Mon, 06 Jul 2020 07:00:10 +0000

The North American Menopause Society via News-Medical Net – Depression has been shown to be prevalent during menopause, affecting as many as 70% of women transitioning into menopause. A new study not only confirms the high prevalence of depression but also the greatest risk factors for it in postmenopausal women, as well as any relationships with anxiety and fear of death. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). With the decrease in hormone production during menopause, women are more prone to a number of psychological problems, including depression, anxiety, irritability, nervousness, sadness, restlessness, memory problems, lack of confidence and concentration, and a loss of libido. At the same time, as women age, the fear of death becomes more pronounced. Depression and anxiety, which are the most common psychological problems that occur during the menopause transition, likely increase that fear. In this new study involving 485 postmenopausal Turkish women aged between 35 and 78 years, researchers sought to determine the frequency of depressive symptoms in postmenopausal women, the variables affecting it, and the levels of anxiety and fear of death. They then evaluated the relationship between all these variables and postmenopausal depression. They found that depression in postmenopausal women is a common and important health problem that requires further study. In this specific study, 41% of the participants were confirmed to experience some form of depression, although it is theorized that this rate was lower than in some previous studies because of the somewhat lower age of participants (average age, 56.3 y). In addition, the researchers identified those risk factors that most affected depression in postmenopause. These included being a widow or separated from one’s spouse, alcohol consumption, any medical history requiring continuous medication, the presence of any physical disability, physician-diagnosed mental illness, and having four or more living children. They did not, however, confirm any relationship between depression and the fear of death, although the somewhat younger age of the study group may have influenced this lack of association. Study results appear in the article “Depression, anxiety and fear of death in postmenopausal women.” “The findings of this study involving postmenopausal Turkish women are consistent with existing literature and emphasize the high prevalence of depressive symptoms in midlife women, particularly those with a history of depression or anxiety, chronic health conditions, and psychosocial factors such as major stressful life events. “Women and the clinicians who care for them need to be aware that the menopause transition is a period of vulnerability in terms of mood,” Dr. Stephanie Faubion, Medical Director, The North American Menopause Society (NAMS) To read the original article click here.

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Is a Hormonal Imbalance Making You Moody, Anxious, and Overweight?

AHA Publisher — Wed, 27 May 2020 07:00:07 +0000

Dr. Caroline Leaf – The hormonal problem and solution with Dr. Anna Cabeca, OB-GYN and hormone expert: We all know that our hormones are important, but did you know that they can impact our mood and mental health as well? In this week’s blog and podcast, I spoke to Dr. Anna Cabeca, an OB-GYN, bestselling author and hormone expert, about the neuroendocrine system, how our hormones affect our mood and mental wellbeing, how the keto diet boosts brain energy and helps us lose excess weight, and what our urine says about our stress levels. Dr. Anna’s desire to help others was inspired by her own life story. After the traumatic death of her young son, Anna’s health started declining as she went through PTSD-induced early menopause. Even though she was a highly-qualified doctor who had trained at one of the best schools in the country, she was at a loss: nothing was working, so she went around the world looking for answers. During her healing journey, Dr. Anna began to realize the importance of lifestyle choices and habits, and the impact they have on our hormonal health and mental and physical wellbeing. She recognized the importance of a holistic mind and body approach to health, and now teaches others how they too can heal and live their best lives! In her incredible book The Hormone Fix, which is filled with helpful questionnaires, recommendations and tests, Dr. Anna tells women that they do not have to suffer like she did. She explains how it takes more than hormones to fix our hormones. To manage our sex hormones well, we need to focus on our lifestyle, as I discussed in a recent blog and podcast (episode #158). This includes nutrition, exercise, bioidentical hormones and stress management. If we focus on our mind and body health, we can take our health into our own hands! Why is this important? When we experience perimenopause and menopause, which generally occurs sometime between the age of 35 and 55, we enter a period of neuroendocrine vulnerability. This often results in mood swings, irregular bleeding, weight gain, fatigue, memory loss and so on, which is typically treated with medications like birth control pills or SSRI’s. However, these drugs often have negative side-effects, and don’t work for everyone. Stress can make this hormonal process worse, as our cortisol levels are controlled by our hormones. Cortisol is good in balanced amounts; it helps us get up in the morning, maintaining a healthy circadian rhythm, and is anti-inflammatory. Yet, if we are constantly stressed, we produce cortisol in excess, which leads to an imbalance in our hormones which affects our neuro-endocrine system. This, in turn, impacts our mental and physical health, making us anxious, forgetful, overweight and potentially insulin resistant. In fact, when our cortisol is up for too long, the brain shuts down the production of cortisol, which also shuts down the production of oxytocin. This can lead to burnout, isolation, despair, depression, inflammation, hair loss, and other health issues! Thankfully, there is a quick and easy way we can monitor our stress levels: the pH level of our urine! Ideally, we want our urine pH to be great than 7, i.e. alkaline. Acidic urine, that is urine with a pH of lower than 7, indicates high cortisol levels, and is warning sign that you need to do some stress management. Dr. Anna has affordable, easy to use urine strips that can help you monitor your pH levels available on her website. You can purchase these strips at your local pharmacy or online. When it comes to our health, we need to remember that the mind-body connection is real. What we think and how we manage stress directly impacts our physical wellbeing, and vice versa! This is why we should not just focus on our symptoms. We also need to look at all our lifestyle choices and how they affect our hormones and mental health, as I talked about in detail my blogand podcast (episode #158). These include: 1. What we eat. As Dr. Anna describes in detail in her new book, Keto Green 16, ketones from a natural, sustainable low carb/high fat diet are a better source of fuel for the brain and body than glucose, and can help with our hormone production and overall mental and physical health. However, for people who are insulin resistant or older, it can be hard to get into ketosis (you can also test this using a urine strip—Dr. Anna has ketosis strips on her website, and you can also purchase these strips at your local pharmacy or online), which is why intermittent fasting is also good, which trains the brain and body to turn our fat to fuel. This doesn’t mean you must eat meat: Dr. Anna has customizable plans for vegans and vegetarians in her book. If you want to learn more, you can also check out Dr. Anna’ workbook Making Keto Work. Of course, it is also important to remember eating is not just about what you eat, but also how and when you eat, which also affects your health, as I discuss in detail in my book Think and Eat Yourself Smart. Like I always say, there is only one rule when it comes to food: eat real food mindfully! 2. Bioidentical hormones. The brain needs energy, and we are only beginning to understand how this process is dependent on our hormones. When we go through perimenopause and menopause, our hormonal balance is affected, which, in turn, impacts the brain’s source of fuel. As a result, we can experience things like memory loss, fatigue, anxiety and so on. Taking bioidentical hormones is a great way to replace these hormones naturally, especially progesterone, which helps balance systems in the brain and body, including cortisol production. 3. Managing your stress! As I mentioned above, we should always be aware of how stress affects us. If we don’t manage toxic stress and the mind, it can mess with our health. This is why we should pay attention to the physical and emotional warning signals our body and brain sends us. Don’t ignore what makes you feel uncomfortable. Face it and deal with it, before it deals with you! This article has been modified. To read the original article click here. For more articles from Dr. Leaf click here.

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