Opioid Dependence Found to Permanently Change Brains of Rats

AHA Publisher — Fri, 07 Feb 2020 08:00:56 +0000

University of California San Diego Health via Newswise – Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, UC San Diego researchers found that opioid dependence produced permanent changes in the brains of rats. Newswise — More specifically, researchers reported that dependence on oxycodone, a potent opioid painkiller, led to permanent neuro-adaptations of the central nucleus of the amygdala (CeA) at the level of the nociceptin system, a brainwide network that modulates transmission of pain. Downregulation or suppression of the nociceptin system in the CeA led to an increase in activation of GABA receptors in rats highly addicted to opioids. The discovery is consistent with previous findings reporting CeA neuroa-daptations after cocaine and alcohol dependence. When researchers restored nociceptin levels in the CeA, it resulted in normalization of GABAergic transmission and a reduction of the rats’ opioid consumption. “This suggests the nociceptin system may be a promising target for the treatment of opioid use disorder,” said senior author Giordano de Guglielmo, PharmD, PhD, assistant professor in the Department of Psychiatry at UC San Diego School of Medicine. “To reveal the role of nociceptin in the central nucleus of the amygdala, we used a multidisciplinary approach with behavioral models, molecular biology and electrophysiology,” said first author Marsida Kallupi, PharmD, PhD, assistant professor in the Department of Psychiatry. “That allowed us to conclude that downregulation of this peptide may be partially responsible for excessive opioid addiction-like behaviors.” Currently, opioid maintenance therapy is the first-line treatment for opioid dependence, which involves using alternative, less damaging medications, such as methadone, buprenorphine and naltrexone. These three drugs are the only treatments approved by the U.S. Food and Drug Administration, but all have limitations, either because they act against different receptors, pose safety concerns or are less effective due to the need for strict adherence to treatment. Both methadone and buprenorphine target mu-opioid receptors in the brain. The new research builds upon past behavioral and neurochemical studies suggesting the nociceptin system and its receptors (NOP) are also involved in opioid tolerance and reward, addiction to multiple drugs and modulation of stress. Interestingly, while the research demonstrates that NOP is implicated in development of opioid dependence, it conversely blocks effects of morphine-based opioids. De Guglielmo said several efforts are already underway testing small molecule drugs that target the nociception system, and have produced positive effects in reducing alcohol-seeking behaviors and biology in rats. The new findings indicate they may offer similar potential therapeutic benefit for opioid addiction. Every day, according to the National Institute on Drug Abuse, more than 130 people in the United States die after overdosing on opioids. Two out of three drug overdose deaths involve an opioid. From 1999 to 2017, the last year for which data is available, almost 400,000 Americans lost their lives to opioids, with 47,600 fatal overdoses in 2017 alone. It’s estimated 2.1 million Americans have an opioid use disorder. To read the original article click here.

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Mindfulness May Reduce Opioid Cravings, Study Finds

AHA Publisher — Wed, 16 Oct 2019 07:00:19 +0000

Rutgers University-New Brunswick via New Wise – Opioid users, chronic pain sufferers may experience fewer relapses and greater well-being. Newswise — People suffering from opioid addiction and chronic pain may have fewer cravings and less pain if they use both mindfulness techniques and medication for opioid dependence, according to Rutgers and other researchers. The study, published in the journal Drug and Alcohol Dependence, examined the effects of mindfulness and methadone therapy on 30 patients with opioid addiction and chronic pain. Mindfulness is the meditative practice of focusing on the present moment and accepting one’s thoughts, feelings and bodily sensations, without judgement. The findings showed that those who received methadone and a mindfulness training-based intervention were 1.3 times better at controlling their cravings and had significantly greater improvements in pain, stress, and positive emotions, even though they were aware of more cravings than those who only received standard methadone treatment and counseling. “Methadone maintenance therapy (MMT) has been an effective form of medication treatment for opioid use disorder,” said Associate Professor Nina Cooperman, a clinical psychologist in the Division of Addiction Psychiatry at Rutgers Robert Wood Johnson Medical School. “However, nearly half of individuals on MMT continue to use opioids during treatment or relapse with six months.” Cooperman said many of those with opioid addictions experience chronic pain, anxiety and depression while on methadone maintenance, which is why mindfulness-based, non-drug interventions are promising treatments. The researchers said mindfulness-based interventions could help people dependent on opioids increase their self-awareness and self-control over cravings and be less reactive to emotional and physical pain. Individuals with an opioid addiction could also be taught to change their negative thoughts and savor pleasant events, which may help them to regulate their emotions and experience more enjoyment. Associate Professor Anna Kline at the Rutgers-Robert Wood Johnson Medical School co-authored the study, which included researchers at the University of Utah. To read the original article click here.

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Opioid Dependence Found to Permanently Change Brains of Rats

Mindfulness May Reduce Opioid Cravings, Study Finds