Some E-Cigarette Chemicals Mimic Nicotine, Possibly Bypassing Regulation

The AHA! Team — Fri, 11 Oct 2024 08:21:24 +0000

Duke Health – In what appears to be an effort to bypass public health regulations covering vaping products, some tobacco companies have begun replacing nicotine in e-cigarettes with related chemicals that have similar properties but unknown health effects, Duke Health researchers report. In a research letter appearing Aug. 7 in JAMA, study authors at Duke and Yale University also found that the quantity of these chemicals, known as nicotine analogs, are not accurately disclosed on the packaging. “Vaping products containing nicotine are subject to federal laws that prohibit sales to people under the age of 21,” said study co-author Sairam V. Jabba, D.V.M., Ph.D., a senior research scientist at Duke University School of Medicine. Nicotine analogs are currently not subject to the FDA process “Nicotine analogs are currently not subject to the FDA process and have not been studied for their health effects,” Jabba said. “Our analysis of some of these analog-containing vaping products sold in the U.S. found significant and concerning inaccuracies in the ingredients these products claim to contain and what they actually contain. Further, it’s possible manufacturers are attempting to avoid FDA tobacco regulation.” One chemical, known as 6-methyl nicotine, has been shown in rodent experiments to be far more potent than nicotine in targeting the brain’s nicotine receptors and more toxic than nicotine. Another, called nicotinamide, is marketed as targeting the same brain receptors as nicotine, despite evidence it does not bind to these receptors. The nicotine analogs were included in flavored e-cigarettes, which prior research has indicated are preferred by youths and those who vape for the first time. Jabba and colleagues, including co-senior author Sven Eric Jordt, Ph.D., analyzed an e-cigarette product sold under the brand name Spree Bar, which comes in at least nine flavors and is listed as containing 5 percent 6-methyl nicotine. Study results showed the actual amount of the chemical was about 88% less than labeled. The e-cigarettes also included an artificial sweetener that is up to 13,000 times sweeter than table sugar, and an artificial coolant that mimics menthol’s effects. A second brand of e-cigarettes — marketed as Nixotine, Nixodine, Nixamide and Nic-Safe – contained a nicotine analog called nicotinamide, also at levels lower than the labels indicated, and combined with undisclosed amounts of 6-methyl nicotine. This brand did not include sweeteners or coolants. These products appear to be designed to circumvent the laws and regulations “These products appear to be designed to circumvent the laws and regulations in place to protect people — especially children — from the harmful effects of smoking and tobacco use,” Jordt said. “We do not know what these chemicals do when they are heated and inhaled. These are questions that should be answered before we allow products on the market.” In addition to Jordt and Jabba, study authors include Hanno C. Erythropel, Peter Silinski, Paul T. Anastas, Suchitra Krishnan-Sarin and Julie B. Zimmerman. Yale’s Tobacco Center of Regulatory Science received funding support for the study from the National Institute on Drug Abuse, which is part of the National Institutes of Health (U54DA036151), and the Center for Tobacco Products of the FDA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the FDA. To read the original article click here.

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A Good Night’s Sleep Is Good for Your Heart: Here Are Some Tips for Better Sleep and a Healthier Heart

AHA Publisher — Wed, 14 Sep 2022 07:00:06 +0000

Lorie Johnson via CBN News – There’s no question that sleep is important to our health and well-being. Now the American Heart Association is emphasizing that it’s also one of the most important paths to heart health. That’s worth our attention because heart disease kills more Americans than any other cause of death. To show the powerful connection of sleep to a healthy heart, the AHA is adding sleep to its overall key measurements. It joins diet, exercise, nicotine exposure, body mass index, blood lipids, blood glucose, and blood pressure. Most health experts and institutions recommend adults get seven to nine hours of sleep each night, preferably with few to no interruptions. Bodies need that time to repair and reset, and doctors say without it, our heart pays the price. Research shows people who regularly sleep less than six hours a night my triple their risk of heart disease. The concern is that’s not enough time spent in the deepest stage of sleep, when blood pressure and heart rate drop as much as 20 percent, reducing stress on the heart. Also during this sleep stage, the brain releases growth hormones that help the heart recover from demands placed on it during the day. Deepak R. Talreja, M.D., a cardiologist with Sentara Healthcare told CBN News sleep is very important to heart health, but unfortunately, today more than half of all U.S. adults don’t get enough, and sleep deprivation is more common now than it was in past generations. “As our society has gotten busier and busier and we’re all available 24/7 with devices that connect us all the time,” he said, “most Americans don’t get enough sleep.” He sees firsthand how that’s taking a toll. “When someone is sleep deprived, it affects their overall functional status, their mental state, they tend to have more problems with depression, pessimism, anxiety,” he explained. “Then there are direct effects on inflammation, on heart rhythm issues, and on the presence of heart disease.” Dr. Talreja tells his patients that the path to better sleep begins with the right environment. The bedroom should be dark, cool (but not too cold), and quiet, which can include a white noise machine to cover up environmental or outside noises. Then establish your best bedtime and stick to it. “Set an alarm to remind you, just like you have a wake-up alarm, a go-to-sleep alarm can be very helpful,” he said. Stay away from electronics well before bedtime and silence them to avoid interruptions during the night. If you do wake up, stay away from the smartphone. “We’re tempted to pull our device quickly if we’re having a little bit hard time sleeping and look at Facebook, Twitter, Instagram, or do things that one, introduce light to our environment, and two rev us up instead of letting us calm down,” said Dr. Talreja. Exercise is also very important to getting a good night’s sleep. “That way when it comes time for sleep, your body’s ready for it. Someone who doesn’t do anything (physical) during the day, they haven’t really worn out their body so they’re not ready to sleep,” Dr. Talreja explained. Dr. Talreja points to a star patient who changed his ways. Severino Tiaba now works out daily and goes to bed at nine o’clock. “Now that I’m getting older, it’s routine,” Severino told CBN News. “The kids are out of the house. It’s just me and my wife.” Severino made a lot of other changes after suffering a heart attack six years ago. “My chest was burning real bad,” he recalled. “I had my wife take me to the emergency room because I felt like I needed to get checked out and it just got worse.” That near-death experience convinced the beer-drinking, cigar-loving, junk food junkie to do a 180. “I want to be around to see my grandkids,” he said. Severino started by following Dr. Talreja’s advice to switch to a more heart-healthy diet. Dr. Talreja recommends a plant-based eating plan that minimizes saturated fat, sugar, and processed foods. Severino enjoys the Mediterranean diet. “I eat a lot of fruits, a lot of vegetables, a lot of grains,” he said. “No more red meat, no more pork. So I eat a lot of cold water fish, salmon, mackerel, and poultry.” He gave up alcohol except an occasional glass of red wine, and ditched the cigars. “The biggest risk factor for heart disease in this era is still smoking,” said Dr. Talreja. “Quitting smoking is far and away the single most important thing a person can do.” Dr. Talreja says some people are better able to improve their heart health by making changes gradually and with the help of others. “First, introduce more fruits and vegetables into your diet. Cut down fried food and fast food, cut down soda,” he advised. “Pick specific goals you can achieve, and then pull other people in your life into it. If a whole family decides together they’re going to eat more healthful, they’re more likely to succeed.” So while heart disease is currently America’s number one killer, that could change. “If we could get the average American to eat better, exercise, pay attention to their other risk factors, and sleep better,” Dr. Talreja said, it would make a world of difference. To read the original article click here.

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nicotine exposure Archives - Amazing Health Advances

Some E-Cigarette Chemicals Mimic Nicotine, Possibly Bypassing Regulation

A Good Night’s Sleep Is Good for Your Heart: Here Are Some Tips for Better Sleep and a Healthier Heart