neuroinflammation Archives - Amazing Health Advances

Oxidized Cholesterol and Alzheimer’s Disease

AHA Publisher — Fri, 13 May 2022 07:00:51 +0000

Michael Greger M.D. FACLM via NutritionFacts – Oxidized cholesterol can be a hundred times more toxic than regular cholesterol, raising additional concerns about foods such as ghee, canned tuna, processed meat, and parmesan cheese. Too much cholesterol in the blood “has long been considered to act as a primary risk factor for developing Alzheimer’s disease and, possibly, Parkinson’s disease.” Striking images on autopsy show that the brain arteries of Alzheimer’s victims are clogged with fat and cholesterol, compared to non-demented elderly controls, as you can see at 0:16 in my video Oxidized Cholesterol as a Cause of Alzheimer’s Disease. But “cholesterol cannot be directly exported across the blood-brain barrier,” so it can’t get directly into—or out of—the brain. What if the brain has too much cholesterol and needs to get rid of some? As a safety valve, an enzyme in the brain can oxidize cholesterol. So, in that form, it can exit the brain and eventually the body. There’s a catch, though. “Although this fact means that the brain can eliminate excess amounts of these oxidation products,” it could be a two-way street. “[I]t could conversely allow toxic amounts of oxysterols [oxidized cholesterol], present in the blood stream, to accumulate in the brain”—that is, to go the other way. This is not just a theoretical concern. An elegant study showed that by measuring oxidized cholesterol levels in the blood coming off the brain, collected from the jugular vein in the neck, compared to the levels going into the brain through the artery, you could determine the difference. The researchers found that if you have too much oxidized cholesterol in your bloodstream, it can end up in your brain. This is a problem, because research shows the accumulation of oxysterols can be “cytotoxic, mutagenic, atherogenic and possibly carcinogenic”—in other words, toxic to cells, toxic to DNA, and contributing to heart disease and maybe also cancer. Yes, samples from atherosclerotic plaques on autopsy contain 20 times more cholesterol than normal arteries, but they contain 45 times higher levels of oxidized cholesterol. Cholesterol oxidation products may be up to a hundred times more pathological, more toxic, than unoxidized cholesterol, contributing not only to heart disease, but potentially also to a variety of different major chronic diseases, including Alzheimer’s, as you can see at 2:03 in my video. How can we cut down on the amount of these oxysterols in our body? One way is by not eating them. Oxidized cholesterol is found in “milk powders, meat and meat products (including fish), cheese, eggs and egg products.” “Until recently, our understanding…has been limited by the lack of analytical procedures [testing methods] to analyse foods with sufficient sensitivity and accuracy”—until now, that is. As you can see at 2:39 in my video, oxidized cholesterol can be found throughout animal products. Canned tuna was surprisingly high, but ghee takes the cake. Ghee, clarified or boiled butter, is commonly used in Indian cooking. Its method of preparation appears to multiply oxidized cholesterol levels tenfold. This dietary exposure to oxidized cholesterol may help explain why the subcontinent of India is ravaged by such heart disease, even though a significant proportion of the population stays away from meat and eggs. (A number of Indian dairy-based desserts are also made in a similar way to ghee.) Oxidized cholesterol in the diet is a source of oxidized cholesterol in the human bloodstream, where it can readily cross the blood-brain barrier into the brain. This could then trigger inflammation inside the brain and the buildup of amyloid “years before the impairment of memory is diagnosed.” Early studies showing the buildup of oxidized cholesterol in the blood of those fed meals rich in oxidized cholesterol, causing a spike in the bloodstream a few hours after eating, as you can see at 3:45 in my video, were done with things like powdered egg, which can be found in a lot of processed foods, but you typically don’t sit down to a meal of it. You get the same types of spikes, though, from eating “ordinary foodstuff.” Give folks some salami and parmesan cheese, which are naturally rich in cholesterol oxidation products (COPs), and later that day, COP is circulating throughout their bodies, as you can see at 4:04in my video. Higher levels are not only associated with mild cognitive impairment, but they’re linked to Alzheimer’s disease as well. “Increased oxysterol concentrations in the brain may promote cellular damage, cause neuron [nerve cell] dysfunction and degeneration, and could contribute to neuroinflammation [brain inflammation] and amyloidogenesis,” the formation of amyloid plaques. You can show the boost in inflammatory gene expression right in a petri dish, as you can see at 4:30 in my video. You can grow human nerve cells in vitro and drip on a little cholesterol, which causes a bump in inflammation. According to a blog on neuropathycure.org, if you add the same amount of oxidized cholesterol, it gets much worse. What’s more, if you look at the changes in brain oxysterols at different stages of Alzheimer’s disease on autopsy, you can see how the three main cholesterol oxidation products appear to be building up, as I show at 4:48 in my video. Levels have been shown to dramatically increase in Alzheimer’s disease brains, adding to the evidence that oxidized cholesterol may be “the driving force behind the development of Alzheimer’s disease.” Cholesterol gets oxidized when animal products are exposed to heat. Are there some cooking methods that are less risky than others? Find out in my video How to Reduce Cholesterol Oxidation. KEY TAKEAWAYS A primary risk factor for the development of Alzheimer’s and possibly Parkinson’s diseases is too much cholesterol in the blood. Although cholesterol can’t be exported directly across the blood-brain barrier, it can be oxidized by an enzyme in the brain and, in that form, exit the brain. However, oxidized cholesterol present in the bloodstream may be able to enter the brain through this two-way street. Accumulation of these oxysterols can be toxic to cells and DNA, as well as contribute to heart disease and possibly cancer. Samples from atherosclerotic plaques on autopsy contain 20 times more cholesterol than normal arteries and 45 times higher levels of oxidized cholesterol, which can be 100 times more toxic than regular unoxidized cholesterol. Oxysterols are found throughout animal products, including dairy, meat (including fish), and eggs, and one way to cut down on the amount of them in our body is by not consuming them. The preparation of ghee, clarified or boiled butter that is commonly used in Indian cooking, appears to multiply oxysterol levels tenfold, which may help explain why heart disease is so rampant on the Indian subcontinent despite a significant percentage of Indians avoiding meat and eggs. The presence of oxidized cholesterol in the brain can trigger inflammation inside the brain and the buildup of amyloid, far before memory impairment is diagnosed. To read the original article click here.

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Improve Digestive Health for the Sake of 7 Other Systems

AHA Publisher — Fri, 22 Apr 2022 07:00:51 +0000

Dr. Don Colbert – Do you deal with digestive issues? If so, you don’t just deal with digestive issues. Digestive issues actually affect many systems in the body. On the flip-side, there’s great news! When you improve digestive health, you positively affect all those systems and whole body health! In fact, the health of your digestive microbiota (bacteria in your digestive tract) affects literally every other part of your body. Brain health. Metabolism and weight management. Immune health. Heart health. Blood sugars. Skin health. Although it may seem far-reaching, this area of medical research is changing the way we think about foods, bacteria, and human health. Here’s how improving digestive health improves your whole body, and how you can start today. Improve Digestive Health to Improve Whole Body Health – 7 Ways 1. ENERGY METABOLISM AND WEIGHT Amazingingly, the gut microbiota (healthy bacteria) contributes not only to how your body digests nutrients, but how it metabolizes, uses, and burns them. In fact, studies have found that altered gut microbiota has been associated with unhealthy weights and metabolic issues related to them (1). In fact, one study concluded that the use of a probiotic alone or together with a prebiotic influenced body fat mass in healthy adults with high weight (2). Another study followed to see if changes in the gut microbiota due to probiotic supplementation improved gut barrier function, metabolism, and obesity-related markers. The researchers found positive correlation in this study (3). When you improve digestive health, you encourage better metabolism! 2. BLOOD SUGARS The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic Altered blood sugars have a huge impact on individual health as well as our health as a society. Can a healthy digestive system help? Amazingly, our digestive tracts have their own “nervous system.” It is outside the central nervous system, and affects the health of systems throughout the body (4, 5). In animal studies, scientists investigated how changes in digestive nervous system cells (enteric-associated neurons) in the lower digestive tract affected glucose metabolism. Specifically, they looked at changes in the microbiota associated with the cells. They found that microbiota depletion led to loss of the neuron cells and impaired glucose regulation (6). While more research is needed, this leads us to believe impaired microbiota hurts glucose metabolism and blood sugars. This has implications for the metabolism, weight, and blood sugar issues that plague more than 50% of American adults. Improve digestive health and support glucose metabolism and healthy blood sugars! 3. IMMUNE HEALTH Before the industrial revolution, humans consumed natural, wild, and pre-agricultural foods. Since then, Western societies have relied on semi-processed and ultra-processed foods as the primary source of nutrition. This change has had a huge impact on the human gastrointestinal (GI) tract and gut health. In fact, The industrialized Western diet and changes in gut microbiota has been shown to have negatively impacted human digestive physiology and immune health (7). How? It’s estimated that 80% of your immune system “lives” in your gut. These immune components form the gut mucosal immune system, and consist of lymph nodes, lamina propria, epithelial cells. They make up a protective barrier for the integrity of the intestinal tract. Studies have found that depressed gut microbiota causes a significant immune system deficiency. On the other hand, healthy, viable microbiota play a vital role in the development and maintenance of a health gut immune system (8). How can you bolster your immune system? Focus on your gut. When you improve digestive health, you support your immune system! 4. BRAIN HEALTH The degradation of immune health that has followed poor digestive health doesn’t stop with immunity. Impaired immune responses in turn cause exaggerated neuroinflammation. This means inflammation of neurons in the brain. Neuroinflammation, unfortunately, is linked with brain impairment and dysfunction. In fact, many experts implicate the modern Western diet in the development of many health and brain issues including memory impairments, neurodegenerative issues, and depressed moods. This propagation of these brain and health impairments are amplified with the consumption of ultra-processed foods and excessive energy intake (9). There is growing evidence that this relationship may be more than just coincidental. In fact, researchers have found that the bidirectional signaling between the brain and gut is vital for maintaining homeostasis and regulation of the central nervous system (CNS) and enteric nervous system (ENS). This communication system between the gut-brain and the brain is called the Microbiota-Gut-Brain Axis (10). This means the health of each nervous system is dependent on the other. When you improve digestive health, you support healthy brain function. 5. HEART HEALTH Take note, cardiovascular illness is still the leading cause of death and disability in developed countries. In fact, it is responsible for approximately ⅓ of deaths in the United States and ¼ of the deaths in Europe (11). What’s more, we’re experiencing a steady increase in many risk factors for poor heart health, including blood sugar impairments, metabolic issues, and unhealthy weights (12). Does the human gut microbiota affect heart health? Microbial sequencing analysis has a lot of information about gut microbiota and heart health issues (13, 14). What’s more, studies also show that changes in gut microbiota affects metabolism, blood sugars, weight, and more (as described above) (15, 16). When it comes to direct effects on heart health, scientists know that gut microbiota produce numerous metabolites that are absorbed into the circulatory system while biologically active (8, 13). This means that gut bacteria communicates directly with organs through circulatory pathways, enzymes, and more, including the heart (17, 18, 19). Want to support heart health? When you improve digestive health, you support the health of your heart! 6. EMOTIONAL AND MENTAL HEALTH The Microbiota-Gut-Brain Axis doesn’t just affect physical health or physical brain function, it affects emotional and mental health as well. While the gut-brain and enteric neurons don’t seem capable of thought like the brain in our heads, they do communicate with the “big brain” in ways that affect emotions. According to a Johns Hopkins Medicine report, “The ENS may trigger big emotional shifts experienced by people coping with irritable bowel syndrome (IBS) and functional bowel problems such as constipation, diarrhea, bloating, pain and stomach upset. Researchers are finding evidence that irritation in the gastrointestinal system may send signals to the central nervous system (CNS) that trigger mood changes” (20, 21, 22). In fact, doctors are reporting that they may have thought of the relationship between digestive issues and anxious or depressed moods backwards for years. In other words, we’ve thought that anxious and depressed moods may trigger digestive issues. Now, studies and anecdotal reports are finding that many people with serious digestive issues develop emotional and mental impairments at a higher-than-normal rate. Since 30-40% of our adult population deal with impaired digestion from time to time, this is a huge issue for mental health (23). What can be done? First, we can start with healthy digestion. When you improve digestion and gut health, you support your mental health. 7. SKIN HEALTH More and more people seem to be suffering from skin impairments, from eczema to psoriasis. Could our modern, processed diets and the resulting damage to the microbiota and immune system be one cause? Scientists are now studying the effects of probiotics and prebiotics on skin health. These studies include both topical and ingested formulations. Here’s what they are finding: Ingested and topical probiotics improve skin and gut microbiota. The skin ecosystem is a complex environment covered with many strains of bacteria. Some are beneficial, some are essentially neutral, and others are harmful or at least potentially harmful. Scientists have found pre- and probiotics can optimize, maintain and restore the microbiota of the skin in different ways. Topical formulations have a direct effect on the skin by enhancing the natural defenses of skin. Ingested probiotics have a positive effect on skin by supporting the immune system and reducing inflammatory responses systemically (throughout the body) (23). Ready for healthier skin? When you improve digestive health, you support skin health! How Can You Support Digestive Health? Start with a great probiotic supplement. Dr. Colbert formulated his Dr. Colbert Beyond Biotics™ with 12 billion healthy probiotic bacteria units that have been proven to encourage optimal digestive health in just 4 weeks! In fact, Beyond Biotics™ contains 3 clinically studied and tested probiotic strains consisting of 12 billion bacteria, supporting the immune response and natural defenses. If you want to encourage great health in all the systems listed above, this is where to start. Next, begin Dr. Colbert’s Healthy Gut Zone Plan. It will teach you, step-by-step, how to improve your digestive health, support your entire body, and improve brain function, alertness and health starting today! Join Dr. Colbert in his challenge to prioritize your gut health. It can make all the difference to your whole body. Continue a Healthy Lifestyle with Beyond Keto! Dr. Colbert’s Beyond Keto program combines Keto Zone and Mediterranean foods to support gut health! In fact, studies have found the Mediterranean diet specifically improves gut microbiota and its associated metabolism functions (24). Get started with Dr. Colbert’s Beyond Keto today and supports digestive and whole-body health! Bottom Line It should be obvious. When you improve digestion, you positively affect every other system in your body. It could not be more important. If you need one health aspect to focus on, start here. Make your digestive health a priority today, and support the health of your entire body. To read the original article click here.

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Brand-New Research Suggests High-Fiber Foods Reduce Dementia Risk

AHA Publisher — Wed, 06 Apr 2022 07:00:45 +0000

Lori Alton via NaturalHealth365 – With its disabling loss of cognition, judgment, and memory, dementia is a truly devastating condition. And it is becoming more widespread. Alzheimer’s disease – the most common cause of dementia among older adults – is currently affecting over 6.2 million Americans. Experts predict that the incidence will double by the year 2050. Many scientists believe they are getting closer to unlocking the mystery of why dementia occurs – and what can be done to help prevent it. In a new Japanese study, researchers found that the risk of dementia may be lowered with a simple intervention (one that natural health experts have been advising all along!) – a high-fiber diet. Let’s look at some of the ways in which a plant-based, high-fiber diet may help promote healthy cognition and reduce the risk of dementia in aging adults. Decades-Long Research on the Effects of a High-Fiber Diet Yields Good News Regarding Dementia Risk In a study published last month in Nutritional Neuroscience, researchers asked over 3,500 participants aged 40 to 64 years to complete surveys that reflected their dietary intake going back 15 years. The participants were then followed up for an additional 20 years. This extensive but simple research technique revealed a clear-cut result: the scientists found that people who ate the highest amount of fiber had the lowest risk of dementia. While the two types of dietary fiber – soluble and insoluble fiber – are both crucial to health, the team reported that soluble fiber from oats and legumes was more effective at lowering dementia risk. Researchers speculated that soluble fiber regulates gut bacteria, thereby helping to decrease the neuroinflammation that triggers dementia. High-fiber diets also may help decrease body weight, reduce blood pressure, lower cholesterol, and improve blood sugar control. In addition to lowering risk factors for heart disease, these changes may cut dementia risk even further. Additional Research Shows That High-Fiber Diets Reduce Production of Inflammatory Molecules This new study is not the only research showing that a high-fiber diet can benefit the brain. Another recent study published in Frontiers in Immunology suggested that eating high-fiber foods might help delay brain aging by spurring butyrate production (a short-chain fatty acid shown in animal studies) to improve memory and reduce inflammation. Fiber-rich diets also appear to cut the expression of interleukin, an inflammatory cytokine produced in the body. In addition, fiber provides fuel for beneficial gut bacteria, which researchers say can strongly influence cognition and mood. But, that isn’t all. A 2021 review published in Antioxidants showed that plant foods are associated with “significant beneficial effects on cognitive function.” The improvements occurred “across the board” in young and elderly participants alike – and benefited them regardless of cognitive status. In other words, those who were cognitively “normal,” those who had mild cognitive impairment, and those with severe dementia all received benefits from the plant-based diet – a very encouraging result. What Are the Top Fiber-Rich Foods for Cognitive Health? Green leafy vegetables – like romaine, spinach, and dandelion greens – and cruciferous vegetables, like Brussels sprouts, bok choy, broccoli, and cauliflower, appear to “rule the roost” when it comes to cognitive benefits. Dandelion greens, in particular, receive high marks for their sky-high levels of fiber, vitamin C, and vitamin A. Cruciferous vegetables contain potent anti-inflammatory compounds known as isothiocyanate. In addition, these high-fiber vegetables are all rich in folate (or vitamin B9), which can reduce levels of homocysteine, an inflammatory chemical linked with heart disease. Close behind veggies in the ability to promote cognitive health are berries. Blueberries, in particular, contain purple/blue plant pigments called anthocyanins, which have been associated with cognitive benefits. In a study published in the Journal of Agriculture and Food Chemistry, supplementation with wild blueberry juice improved memory in older adults. As for ruby-red strawberries, these feature a compound known as fisetin, which has been linked with improvements in memory and cognition. One influential study found that subjects who ate larger amounts of strawberries were less likely to develop Alzheimer’s disease than those who didn’t indulge in berries! Blackberries, raspberries, and mulberries are also good choices for promoting cognitive health. Other foods believed to promote healthy brain function include nuts, oats, beans, olive oil, avocados, cold-water fatty fish, poultry, and green tea. Slow Down Cognitive Decline With Proper Nutrition and Wise Lifestyle Choices Although no diet can reverse advanced dementia, many natural health experts believe that proper nutrition has the potential to slow the early stages of cognitive decline and dementia. When it comes to specific diets to combat the onset of dementia, many natural health experts advise the MIND diet, short for the Mediterranean-DASH Intervention for Neurodegenerative Disease. This healthy way of eating combines aspects of the heart-healthy Mediterranean diet with those of the DASH (Dietary Approaches to Stop Hypertension) diet. Note: Whether it’s lurking in condiments such as ketchup or hiding in plain sight on powdered doughnuts, refined sugar is truly “bad news” for cognitive health. (Likewise for fried and processed foods, which may contain harmful trans fats). Excessive sodium (salt) intake can also threaten cognitive health. Opt instead for lemon, black pepper, and spices like basil and rosemary. By the way, the Academy of Nutrition and Dietetics advises that adults get 25 to 38 grams of fiber a day, with 21 to 30 grams recommended for people over 50. But experts say that only a meager 5 percent of Americans meet the daily adequate dietary intake level for fiber. This is unfortunate – because when it comes to maintaining health, multiple studies have confirmed the superiority of a plant-based, high-fiber diet over the conventional Standard American Diet (aptly abbreviated as S.A.D.!) Maybe it’s time to consider phasing out the SAD-ness – and incorporating more plant-based foods into your meals. Your body – and your mind! – will thank you. Sources for this article include: ScienceDaily.com PrimeHealthDenver.com MDPI.com NIH.gov NIH.gov MedicalNewsToday.com CDC.gov To read the original article click here.

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Fighting Autism Brain Inflammation with Food

AHA Publisher — Fri, 09 Apr 2021 07:00:30 +0000

Michael Greger M.D. FACLM via NutritionFacts – One food may be able to combat all four purported causal factors of autism: synaptic dysfunction, oxidative stress, mitochondrial dysfunction, and neuroinflammation. In a keynote address at an autism conference, Harvard neurologist Martha Herbert said, “I think we need to conduct research as if we know this is an emergency.” Already, up to 1.5 percent of American children have autism, and it appears to be on the rise. What about fever’s dramatic effect? “Dramatic relief of autistic behavior by infectious fever continues to tantalize parents and practitioners” and, indeed, from a research standpoint, “what could be more revealing than a common event that virtually ‘normalizes’ autistic behavior for a time?” But, “[t]here’s so much going on during fever.…Where to begin?” Once it became understood that one cause of autism may reside in the synapses—the “soul of the brain,” the nerve-to-nerve junctions where information is transmitted—attention turned to heat shock proteins, which are released by the brain when you have a fever. They can improvesynaptic transmission and, thus, may be capable of improving long-range brain connectivity, which is depressed in autism. A compound, sulforaphane, upregulates those heat shock proteins, so you could potentially get the benefits without the fever. Which drug company makes it? What do I ask for at the pharmacy? You don’t. As I discuss in my video Fighting Autism Brain Inflammation with Food, you just need to check out the produce section at your local market. Sulforaphane is not made in a chemical plant—it’s made by a plant. Sulforaphane is made by broccoli, kale, cabbage, collards, and cauliflower—in other words, cruciferous vegetables. Perhaps if we give broccoli to those with autism, it will make things better by boosting the heat shock proteins. But, as you can see at 1:57 in my video, synaptic dysfunction is not the only contributing cause of autism. There’s also oxidative stress. “The brain is particularly vulnerable to oxidative stress” because lots of free radicals are forged in the brain, which has few “antioxidant defense capacities.” And indeed, there is “a long history of studies showing that ASD [autism] is associated with oxidative stress and diminished antioxidant capacity.” Nrf2 levels are cut nearly in half, which is what triggers our body’s antioxidant response. Nrf2? What is that? It’s “considered to be a master regulator” of our body’s response to environmental stressors. If only there were a way to boost Nrf2 with foods. Well, there is. Sulforaphane just so happens to be perhaps “the most potent naturally occurring inducer” of Nrf2 on the planet. Under any kind of stress—oxidative stress, inflammatory stress—Nrf2 triggers our antioxidant response elements, activating all sorts of cell-protective genes that balance out and detoxify the free radicals and facilitate protein and DNA repair. So, maybe if we give some broccoli to those with autism, it will also make things better by triggering Nrf2, which activates those antioxidant response elements. There’s also the mitochondrial dysfunction. Children with autism are more likely to suffer from dysfunctional mitochondria, the little powerplants within our cells where metabolism takes place. If only there were some food that could improve mitochondrial function. And, there is: “A diet rich in cruciferous vegetables effectively retunes our metabolism by…restoring metabolic homeostasis,” or metabolic balance. Power plants for our cellular powerplants. As you can see at 3:58 in my video, not only can sulforaphane boost the gene expression of heat shock proteins as much as sixfold within six hours, but it can also double the mass of mitochondria in human cells growing in a petri dish. So, maybe if we give some broccoli to those with autism, it will also make things better by relieving some of that mitochondrial dysfunction that is creating even more free radicals. Can we just try giving these kids some broccoli already? Before we do, there’s one final factor. Neuroinflammation—brain inflammation—is another causal factor in autism. If, at autopsy, you look at brain tissue of those with autism, you can see inflammation throughout the white matter, and if you do a spinal tap, you’ll find up to 200 times the levels of inflammatory mediators, such as interferon, bathing their brains. What’s causing all that inflammation? Well, the master regulator of the inflammatory cascade is a protein called NF-kappa-beta, which induces inflammation. If overexpressed, as in autism, it can lead to chronic or excessive inflammation. If only there were a food… Really? Broccoli does that, too? Yes! In fact, the major anti-inflammatory mechanism for sulforaphane is inhibiting NF-kappa-beta. That completes the picture. Give broccoli to someone with autism, and heat shock proteins are released to boost synaptic transmission, Nrf2 is activated to wipe out the free radicals, mitochondrial function is restored, and we suppress the inflammation triggered by NF-kappa-beta. One food counters all four purported causal factors of autism. That’s one of the differences between foods and drugs. Drugs tend to have single effects. But, autism spectrum disorder ismultifactorial, so it’s no wonder there are no drugs that work. But “strategies using multi-functional phytochemicals” such as sulforaphane, or even better, the whole plants themselves “are highly attractive”…in theory. But you don’t know until you put it to the test, which I cover in my video Best Foods for Autism. You can also check: Flashback Friday: The Best Foods for Fighting Autism and Brain Inflammation. This article has been modified. To read the original article click here.

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