Nervous System Archives - Amazing Health Advances

Chemotherapy Linked to Persistent Nerve Pain in 4 in 10 Cancer Patients

The AHA! Team — Mon, 10 Mar 2025 06:33:48 +0000

BMJ Group via News-Medical – The drugs used to treat cancer damage healthy cells and tissues, including the nervous system. Worldwide, cancer chemotherapy is linked to persistent severe peripheral nerve pain (neuropathy) for around 4 in every 10 patients treated with these drugs, suggests a pooled data analysis of the available evidence, published in the open access journal Regional Anesthesia & Pain Medicine. Notwithstanding wide regional variations, platinum based drugs, taxanes, and lung cancer seem to be associated with the highest rates of persistent painful neuropathy, lasting at least 3 months, the findings suggest, prompting the researchers to call for tailored approaches to pain relief. The drugs used to treat cancer damage healthy cells and tissues, including the nervous system. The effects can manifest in movement disturbances, such as loss of balance or coordination, and sensory disturbances, such as loss of sensation; numbness, tingling, “pins and needles”; or a burning sensation on the skin. Several factors influence the frequency and severity of chronic peripheral neuropathic pain, including type and dose of chemotherapy, pre-existing neuropathy, and the use of other drugs that can damage the nervous system, explain the researchers. The condition is thought to be caused by direct peripheral nerve cell damage which disrupts or rewires normal nerve signalling pathways, resulting in persistent pain, they add. Prompted by the growing number of cancer survivors and increasingly aggressive treatment of the disease, the researchers wanted to gauge the global prevalence of chronic painful peripheral neuropathy linked to chemotherapy. They scoured research databases for relevant studies published between 2000 and 2024, focusing on potentially influential sociodemographic, clinical, and methodological (study design, funding source, for example) factors. In all, they pooled the results of 77 eligible studies, involving 10,962 participants from 28 countries, all of whom had peripheral neuropathy that was associated with cancer drug treatment. In 4545 of these participants, this was painful and persistent, lasting for at least 3 months. The highest number of studies were carried out in the US (13) and Japan (10), and almost half were prospective observational studies. The cancers that featured most often were those of the bowel (25; 33%) and breast (17; 22%), while the largest proportion of studies focused on patients treated with either platinum based agents (13;17%), or taxanes (11; just over 14%), or both (6 ;8%), or the FOLFOX combination of folinic acid plus 5-fluorouracil plus oxalplatin (5; 6.5%). Pooled data analysis of the study results showed that the overall prevalence of persistent painful peripheral neuropathy was just over 41%. When stratified further, the analysis indicated that the highest prevalence was among patients treated with platinum based agents (40.5%) and taxanes (just over 38%). Prevalence was lowest among those treated with the FOLFOX combination (16.5%). Prevalence was also highest among those with primary lung cancer (just over 62%), possibly because of the complexities of treatment for this disease, suggest the researchers. Prevalence was lowest among those with primary ovarian cancer (31.5%) and lymphoma (36%). When stratified by continent, studies of patients in Asia reported the highest prevalence of persistent painful neuropathy (46.5%), while studies of patients in Europe reported the lowest (36%). Prevalence rates were similar in both men and women. The researchers emphasize that the design and methodology of the included studies differed substantially. And the overall certainty of evidence was considered to be low. Researchers emphasize that the design and methodology of the included studies differed substantially But they write: “Understanding the prevalence and predictors of chronic painful [chemotherapy induced peripheral neuropathy] is critical for promoting early diagnosis and developing personalized treatment strategies. “Our findings emphasize that chronic painful [chemotherapy induced peripheral neuropathy] represents a substantial global health challenge, affecting more than 40% of those diagnosed with [it].” And they conclude: “The wide variability in prevalence rates across different countries, continents, chemotherapy regimens, and primary cancer history underscores the need for tailored strategies to address this debilitating condition. “Future studies should focus on elucidating the mechanisms underlying these disparities and developing interventions that can reduce the burden of chronic painful [chemotherapy induced peripheral neuropathy] globally.” Source: BMJ Group Journal reference: D’Souza, R. S., et al. (2025). Global estimates of prevalence of chronic painful neuropathy among patients with chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis of data from 28 countries, 2000–24. Regional Anesthesia & Pain Medicine. doi.org/10.1136/rapm-2024-106229 To read the original article click here.

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Gut Flora Disruption in Infancy Linked to Autism & ADHD

The AHA! Team — Thu, 09 May 2024 20:05:19 +0000

Linköping University via News-Medical – Disturbed gut flora during the first years of life is associated with diagnoses such as autism and ADHD later in life. This is according to a study led by researchers at the University of Florida and Linköping University and published in the journal Cell. The study is the first forward-looking, or prospective, study to examine gut flora composition and a large variety of other factors in infants, in relation to the development of the children’s nervous system. The researchers have found many biological markers that seem to be associated with future neurological development disorders, such as autism spectrum disorder, ADHD, communication disorder and intellectual disability. “The remarkable aspect of the work is that these biomarkers are found at birth in cord blood or in the child’s stool at one year of age over a decade prior to the diagnosis,” says Eric W Triplett, professor at the Department of Microbiology and Cell Science at the University of Florida, USA, one of the researchers who led the study. 16,000 children born in 1997-1999, representing the general population, have been followed from birth into their twenties The study is part of the ABIS (All Babies in Southeast Sweden) study led by Johnny Ludvigsson at Linköping University. More than 16,000 children born in 1997-1999, representing the general population, have been followed from birth into their twenties. Of these, 1,197 children, corresponding to 7.3 percent, have been diagnosed with autism spectrum disorder, ADHD, communication disorder or intellectual disability. A large number of lifestyle and environmental factors have been identified through surveys conducted on several occasions during the children’s upbringing. For some of the children, the researchers have analysed substances in umbilical cord blood and bacteria in their stool at the age of one. “We can see in the study that there are clear differences in the intestinal flora already during the first year of life between those who develop autism or ADHD and those who don’t. We’ve found associations with some factors that affect gut bacteria, such as antibiotic treatment during the child’s first year, which is linked to an increased risk of these diseases,” says Johnny Ludvigsson, senior professor at the Department of Biomedical and Clinical Sciences at Linköping University, who led the study together with Eric W. Triplett. Children who had repeated ear infections during their first year of life had an increased risk of being diagnosed with a developmental neurological disorder later in life. It is probably not the infection itself that is the culprit, but the researchers suspect a link to antibiotic treatment. They found that the presence of Citrobacter bacteria or the absence of Coprococcus bacteria increased the risk of future diagnosis. One possible explanation may be that antibiotic treatment has disturbed the composition of the gut flora One possible explanation may be that antibiotic treatment has disturbed the composition of the gut flora in a way that contributes to neurodevelopmental disorders. The risk of antibiotic treatment damaging the gut flora and increasing the risk of diseases linked to the immune system, such as type 1 diabetes and childhood rheumatism, has been shown in previous studies. “Coprococcus and Akkermansia muciniphila have potential protective effects. These bacteria were correlated with important substances in the stool, such as vitamin B and precursors to neurotransmitters which play vital roles orchestrating signaling in the brain. Overall, we saw deficits in these bacteria in children who later received a developmental neurological diagnosis.” -Angelica Ahrens, Assistant Scientist in Eric Triplett’s research group at the University of Florida and first author of the study The present study also confirms that the risk of developmental neurological diagnosis in the child increases if the parents smoke. Conversely, breastfeeding has a protective effect, according to the study. In cord blood taken at the birth of children, the researchers analysed the amounts of various substances from the body’s metabolism, such as fatty acids and amino acids. They also measured some harmful substances that come from outside, such as nicotine and environmental toxins. They compared substances in the umbilical cord blood of 27 children diagnosed with autism with the same number of children without a diagnosis. Children who were later diagnosed had low levels of several important fats in the umbilical cord blood It turned out that children who were later diagnosed had low levels of several important fats in the umbilical cord blood. One of these was linolenic acid, which is needed for the formation of omega 3 fatty acids that are anti-inflammatory and have several other effects in the brain. The same group also had higher levels than the control group of a PFAS substance, a group of substances used as flame retardants and shown to negatively affect the immune system in several different ways. PFAS substances can enter the body via drinking water, food and the air we breathe. It is not certain that the relationships that the research team found in the Swedish children can be generalised to other populations, but these issues need to be studied in other groups as well. Another question is whether gut flora imbalance is a triggering factor or whether it has occurred as a result of underlying factors, such as diet or antibiotics. However, even when the researchers accounted for risk factors that might affect the gut flora, they found that the link between future diagnosis remained for many of the bacteria. This indicates that some of the differences in gut flora between children with and without future diagnosis are not explained by such risk factors. The research is at an early stage and more studies are needed, but the discovery that many biomarkers for future developmental neurological disorders can be observed at an early age opens up the possibility of developing screening protocols and preventive measures in the long term. The study has been funded with support from, among others, JDRF, Horizon Europe, Barndiabetesfonden (the Swedish Child Diabetes Foundation), Forte and the Swedish Research Council. Source: Linköping University Journal reference: Ahrens, A. P., et al. (2024). Infant microbes and metabolites point to childhood neurodevelopmental disorders. Cell. doi.org/10.1016/j.cell.2024.02.035. To read the original article click here.

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One of the Best & Most Easily Accessible “Anti-Depressants”

AHA Publisher — Wed, 23 Feb 2022 08:00:38 +0000

Dr. Caroline Leaf – In this podcast (episode #358) and blog I talk about something we all do: laughing! Have you ever thought about why emitting sounds from our mouths gives us so much joy? Even when those sounds can sometimes come out like a cackle, grunt, wheeze or even a snort? When we do this, we are most likely filled with joy, although there are times when people laugh out of discomfort, shock, anger, and/or sadness. In almost all these situations, however, there is something about laughing that relieves us—it releases tension and can improve our mood in tangible ways. But what even is laughter? Physiologically, laughter is a sound that comes from our lungs with an exhalation of air. Our facial muscles contort when we laugh, and this is considered a somewhat involuntary or automatic response to some kind of stimulation. And if you think of it, laughter is literally a form of communication. It’s an intrinsic part of our language; it is part of how we understand and connect with other humans. There are even some studies that show humans laugh 17 times a day! Many of us love to laugh, which makes sense because it activates several reward systems in the brain. Studies have shown that laughing is heavily involved with the limbic system. The limbic system is the part of the brain involved in our behavioral and emotional responses. It responds to the energy of the mind by facilitating memory storage and retrieval, and in establishing our emotional states. The limbic system also becomes very active when we self-regulate (by paying focused attention to what the nonconscious mind is sending us up through the conscious mind), and links our conscious, intellectual functions of the cerebral cortex to the unconscious, autonomic functions of the brain stem. Essentially, the limbic system is involved in our emotional and behavioral responses, like laughing, that we need to live our lives. Indeed, the limbic system is connected to feeding, reproduction, caring for our young, and our “fight, flight, freeze or fawn” response. This suggests that laughing is literally one of our most intrinsic human behaviors! Laughter changes the neurochemicals in the brain, especially in the frontal lobe, which is associated with our emotions but also affects other parts of the brain. So, its impact is quite widespread! Studies have shown that laughter can have a similar effect on the brain as antidepressants. Laughing can activate the release of the neurotransmitter serotonin, the same brain chemical affected by the most common types of antidepressants, which helps regulate our mood and causes the release of oxytocin. Often called the empathy hormone, oxytocin helps individuals bond and form groups and communities. Laughter can also alter dopamine activity, while the endorphins secreted when we laugh can help us when we feel uncomfortable or depressed. Laughter can also reduce the level of stress hormones like cortisol and epinephrine, which can make us more resilient to the impacts of toxic stress. Laughing literally increases the amount of oxygen we have in our lungs. This, in turn, increases the amount of oxygen that flows throughout our body (in our blood), which goes to the heart and lungs and can increase the level of endorphins in our brain. This, in turn, helps us feel good and regulates our mood. The increased oxygen and blood flow can also help relieve muscle tension and help us think more clearly in the moment and make better decisions. Laughter can even act as a pain reliever by increasing blood and oxygen flow and releasing tension. Some studies have shown that laughing can result in a release of neuropeptides. These are short strings of amino acids that are synthesized in and released by neurons or glia, and can affect the function of the nervous system in the body. Neuropeptides can be extremely beneficial in fighting toxic stress, and can even increase our immune system functionality. If we think about the mind-brain-body connection, we know that what we think and feel will also affect our physical health. Negative thoughts can potentially affect our health if left unmanaged because thoughts are real structures in the brain. The neuropeptides that are released when we laugh can help us manage any toxic stress we have and can potentially make us more resilient. Laughter can even keep our telomeres healthy, which, as we observed in our recent clinical trials and I discussed in my book Cleaning Up Your Mental Mess, plays an important part of managing our mental health and resilience. Laughter is also good exercise! Some researchers estimate that laughing 100 times is equal to 10 minutes on the rowing machine or 15 minutes on an exercise bike. Indeed, many times people feel exhausted after laughing because of all the muscles it activates—it really is like a workout! We all know that when we laugh at something humorous, we tend to feel better. When something makes us laugh, like a funny video or silly joke, we essentially give our mind and body a break, which is also great for our wellbeing. A therapist friend of mine recently told me how she uses laughing to manage the stress of their job and not feel broken by listening to people’s deepest pains and fears all day long. She said that every morning while she gets ready and drives to work she listens to a podcast that makes her laugh. She uses this time to focus her mind on funny things and give her brain an opportunity to rest before starting the day. By doing this every day, she gives herself time to prepare herself mentally for the day ahead and not feel worn out by the time she gets to work. We should all try to laugh more, regardless of what we do for a living. As mentioned above, all the neurochemicals and endorphins that begin to flow in our brains when we laugh can help with feelings of depression, sadness and anxiety we all experience. Even in situations when we are angry or sad, laughing can help ease our pain and frustration. No wonder more and more psychologists and mental health professionals are promoting different types of “laughing therapy”. The idea behind laughing therapy is to teach people how to use humor as a healthy coping mechanism. Laughing is cathartic, it makes us feel joy, and it relieves our tension. It is an emotional release, so laugh more! It’s a fun kind of therapy! I recommend finding out what makes you laugh and incorporating that into your daily schedule. I personally love watching my dogs play with each other, which never fails to make me laugh, or watching silly animal videos online! Read funny memes, watch funny TV shows, go to comedy shows, spend more time with funny people—whatever you love best! Check out this helpful link to find more things to make you laugh. To read the original article click here.

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Anesthetize Nerve Cells to Shrink Breast Tumors?

AHA Publisher — Wed, 10 Nov 2021 08:00:09 +0000

Abigail Klein Leichman via Israel21c – Researchers at the Technion-Israel Institute of Technology have developed an innovative treatment for breast cancer, based on analgesic nanoparticles that target the nervous system. The researchers found that cancer cells stimulate infiltration of nerve cells into the tumor, and these cells then help the cancer cells proliferate, grow and migrate. Based on these findings, they tried targeting the tumor through the nerve cells. Nanoparticles containing an anesthetic are injected into the bloodstream. Once they reach the tumor, they accumulate around its nerve cells and paralyze the local nerves — and communication between the nerve cells and cancer cells. When tested on cancer cell cultures and on lab mice, the method led to a significant inhibition of tumor development and of metastasis to the lungs, brain and bone marrow. The study, published in Science Advances, was led by Prof. Avi Schroeder and chemical engineering PhD student Maya Kaduri. Schroeder, head of the Louis Family Laboratory for Targeted Drug Delivery & Personalized Medicine Technologies, develops innovative cancer treatments, including for breast cancer and specifically for aggressive triple-negative breast cancer. He encapsulates drug molecules in nanoparticles, which transport the drug to the tumor and release it inside, without damaging healthy tissue. Kaduri explained that blood vessels formed in tumors contain nano-sized holes that enable penetration of nanoparticles, while healthy tissue does not have such holes. “We know how to create the exact size of particles needed, and that is critical because it’s the key to penetrating the tumor,” she said. “The fact that this is a very focused and precise treatment enables us to insert significant amounts of anesthetic into the body because there is no fear that it will harm healthy and vital areas of the nervous system.” The researchers believe the new approach may be relevant for treating breast cancer in humans. The study was supported by the Rappaport Technion Integrated Cancer Center as part of the Steven & Beverly Rubenstein Charitable Foundation Fellowship Fund for Cancer Research, and by Teva, as part of its National Forum for BioInnovators. The research was conducted in cooperation with the Faculty of Medicine at Hebrew University of Jerusalem and the Institute of Pathology at Tel Aviv Sourasky Medical Center. To read the original article click here.

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Roswell Park Researchers Identify Key Link Between Stress and Cancer

AHA Publisher — Mon, 08 Nov 2021 08:00:50 +0000

Roswell Park Comprehensive Cancer Center via Newswise – BUFFALO, N.Y. — Stress can have a significant negative effect on health, but our understanding of how stress impacts the development and progression of cancer is just beginning. A team from Roswell Park Comprehensive Cancer Center has identified an important mechanism by which chronic stress weakens immunity and promotes tumor growth. Their findings, just published in Cell Reports, point to the beta-adrenergic receptor (β-AR) as a driver of immune suppression and cancer growth in response to stress, opening the possibility of targeting this receptor in cancer therapy and prevention. Using a preclinical model of triple-negative breast cancer, a research team led by Hemn Mohammadpour, PhD, DVM, a postdoctoral research affiliate in the lab of Elizabeth Repasky, PhD, and Dr. Repasky, who is Co-Leader of the Cell Stress and Biophysical Therapies Program and the Dr. William Huebsch Professor in Immunology at Roswell Park, found that as tumors grow, they become more sensitive to stress signals coming from the nervous system. Specifically, the researchers discovered that a population of immune cells known as myeloid derived suppressor cells (MDSCs) show an increase in the expression of β-AR, a molecule that controls the function of key immune cells. The findings will help researchers better understand why prolonged exposure to stress often makes our immune system less effective, and build on Roswell Park’s pioneering research into the relationship between stress and cancer. “This increase in β-AR expression on myeloid-derived suppressor cells allows these cells to be stimulated by the stress hormone norepinephrine, which fosters an immunosuppressed environment that promotes tumor growth by increasing MDSCs’ ability to generate and process energy and suppress anti-tumor immune response,” says Dr. Mohammadpour, the paper’s first author. “This study provides some very important clues that help explain the specific mechanisms by which prolonged stress stimulates tumor growth and decreases lifespan.” While there has been a longstanding recognition that long periods of stress, or chronic activation of nerves, are harmful to overall health, details about how this occurs are unclear, especially in the setting of cancer. A better understanding of the specific ways in which stress influences cancer, particularly in terms of lowering immunity against tumor cells, could be used to design new drugs or therapies that can help to minimize negative effects of chronic stress and boost cancer immunotherapy. Based on these findings, Dr. Repasky’s team is planning new clinical and laboratory studies to identify therapies — including existing therapies already approved for other applications — that can block these harmful stress signals and stop the negative cycle of cancer growth and metastasis. “This is especially important for cancer patients, who frequently endure greatly increased levels of stress after their diagnosis, including anxiety, depression and worry about factors like finances and family interactions,” adds Dr. Mohammadpour. Several clinical trials are planned or underway to investigate which interventions are most effective at mitigating the effects of stress in patients with cancer. Roswell Park is currently studying the effects of combining the β-AR blocker propranolol, which is traditionally used to treat migraine headache and various heart problems, with immunotherapy. The study, “β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME,” was supported by the National Institutes of Health and National Cancer Institute (grants R01CA205246, R01CA099326, R01CA172105, F32CA239356, K99 HL155792, T32CA085183 and F30CA265127 and P30CA016056, Roswell Park’s core grant from the NCI) and by the Roswell Park Alliance Foundation. Co-authors include Philip McCarthy, MD, Professor of Oncology and Internal Medicine and Director of Roswell Park’s Transplant & Cellular Therapy Center; Scott Abrams, PhD, Co-Leader of Roswell Park’s Tumor Immunology and Immunotherapy Program; and Cameron MacDonald, a predoctoral trainee in immunology. To read the original article click here.

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Tuna Pasta Salad with Kalamata Olives and Cherry Tomatoes Recipe

AHA Publisher — Thu, 05 Aug 2021 07:00:22 +0000

Dr. Josh Axe, DC, DNM, CN – Like tuna mac and cheese, tuna pasta salad is an easy way to take a classic pasta dish and significantly up its protein content. No matter your age or athletic activities, getting enough protein in your diet is important for everyone. Signs of a protein deficiency can range from moodiness to poor sleep to slow healing. This tuna macaroni salad recipe is a perfect and delicious way to get more protein in your diet. Plus, it’s such an easy dish to make. Key Ingredients But wait, is this recipe healthy? Tuna pasta salad, also called tuna macaroni salad or tuna noodle salad, is as healthy as the ingredients you put into it. In this case, we use a low-mercury tuna, gluten-free pasta and a whole lot of nutrient-rich ingredients, including olives, tomatoes, bell pepper, capers and red onion. This cold tuna pasta salad recipe is perfect to make on a Sunday evening, so you have a quick and easy, yet well-balanced and healthy, lunch option for the week ahead! Tuna is very high in protein as well as anti-inflammatory omega-3 fatty acids. It’s also rich in important nutrients, like: vitamin D selenium niacin riboflavin vitamin B12 vitamin B6 potassium zinc magnesium As a rich source of niacin, tuna is excellent for cardiovascular health and balancing cholesterol levels. Niacin is also key to the healthy function of the skin, nervous system and digestive system. Tuna’s impressively high vitamin B6 content means it’s a great choice for brain function, mood, energy levels and blood flow. There are actually several varieties of tuna, and some can definitely be healthier than others. For example, Atlantic bluefin tuna’s high mercury content — plus its near extinction due to overfishing — lands it on my list of 17 Fish You Should Never Eat + Safer Seafood Options. Mercury poisoning is definitely a concern when it comes to eating seafood. It’s an important topic in general, but it’s especially important when it comes to young children and pregnant women since excessive consumption of mercury-contaminated fish is known to have major negative effects on a child’s development. So, what about canned tuna? There are two main varieties of canned tuna you can find on store shelves: white albacore tuna or light tuna, which is typically skipjack. According to data from the Environmental Protection Agency, canned light skipjack tuna usually has about a third of the mercury levels of albacore canned tuna. The EPA labels light canned tuna as a “best choice,” while white albacore canned tunas is a “good choice.” For kids, the EPA recommends that a “best choice,” like light canned tuna from skipjack, can be eaten two times per week in the following amounts: Age 2: 1 ounce per serving Age 6: 2 ounces per serving Age 9: 3 ounces per serving Age 11 and up: 4 ounces per serving The Food and Drug Administration recommends that women of childbearing age (between 16 and 49 years), especially pregnant and nursing women, eat two to three servings of “best choices” or one serving of a “good choice” fish per week. Again, light canned tuna makes the best choice list, while white albacore is on the good list. For more information, check out the FDA’s Eating Fish: What Pregnant Women and Parents Should Know. If you’re going to eat tuna, look for tuna that is light and skipjack. However, beware of light canned tuna that is from yellowfin tuna because this is said to have higher mercury levels similar to albacore. In addition to tuna nutrition benefits, some other nutritional highlights of this creamy tuna pasta salad with veggies recipe include: Brown rice pasta: Pasta made from brown rice does provide carbohydrates like other pastas. However, brown rice pasta is gluten-free, and it is also full of vitamins and minerals, as well as fiber and protein to balance its carb content. Red onion: A red onion provides beneficial onion nutrition — plus it is especially high in quercetin, which has been shown to have anti-inflammatory and antioxidant effects. Bell pepper: Bell peppers are rich in vitamin C and vitamin A. They are also high in carotenoids called lutein and zeaxanthin. Research has shown that increased consumption of these carotenoids may decrease the risk of developing age-related macular degeneration. How to Make Tuna Pasta Salad Macaroni salad with tuna doesn’t require any serious culinary skills, so this recipe is friendly to even the most novice of cooks. To prep for this recipe, you’ll need to have the olives, tomatoes, onion and peppers chopped up. You’ll also need to have your pasta cooked according to the package directions and allow it to cool down before adding it to the mixture. That’s it! Now you’re ready to combine everything together. First, you can add the cooked pasta and tuna to a large bowl. Add in the red onion. Toss in the Kalamata olives. The bell pepper (red, green and/or yellow) can go in next. Add in the capers. Last but not least, add the Paleo mayonnaise and Dijon mustard to the bowl. Mix it all together until well-combined. Before serving, top the macaroni tuna salad with chopped green onions and microgreens for a boost of flavor and nutrients. If you’re not going to eat the tuna pasta salad right away, keep it covered and refrigerated until ready to serve. Enjoy! Tuna Pasta Salad with Kalamata Olives and Cherry Tomatoes DESCRIPTION Like tuna mac and cheese, tuna pasta salad is an easy way to take a classic pasta dish and significantly up its protein content. INGREDIENTS One 12-ounce box brown rice macaroni pasta, cooked Two 5-ounce cans wild-caught tuna ½ red onion, chopped ½ cup kalamata olives, pitted ½ cup bell peppers, chopped 2 tablespoons capers 1 cup cherry tomatoes, sliced ⅓ cup Paleo mayo ⅓ cup Dijon mustard ½ teaspoon salt ½ teaspoon pepper TOPPINGS: ½ cup green onions, chopped ¼ cup microgreens INSTRUCTIONS Cook the pasta and chop the veggies. Add all the ingredients to a large bowl, mixing until well-combined. Keep refrigerated until ready to serve. Top with chopped green onions and micro greens. NOTES Top the salad with green onions and microgreens if you choose for added flavor and nutrition. If you want to avoid mayo, you can use mashed avocado as the binder. Feel free to customize this recipe with your choice of vegetables added. To read the original article click here.

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NEW STUDY Shows This Extract Reduces the Harmful Effects of EMF Radiation

AHA Publisher — Mon, 07 Dec 2020 08:00:12 +0000

Edit Lang via NaturalHealth365 – Although the wireless industry claims that exposure to wireless radiation is “safe,” numerous studies have shown that EMF radiation is harmful to the human body. Each day, we are exposed to more wireless, cellular, microwave, and electric fields than ever before in history. No matter how hard we try, it is impossible to completely avoid EMF exposure and still participate in our modern society. Thankfully, new research reveals an easy way to help protect ourselves against the damaging effects of EMF radiation. Is 5G a breakthrough innovation or a threat to human health? The use of radiofrequency (RF) EMF is on the rise, despite the overwhelming evidence revealing its potential to harm humans. One of the most alarming ways RF-EMF damages the body is by increasing oxidative stress. Free radical damage and oxidative stress are involved in cancer onset and numerous chronic diseases. Even though EMF safety is highly controversial, plenty of evidence exists to justify the WHO IARC’s decision to classify RF-EMF as a “possible human carcinogen.” Many are concerned with the potential danger that 5G has in store for humankind. Governments around the world are aggressively rolling out their 5G infrastructure. The technology uses submillimeter and millimeter waves and relies on EHF (extremely high frequency) ranges between 6 GHz and 100 GHz – and beyond. Although the physiological effects of 5G systems are unknown, preliminary observations showed that millimeter waves trigger a host of processes that can be devastating to our bodies. Hundreds of members of the international scientific community have been urging regulators to conduct further studies to explore how millimeter waves affect human health. WARNING: EMF harms your health in many ways A substantial body of evidence confirms that EMF exposures inflict widespread damage on the human body. EMFs attack our nervous and endocrine systems and produce oxidative stress. The radiation can alter our cells’ DNA, elevate programmed cell death, lower fertility, and even cause cancer. The risks are real, yet, most users are unaware of the potential harm. EMFs have also been linked to life-threatening cardiac effects, early-onset dementia, and even Alzheimer’s. Pregnant women and children are at particularly high risk. Evidence shows that EMF exposure before and shortly after birth can lead to ADHD and autism. “FCC-compliant” radiation levels do not equal “safe” Tragically enough, the over 2,000 peer-reviewed studies documenting the biological and health effects inflicted on humans by non-ionizing radiation were not enough to warrant the adoption of federal safety standards. Hundreds of recent studies demonstrate adverse health effects from headaches to many types of cancer, including brain cancer caused by levels far lower than those considered acceptable by the FCC. Nonetheless, governing bodies conducted no long-term studies to ensure public safety. Instead, the US government issued “guidelines” developed by the industry, using outdated research. Rosemary extract protects against the harmful effects of EMF Although the repercussions of long-term EMF exposure can be severe, the good news is, you can help buffer your body against its damaging effects. A popular culinary herb may allow your cells to recover from overexposure and remove some of the radiation from your body. Rosemary is a common herb that is well-known for its potent antioxidant and anti-inflammatory properties. In a 2020 study, scientists tested the antioxidant property of rosemary extract by exposing rats to electromagnetic fields. Results showed that rosemary extract reduced EMFs’ destructive effect, confirming its potential preventative benefits. In a 2016 study, a group of researchers came to similar conclusions after exposing rats to mobile phone EMFs. In rats not treated with rosemary, EMF exposure induced structural changes in connective tissues, and increased oxidative stress. Rats treated with rosemary extract faired much better and experienced a boost in antioxidant activity. How to use rosemary for EMF protection You can take rosemary extract in a tincture or capsules. However, drinking a cup of rosemary tea daily may be the easiest way to benefit from the herb’s protective compounds. Boil 1-2 cups of water. Add 1-2 inches of finely chopped rosemary leaves to your cup. Pour hot water over the leaves. Allow to steep for 10 minutes, strain, and enjoy! Sources for this article: NIH.gov, NaturalHealthResearch.org , NaturalHealth365.com

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Novel Formulation Permits Use of Toxin from Rattlesnake Venom to Treat Chronic Pain

AHA Publisher — Mon, 17 Feb 2020 08:00:53 +0000

FUNDAÇÃO de AMPARO À PESQUISA DO ESTADO DE SÃO PAULO via EurekAlert – Researchers Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica — the results of tests in an animal model of neuropathic pain are promising. Crotoxin, extracted from the venom of the South American rattlesnake Crotalus durissus terrificus, has been studied for almost a century for its analgesic, anti-inflammatory and antitumor activities and as an even more powerful muscle paralyzer than botulinum toxin. However, the toxicity of crotoxin limits its medicinal use. A new study, published by Brazilian researchers in the journal Toxins, shows that crotoxin’s therapeutic effects can be enhanced and its toxicity reduced when it is encapsulated in nanostructured SBA-15 silica, a material originally developed for use in vaccine formulations. The study was conducted under the aegis of Brazil’s National Science and Technology Institute (INCT) on Toxins, one of the INCTs supported by FAPESP (São Paulo Research Foundation) in São Paulo State in partnership with the National Council for Scientific and Technological Development (CNPq), an agency of the Brazilian government. The INCT’s principal investigator is Osvaldo Augusto Sant’Anna. The study was part of the doctoral research of Morena Brazil Sant’Anna, whose thesis advisor is Gisele Picolo. Picolo herself was the principal investigator for a project on the same topic. Researchers Flavia Souza Ribeiro Lopes and Louise Faggionato Kimura participated in the study, which was performed at Butantan Institute in São Paulo. Osvaldo Sant’Anna is the principal investigator for a Thematic Project at Butantan Institute to study mesoporous silica as a vaccine adjuvant in collaboration with Márcia Fantini, a professor at the University of São Paulo’s Physics Institute (IF-USP). An adjuvant is an agent used in conjunction with a vaccine antigen to augment the host’s antigen-specific immune response. “People who respond badly to vaccines usually have macrophages that catabolize the antigen very quickly, so there isn’t time for their lymphocytes to induce a complete response in terms of producing antibodies,” Osvaldo Sant’Anna told Agência FAPESP. “Research has shown that nanostructured silica slows the macrophages down.” Osvaldo Sant’Anna’s studies show that mice produce more antibodies against an antigen when it is administered with silica, which is made up of microstructures and can be molded to encapsulate molecules of varying shapes and sizes. When silica was tested with other toxins, a novel protective effect was discovered. “In tests conducted in horses to produce anti-diphtheria serum and with tetanus toxin, we found that silica makes antigens less potent and reduces the adverse effect of diphtheria toxin,” Osvaldo Sant’Anna said. These findings were welcomed by Picolo and Morena Brazil Sant’Anna, colleagues of Osvaldo Sant’Anna at Butantan Institute. “I’ve been studying crotoxin since 2011. The results are positive in terms of its analgesic effect, but its toxicity has always been a constraint. Using silica was a great idea. This is the first time the two molecules have been combined,” Picolo said. Neuropathic Pain The article published in Toxins reports on a study designed to investigate the effects of crotoxin combined with SBA-15 silica when used to treat neuropathic pain, a chronic condition caused by injuries to sensitized nerves. Treating chronic pain is a challenge for physicians because ordinary painkillers such as anti-inflammatory drugs and opioids do not have the desired effect. To evaluate crotoxin’s therapeutic potential in this setting, the researchers conducted experiments with mice, inducing a condition similar to neuropathic pain by injuring the sciatic nerve. The first positive finding resulted from a test to determine the maximum dose of crotoxin with and without silica. “We observed that a larger amount of the toxin combined with silica could be administered without adverse side effects and that the dose could therefore be increased,” Morena Brazil Sant’Anna said. It was possible to administer a 35% larger dose of crotoxin when it was combined with silica. The next step was to test the formulation in animals. They were given the crotoxin/silica complex (CTX:SBA-15) while experiencing acute pain (immediately after a sciatic nerve injury procedure) or chronic pain (a fortnight later). In both cases, the complex was administered in a single dose or in five doses (one daily dose for five consecutive days). In the acute stage as well as the chronic stage, the analgesic effect lasted longer when crotoxin was combined with silica. In one of the tests, a single dose was sufficient to reverse hypernociception (heightened sensitivity to painful stimuli) until 48 hours after it was administered. Action Mechanisms Crotoxin is a powerful painkiller because it acts on different pain pathways. To determine whether its action mechanisms would be the same in the new formulation, the researchers administered antagonists of the receptors involved in pain shortly before the crotoxin/silica complex. If the complex was effective even with the receptors blocked, this would mean its action mechanism could be different from that of the conventional molecule. “We found that muscarinic and adrenergic receptors, which act on the nervous system, and formyl receptors, which are targets for natural anti-inflammatory compounds, were involved in the action of the crotoxin/silica complex. In other words, there was no change in the action mechanism,” Morena Brazil Sant’Anna said. The team observed changes in the levels of pro- and anti-inflammatory cytokines. “Expression of interleukin 6 [IL-6], which is associated with inflammation, decreased, while the level of IL-10, which controls the inflammatory process, increased. We also observed a reduction in activation of astrocytes and microglia, central nervous system cells involved in inflammatory responses,” Picolo said. Because silica influences the immune response, the researchers decided to see whether the defense against toxicity it triggers would end up hindering crotoxin’s beneficial action. This possibility was tested and ruled out in the study. The mice produced high levels of antibodies, but this did not affect the outcome, according to Picolo. “Probably because the crotoxin was encapsulated and the antibodies produced were unable to reach it,” she said. The complex gains another advantage from this protection: it could be administered orally to mice, for the first time, with positive results. This was possible because the structure of SBA-15 is similar to that of a honeycomb, protecting the active ingredient against breakdown in the stomach. “It also guarantees controlled release of the crotoxin in the organism, which may explain the lasting analgesic effect,” Picolo said. Next Steps The researchers are now investigating whether the combination of crotoxin with SBA-15 can be used to treat multiple sclerosis. The results of this research have also been positive so far, and an article will soon be published. However, more studies will be necessary before the combination can become medication. “Crotoxin is a large molecule with a complex structure that’s hard to replicate in the laboratory, so scaled-up use is a long away off,” Picolo said. Some form of synthesis would be the ideal solution. Trials are currently ongoing with purified venom extracted directly from the rattlesnake. To read the original article click here.

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New Compound Promotes Healing of Myelin in Nervous System Disorders

The AHA! Team — Mon, 09 Sep 2019 07:00:00 +0000

Oregon Health and Science University via EurekAlert – OHSU-led research could lead to clinical trials in people with multiple sclerosis or other neurodegenerative conditions. Scientists have developed a compound that successfully promotes rebuilding of the protective sheath around nerve cells that is damaged in conditions such as multiple sclerosis. In a study published today in the journal Glia, scientists described successfully testing the compound in mice. Researchers at Oregon Health & Science University have already started to apply the compound on a rare population of macaque monkeys at the Oregon National Primate Research Center at OHSU who develop a disease that is similar to MS in humans. “I think we’ll know in about a year if this is the exact right drug to try in human clinical trials,” said senior author Larry Sherman, Ph.D., an OHSU professor in the Division of Neuroscience at the primate center. “If it’s not, we know from the mouse studies that this approach can work. The question is, can this drug be adapted to bigger human brains?” The discovery culminates more than a decade of research following a 2005 breakthrough by Sherman’s lab. In that study, scientists discovered that a molecule called hyaluronic acid, or HA, accumulates in the brains of patients with MS. Further, the scientists linked this accumulation of HA to the failure of cells called oligodendrocytes to mature. Oligodendrocytes generate myelin. Myelin, in turn, forms a protective sheath covering each nerve cell’s axon – the threadlike portion of a cell that transmits electrical signals between cells. Damage to myelin is associated with MS, stroke, brain injuries, and certain forms of dementia such as Alzheimer’s disease. In addition, delay in myelination can affect infants born prematurely, leading to brain damage or cerebral palsy. Subsequent studies led by the Sherman lab showed that HA is broken down into small fragments in multiple sclerosis lesions by enzymes called hyaluronidases. In collaboration with Stephen Back, M.D., Ph.D., a professor of pediatrics in the OHSU School of Medicine, Sherman discovered that the fragments of HA generated by hyaluronidases send a signal to immature oligodendrocytes not to turn on their myelin genes. That led researchers to explore how they might block hyaluronidase activity and promote remyelination. For the past decade, an international team of researchers led by OHSU has been working to develop a compound that neutralizes the hyaluronidase in the brains of patients with MS and other neurodegenerative diseases, thereby reviving the ability of progenitor cells to mature into myelin-producing oligodendrocytes. The study published today describes a modified flavonoid – a class of chemicals found in fruits and vegetables – that does just that. The compound, called S3, reverses the effect of HA in constraining the growth of oligodendrocytes and promotes functional remyelination in mice. Lead author Weiping Su, Ph.D., senior scientist in the Sherman lab, dedicated years of intensive research to make the discovery. “It’s not only showing that the myelin is coming back, but it’s causing the axons to fire at a much higher speed,” Sherman said. “That’s exactly what you want functionally.” The next phase of research involves testing, and potentially refining, the compound in macaque monkeys who carry a naturally occurring version of MS called Japanese macaque encephalomyelitis. The condition, which causes clinical symptoms similar to multiple sclerosis in people, is the only spontaneously occurring MS-like disease in nonhuman primates in the world. To read the original article click here.

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