Expiring Medications Could Pose Challenge on Long Space Missions

The AHA! Team — Fri, 18 Oct 2024 08:11:11 +0000

Duke Health – Medications used by astronauts on the International Space Station might not be good enough for a three-year journey to Mars. A new study led by Duke Health shows that over half of the medicines stocked in space — staples such as pain relievers, antibiotics, allergy medicines, and sleep aids — would expire before astronauts could return to Earth. Astronauts could end up relying on ineffective or even harmful drugs, according to the study appearing July 3 in npj Microgravity, a Nature journal. “It doesn’t necessarily mean the medicines won’t work, but in the same way you shouldn’t take expired medications you have lying around at home, space exploration agencies will need to plan on expired medications being less effective,” said senior study author Daniel Buckland, M.D., Ph.D., an assistant professor of emergency medicine at Duke University School of Medicine and an aerospace medicine researcher. Expired medications can lose their strength by a little – or a lot. The actual stability and potency of medications in space compared to Earth remain largely unknown. The harsh space environment, including radiation, could reduce the effectiveness of medications. Buckland and co-author Thomas E. Diaz, a pharmacy resident at The Johns Hopkins Hospital, noted that expired medications could pose a challenge as space agencies plan for long-duration missions to Mars and beyond. Diaz used a Freedom of Information Act Request to obtain information about the space station formulary, assuming NASA would use similar medications for a Mars mission. Using a database of international drug expiration dates, the researchers determined that 54 of the 91 medications had a shelf-life of 36 months or less. Using the most optimistic estimates, about 60% of these medications would expire before a Mars mission concludes. Under more conservative assumptions, the figure jumps to 98%. The study did not assume accelerated degradation but focused on the inability to resupply a Mars mission with newer medicines. This lack of resupply affects not only medications but also other critical supplies, such as food. Increasing the number of medications brought on board could also help compensate for lowered efficacy of expired meds, authors said. “Those responsible for the health of space flight crews will have to find ways to extend the expiration of medications to complete a Mars mission duration of three years, select medications with longer shelf-lives, or accept the elevated risk associated with administering expired medication,” Diaz said. “Prior experience and research show astronauts do get ill on the International Space Station, but there is real-time communication with the ground and a well-stocked pharmacy that is regularly resupplied, which prevents small injuries or minor illnesses from turning into issues that affect the mission,” Buckland said. Additional authors include Emma Ives and Diana I. Lazare. The study received no external funding. To read the original article click here.

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Chemist Aims at COVID-19 Following Success With Related Virus

AHA Publisher — Tue, 31 Mar 2020 07:00:15 +0000

Case Western Reserve University via Newswise – International group led by Ohio researcher Blanton seeks expanded NIH support to ‘target virus at molecular level.’ Newswise — CLEVELAND—A team of scientists, led by Case Western Reserve University chemistry Professor Blanton Tolbert and his research lab, are conducting the underlying research to develop an antiviral to slow the spread of novel coronavirus that causes COVID-19. Tolbert said he and research partners from Duke and Rutgers universities hope to hear soon from the National Institutes of Health (NIH) whether their project to develop an antiviral against the novel coronavirus behind the global pandemic of COVID-19 will receive funding. The research team recently laid the groundwork to develop novel antivirals against Enterovirus 71 (EV71), a similar RNA virus that causes hand, foot and mouth disease. Tolbert said they are now poised to make significant inroads into identifying vulnerable COVID-19 targets. “We’ve already shown the necessary ‘proof of concept’ with EV71, which shows we know how to get things done,” Tolbert said. “And now we have assembled an expanded international group to include scientists from the University of Michigan, the United Kingdom and Taiwan, where they isolated some very early COVID-19 viruses from two infected patients at Chang Gung Memorial Hospital.” Tolbert said that his Taiwanese collaborators have been able to clone the novel coronavirus in the lab, providing a copy to study at the molecular level—the first step in learning how it works. Tolbert’s lab studies basic biochemical processes of ribonucleic acid (RNA) viruses, working to better understand the physical interactions between the virus and host. Their most recent work has determined the 3D structures of pieces of viruses from HIV and EV71, he said. While EV71 is not a coronavirus, both fall under “the bigger umbrella of positive-sense RNA viruses that infect humans,” he said. “And if you can figure out how the virus interacts with the cellular environment it has infected, where the real activity takes place, you can understand it better,” Tolbert said. “You can look at how it takes over the cellular machinery with the ultimate goal of making drugs to block those processes. But first you have to know how it hijacked the cells in the first place.” Early Start on Coronavirus Focus It was still early February of this year when Tolbert sat in a conference room in Durham, North Carolina, with colleagues from Rutgers and host Duke University. They were meeting to celebrate their recent success with EV71 and to talk about next steps in publishing (their work is published on a pre-print site, but not yet in a named journal) and expanding their work on that particular virus. But a new, still barely known novel virus, which had just appeared in Wuhan, China, was also on their minds. China had just recently shared the genetic sequence of the novel coronavirus on Jan. 12, and soon the World Health Organization would declare a public health emergency of international concern over the global outbreak of the novel coronavirus, then referred to as nCoV. So when Tolbert and his colleagues turned their attention and expertise toward COVID-19, they were ahead of the curve, he said. The NIH didn’t even announce for another two weeks that emergency funds to fight COVID-19 were available. “We were already working on something for which there are no antivirals, something with high mortality and morbidity (illness and other conditions associated with the virus) rates—especially for children in Southeast Asia,” he said. “So when we saw the early signs that this coronavirus had no antivirals or vaccine, we decided to see how we might get involved, knowing we already had that proof-of-concept with this other virus.” He said how quickly the research group hears from the NIH on whether it will get a new influx of funding to tackle COVID-19 will likely depend on whether the agency considers the work urgent enough—either for “flattening the curve,” the phrase for leveling out over time the rapidly rising number of cases, or finding a permanent antiviral. “I cannot anticipate what is coming next,” he said. “This is something that needs to be done if an antiviral is going to be achieved. The bottom line is that we believe we are equipped and ready to go, and we can make a difference. “I don’t know if that means it will lead directly to an antiviral yet, but I believe we can find ways to target this at the molecular level.” To read the original article click here.

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Expiring Medications Could Pose Challenge on Long Space Missions

Chemist Aims at COVID-19 Following Success With Related Virus