liver disease Archives - Amazing Health Advances

Obesity’s Impacts on Our Immune System & Kidney & Liver Diseases

The AHA! Team — Wed, 18 Jun 2025 05:24:00 +0000

Michael Greger M.D. FACLM via Nutrition Facts – What are the effects of weight loss on natural killer cell function, our first line of immune defense against cancer, kidney function, and fatty liver disease? In the ABCs of the health consequences of obesity, I is for Immunity. The SOS trial followed the fates of thousands of bariatric surgery patients for a decade or two, compared to a control group who maintained their weight. Those who surgically lost about 20 percent of their body weight not only lived longer, thanks in part to less diabetes and less cardiovascular disease, but they also got less cancer. This may be because anti-tumor immunity appears to be affected by weight. Natural killer cells are our immune system’s first line of defense against cancer cells and many viral infections, “and their function is severely impaired in individuals with obesity.” When individuals who were obese were randomized to a weight-loss program, researchers found a significant reactivation of the participants’ natural killer cell function within just three months. The program involved an exercise component, though, so it’s hard to tease out the impact of the weight loss itself since physical activity on its own can boost natural killer cell activity. On the other end of the immune spectrum, obesity is suspected to be a causal risk factor for the development of the autoimmune disease multiple sclerosis. This suggests obesity is associated with the worst of both worlds when it comes to immune function: underactivity when it comes to protecting against cancer and infection, and overactivity when it comes to certain inflammatory autoimmune conditions. J is for Jaundice. Thanks to the obesity epidemic, nonalcoholic fatty liver disease is now the most common liver disorder in the industrialized world. Fat doesn’t just end up in our belly and thighs but inside some of our internal organs. More than 80 percent of individuals with abdominal obesity may have fatty infiltration into their liver, and in those with severe obesity, the prevalence can exceed 90 percent. This can lead to inflammation, scarring, and, ultimately, cirrhosis and liver cancer, as you can see below and a 2:10 in my video The Effects of Obesity on the Immune System and Kidney and Liver Diseases. Currently, this nonalcoholic fatty hepatitis is the leading cause of liver transplants in American women. K is for Kidneys. Obesity is also “one of the strongest risk factors for new-onset chronic kidney disease.” Our kidneys compensate for the metabolic demands of excess weight by red-lining into what’s called “hyperfiltration” to deal with the extra workload. This resulting increased pressure within our kidneys can damage the sensitive structures and increase the risk of kidney failure over the long term. What about L, M, N, O, P through Z? If you want to continue through the alphabet, L could be for diminished lung function, M could be for metabolic syndrome, and so on. There is even an X—for xiphodynia—pain at the tip of the bottom of the breastbone from being bent forward by an expanding abdomen. Given the myriad health conditions associated with excess weight, “annual medical spending attributable to an obese individual” is nearly $2,000 per year and workers who are obese with multiple conditions can cost companies up to $10,000 more in healthcare coverage compared to “their lean counterpart.” Wage Gap This may account for some of the wage gap that employees who are obese may experience, as companies try to pass along these costs of “their higher health insurance premiums,” beyond just brazen discrimination. Between healthcare costs and diminished productivity in terms of lost workdays, the total lifetime costs of obesity for children and teens have been estimated to exceed $150,000. Estimates Some estimates peg the annual “medical care costs of obesity in the United States” at about $150 billion, with another $50 billion per year added by 2030 as our increasingly heavy Baby Boomers continue to age. Others diametrically disagree, based on the morbid fact that individuals who are obese may not live as long. Just as “the high medical costs of smoking-related diseases are more than offset by lower survival of smokers,” the lifetime healthcare costs of individuals who are obese may turn out to be lower because they are expected to die so much sooner. So, the true cost may be more in lives, rather than dollars. How much does being overweight cut your life short? I’ll explore just that question next. If you missed the previous blog posts in my series on the ABCs of obesity, see related posts below. I continue the topic of obesity and weight with these videos: Is the Obesity Paradox Real or a Myth? and Friday Favorites: What’s the Ideal BMI and Waist Size?. For more on the health conditions discussed in this video, see the immune function, kidney disease, and liver health topic pages. Key Takeaways In the SOS trial, individuals who lost 20 percent of their body weight through surgery lived longer and had lower rates of diabetes, cardiovascular disease, and cancer, possibly due to improved immune function. Obesity impairs natural killer cells, weakening the body’s defense against cancer and infections, while also increasing the risk of autoimmune diseases like multiple sclerosis. Obesity is a major cause of nonalcoholic fatty liver disease, which can lead to liver inflammation, cirrhosis, and liver cancer, now the leading cause of liver transplants in U.S. women. Excess weight places metabolic stress on the kidneys, leading to hyperfiltration and increasing the risk of chronic kidney disease and eventual kidney failure. Obesity-related health conditions contribute to higher medical costs, lost productivity, and a lifetime financial burden, with annual obesity-related medical costs in the United States, for instance, estimated at $150 billion. To read the original article click here.

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The Hidden Benefits of Camu Camu: This Amazonian Superfruit May Help Reverse Non-Alcoholic Fatty Liver Disease

The AHA! Team — Fri, 01 Nov 2024 05:03:32 +0000

Olivia Cook via Natural News – This Amazonian superfruit may help reverse non-alcoholic fatty liver disease. For years, doctors have faced challenges in treating non-alcoholic fatty liver disease (NAFLD), a condition affecting over 25 percent of adults globally. But a recent discovery points to an unexpected remedy: the Camu Camu berry from the Amazon rainforest. NAFLD is marked by fat buildup in the liver, which can lead to inflammation, scarring and even liver failure if not addressed. It’s closely associated with diabetes, metabolic disorders and obesity, making it a significant health concern as global obesity rates climb. Currently, there are no approved medications for NAFLD, leaving diet and exercise as the primary treatments for this disease. This is why researchers are examining the Camu Camu berry, a small red fruit native to the Amazon rainforest. The berry is rich in antioxidants, fiber and polyphenols – plant compounds with evidence-based health benefits. The Camu Camu berry, a small red fruit native to the Amazon, is rich in antioxidants, fiber and polyphenols–plant compounds with evidence-based health benefits. In this study, 30 obese or overweight adults with high triglycerides were enrolled in a randomized, double-blind, placebo-controlled trial. They were split into two groups: one received 1.5 grams of Camu Camu powder daily, while the other got a placebo (maltodextrin) for 12 weeks, followed by a four-week break before switching treatments. Researchers focused on measuring liver fat content using magnetic resonance imaging (MRI), along with other indicators of liver and metabolic health and changes in gut bacteria. After 12 weeks, those taking camu camu saw a notable 15.85 percent reduction in liver fat, while the placebo group experienced an 8.42 percent increase. Camu Camu also lowered liver enzymes ALT and AST, which are markers of liver damage. Additionally, the Camu Camu group had beneficial changes in their gut microbiome, including more good bacteria, like Lactobacillus, and fewer harmful ones linked to NAFLD. However, there were no changes in body weight or overall body fat between the two groups. (Related: Camu Camu ground to speed up metabolism and reduce weight gain.) Evidence-based health benefits of Camu Camu Scientifically known as Myrciaria dubia, camu camu has more proven health benefits. Here are some of them: Rich in vitamins and minerals Camu camu stands out for its high vitamin C content. Vitamin C helps with boosting the immune system, collagen production, iron absorption and wound healing. A 100-gram serving of camu camu fruit pulp contains between 877 to 3,133 milligrams of vitamin C, although levels can vary depending on where the plant is grown. Besides vitamin C, camu camu also provides calcium, copper, magnesium, manganese, potassium, sodium and zinc. Boosts the immune system The antioxidants in Camu Camu, including anthocyanins, support immune health by affecting key immune cells (dendritic cells, lymphocytes and macrophages). Vitamin C in Camu Camu helps keep cells healthy by protecting them from damage caused by harmful molecules produced during inflammation. It boosts the ability of immune cells to engulf and destroy harmful particles and germs (phagocytosis). Vitamin C also helps white blood cells, called neutrophils, move to infection sites to fight off invaders. At the same time, it helps prevent too much damage to tissues by supporting the natural process of cell death and clearing away damaged cells. Has anti-bacterial, anti-malarial and anti-viral properties Research has identified various beneficial bioactive compounds in Camu Camu, such as polyphenols and those correlated with anti-parasitic properties which could be useful in treating diseases, like malaria and schistosomiasis. Seed extracts have shown potential as sources for new treatments. Supports healthy blood sugar levels Research published in the open access, peer-reviews journal Metabolites showed that the lowest dose of Camu Camu extract effectively reduced non-HDL cholesterol, which includes all the harmful types of cholesterol and free fatty acids. Only the highest dose of Camu Camu extract prevented fat accumulation, issues related to high-fat diets, such as insulin resistance, liver cholesterol buildup, liver triglyceride accumulation and weight gain. Both low and high doses of the fruit extract were found to be effective in lowering blood sugar levels and enhancing glucose tolerance. Promotes eye health With its high content of vitamin E and carotenoids, Camu Camu helps protect against eye damage and can slow the progression of age-related conditions, like cataracts and macular degeneration. Improves oral and gum health Camu Camu’s antioxidant and anti-inflammatory properties can help combat gingivitis and other gum disease. It reduces oxidative stress, which can otherwise lead to gum and periodontal concerns. Supports cardiovascular health Camu Camu is beneficial for heart health. It can improve blood pressure and promote better blood flow – helping protect the heart and arteries from diseases. Learn about the amazing health benefits of organic camu camu by watching the following video. This video is from the Daily Videos channel on Brighteon.com. More related stories: Camu camu fruits are rich in an anthocyanin that stops tumors from growing. Camu Camu: What you need to know about the most potent food source of vitamin C on the planet. Study: Exotic fruit Camu Camu can help speed up metabolism and improve gut health. Sources include: StudyFinds.org OrganicFacts.net NCBI.NLM.NIH.gov 1 NCBI.NLM.NIH.gov 2 ScienceDirect.com NCBI.NLM.NIH.gov 3 NCBI.NLM.NIH.gov 4 Brighteon.com To read the original article, click here: https://www.naturalnews.com/2024-08-27-camu-camu-superfood-reverse-fatty-liver-disease.html

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Scientists Uncover Cell Responsible for Repairing Liver Tissue

The AHA! Team — Mon, 06 May 2024 18:05:40 +0000

University College London via News-Medical – A type of cell responsible for repairing damaged liver tissue has been uncovered for the first time by a team of scientists, including Professor Rajiv Jalan (UCL Liver & Digestive Health). The study, published in Nature, showed how these new-found cells migrate to the site of damage, providing new insights into the way the liver heals itself. The authors say the findings could spur the development of new therapies that harness the liver’s unique capacity to regenerate. During acute liver failure, the organ’s ability to repair and regenerate is often overwhelmed, with patients requiring an emergency liver transplant to regain liver function. Scientists from the University of Edinburgh studied human liver tissue from patients with acute liver failure for signs of cell proliferation and regeneration following the rapid loss of liver function. They found that a significant proportion of cells retained the ability to multiply. There were, however, still substantial areas of damage in the patients’ livers, suggesting that processes other than cell proliferation are critical during regeneration. The research team profiled the genes within every liver cell in both healthy and regenerating human liver tissue to better understand the regeneration process, using a technique called single-cell RNA sequencing. The findings uncovered a previously undetected population of wound-healing liver cells that emerge during human liver regeneration to aid recovery. Working with University of Glasgow scientists at the Cancer Research UK Scotland Institute, the team used special imaging techniques in mice to view the wound-healing cells in action. Researchers from the UCL Institute for Liver & Digestive Health and the Royal Free Hospital then provided important clinical validation of the novel mechanism of liver repair in humans. “We investigated whether the ‘liver repair’ mechanisms that the team from Edinburgh and Glasgow discovered in animal models also occurred in humans, and found that the mechanisms were present in patients with severe acute indeterminate hepatitis. This provides evidence that the observations made in the study are likely to be clinically relevant for the treatment of liver diseases in humans.” -Professor Rajiv Jalan, UCL Liver & Digestive Health During liver regeneration, so-called leader cells appear at the edge of the healthy tissue, dragging the tissue together to close the wound – similarly to how skin heals after a cut. Imaging also revealed that the population of healing liver cells appears before cell proliferation begins. Widespread infection is a major concern following acute liver failure. Bacteria from the gut can escape into the liver when the liver is damaged. This can lead to sepsis if the liver is unable to clear the infection. The liver may prioritise the healing of wounds before cell proliferation to restore the gut-liver barrier and prevent the spread of bacteria, experts say. Professor Neil Henderson, principal investigator of the study from the University of Edinburgh’s Centre for Inflammation Research, said: “Cutting-edge technologies have allowed us to study human liver regeneration in high definition for the first time, facilitating the identification of a cell type that is critical for liver repair. “We hope that our findings will accelerate the discovery of much-needed new treatments for patients with liver disease.” The research team also included scientists from the Universities of Birmingham, Cambridge and Texas, and the United States Acute Liver Failure Study Group network. This work was funded by Wellcome. Journal reference: Matchett, K. P., et al. (2024). Multimodal decoding of human liver regeneration. Nature. doi.org/10.1038/s41586-024-07376-2. To read the original article click here.

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Overweight or Obesity Amplifies Harmful Effects of Alcohol on the Liver

AHA Publisher — Fri, 04 Jun 2021 07:00:55 +0000

University of Sydney via News-Medical – Led by the University of Sydney’s Charles Perkins Centre, the study looked at medical data from nearly half a million people and found having overweight or obesity considerably amplified the harmful effects of alcohol on liver disease and mortality. “People in the overweight or obese range who drank were found to be at greater risk of liver diseases compared with participants within a healthy weight range who consumed alcohol at the same level. Even for people who drank within alcohol guidelines, participants classified as obese were at over 50 percent greater risk of liver disease.” (Professor Emmanuel Stamatakis, senior author and research program director, Charles Perkins Centre and the Faculty of Medicine and Health) The researchers drew upon data from the UK Biobank – a large-scale biomedical cohort study containing in-depth biological, behavioural, and health information from participants in the United Kingdom (UK). According to the researchers, this is one of the first and largest studies looking at increased adiposity (overweight or obesity) and level of alcohol consumption together, in relation to future liver disease. Information was examined from 465,437 people aged 40 to 69 years, with medical and health details collected over an average of 10.5 years. The findings were published in the European Journal of Clinical Nutrition. Lead author Dr Elif Inan-Eroglu, a postdoctoral research fellow with the Charles Perkins Centre, said the results suggest people carrying excess weight may need to be more aware of risks around alcohol consumption. “With the most recent data suggesting two in three people – or 67 percent of the Australian population are in the overweight or obesity range, this is obviously a very topical issue.” Key Findings The researchers reviewed data on participants classified as overweight/obese based on their body mass index (BMI) and waist circumference, self-reported alcohol consumption according to UK alcohol guidelines, and liver disease incidence and liver disease as cause of death. BMI is based on both weight and height. A BMI of over 25 denotes overweight, and over 30 denotes obesity. For waist circumference, researchers used the World Health Organization (WHO) classification: normal (<80 cm for women, <94 cm for men), overweight (>80 cm for women, >94 cm for men), and obese (>88 cm for women, >102 cm for men). The level of risk was given a number called a ‘hazard ratio’. The higher the number than 1, the higher the risk. People who drank above UK alcohol guidelines had, compared to within guideline drinkers: oA nearly 600 percent higher risk of being diagnosed with alcoholic fatty liver disease(5.83 hazard ratio). oA nearly 700 percent higher risk of death caused by alcoholic fatty liver disease (6.94 hazard ratio). People with overweight or obesity who drank within or above alcohol guidelines had over 50 percent greater risk of developing liver disease compared to normal weight participants who consumed alcohol at the same level. To read the original article click here.

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Machine Keeps Human Livers Alive for One Week Outside of the Body

AHA Publisher — Tue, 14 Jan 2020 08:00:17 +0000

University of Zurich via Newswise – Researchers in Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week. Newswise — Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week. This breakthrough may increase the number of available organs for transplantation saving many lives of patients with severe liver diseases or cancer. Until now, livers could be stored safely outside the body for only a few hours. With the novel perfusion technology, livers – and even injured livers – can now be kept alive outside of the body for an entire week. This is a major breakthrough in transplantation medicine, which may increase the number of available organs for transplantation and save many lives of patients suffering from severe liver disease or a variety of cancers. Injured cadaveric livers, initially not suitable for use in transplantation, may regain full function while perfused in the new machine for several days. The basis for this technology is a complex perfusion system, mimicking most core body functions close to physiology. The corresponding study was published on January 13 in the scientific journal Nature Biotechnology. Offering What Other Machines Cannot “The success of this unique perfusion system – developed over a four-year period by a group of surgeons, biologists and engineers – paves the way for many new applications in transplantation and cancer medicine helping patients with no liver grafts available” explains Prof. Pierre-Alain Clavien, Chairman of the Department of Surgery and Transplantation at the University Hospital Zurich (USZ). When the project started in 2015, livers could only be kept on the machine for 12 hours. The seven-day successful perfusion of poor-quality livers now allows for a wide range of strategies, e.g. repair of preexisting injury, cleaning of fat deposits in the liver or even regeneration of partial livers. Liver4Life: A project from Wyss Zurich The Liver4Life project was developed under the umbrella of Wyss Zurich institute, which brought together the highly specialized technical know-how and biomedical knowledge of experts from the University Hospital Zurich (USZ), ETH Zurich and the University of Zurich (UZH). “The biggest challenge in the initial phase of our project was to find a common language that would allow communication between the clinicians and engineers,” explains Prof. Philipp Rudolf von Rohr, Professor of Process Engineering at ETH Zurich and co-leader with Professor Clavien of the study now published in Nature Biotechnology. Technology With Great Potential The inaugural study shows that six of ten perfused poor-quality human livers, declined for transplantation by all centers in Europe, recovered to full function within one week of perfusion on the machine. The next step will be to use these organs for transplantation. The proposed technology opens a large avenue for many applications offering a new life for many patients with end stage liver disease or cancer. To read the original article click here.

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