leaky gut syndrome Archives - Amazing Health Advances

Leaky Gut Syndrome: 7 Signs You May Have It

The AHA! Team — Mon, 18 Nov 2024 06:19:53 +0000

Kathleen McCoy, BS via Dr. Axe – As more Americans are affected by poor diet choices, chronic stress, toxic overload and bacterial imbalance, it appears that the prevalence of leaky gut is potentially reaching epidemic proportions. The medical profession is just now agreeing this condition even exists, which is especially shocking considering that “intestinal permeability” (another name for leaky gut) has been discussed in the medical literature for over 100 years! Why should leaky gut syndrome concern you? In recent years, studies consider leaky gut a “danger signal for autoimmune disease.” Below is a brief description of common leaky gut syndrome symptoms seen in people struggling with this condition. A four-step process is recommended to help promote healing — including trigger foods to remove from your diet and beneficial supplements to add in. What Is Leaky Gut Syndrome? The father of modern medicine, Hippocrates, said, “All disease begins in the gut.” More than two millennia after his death, scientific research has now proved he was on to something all those years ago. For over three decades, study after study has been published (several thousand articles exist to date) discussing our growing understanding of immunity, gut function, and how modern diets and lifestyles negatively contribute to overall health by damaging the digestive system. This particular phenomenon is called leaky gut syndrome. In the medical literature, leaky gut is also referred to as “increased intestinal hyperpermeability.” What happens when you have leaky gut? The intestines are protected by a single layer of specialized epithelial cells that are linked together by tight junction (or TJ) proteins. As one 2020 review explains, leaky gut symptoms are a consequence of intestinal TJ malfunction. These TJ proteins are the gateway between your intestines and your bloodstream. They control what is allowed to pass into the bloodstream from your digestive system. More than 40 different TJ proteins have now been recognized to play a role in gut health. TJ proteins have a very precise job. They have to maintain the delicate balance between allowing vital nutrients to enter your bloodstream, while remaining small enough to prevent xenobiotics (disease-causing substances like toxins and bacteria) from passing out of your digestive system into the rest of your body. Here’s how a report published in the journal Frontiers in Immunology describes the pathology of intestinal permeability: “The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the bloodstream creating a ‘leaky gut.’” Symptoms (Plus Related Conditions) According to one review focusing on medically reviewed research about intestinal permeability (among other sources), the chronic condition of hyperpermeability may be linked to numerous symptoms and health conditions, including some autoimmune diseases. What are the symptoms of leaky gut? Some of the most prominent signs you may have this condition include: Gastric ulcers Joint pain Infectious diarrhea Irritable bowel syndrome Inflammatory bowel diseases (Crohn’s, ulcerative colitis) Small intestine bacterial overgrowth Celiac disease Esophageal and colorectal cancer Allergies Respiratory infections Acute inflammation conditions (sepsis, SIRS, multiple organ failure) Chronic inflammatory conditions (such as arthritis) Thyroid disorders Obesity-related metabolic diseases (fatty liver, type II diabetes, heart disease) Autoimmune diseases (such as lupus, multiple sclerosis, type I diabetes, Hashimoto’s and more) Parkinson’s disease Chronic fatigue syndrome Propensity toward weight gain or obesity Leaky gut may not directly cause any of these conditions — it’s more that people who have gut issues are more likely to have a number of other health problems. So while the scientific evidence has not yet proved that increased intestinal hyperpermeability is actually responsible for these conditions, it strongly suggests that leaky gut and other dysfunctions tend to occur simultaneously. Common Leaky Gut Problems Here’s more about some of these problems can develop due to gut dysfunction: 1. Food sensitivities Some research suggests that intestinal hyperpermeability can cause the immune system to overproduce various antibodies, which may make some more susceptible to antigens in certain foods (especially gluten and dairy). In studies involving rats and human children, leaky gut and food allergies have been linked. Allergies are believed to be one of the most common symptoms. 2. Inflammatory bowel disease Researchers from Hungary uncovered in 2012 that elevated gut permeability is oftentimes localized to the colon in people suffering from irritable bowel syndrome and ulcerative colitis. As far back as 1988, scientists suggested that Crohn’s disease may be more of a risk for people with leaky gut. A small study (observing 12 patients) discovered that zinc supplementation may help resolve the TJ dysfunction in these cases, although more medically reviewed research is required on a larger scale to confirm these results. 3. Autoimmune disease The key to understanding how leaky gut can cause autoimmune diseases is through research done on a protein known as “zonulin.” According to a one article published in the journal Physiologic Reviews: “Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur.” Eating certain food allergens, such as gluten, may trigger this dangerous cascade. University of Maryland School of Medicine researchers uncovered that gluten “activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.” The good news is that it seems possible to reverse these autoimmune reactions’ problematic immune responses. 4. Thyroid problems One of the autoimmune diseases that leaky gut syndrome may directly affect is Hashimoto’s disease. Also known as “chronic thyroiditis,” this disorder is displayed with hypothyroidism (low thyroid function), impaired metabolism, fatigue, depression, weight gain and a host of other concerns. 5. Nutrient malabsorption Various nutritional deficiencies can also result from leaky gut, including vitamin B12, magnesium and digestive enzymes. Those common nutrient deficiencies are one reason why many functional medicine practitioners prescribe a whole-food multivitamin in addition to probiotics for people suffering from this condition. 6. Inflammatory skin conditions First described over 70 years ago, the “gut-skin connection theory” describes how increased intestinal hyperpermeability can cause a slew of skin conditions, particularly acne and psoriasis. Creams and drugs with endless lists of (sometimes dangerous) side effects are often prescribed for these skin disorders, yet there has been evidence for several decades that part of the root cause might exist in the gut. 7. Mood issues and autism According to a study published in the journal Neuroendocrinology Letters, intestinal permeability has been shown to contribute to various neurocognitive disorders. For example, the inflammatory response characteristic of intestinal hyperpermeability triggers the release of pro-inflammatory cytokines and other chemicals that are thought to induce depression. A study published in the journal Nutritional Neuroscience described the “vicious circle between immune system impairment and increasing dysbiosis that leads to leaky gut and neurochemical compounds and/or neurotoxic xenobiotics production and absorption.” The authors described findings from a number of studies that point to their theory that autism may be connected to problems in the microbiome, particularly within the first year of life. It is actually now a common hypothesis in modern science. Causes What is the main cause of leaky gut? As explained above, it occurs when certain tiny particles that should never be able to enter your bloodstream start to make their way through due to dysfunction of the mucosal barrier in the gut. There also commonly are abnormalities in the gut stemming from antimicrobial molecules, immunoglobulins and cytokine activities. This presents a major problem, as the vast majority of your immune system is found inside the gut (sometimes called the microbiome). The result is a disruption of acute inflammation and sometimes autoimmune reactions. A normal part of your immune response that serves to fight infections and diseases winds up over-performing, leading to chronic inflammation, which is at the root of most diseases. Some of the underlying causes of leaky gut include: Genetic predisposition — Certain people may be more predisposed to developing this condition because they are sensitive to environmental factors that “trigger” their bodies into initiating autoimmune responses. Poor diet — Especially a diet that includes allergens and inflammatory foods, such as unsprouted grains, added sugar, GMOs, refined oils, synthetic food additives, conventional dairy products and alcohol. Chronic stress Toxin overload — This includes “chronic stressors,” such as high drug and alcohol consumption. We come into contact with more than 80,000 chemicals and toxins every single year, but the worst offenders for causing leaky gut include antibiotics, pesticides, tap water, aspirin and NSAIDs. It’s recommended to buy a high-quality water filter to eliminate chlorine and fluoride and look to natural plant-based herbs to reduce inflammation in your body. Bacterial imbalance — Also called dysbiosis, which means an imbalance between beneficial and harmful species of bacteria in your gut. A large body of evidence now shows that gut microbiota is important in supporting the epithelial barrier and preventing autoimmune reactions. At least 10 percent of all gene transcriptions found in intestinal epithelial cells that are related to immunity, cell proliferation and metabolism are regulated by gut microbiota. Controversies Do most conventional doctors support the idea that leaky gut is real? Not exactly, as it the topic remains controversial. WebMD refers to leaky gut as “something of a medical mystery.” This isn’t surprising, since it’s not a diagnosis that most doctors have been taught in medical school. “From an MD’s standpoint, it’s a very gray area,” says gastroenterologist Donald Kirby, M.D., director of the Center for Human Nutrition at the Cleveland Clinic. In his opinion, “Physicians don’t know enough about the gut, which is our biggest immune system organ.” However, a roundtable review quotes the researchers at seven different European universities in 2014 agreeing upon the following: “Alteration of the gut barrier seems to have multiple consequences facilitating the onset of a variety of diseases depending on other hits and on genetic or epigenetic constellations, respectively. The growing significance of the gut barrier and bacterial translocation raises the questions of how we can improve gut barrier functions and gut microbiota.” While it’s encouraging that science is coming around to leaky gut syndrome being a real problem, we are by no means at a point where there are standard diagnostic tools for testing and treating this problem. This means that doctors are often left with no other choice than to follow what they believe to be the “safe path” and prescribe drugs that only treat symptoms. For example, medications (like proton pump inhibitors or antacids) can be used to manage symptoms like acid reflux medications, but these drugs don’t solve the root problem. Because there is so much unknown about leaky gut syndrome, it’s critical that you understand what leaky gut is and what to look out for in case you or a loved one is affected by it. The good news is that many functional and integrative medicine practitioners have a greater understanding of this condition than they did even a decade ago. Treatment Several leaky gut syndrome tests are available that can help confirm a diagnosis and point you in the right treatment direction. Tests are helpful for identifying specific sensitivities and uncovering which types of toxins or deficiencies are contributing to your symptoms. Available tests include: Zonulin or Lactulose Tests IgG Food Intolerance Test Stools Tests Organic Acid Vitamin and Mineral Deficiencies Tests Lactulose Mannitol Test What leaky gut treatments are available? A four-step process can help treat leaky gut. We cover this process in a leaky gut diet and treatment plan. The basic steps to healing leaky gut are as follows: Remove foods and factors that damage the gut. Replace these with healing foods that are part of an anti-inflammatory diet. Repair the gut with specific leaky gut supplements like butyric acid. Rebalance your microbiome with probiotics (beneficial bacteria). This is key because bacteria in your...

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The Chronic Effects of Low-Dose Mercury Exposure

The AHA! Team — Mon, 03 Jun 2024 05:12:24 +0000

Lori Alton via NaturalHealth365 – Although mercury can enter the body through contaminated seafood, vaccines, and emissions from factories and coal power plants, the main source of exposure is dental amalgams. Natural health experts are sounding the alarm on chronic (low-level) mercury exposure, calling it a “biochemical train wreck” and an “under-recognized epidemic.” Mercury, a known neurotoxin, binds to molecules, tissues, and cells in the body and sets the stage for a host of serious chronic diseases – although both the American Dental Association and the FDA continue to minimize and deny its toxic effects. Yet, there are millions and millions of people suffering from mercury poisoning, and neurodevelopmental disorders have surged by over 30 percent in the last decade. What you need to know about mercury exposure Although mercury can enter the body through contaminated seafood, vaccines, and emissions from factories and coal power plants, the main source of exposure is dental amalgams. The World Health Organization (WHO) notes that the typical absorbed dose from amalgams is 100 micrograms a day. One of the most disturbing facts about mercury exposure is its association with neurological disorders, behavioral problems, autism spectrum disorder, and mental illness. Many experts point to the soaring rates of neurodevelopmental disorders in this country as a testament to the toxic effects of mercury. Mercury, which can destroy the protective myelin sheath that covers the nerves, is highly damaging to the neurological system. In fact, researchers report that autism is often accompanied by oxidative stress, mitochondrial dysfunction, and increased inflammation – all of which are consistent with mercury poisoning. In addition, mercury exposure can cause deficiencies and imbalances of essential minerals such as zinc and copper, a condition associated with ADHD. Mercury exposure also interferes with the production and function of various neurotransmitters, including the “calming” body chemical GABA – thereby promoting the development of depression, anxiety, and sleep disorders. Mercury interferes with antioxidant defenses Chronic mercury exposure also depletes nutrients in the body, promoting oxidative stress and interfering with antioxidant defenses. Mercury’s ability to bind to sulfur and selenium severely limits the beneficial oxidation-fighting and cancer-fighting effects of these antioxidant minerals. This interferes with the immune system’s ability to identify cancerous cells and causes it to attack normal, healthy cells, triggering the development of autoimmune disease and cancer. Mercury also binds to glutathione, the body’s premier antioxidant, which is designed to detoxify mercury and other heavy metals. In addition, mercury attacks the disulfide bonds in collagen, triggering arthritis and connective tissue disorders while also damaging the cell mitochondria that synthesize energy. Mercury exposure promotes cardiovascular and digestive diseases Mercury exposure contributes to heart disease by causing the oxidation of blood vessels and creating endothelial dysfunction. In one study of patients with heart failure, mercury levels in the myocardium, or middle layer of the heart wall, were found to be 22,000 times higher than normal. Mercury alters intestinal flora, increasing the presence of undesirable bacteria and pathogens such as candida. Digestion is impaired because of mitochondrial dysfunction. Mercury also increases the risk of food sensitivities, especially gluten and casein, and contributes to a “leaky gut.” As if this weren’t damaging enough, chronic exposure to mercury is linked with insulin resistance, hypoglycemic symptoms, and metabolic syndrome – a constellation of unhealthy conditions that include high blood pressure, high blood sugar, excess abdominal fat, and excess levels of LDL cholesterol. Susceptibility to mercury varies with the individual Vulnerability to mercury depends on a variety of factors, including exposure, nutrient status, lifestyle, and genetics. Over the last ten years, however, researchers have documented over a dozen common genetic variations that cause increased vulnerability to mercury toxicity – and many more are likely in existence. It can be difficult to diagnose mercury toxicity, as mercury can accumulate throughout the body without showing up in blood, urine, or hair. In addition, symptoms of mercury toxicity are common to many other illnesses and may appear long after exposure. Following a nutrient-dense diet and taking supplements advised by a knowledgeable holistic physician can help modulate the effects of mercury exposure. But, the bottom line is: if you have mercury-based, “silver” fillings in your mouth … get them removed (as soon as possible) by a qualified (holistic) dentist and begin the process of mercury detoxification – slowly and consistently. You can search for a holistic dentist at this web site: IAOMT.org. In addition, in terms of good food, high-quality fats, organ meats such as liver, organic olive oil, and bone broth can help replace depleted minerals and amino acids, while probiotic foods such as sauerkraut and kimchi can help restore the balance of friendly bacteria in the intestine. Foods high in vitamin C can provide antioxidant benefits and rebuild damaged collagen, with Brazil nut, sesame, and pine nuts helping to replace magnesium, zinc, and selenium. Obviously, if you’ve been poisoned with mercury, the process of detoxification will take some time and effort. But, remember, your future health depends on you taking action today. Editor’s note: Discover the best ways to remove toxic mercury from the mouth and correct other dental problems, own the Holistic Oral Health Summit created by NaturalHealth365 Programs. Sources for this article include: NIH.gov Townsendletter.com To read the original article click here.

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Is Flatulence Good for You? (Does It Depend on the Smell?)

The AHA! Team — Mon, 13 May 2024 08:00:18 +0000

Jillian Levy, CHHC via Dr. Axe – Most of us have been there: experiencing excessive farting that feels out of our control and causes a whole heck of a lot of embarrassment. While the average person farts nearly every day, some people deal with a bloated stomach and excessive flatulence more often than others. One of the most aggravating things about having gas is that it can seem impossible to minimize and to narrow down the exact culprit, considering dozens of different things can potentially be to blame. As you’ve probably experienced firsthand many times, some farts can be pretty foul-smelling and noisy, while others easily slip below the radar. Wondering how much farting is too much? A mostly healthy person might pass gas 14–18 times per day, sometimes not even realizing it because the farts are mostly silent and odorless. A mostly healthy person might pass gas 14–18 times per day Rather than how often you fart, however, you might want to take a look at the smelliness of your flatulence and to examine other digestive symptoms present in order to determine if it’s really become a problem. Is there likely anything to be worried about when it comes to your gas? Yes and no. Some flatulence is normal, especially when eating a whole foods, high-fiber diet — but excessive gas coupled with other symptoms can be a sign that something inside is going wrong, especially when it comes to digestion of certain foods. Too much farting can be a warning sign that normal intestinal gas dynamics have become compromised. This might result in subtle dysfunctions in intestinal motility, bacteria growth or changes in the microbiome composition taking place. Keep reading to learn more about flatulence and when you should and should not be concerned about your farts. What Is Flatulence? What is a fart exactly? A fart, also called gas, “passing wind” or flatulence, is caused by the internal buildup of gases that are formed during the process of digestion and respiration. The causes of farts, and how they develop within the digestive tract vary considerably depending on the person and circumstance. The main type of gas that gets trapped inside the body and leads to flatulence is nitrogen, which researchers estimate accounts for about 20 percent to 90 percent of all the gas that causes farts. Followed by nitrogen, carbon dioxide also contributes to the gaseous volume of farts (about 10 percent to 30 percent) along with oxygen (up to 10 percent), methane (around 10 percent) and hydrogen (about 10 percent to 50 percent). Methane and hydrogen are actually both flammable gases — which explains why you might have seen some cartoon characters light their farts with a flame when you were a kid. The combination of gases described above usually causes a smell because some contain sulfur, the same smelly compound found in foods like eggs or cruciferous vegetables. Why is there such a range in the percentages of gases within a fart and the level of smelliness, depending on the specific person? This has to do with how much air is swallowed by someone in a typical day, the types of foods within someone’s diet, and also the internal chemical reactions taking place within the microbiome or intestines during digestion. The severity of smells associated with flatulence mostly has to do with the percentage of different gases present in the body at any given time. Surprisingly, most of the gas within a fart is odorless, and only a very small percent (around 1 percent) causes the signature foul smell of farts. The reason for stinkiness in general comes down to how much sulfurous gasses form within the intestines. Within a fart, several sulfur-related compounds develop that contribute to the intensity of the fart’s smell. These include: Hydrogen sulphide: This is the component of a fart that usually smells like rotten eggs. Not only does it smell unpleasant, but it’s also flammable and can be toxic when consumed in large amounts. The human body makes some of its own hydrogen sulphide, but interestingly, it’s also produced within the environment in things like swamps, sewage systems and certain types of explosive volcanic rock. Methanethiol: This is found naturally within the human body, mostly within the blood and brain. Ever open up your refrigerator and get a strong whiff of leftover veggies? Methanethiol has a strong smell similar to cruciferous veggies, including broccoli or cabbage. This same compound also contributes to other types of body odors, including bad breath. Dimethyl sulphide: Here’s another chemical compound that contributes to the smelliness of veggies. This is responsible for the smell produced when you cook things like Brussels sprouts. It’s present in foods along with methanethiol and created from the formation of certain bacteria. Causes You’re probably wondering what causes your gas accumulation, right? Excessive gas and gas pains can be attributed to all sorts of health problems, normal variations in hormonal levels that affect digestion (such as your menstrual cycle) or specific foods. While the triggers are somewhat different from person to person, the way that gas forms in the body is mostly the same. Within the body, gas travels down the same pathway in your digestive system as poop does. Eventually, accumulated gas makes its way to through your intestines and out of your colon, just like feces. Along the way, certain things can stop or interfere with the normal release of built-up gas, causing gas pains, bloating and indigestion. This unpleasant feeling is a sign that you’re having a hard time ridding your body of excess gas — possibly because certain foods in your diet are irritating your gut or digestive organs, causing side effects like bacteria growth or fermentation along the way. Bloating and gas usually go hand in hand because when a certain amount of gas is retained within the gut, people develop abdominal distension (a puffy belly) and various gassy symptoms. Just like farting, abdominal distension is related to the volume of gas within the gut and depends both on intestinal motor activity (gas is better tolerated when the gut and digestive muscles are relaxed) and the inner distribution of gas. Some of the reasons gas gets trapped inside the body abnormally include: Swallowing air (aerophagia): This involves inadvertently swallowing air that accumulates in the stomach and is then released by belching or farting. This process is triggered by changes in the muscles that control the intake of air, followed by repetitive and ineffective attempts of belching that causes air to be introduced into the stomach. One reason you might be swallowing air and farting as a consequence? You could be eating too fast and therefore not chewing your food properly. Gaseous odor accumulation: Smelly farts are usually the cause of gas produced by colonic bacteria during fermentation of unabsorbed food residues arriving into the colon. Changes in the microflora: Gas also depends on the composition of the colonic flora — in other words the type of bacteria living within the digestive system. We know that each person is different in terms of microbiome composition, which means inter-individual variations exist that might contribute to, or protect us from, excessive gas production and evacuation. Constipation: Impaired anal evacuation produces gas retention. Constipation also prolongs the fermentation process of foods in the digestive system, increasing internal gas production. Here’s the million-dollar question: Why do some farts make a noticeable sound, while others are “silent but deadly”? This has to do with the alignment of muscles within your colon or rectum. Certain muscles help control how quickly gas is released, either tightly keeping gases inside or allowing them to be released more quickly, which can cause a sound. Know someone who can “fart on demand”? That’s likely because that person’s sphincter muscles, the ones that control the gateway of gas and waste out of the body, are easily relaxed, which lets them release internal gases whenever they want to. Of course, diet has an effect on flatulence as well, and underlying conditions can contribute to gas and farting. Are Farts Bad for You (or Beneficial)? Farting is considered a normal reaction within the human body and something we all deal with at one time or another. Because it’s the act of releasing internal gas from the body, just like a burp or even breathing, it’s usually harmless and in fact needed for normal metabolic functions. Most of the time your farts are just inconvenient but not something to necessarily get riled up about. In fact, they might even be protective in some instances! That’s right — your farts might be a clue that your “gut bugs” are well-fed and working hard and that your diet is a mostly healthy one. Diets high in fiber-rich foods after all tend to cause gas, but they also feed good bacteria that make up your immune system and help protect you from various diseases, like heart disease, cancer, diabetes and obesity. Aside from being a sign that you’re eating plenty of fiber, gases within your farts might even be beneficial. Farts contain hydrogen sulphide, a gas produced by certain natural bodily processes and needed as part of cellular functions. While I wouldn’t necessarily go smelling yours, or anyone else’s, farts just yet, it’s possible that inhaling hydrogen sulphide (yes, from your very own farts!) in small doses might help protect cells’ mitochondria and stop cellular damage at some level. On the other hand, excessive farting can be a sign that digestive processes are going amuck and that an underlying issue might be blame. Some underlying reasons for excessive gas accumulation can include: food sensitives or intolerances (see the list of common culprits below) fermentation of bacteria within the gut from eating FODMAP foods leaky gut syndrome or digestive disorders, including Crohn’s, celiac disease and irritable bowel syndrome constipation SIBO (small intestinal bacteria overgrowth)/excessive bacteria in the small intestine. Normally food intermingles with digestive juices in the intestines and nutrients are absorbed into the bloodstream while waste is sent to the colon, but with SIBO, malabsorption occurs, particularly of fat-soluble vitamins and iron, leading to abnormal bacteria growth and gas. How do you know if your gas is something to actually be worried about? Check if you experience other warning signs at the same time as being very gassy. When you’re up against a lot of flatulence, look for other abnormal symptoms including: weakness or fatigue skin rashes, acne or hives signs of allergies, like watery eyes and itchy throat constipation or diarrhea blood in your stool or urine pain around your lymph nodes, including in your groin, throat or armpits changes in your body temperature, weight, sleep and menstrual cycle Natural Remedies If you find yourself repeatedly dealing with bad gas, the first thing to do is address your diet. You might be having trouble breaking down certain foods or experiencing an accumulation of sulfur, bacteria or yeast. The tendency for foods to cause excessive gas varies from person to person considerably, so it usually takes some trial and error to figure out what your biggest triggers are. That being said, there are some “common culprits” in the world of farting that are likely involved in your struggle. Some of the Worst Foods for Gas Beans: Perhaps more than any other food, beans are notorious for causing gas. That’s because they contain a type of carbohydrate called polysaccharides, which easily ferment once they enter the gut. The bacteria living in your gut thrive off of these carbohydrates, which causes fermentation and an increase in gas. Luckily you don’t have to avoid beans and legumes all together — soaking them overnight prior to cooking helps make them more digestible (the same applies to nuts, which are similar in terms of their carb content), which is good news considering they can provide plenty of nutrients and fiber. Dairy: Lactose intolerance is a common digestive problem worldwide, although many people might be unaware that they cannot properly digest foods containing milk, cheese, yogurt or traces of...

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Could Our Next Superfood Be Colostrum From Cows?

AHA Publisher — Mon, 03 Oct 2022 07:00:22 +0000

Brian Blum via Israel21c – Here’s a riddle: What can strengthen the immune system, balance digestion and aid in brain and bone development? The answer is something most of us take for granted: breastmilk. More specifically, the colostrum “first milk” produced by the mammary glands in the first few days postpartum. Biomedical engineer Maya Ashkenazi-Otmazgin was thinking about the magical qualities of breastmilk when she had a baby four years ago. “There’s this one substance that contains all the important molecules necessary for our biological system to grow and evolve,” she tells ISRAEL21c. “Because of this milk, we are here, alive and kicking.” She wondered if the health benefits of breastmilk and colostrum could be harnessed to create a superfood that would be available to everyone – adults, athletes, the elderly… even pets. But Ashkenazi-Otmazgin didn’t envision asking mothers in the first few days of nursing to donate their colostrum. There was another source, whose proteins are 95% biosimilar to human breastmilk and is available in such abundance that 5 billion liters of it are thrown away every year around the world. Bovine colostrum. Modern dairy farms only allow a newborn calf to ingest the colostrum from its mother for a day or two before transitioning the calf to a set diet. But the mother cow produces colostrum for up to five days. That means a lot of colostrum is going to waste – some 25 to 35 liters per cow – and dairy producers can’t put it in the regular milk for both regulatory and taste reasons. “I wondered why we were not understanding the proteins inside breastmilk and trying to find bioequivalents in other sources,” Ashkenazi-Otmazgin says. After all, “breastmilk is the ‘gold standard’ for nutrients and grownups are being deprived of one of life’s greatest resources.” Functional Milk Protein In 2018, Ashkenazi-Otmazgin teamed up with Dr. Ariel Orbach and Eli Lerner. They raised $3.2 million in seed funding to start Maolac (M.A.O. are her initials, combined with “lac” for lactose), dedicated to introducing “human functional milk proteins into new segments,” Ashkenazi-Otmazgin, now the company’s CEO, says. Maolac uses the colostrum from days two to five. That ensures the calf isn’t being shortchanged for the benefit of human yogurt lovers. The Maolac team started by mapping out some 1,500 bioactive proteins in human breastmilk and then identifying the overlap with bovine colostrum. It turns out there are over 400 homologue proteins – that is, proteins containing genes similar in structure and evolutionary origin to genes in another species. “We created a smart algorithm that uses bioinformatic tools and proteomics to understand the combinations of several proteins for different indications,” Ashkenazi-Otmazgin says. “We were then able to find the same in bovine colostrum.” Improving Nature’s Recipe Maolac tranforms the bovine colostrum into a white powder that can be added to various foods – ice cream will be among Maolac’s first products – but Ashkenazi-Otmazgin stresses that it can be added to cooked foods such as pasta without losing functionality. The additive has no discernible taste, so it won’t ruin the flavor of your fettuccini al colostrum. “We found a way to take nature’s recipe and bring it into the 21st century,” Ashkenazi-Otmazgin says. Maolac’s business proposition is solidly win-win. If, in the past, farmers had to pay to dispose of biological waste like colostrum, Maolac flips that model and pays the farmers to take it off their hands. Food manufacturers can expect to pay around $500 per kilogram, similar to other protein supplements in the market, although Ashkenazi-Otmazgin says it takes less colostrum powder to achieve the same benefits, making the final price cheaper. Maolac’s first target audience is athletes, a $65 billion market. Because colostrum has anti-inflammatory properties, Ashkenazi-Otmazgin says consuming a food or beverage with “Maolac inside” should reduce muscle strain and improve recovery time. The same formula may also help improve mobility in the elderly. Moving beyond athletes, Ashkenazi-Otmazgin hopes Maoloc’s products will help with overall intestinal issues including IBD (inflammatory bowel disease) and leaky gut syndrome. IBD-related treatments are a $20 billion market, Ashkenazi-Otmazgin notes. “For IBD, our product is very effective even in very small doses of just a few hundred milligrams a day,” Ashkenazi-Otmazgin says. “That makes it easy to put in an energy bar or a beverage. If we can reduce cases of inflammation in the gut, we can allow someone to return to a normal routine. You would be able to go to a restaurant and not be afraid of what could happen. It wouldn’t influence your love life. And all this is happening by helping your body through its own immune mechanism to do the healing process. It’s not done in a synthetic way.” Ashkenazi-Otmazgin contrasts the Maolac approach to probiotics, where “you’re bringing to your own microbiome things from the outside. We support the natural healing process of the digestive system.” New Sources of Protein If Maolac’s timeframe holds, the first products should hit the market in the second half of 2023. Maolac was initially supported by the Strauss Group’s The Kitchen food-tech accelerator; the company now has its own offices in Tirat HaCarmel, south of Haifa. The total amount raised by the 12-person company is just over $4 million. The latest funding round, led by OurCrowd and The Kitchen, will go to building a small-scale pilot production facility. OurCrowd CEO Jon Medved calls “the idea of transforming the first, nutrient-rich milk of cows that have just given birth into a source for human protein a stroke of pure genius.” In a world “desperately searching for new sustainable sources of protein,” he adds, “the company is a perfect example of the circular economy in action” as it turns a waste product into a valuable item. Maoloc currently has a ready-to-go product and the company is in discussions with potential customers and third-party manufacturers, Ashkenazi-Otmazgin says. Plant-Based Product Planned Bovine colostrum is not the end of the Maolac story. “We can use our proteomics discovery platform to create new ingredients from plants – from fungi and algae,” Ashkenazi-Otmazgin says, although proteins created this way will have only 60% to 80% biosimilarity, compared with 95% for bovine colostrum. Nevertheless, “We wanted a solution for vegans. We need to respect everyone,” she says. “In the end, we will have a portfolio of products to sell to food companies, cosmetics companies, supplement companies. They will implement the ingredients in the finished product while we will do all the regulatory work and the clinical studies to prove the effectiveness and safety of each product,” Ashkenazi-Otmazgin says. For more information, click here To read the original article click here.

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The Best Supplements for Your Brain According to Leading Functional Medicine Practitioner

AHA Publisher — Thu, 11 Feb 2021 08:00:42 +0000

Dr. Will Cole via Dr. Caroline Leaf – We can’t overlook the importance of keeping our brain healthy. With mild problems like mild brain fog on one end, to anxiety and depression in the middle, and severe diseases like Alzheimer’s on the other – the spectrum of brain health problems can make daily life a struggle. In my telehealth functional medicine clinic, I see these problems a lot more often than one might expect. In fact, the research confirms brain problems are on the rise with autism, dementia, and anxiety and depression rates continuing to climb. So, the question is, how can we prevent these problems before they occur? And if you are currently struggling with one of these problems, how can you alleviate symptoms? While I believe that our diet is foundational, sometimes we need a little extra help. And that’s where supplements come in. These are the supplements I turn to the most often to help optimize brain health and function. 1. Probiotics Your gut and brain are inextricably linked through what is known as the gut-brain axis – what affects one can affect the other. For example Occludin and Zonulin are two proteins that govern gut permeability as well as the permeability of your blood-brain barrier. In my clinic, it’s not uncommon that I have a patient come in looking for help with depression or brain fog and have further diagnostic testing reveal that they also have leaky gut syndrome. It just goes to show that digestive problems can still be a factor even if you aren’t experiencing symptoms. A probiotic with Lactobacillus and Bifidobacterium is a good choice to rebalance your microbiome and start healing any gut dysfunction. 2. Lion’s Mane This adaptogenic mushroom has potent neuroprotective properties, that help enhance mental clarity and boost cognitive function. Lion’s mane contains nerve growth factors that work to protect and regenerate brain tissue with studies finding that those who supplemented with lion’s mane had higher cognitive function compared to those who didn’t. 3. St. John’s Wort This herb is recommended by doctors more often in Germany than antidepressants like Prozac. While long-term studies have shown its ability to stabilize mood more research needs to be done to better determine just how effective it is. 4. Omega-3 Fish Oil Your brain is 60 percent fat, so it only makes sense that not getting enough fat in your diet can contribute to brain problems. You can only deprive your brain of it’s building blocks for so long before it starts to show. Healthy fats can be found in a variety of foods including wild-caught seafood however, some people may find it difficult to get enough from food alone. If this is the case for you, you might want to consider an omega-3 fish oil supplement. Although omega fats can be found in plant sources such as flax, it’s not as bioavailable because it has to be converted into DHA or EPA by the body before it is usable. I suggest either fish oil supplement from krill, salmon, or sardines. An ideal dosage is 2250mg EPA / 750 mg DHA per day. 5. CoQ10 CoQ10 stands for coenzyme Q10 and is found in each cell of the body, specifically the energy center of the cell – the mitochondria. If your brain’s cells are depleted of this nutrient, chances are it isn’t going to function optimally. A study published in the Journal of Clinical Psychopharmacology found that in 18 people with depression, 400 to 800 mg/day of CoQ10 for a month decreased the severity of depression symptoms and significantly improved symptoms of fatigue, sadness, and brain fog. 6. Vitamin D Low levels of vitamin D have been linked to poor memory and brain fog. Sunshine is the most bioavailable source of this nutrient but it’s not always possible to spend enough time in the sun, especially if you live in a place with dark, cloudy winters. Thankfully, certain foods such as salmon and tuna are rich in vitamin D. And if you pair them with fat-soluble vitamins like A, E, and K2 to increase the bioavailability of vitamin D. When looking for supplements, be sure to research brands and look for transparency in their sourcing and avoid any unnecessary additives. So, give your brain a boost, and add in one or more of these supplements to your routine! As always, I don’t recommend trying to supplement your way out of a poor diet. Food comes first. Moreover, you can amplify the brain boosting benefits of food as medicine and these supplements with flexible intermittent fasting. This is something I explore in detail in my new book Intuitive Fasting. To read the original article click here. For more articles from Dr. Leaf click here.

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