Postpartum Female Preference for Cooler Temperatures Linked to Brain Changes

The AHA! Team — Mon, 11 Aug 2025 05:35:50 +0000

Baylor College of Medicine via EurekAlert! – Mothers experience major metabolic adaptations during pregnancy and lactation to support the development and growth of the new life. Although many metabolic changes have been studied, body temperature regulation and environmental temperature preference during and after pregnancy remain poorly understood. Researchers at Baylor College of Medicine and collaborating institutions show in the journal Molecular Metabolism that postpartum female mice develop new environmental temperature preferences and reveal brain changes mediating these changes. Humans and mice body temperature “In both humans and mice, body temperature increases during early pregnancy, drops to normal temperature during late pregnancy and then goes up again during lactation,” said co-corresponding author Dr. Chunmei Wang, assistant professor of pediatrics at USDA/ARS Children’s Nutrition Research Center at Baylor. In this study, Wang and her colleagues investigated what changes occurred in the brain that mediated the new temperature preference. “We worked with mice and found that female mice prefer a cooler environment starting from late pregnancy and persisting in long-term postpartum,” Wang said. “For more than four weeks post-weaning female mice had a lower body temperature and preferred cooler environments; they lost their typical preference for warm environments (30 °C/86 °F) but still avoided cold environments (15 °C/59 °F).” To identify the biological underpinnings of these changes, the researchers studied the preoptic area (POA), a brain region important for sensing and regulating body temperature. “We discovered that the change in temperature preference in postpartum female mice was associated with a significant decrease in a particular group of neurons, estrogen receptor alpha (ERα)-expressing neurons in the preoptic area of the brain (ERαPOA neurons),” Wang said. Supporting this finding, the researchers found that virgin females in which the estrogen receptor alpha had been deleted in ERαPOA neurons also preferred lower temperatures and avoided warmer locations, mimicking postpartum females. Looking closely into the ERαPOA neurons, the researchers found that these neurons vary in their ability to sense warm or cold temperatures – one group of ERαPOA neurons can directly respond to warmth, while another group responds to cooler temperatures. “Interestingly, compared to female mice that had not been pregnant, ERαPOA neurons of postpartum females had reduced response to warmth and an enhanced response to cold,” Wang said. Together, the results support that the ability of ERαPOA neurons to sense warmth and cold is regulated by reproductive experience and leads to changes in temperature preferences that alter the animal’s warmth-seeking behavior. Currently, the researchers are exploring the function of each group of ERαPOA neurons on the regulation body temperature and thermal preference. Other contributors to this work include Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C. Bean, Qingzhuo Liu, Benjamin P. Eappen, Yang He, Kristine M. Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen and co-corresponding authors Tianshu Zeng and Yanlin He. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine, Huazhong University of Science and Technology, Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases, Louisiana State University, South-central Minzu University and the University of Illinois. This work was supported by grants from the USDA/CRIS (3092-51000-062-04(B)S), Pennington Biomedical Research Center institutional funding and the National Natural Science Foundation of China. ### Journal Molecular Metabolism DOI 10.1016/j.molmet.2025.102108 To read the original article click here.

The post Postpartum Female Preference for Cooler Temperatures Linked to Brain Changes appeared first on Amazing Health Advances.

High Fructose Diet in Pregnancy Impacts Metabolism of Offspring, Study Finds

AHA Publisher — Fri, 21 Aug 2020 07:00:30 +0000

University of Otago via Newswise – An increased level of fructose intake during pregnancy can cause significant changes in maternal metabolic function and milk composition and alter the metabolism of their offspring, researchers from the University of Otago, Wellington, have found. The research, which was led by Dr Clint Gray, a Research Fellow in the Department of Paediatrics and Child Health, found increasing the fructose in the diets of female guinea pigs led to highly significant and consistent changes in the free fatty acids circulating in the blood of their offspring. This was despite the offspring consuming no fructose themselves. The research is published in the international journal Frontiers in Endocrinology. First author, PhD student Erin Smith, says “previous research has shown poor quality nutrition during pregnancy can predispose offspring to long-term consequences, including the development of obesity, diabetes and cardiovascular disease later in life”. “However, there has been a lack of data examining the impact of increased fructose intake before and during pregnancy and subsequent adverse effects on lactation, fetal development and offspring metabolic function.” The two experimental groups were fed either a control diet or a fructose diet prior to and during pregnancy. The fructose group was given supplementary fructose water to replicate increased sugar-sweetened beverage intake 60 days prior to mating and until the delivery of their offspring. Fructose made up 16.5 per cent of their diets, closely resembling the average human consumption of fructose/sugar in Western countries, which is estimated at about 14 per cent of average daily caloric intake. “We found fructose had a significant impact on a pregnant females’ metabolic status and the free fatty acid content of their milk. We also provide the first evidence that offspring born from fructose-fed mothers display a very specific pattern of increased free fatty acids and altered lipid metabolism that persists throughout early life.” Ms Smith says it is well known that increased levels of circulating free fatty acids increases the risk of obesity, insulin resistance, type 2 diabetes and cardiovascular disease – with increased fatty acid synthesis shown to occur following fructose consumption. She says the evidence suggests suboptimal maternal diets, such as diets high in fructose and refined sugars, may be contributing to the rise in metabolic diseases in humans observed during the past 40 to 50 years. “Our study emphasises the importance of limiting added refined fructose, such as sugar-sweetened beverages, and striving for a more nutritionally balanced diet in women prior to and during pregnancy and lactation.” To read the original article click here.

The post High Fructose Diet in Pregnancy Impacts Metabolism of Offspring, Study Finds appeared first on Amazing Health Advances.

lactation Archives - Amazing Health Advances

Postpartum Female Preference for Cooler Temperatures Linked to Brain Changes

High Fructose Diet in Pregnancy Impacts Metabolism of Offspring, Study Finds