inflammatory autoimmune disease Archives - Amazing Health Advances

Leaky Gut Syndrome: 7 Signs You May Have It

The AHA! Team — Mon, 18 Nov 2024 06:19:53 +0000

Kathleen McCoy, BS via Dr. Axe – As more Americans are affected by poor diet choices, chronic stress, toxic overload and bacterial imbalance, it appears that the prevalence of leaky gut is potentially reaching epidemic proportions. The medical profession is just now agreeing this condition even exists, which is especially shocking considering that “intestinal permeability” (another name for leaky gut) has been discussed in the medical literature for over 100 years! Why should leaky gut syndrome concern you? In recent years, studies consider leaky gut a “danger signal for autoimmune disease.” Below is a brief description of common leaky gut syndrome symptoms seen in people struggling with this condition. A four-step process is recommended to help promote healing — including trigger foods to remove from your diet and beneficial supplements to add in. What Is Leaky Gut Syndrome? The father of modern medicine, Hippocrates, said, “All disease begins in the gut.” More than two millennia after his death, scientific research has now proved he was on to something all those years ago. For over three decades, study after study has been published (several thousand articles exist to date) discussing our growing understanding of immunity, gut function, and how modern diets and lifestyles negatively contribute to overall health by damaging the digestive system. This particular phenomenon is called leaky gut syndrome. In the medical literature, leaky gut is also referred to as “increased intestinal hyperpermeability.” What happens when you have leaky gut? The intestines are protected by a single layer of specialized epithelial cells that are linked together by tight junction (or TJ) proteins. As one 2020 review explains, leaky gut symptoms are a consequence of intestinal TJ malfunction. These TJ proteins are the gateway between your intestines and your bloodstream. They control what is allowed to pass into the bloodstream from your digestive system. More than 40 different TJ proteins have now been recognized to play a role in gut health. TJ proteins have a very precise job. They have to maintain the delicate balance between allowing vital nutrients to enter your bloodstream, while remaining small enough to prevent xenobiotics (disease-causing substances like toxins and bacteria) from passing out of your digestive system into the rest of your body. Here’s how a report published in the journal Frontiers in Immunology describes the pathology of intestinal permeability: “The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the bloodstream creating a ‘leaky gut.’” Symptoms (Plus Related Conditions) According to one review focusing on medically reviewed research about intestinal permeability (among other sources), the chronic condition of hyperpermeability may be linked to numerous symptoms and health conditions, including some autoimmune diseases. What are the symptoms of leaky gut? Some of the most prominent signs you may have this condition include: Gastric ulcers Joint pain Infectious diarrhea Irritable bowel syndrome Inflammatory bowel diseases (Crohn’s, ulcerative colitis) Small intestine bacterial overgrowth Celiac disease Esophageal and colorectal cancer Allergies Respiratory infections Acute inflammation conditions (sepsis, SIRS, multiple organ failure) Chronic inflammatory conditions (such as arthritis) Thyroid disorders Obesity-related metabolic diseases (fatty liver, type II diabetes, heart disease) Autoimmune diseases (such as lupus, multiple sclerosis, type I diabetes, Hashimoto’s and more) Parkinson’s disease Chronic fatigue syndrome Propensity toward weight gain or obesity Leaky gut may not directly cause any of these conditions — it’s more that people who have gut issues are more likely to have a number of other health problems. So while the scientific evidence has not yet proved that increased intestinal hyperpermeability is actually responsible for these conditions, it strongly suggests that leaky gut and other dysfunctions tend to occur simultaneously. Common Leaky Gut Problems Here’s more about some of these problems can develop due to gut dysfunction: 1. Food sensitivities Some research suggests that intestinal hyperpermeability can cause the immune system to overproduce various antibodies, which may make some more susceptible to antigens in certain foods (especially gluten and dairy). In studies involving rats and human children, leaky gut and food allergies have been linked. Allergies are believed to be one of the most common symptoms. 2. Inflammatory bowel disease Researchers from Hungary uncovered in 2012 that elevated gut permeability is oftentimes localized to the colon in people suffering from irritable bowel syndrome and ulcerative colitis. As far back as 1988, scientists suggested that Crohn’s disease may be more of a risk for people with leaky gut. A small study (observing 12 patients) discovered that zinc supplementation may help resolve the TJ dysfunction in these cases, although more medically reviewed research is required on a larger scale to confirm these results. 3. Autoimmune disease The key to understanding how leaky gut can cause autoimmune diseases is through research done on a protein known as “zonulin.” According to a one article published in the journal Physiologic Reviews: “Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur.” Eating certain food allergens, such as gluten, may trigger this dangerous cascade. University of Maryland School of Medicine researchers uncovered that gluten “activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.” The good news is that it seems possible to reverse these autoimmune reactions’ problematic immune responses. 4. Thyroid problems One of the autoimmune diseases that leaky gut syndrome may directly affect is Hashimoto’s disease. Also known as “chronic thyroiditis,” this disorder is displayed with hypothyroidism (low thyroid function), impaired metabolism, fatigue, depression, weight gain and a host of other concerns. 5. Nutrient malabsorption Various nutritional deficiencies can also result from leaky gut, including vitamin B12, magnesium and digestive enzymes. Those common nutrient deficiencies are one reason why many functional medicine practitioners prescribe a whole-food multivitamin in addition to probiotics for people suffering from this condition. 6. Inflammatory skin conditions First described over 70 years ago, the “gut-skin connection theory” describes how increased intestinal hyperpermeability can cause a slew of skin conditions, particularly acne and psoriasis. Creams and drugs with endless lists of (sometimes dangerous) side effects are often prescribed for these skin disorders, yet there has been evidence for several decades that part of the root cause might exist in the gut. 7. Mood issues and autism According to a study published in the journal Neuroendocrinology Letters, intestinal permeability has been shown to contribute to various neurocognitive disorders. For example, the inflammatory response characteristic of intestinal hyperpermeability triggers the release of pro-inflammatory cytokines and other chemicals that are thought to induce depression. A study published in the journal Nutritional Neuroscience described the “vicious circle between immune system impairment and increasing dysbiosis that leads to leaky gut and neurochemical compounds and/or neurotoxic xenobiotics production and absorption.” The authors described findings from a number of studies that point to their theory that autism may be connected to problems in the microbiome, particularly within the first year of life. It is actually now a common hypothesis in modern science. Causes What is the main cause of leaky gut? As explained above, it occurs when certain tiny particles that should never be able to enter your bloodstream start to make their way through due to dysfunction of the mucosal barrier in the gut. There also commonly are abnormalities in the gut stemming from antimicrobial molecules, immunoglobulins and cytokine activities. This presents a major problem, as the vast majority of your immune system is found inside the gut (sometimes called the microbiome). The result is a disruption of acute inflammation and sometimes autoimmune reactions. A normal part of your immune response that serves to fight infections and diseases winds up over-performing, leading to chronic inflammation, which is at the root of most diseases. Some of the underlying causes of leaky gut include: Genetic predisposition — Certain people may be more predisposed to developing this condition because they are sensitive to environmental factors that “trigger” their bodies into initiating autoimmune responses. Poor diet — Especially a diet that includes allergens and inflammatory foods, such as unsprouted grains, added sugar, GMOs, refined oils, synthetic food additives, conventional dairy products and alcohol. Chronic stress Toxin overload — This includes “chronic stressors,” such as high drug and alcohol consumption. We come into contact with more than 80,000 chemicals and toxins every single year, but the worst offenders for causing leaky gut include antibiotics, pesticides, tap water, aspirin and NSAIDs. It’s recommended to buy a high-quality water filter to eliminate chlorine and fluoride and look to natural plant-based herbs to reduce inflammation in your body. Bacterial imbalance — Also called dysbiosis, which means an imbalance between beneficial and harmful species of bacteria in your gut. A large body of evidence now shows that gut microbiota is important in supporting the epithelial barrier and preventing autoimmune reactions. At least 10 percent of all gene transcriptions found in intestinal epithelial cells that are related to immunity, cell proliferation and metabolism are regulated by gut microbiota. Controversies Do most conventional doctors support the idea that leaky gut is real? Not exactly, as it the topic remains controversial. WebMD refers to leaky gut as “something of a medical mystery.” This isn’t surprising, since it’s not a diagnosis that most doctors have been taught in medical school. “From an MD’s standpoint, it’s a very gray area,” says gastroenterologist Donald Kirby, M.D., director of the Center for Human Nutrition at the Cleveland Clinic. In his opinion, “Physicians don’t know enough about the gut, which is our biggest immune system organ.” However, a roundtable review quotes the researchers at seven different European universities in 2014 agreeing upon the following: “Alteration of the gut barrier seems to have multiple consequences facilitating the onset of a variety of diseases depending on other hits and on genetic or epigenetic constellations, respectively. The growing significance of the gut barrier and bacterial translocation raises the questions of how we can improve gut barrier functions and gut microbiota.” While it’s encouraging that science is coming around to leaky gut syndrome being a real problem, we are by no means at a point where there are standard diagnostic tools for testing and treating this problem. This means that doctors are often left with no other choice than to follow what they believe to be the “safe path” and prescribe drugs that only treat symptoms. For example, medications (like proton pump inhibitors or antacids) can be used to manage symptoms like acid reflux medications, but these drugs don’t solve the root problem. Because there is so much unknown about leaky gut syndrome, it’s critical that you understand what leaky gut is and what to look out for in case you or a loved one is affected by it. The good news is that many functional and integrative medicine practitioners have a greater understanding of this condition than they did even a decade ago. Treatment Several leaky gut syndrome tests are available that can help confirm a diagnosis and point you in the right treatment direction. Tests are helpful for identifying specific sensitivities and uncovering which types of toxins or deficiencies are contributing to your symptoms. Available tests include: Zonulin or Lactulose Tests IgG Food Intolerance Test Stools Tests Organic Acid Vitamin and Mineral Deficiencies Tests Lactulose Mannitol Test What leaky gut treatments are available? A four-step process can help treat leaky gut. We cover this process in a leaky gut diet and treatment plan. The basic steps to healing leaky gut are as follows: Remove foods and factors that damage the gut. Replace these with healing foods that are part of an anti-inflammatory diet. Repair the gut with specific leaky gut supplements like butyric acid. Rebalance your microbiome with probiotics (beneficial bacteria). This is key because bacteria in your...

The post Leaky Gut Syndrome: 7 Signs You May Have It appeared first on Amazing Health Advances.

Anti-Inflammatory Compounds in Rosemary Offer Powerful Arthritis Relief, Studies Show

AHA Publisher — Fri, 07 Jan 2022 08:00:47 +0000

Lori Alton via NaturalHealth365 – Roughly a quarter of all adults in the United States – 58.5 million people – are affected by arthritis, a potentially debilitating condition that can jeopardize physical, emotional, and financial health. For example, over 8 million working-age adults declare that their ability to work is limited by arthritis. In addition, the sheer cost of the disease is staggering, with the Centers for Disease Control reporting that arthritis currently costs the country an astounding $303.5 billion a year. While mainstream medicine may attempt to address arthritis with non-steroidal anti-inflammatory drugs, these can feature a range of toxic side effects – especially when used long-term. However, a common cooking seasoning may offer a ray of hope. Recent research has showcased the ability of compounds found in rosemary to suppress the inflammation that triggers arthritis. Let’s see how this fragrant, flavorful herb accomplishes this feat and provides arthritis relief. Chronic Systemic Inflammation Can Wreak Havoc on Health Experts say that inflammation is a protective response against injury, pathogens, and toxins – and is a normal part of the healing process. However, when inflammation becomes excessive and chronic (usually the result of an abnormal immune response) disease can result. In inflammatory diseases – such as arthritis, inflammatory bowel disease, asthma, periodontitis, fatty liver disease, and type 2 diabetes – immune cells known as macrophages and T-lymphocytes produce excessive amounts of inflammatory enzymes, including cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). In fact, it is COX and 5-LOX, among other enzymes, that produce the redness, pain, swelling, and loss of function that characterize arthritis. Rosmarinic Acid from Rosemary Offers Arthritis Relief by Slashing Inflammation In a new scientific review published in Frontiers in Pharmacology, the researchers evaluated dozens of test tube, animal, and human studies to assess the potential of rosmarinic acid in rosemary to reduce inflammation and pain from arthritis. They examined the compound’s effect on the two most common forms of arthritis: osteoarthritis – a degenerative disease of the cartilage – and rheumatoid arthritis, classified as a chronic inflammatory autoimmune disease. The findings were promising. Rosmarinic acid appeared to not only alleviate symptoms but also slow down cartilage degeneration. In one clinical study, participants with osteoarthritis who drank a tea rich in rosmarinic acid every day for 16 weeks significantly improved stiffness and physical disability. Rosmarinic acid also caused apoptosis, or cell suicide, in potentially disease-causing T-cells in patients with rheumatoid arthritis. And, in a 2021 animal study published in BMC Complementary Medicine and Therapies, researchers concluded that a nanoemulsion of rosemary and peppermint essential oils reduced osteoarthritis pain. The scientists noted that the emulsion appeared to increase antioxidant capacity, meaning it increased the scavenging of disease-causing free radicals. (In addition to rosmarinic acid, rosemary contains the potent antioxidants carnosic acid, carnisol, hesperidin, and cineole. It has also been shown to elevate levels of superoxide dismutase and glutathione, important antioxidants produced in the body). Good News for Eczema Sufferers: Rosmarinic Acid Improves Atopic Dermatitis Atopic dermatitis, also known as atopic eczema, is an inflammatory skin disease that causes lesions, itching, swelling, and redness, along with thickening, flaking skin. When the review authors looked at studies evaluating rosmarinic acid against atopic dermatitis, they found that it interfered with the production of an inflammatory compound known as interleukin, thereby inhibiting the development of lesions and thickening of the skin. While the bulk of the research was performed on animals, several human studies supported the promising findings. In a study published in the Journal of Dermatology, patients with atopic dermatitis were treated with a topical application of a 3 percent rosmarinic acid emulsion twice a day for eight weeks. Participants experienced significant reductions in itchiness and dry skin. Noting that the intervention caused no dermal irritation, the researchers praised rosmarinic acid as a potential treatment for eczema. Studies Show Rosemary Alleviates Asthma — and More Studies have shown that rosemary’s therapeutic compounds can offer arthritis relief, using multiple mechanisms to help improve cough, wheezing, and production of sputum in asthmatic patients. For example, rosmarinic acid inhibits airway inflammation, regulates the synthesis and secretion of pro-inflammatory mediators, and decreases the number of total inflammatory cells and eosinophils in the lungs. These promising findings prompted scientists to “strongly support” the potential use of rosmarinic acid as an anti-inflammatory drug for the treatment of asthma. With asthma currently affecting over 7 and 8 percent of all Americans, the use of safe, natural rosemary extracts as an intervention certainly deserves further study! By the way, the authors of the Frontiers in Pharmacology review noted that rosmarinic acid also benefits Crohn’s disease, ulcerative colitis, pancreatitis, fatty liver disease, allergic rhinitis, and periodontitis. Use Antioxidant, Anti-Inflammatory Rosemary for Natural Arthritis Relief You can access the benefits of rosemary and support joint health by using the fresh or dried herb in recipes for chicken, fish, beef, soups, and stews. For a savory tea that may help soothe achy joints, steep one teaspoon of dried rosemary in eight ounces of water for five minutes. Flavor with lemon or honey, if desired. Natural health experts advise drinking one or two cups daily. Rosemary essential oil may be applied topically to the affected area, after being diluted with a carrier oil such as olive oil. However, essential oils should not be ingested. Rosemary extracts are also available – but check with your integrative doctor before supplementing. While rosemary is considered generally safe in quantities normally found in food, excessive amounts can cause upset stomach, vomiting, and changes in blood pressure. For centuries, rosemary has been prized by herbal healers for its ability to reduce inflammation and pain. The use of this trusted herb for arthritis relief is a technique that is not only time-honored but evidence-based as well. Sources for this article include: Biomed.central NIH.gov FlushingHospital.org NIH.gov MedicalNewsToday.com CDC.gov EczemaHeadquarters.com To read the original article click here.

The post Anti-Inflammatory Compounds in Rosemary Offer Powerful Arthritis Relief, Studies Show appeared first on Amazing Health Advances.