Study Shows How Liver Damage from Stress & Aging Might Be Reversible

The AHA! Team — Thu, 18 Jul 2024 08:48:45 +0000

Duke Health – DURHAM, N.C. – While the liver is one of the body’s most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure. A Duke Health research team now might have found a way to turn back time and restore the liver. In experiments using mice and liver tissue from humans, the researchers identified how the aging process prompts certain liver cells to die off. They were then able to reverse the process in the animals with an investigational drug. The finding, which appears in the journal Nature Aging, holds high promise for the millions of people who have some degree of liver damage – livers that are essentially old due to the metabolic stresses of high cholesterol, obesity, diabetes or other factors. “Our study demonstrates that aging is at least partially reversible,” said senior author Anna Mae Diehl, M.D., the Florence McAlister Distinguished Professor of Medicine at the Duke University School of Medicine. “You are never too old to get better.” Diehl and colleagues set out to understand how non-alcoholic liver disease develops into a severe condition called cirrhosis, in which scarring can lead to organ failure. Aging is a key risk factor for cirrhosis among those who have been diagnosed with non-alcoholic liver disease, known as metabolic dysfunction-associated steatotic liver disease, or MASLD. One in three adults worldwide have the disease. Studying the livers of mice, the researchers identified a genetic signature distinct to old livers. Compared to young livers, the old organs had an abundance of genes that were activated to cause degeneration of hepatocytes, the main functioning cells of the liver. “We found that aging promotes a type of programmed cell death in hepatocytes called ferroptosis, which is dependent on iron,” Diehl said. “Metabolic stressors amplify this death program, increasing liver damage.” Armed with their genetic signature of old livers, the researchers analyzed human liver tissue and found that the livers of people diagnosed with obesity and MASLD carried the signature, and the worse their disease, the stronger the signal. Importantly, key genes in the livers of people with MASLD were highly activated to promote cell death through ferroptosis. This gave the researchers a definitive target. “There are things we can use to block that,” Diehl said. Again turning to mice, the researchers fed young and old mice diets that caused them to develop MASLD. They then gave half the animals a placebo drug and the other half a drug called Ferrostatin-1, which inhibits the cell death pathway. Upon analysis after treatment, the livers of the animals given Ferrostatin-1 looked biologically like young, healthy livers — even in the old animals that were kept on the disease-inducing diet. “This is hopeful for all of us,” Diehl said. “It’s like we had old mice eating hamburgers and fries, and we made their livers like those of young teenagers eating hamburgers and fries.” Diehl said the team also looked at how the ferroptosis process in the liver impacts the function of other organs, which are often damaged as MASLD progresses. The genetic signature was able to differentiate between diseased and healthy hearts, kidneys and pancreases, indicating that damaged livers amplify ferroptotic stress in other tissues. “Together, we’ve shown that aging exacerbates non-alcoholic liver disease by creating ferroptic stress, and by reducing this impact, we can reverse the damage,” Diehl said. In addition to Diehl, study authors include Kuo Du, Liuyang Wang, Ji Hye Jun, Rajesh K. Dutta, Raquel Maeso-Díaz, Seh Hoon Oh and Dennis C. Ko. The study received funding support from the 021 AASLD Pinnacle Award, the National Institutes of Health (R01 AA010154, R01 DK077794, R56 DK134334); and Boehringer Ingelheim Pharmaceuticals, Inc. To read the original article click here.

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Powerful UPDATE: Improve Your Heart Function with These Simple Interventions

AHA Publisher — Tue, 16 Nov 2021 08:00:40 +0000

Edit Lang via NaturalHealth365 – [Lately it seems] we give little to no consideration to the number one killer of American people – heart disease. It is incomprehensible how a disease claiming the lives of 659,000 Americans every year gets no real attention from mainstream media and health authorities. But we are here to change that. In another captivating interview, we bring you real, practical health information that you can use to take charge of your heart health. You will not want to miss this conversation between Jonathan Landsman of NaturalHealth365 and Dr. Robert DeMaria, America’s Drugless Doctor. A Healthy Heart Starts with a Healthy Liver, Here Is Why Few people are aware of the intricate connection that exists between the heart and the liver. As Dr. Bob explains, blood flows up through the legs through the liver to the heart. Therefore, it’s critical to consider what we put in and on our bodies when working to improve heart health because it affects the liver’s health. When the liver is compromised, the blood flowing back to the heart will become impeded. Watch the video (above) to hear his explanation and find out what you can do to improve the health of your liver and cardiovascular system. What You Eat Can Impact Heart Function We have all heard the expression, “you are what you eat.” It turns out, what you eat also has a drastic effect on your heart. For instance, most people don’t know that sugar removes B vitamins from the body. Why does that matter? Because B vitamins are necessary to protect the integrity of heart valves. Scientists have confirmed this in a recent study that found people who ate a diet rich in B-vitamins are less likely to succumb to cardiovascular disease. Heart WARNING About Dehydration, Toxins in Our Food and the Environment Eating the wrong foods, exposure to environmental toxins, and chronic dehydration also exacerbate heart issues. Dehydration is particularly damaging, yet, most do not make the connection between lack of hydration and heart function. Dr. Bob gives a simple yet often overlooked explanation, revealing how inadequate hydration causes red blood cells to stick together, resulting in reduced oxygen levels, causing oxygen deprivation in the heart. Conversely, drinking more water causes the blood cells to separate, carrying more oxygen, increasing energy. Listen to Dr. Bob’s tip on how to stay on top of your hydration using an Oximeter. What’s the Bottom Line? If you want to improve your heart health, you have no other choice but to take charge of your health. Be proactive and take the time to understand how your bodily systems work. Ultimately, in the body, everything is interconnected. By nourishing your liver, removing environmental toxins, eliminating toxic foods, and maintaining optimum blood circulation, you will be well on your way to a heart-healthy you. Share this video with your friends and family to help empower them to embark on this journey with you. Sources used for this article: CDC.gov Rumble.com NIH.gov To read the original article click here.

The post Powerful UPDATE: Improve Your Heart Function with These Simple Interventions appeared first on Amazing Health Advances.

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Study Shows How Liver Damage from Stress & Aging Might Be Reversible

Powerful UPDATE: Improve Your Heart Function with These Simple Interventions