healthy gut bacteria Archives - Amazing Health Advances

Food Allergies Can Be Reversed in Mice by Targeting the Microbiome

AHA Publisher — Wed, 24 Aug 2022 07:00:45 +0000

American Chemical Society (ACS) via Newswise – CHICAGO, Aug. 21, 2022 — Although many people with dietary allergies experience mild symptoms when exposed to triggering foods, some face potentially fatal consequences. A bacterial compound called butyrate that’s made by healthy microbiomes has shown promise against allergic reactions in lab tests, but it’s nasty to take orally. Today, scientists describe a more palatable way to deliver this compound and report that their “polymeric micelles” are effective against peanut allergies in mice. The treatment could someday counteract many types of food allergies and inflammatory diseases. The researchers will present their results at the fall meeting of the American Chemical Society (ACS). ACS Fall 2022 is a hybrid meeting being held virtually and in-person Aug. 21–25, with on-demand access available Aug. 26-Sept. 9. The meeting features nearly 11,000 presentations on a wide range of science topics. Some of the bacteria in the gut microbiome produce metabolites, such as butyrate, that foster the growth of beneficial bacteria and maintain the lining of the gut. If a person’s microbiome is unhealthy and lacks these butyrate-producing bacteria, fragments of partially digested food can leak out of the gut and produce an immune reaction that results in an allergic response. One way to treat those with allergies would be to provide the missing bugs to them orally or with a fecal transplant, but that hasn’t worked well in the clinic, according to Jeffrey Hubbell, Ph.D., one of the project’s principal investigators (PIs). “So we thought, why don’t we just deliver the metabolites — like butyrate — that a healthy microbiome produces?” “But butyrate has a very bad smell, like dog poop and rancid butter, and it also tastes bad, so people wouldn’t want to swallow it,” says Shijie Cao, Ph.D., who is presenting the results at the meeting for the team, which is at the University of Chicago. And even if people could choke it down, butyrate would be digested before reaching its destination in the lower gut. To overcome these challenges, the researchers, including co-PI Cathryn Nagler, Ph.D., and Ruyi Wang, Ph.D., designed a new delivery system. They polymerized butanoyloxyethyl methacrylamide — which has a butyrate group as a side chain — with methacrylic acid or hydroxypropyl methacrylamide. The resulting polymers self-assembled into aggregates, or polymeric micelles, that tucked the butyrate side chains in their core, thus cloaking the compound’s foul smell and taste. The researchers administered these micelles to the digestive systems of mice lacking either healthy gut bacteria or a properly functioning gut lining. After digestive juices released the butyrate in the lower gut, the inert polymers were eliminated in the feces. The treatment restored the gut’s protective barrier and microbiome, in part by increasing production of peptides that kill off harmful bacteria, which made room for butyrate-producing bacteria. Most importantly, dosing allergic mice with the micelles prevented a life-threatening anaphylactic response when they were exposed to peanuts. “This type of therapy is not antigen specific,” Cao notes. “So theoretically, it can be broadly applied to any food allergies through the modulation of gut health.” Next up are trials in larger animals, followed by clinical trials. If those trials succeed and the U.S. Food and Drug Administration approves the oral treatment, the micelles could be marketed in small packets; consumers would tear open a packet and stir the contents into a glass of water or juice. In other work with the micelles, the team is analyzing data on treating inflammatory bowel diseases with the oral therapy. The team is also investigating administration via injection. The researchers have shown that this method allows the micelles and their butyrate cargo to accumulate in lymph nodes, which are part of the immune system. They found that this approach is effective in treating peanut allergies in mice, but it could also be used to suppress immune activation locally — rather than throughout the body. For example, injections could be helpful in patients who have had an organ transplant or who have a localized autoimmune and inflammatory condition, such as rheumatoid arthritis. The researchers acknowledge support and funding from their start-up company, ClostraBio, and the University of Chicago. To read the original article click here.

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Can Healthy Gut Bacteria Reduce the Risk of Dementia?

AHA Publisher — Tue, 09 Mar 2021 08:00:57 +0000

Dr. Don Colbert – Is it possible that your gut bacteria affect your brain health? Even reduce the risk of dementia? We know that gut health and bacteria is imperative to immune health, hormone balance, healthy digestion, metabolic health and more. But, the brain? That can seem like a stretch. This study tried to answer this question. Here’s what was found and what it means to you. The Study: Gut Bacteria to Reduce the Risk of Dementia In January 2019, Scientific Reports published a study investigating the link between gut bacteria and dementia (1). The study aimed to determine if having healthy gut bacteria (and lack of harmful bacteria) affected the risk of developing dementia. The study involved 128 people who visit an outpatient memory clinic. The participants were 59% female and had a mean age of 74.2 years. To study gut bacteria vs. dementia risk, researchers assessed cognitive function using neuropsychological tests and brain MRI scans. The scientists divided the participants into demented and non-demented groups based on multivariable logistic regression models, silent lacunar infarcts and cerebral microbleeds, and more. Then, they collected fecal samples to study gut microbiotic. What Is the Gut Microbiome? The gut microbiome is made up of all the microorganisms that live in the digestive tract. There are about a trillion cells composed of about a thousand different species of bacteria! This microbiome plays a huge role in human health. Recent research has correlated certain changes in gut bacteria with inflammatory and autoimmune conditions, hormone balance, bone density and mineral uptake, and more. In addition, some studies show that various lifestyle factors, including diet, exercise, and stress can alter gut bacteria. Many experts believe that most modern chronic diseases have correlations within the body. Healthy gut microbiome is one believed to impact many diseases. Gut Bacteria, Dementia, and Study Results In this study, the researchers found that the dementia group and non-dementia group had differences in types and amounts of gut microbiota. For example, levels of Bacteroides (one type of beneficial bacteria that normally live in the intestines) were decreased in the dementia group. Another bacteria, called enterotype III, were consistently increased in the group with dementia. These bacteria variations between groups were significant and independent of other variables that were studied, suggesting a link. What’s more, ammonia, indole, skatole, and phenol were all higher in the feces of the dementia group vs. the non-dementia group. In conclusion, the results suggested that these gut microbiome irregularities are independently and strongly associated with dementia. Specifically, beneficial bacteria may reduce the risk of dementia. Limitations of the Study Of course, no one study is perfect and this one had limitations. First of all, it was able to link the gut bacteria with the risk of dementia, but it did not show that it caused it. It also only had 128 participants, which is considered a small number. Since all the participants were regular patients at the out-patient center, it is possible that they experienced commonalities in the environment unaccounted for. Still, it is a strong study that indicates the need the further investigation. Are Probiotic Supplements the Answer? At the end of the study, the lead researcher suggested that probiotic supplements could play a role in improving the health of gut bacteria and reduce the risk of dementia. He pointed to a recent small study of 27 subjects that suggested that supplementation of a bacteria called Bifidobacterium breve A1 improved brain function in adults with mild cognitive impairment (2). The study found that 2 significant cognitive test scores improved during the probiotic supplementation intervention. Still, most researchers do not believe supplementation alone is the answer. Eating for Gut Health? Can diet alone boost beneficial gut bacteria enough to affect cognition? It’s possible. It’s important to eat a diet that includes many real foods with prebiotic fibers (in many vegetables) and fermented ingredients. However, many researchers believe that healthy gut bacteria is a result of multiple lifestyle factors including diet, medication use, supplements, and more. Bottom Line This new study indicates that there is a link between healthy gut bacteria, cognitive function, and reducing the risk of dementia. Taking care of healthy gut bacteria through supplements, diet, and a healthy lifestyle may be one key to brain health. More and more, science is proving that a healthy digestive system is the key to a healthy brain and body—and the power to keep your gut healthy lies directly with you! Get Dr. Colbert’s Healthy Gut Zone book today to help you understand the connection between your gut and your health. You will learn that whatever inflames your gut will eventually inflame your brain and the rest of your body. Making the right food choices will become the medicine in which you will walk and live in divine health. To read the original article click here. For more articles from Dr. Colbert click here.

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5 Ways a Healthy Weight Supports Immune Function. Achieve Yours

AHA Publisher — Thu, 12 Nov 2020 08:00:23 +0000

Dr. Don Colbert – If you’re overweight, you can make a significant difference in your immune function, starting today! By working towards a healthy weight, you can improve the health of your body systems that spur immune health. While this is easier said than done, even prudent changes in weight can make a huge difference. In fact, a healthy weight supports immune function by supporting heart function, hormones, digestion, and more. Notably, there is a direct and measurable improvement in immune function outcomes and the incidence of sickness during and after healthy weight changes. It will take work and dedication to improve your weight. We are here to help and have a plan that will guide you towards a healthy weight and lifestyle. Are you ready to support your immune function with a healthier weight? UNHEALTHY WEIGHT AND INCIDENCE OF SICKNESS During the past few decades, experts have come to understand that being at an unhealthy weight, directly and indirectly, increases the risk of seasonal sickness and poor immune function. In fact, they believe that being overweight can cause a chronic state of inflammation that harms immune function. This can result in a blunted immune response to harmful invaders and microbes, poor recovery, and even a decreased response with medications (1). As the number of overweight individuals continues to increase in the population, health experts are bracing for more and more community sickness. But, there’s good news. Even just a small change in weight or a loss of about 5-10% can make a big difference in immune function. And, the more an individual moves towards a healthy weight, the better the results become. Here are 5 ways a healthy weight supports immune function. 5 WAYS A HEALTHY WEIGHT SUPPORTS IMMUNE FUNCTION 1. HEALTHIER GUT BACTERIA AND REDUCED INFLAMMATION Did you know that gut microbiota (bacteria) is altered in an overweight or obese individual compared to one at a healthy weight? It’s true. It’s in an unhealthy state. This unhealthy state has big implications for immune function and overall health. Human gut bacteria plays many roles, and an immune function is highly dependent on it. What’s not so clear is whether being obese causes healthy bacteria to change and become unhealthy, or whether the altered gut bacteria contribute to obesity. Experts believe the answer is a bit of both. There are several mechanisms linking the gut microbiota with obesity, altered insulin reactions, inflammation, metabolic issues, failing liver function, and more. The unhealthy gut bacteria may actually contribute to an altered hormone state that perpetuates fat gain (2). More fat gain further deteriorates healthy gut bacteria. This unhealthy cycle continues and reaps havoc on immune function. So, how does a healthy weight affect the gut and immune system? As an individual works towards and achieves a healthy weight, there are significant changes in gut microbial composition. These changes continue to spur advances toward a healthy weight. This is true for both diet-induced weight changes and bariatric surgery (3). Adding healthy bacteria to the diet during the effort can further support digestion and immune function. 2. NORMALIZED BLOOD SUGARS WITH A HEALTHY WEIGHT Did you know the presence of high blood sugars increases the incidence of sickness and infection? Thankfully, a healthy weight can normalize blood sugars. In fact, when blood sugars are high, sickness can induce a stress reaction which may lead to the secretion of hyperglycemic hormones, abnormal glucose variability, and health complications. What’s more, infections increase blood sugar levels which perpetuates the problem. The opposite is true when an individual works towards a healthy weight. In one study, researchers reported that improvements in weight were strongly associated with improvements in blood sugars, blood pressure, triglyceride levels, and HDL cholesterol. They stated that a modest weight loss of just 5-10% was enough to improve health (4). 3. HEALTHY WEIGHT MEANS A HEALTHIER HEART Another organ vital to overall health and immune function is the heart. Unfortunately, obesity is associated with an increased risk of developing cardiovascular illnesses. Why? Being overweight stresses the heart, and this can lead to increased inflammation, elevated blood pressure, and changes in heart structure. What’s more, pro-inflammatory cytokines produced by adipose tissue can induce cardiac dysfunction (5). On the other hand, most illnesses can hurt the heart, and harmful microbes can promote the development of cardiovascular disorders and injury. An unhealthy or weak heart diminishes immune strength (6). Achieving a healthy weight supports immune function and heart health! 4. A HEALTHY WEIGHT PROMOTES A HEALTHIER LIVER The liver is extremely important to immune function and the detoxification of the human body. Unfortunately, an unhealthy weight can impair liver function. If you’re worried about your weight, liver, and immune system, there’s good news. A recent study found that a 5% decrease in BMI (body mass index) in overweight participants resulted in a decrease in liver fat and liver volume. They saw improvements in liver health with this weight decrease (7). As you achieve a healthy weight, you can support liver and immune function! 5. HEALTHY LUNGS Many people don’t think of the lungs when they think of immune health. However, they are vital. Healthy alveoli (tissues at the ends of bronchi in the lungs) are responsible for gaseous exchange in and out of the lungs and blood supply. They also work as an emergency exit for toxins. When your lungs are healthy, they support immune function by helping rid the body of toxic substances, microbes, and byproducts. However, being overweight can impair lung function. It causes substantial changes to the mechanics of the lungs and chest wall. This can result in asthma-like symptoms and inflammation in the lungs. Positive changes in BMI can help! In fact, several studies have found that improved weights result in increases in lung volumes and overall lung health (8). In addition to a healthy weight, it’s vitally important for lung health to abstain from smoking. HOW TO WORK TOWARDS A HEALTHY WEIGHT STARTING TODAY If you are interested in supporting your immune system and overall health by achieving a healthy weight, we have plans for you! In fact, you can start with Dr. Colbert’s 21 Day Detox and Fast. It’s free and will help you improve the health of every system mentioned here. Then, you can make real lifestyle changes and achieve a healthy weight with Keto Zone. Start by joining our FREE Keto Zone 21-Day-Challenge. Next, keep going with the Keto Zone Starter Kitincluding Dr. Colbert’s Keto Zone Diet Book. BOTTOM LINE You can support your immune system, but it takes working towards a healthy weight. Work towards your goals, and let us help with proven programs for health, immunity, and lifestyle change! You can start for free today! To read the original article click here. For more articles from Dr. Colbert click here.

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