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Cells ‘Vomit’ Waste to Promote Healing, Mouse Study Reveals

The AHA! Team — Wed, 03 Sep 2025 05:36:33 +0000

Washington University in St. Louis via Newswise – Newly discovered purging process in gastric cells hints at how injury recovery can go wrong – The researchers dubbed the new purging process “cathartocytosis,” combining Greek root words meaning cellular cleansing. When injured, cells have well-regulated responses to promote healing. These include a long-studied self-destruction process that cleans up dead and damaged cells as well as a more recently identified phenomenon that helps older cells revert to what appears to be a younger state to help grow back healthy tissue. Now, a new study in mice led by researchers at Washington University School of Medicine in St. Louis and the Baylor College of Medicine reveals a previously unknown cellular purging process that may help injured cells revert to a stem cell-like state more rapidly. The investigators dubbed this newly discovered response cathartocytosis, taking from Greek root words that mean cellular cleansing. Published online in the journal Cell Reports, the study used a mouse model of stomach injury to provide new insights into how cells heal, or fail to heal, in response to damage, such as from an infection or inflammatory disease. “After an injury, the cell’s job is to repair that injury. But the cell’s mature cellular machinery for doing its normal job gets in the way,” said first author Jeffrey W. Brown, MD, PhD, an assistant professor of medicine in the Division of Gastroenterology at WashU Medicine. “So, this cellular cleanse is a quick way of getting rid of that machinery so it can rapidly become a small, primitive cell capable of proliferating and repairing the injury. We identified this process in the GI tract, but we suspect it is relevant in other tissues as well.” Jettisoning of waste Brown likened the process to a “vomiting” or jettisoning of waste that essentially adds a shortcut, helping the cell declutter and focus on regrowing healthy tissues faster than it would be able to if it could only perform a gradual, controlled degradation of waste. As with many shortcuts, this one has potential downsides: According to the investigators, cathartocytosis is fast but messy, which may help shed light on how injury responses can go wrong, especially in the setting of chronic injury. For example, ongoing cathartocytosis in response to an infection is a sign of chronic inflammation and recurring cell damage that is a breeding ground for cancer. In fact, the festering mess of ejected cellular waste that results from all that cathartocytosis may also be a way to identify or track cancer, according to the researchers. A novel cellular process The researchers identified cathartocytosis within an important regenerative injury response called paligenosis, which was first described in 2018 by the current study’s senior author, Jason C. Mills, MD, PhD. Now at the Baylor College of Medicine, Mills began this work while he was a faculty member in the Division of Gastroenterology at WashU Medicine and Brown was a postdoctoral researcher in his lab. In paligenosis, injured cells shift away from their normal roles and undergo a reprogramming process to an immature state, behaving like rapidly dividing stem cells, as happens during development. Originally, the researchers assumed the decluttering of cellular machinery in preparation for this reprogramming happens entirely inside cellular compartments called lysosomes, where waste is digested in a slow and contained process. From the start, though, the researchers noticed debris outside the cells. They initially dismissed this as unimportant, but the more external waste they saw in their early studies, the more Brown began to suspect that something deliberate was going on. He utilized a model of mouse stomach injury that triggered the reprogramming of mature cells to a stem cell state all at once, making it obvious that the “vomiting” response — now happening in all the stomach cells simultaneously — was a feature of paligenosis, not a bug. In other words, the vomiting process was not just an accidental spill here and there but a newly identified, standard way cells behaved in response to injury. Although they discovered cathartocytosis happening during paligenosis, the researchers said cells could potentially use cathartocytosis to jettison waste in other, more worrisome situations, like giving mature cells that ability to start to act like cancer cells. The downside to downsizing While the newly discovered cathartocytosis process may help injured cells proceed through paligenosis and regenerate healthy tissue more rapidly, the tradeoff comes in the form of additional waste products that could fuel inflammatory states, making chronic injuries harder to resolve and correlating with increased risk of cancer development. “In these gastric cells, paligenosis — reversion to a stem cell state for healing — is a risky process, especially now that we’ve identified the potentially inflammatory downsizing of cathartocytosis within it,” Mills said. “These cells in the stomach are long-lived, and aging cells acquire mutations. If many older mutated cells revert to stem cell states in an effort to repair an injury — and injuries also often fuel inflammation, such as during an infection — there’s an increased risk of acquiring, perpetuating and expanding harmful mutations that lead to cancer as those stem cells multiply.” More research is needed, but the authors suspect that cathartocytosis could play a role in perpetuating injury and inflammation in Helicobacter pylori infections in the gut. H. pylori is a type of bacteria known to infect and damage the stomach, causing ulcers and increasing the risk of stomach cancer. The findings also could point to new treatment strategies for stomach cancer and perhaps other GI cancers. Brown and WashU Medicine collaborator Koushik K. Das, MD, an associate professor of medicine, have developed an antibody that binds to parts of the cellular waste ejected during cathartocytosis, providing a way to detect when this process may be happening, especially in large quantities. In this way, cathartocytosis might be used as a marker of precancerous states that could allow for early detection and treatment. “If we have a better understanding of this process, we could develop ways to help encourage the healing response and perhaps, in the context of chronic injury, block the damaged cells undergoing chronic cathartocytosis from contributing to cancer formation,” Brown said. Brown JW, Lin X, Nicolazzi GA, Liu X, Nguyen T, Radyk MD, Burclaff J, Mills JC. Cathartocytosis: jettisoning of cellular material during reprogramming of differentiated cells. Cell Reports. Online July 20, 2025. DOI: 10.1016/j.celrep.2025.116070. To read the original article click here.

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Need Thyroid or Hormone Support? Take Our Quiz Today!

AHA Publisher — Mon, 07 Nov 2022 05:47:26 +0000

Dr. Don Colbert – A woman’s body is constantly changing. Every decade, every year, even within each month, women experience hormone ebbs and flows, and changing bodies. While this may seem unsettling, it doesn’t have to be. In fact, it can be a great opportunity to learn to nourish your body with thyroid and/or hormone support as needed. You may be at the point in your life where some extra nutrients are needed. Your body may no longer be in balance. Here are 12 signs you can benefit from thyroid or hormone support (1, 2, 3). Thyroid and Hormone Support Quiz Are any of the following true for you? You feel chronically fatigued, and you can’t explain why. You are increasingly sensitive to cold or heat. You cannot lose weight no matter what you try. You’ve suddenly lost weight and did not want to. You’re experiencing thinning hair including eyelashes and/or eyebrows. You’re experiencing unwanted hair growth (on face, etc). You’re experiencing newly on-set acne, especially along your jawline. Your muscles and joints feel increasingly stiff or painful. You are experiencing night sweats or sweating profusely during the day. You are experiencing newly-onset urinary incontinence. You are experiencing sleep disturbances; trouble falling asleep and/or staying asleep. You feel like you are constantly in a PMS state: feeling anxious, overwhelmed, irritable, crampy, bloated, etc. Why These Symptoms Are Important If you answered yes to at least 3 of these questions, you may benefit from all-natural thyroid and/or hormone support. Unfortunately, for decades or even centuries, most of these symptoms have simply been chaulked up to “aging” or menopause. While women certainly age and experience body changes, and go through menopause and experience body changes, we don’t have to experience many of the negative and uncomfortable symptoms that come with them. In fact, most of these issues are easily soothed with thyroid and hormone support. The right nutrients can actually reduce many negative symptoms, improve balance within your body, and support whole-body wellness. You don’t have to feel poorly year after year. You can feel great again! Here’s how. How Thyroid Zone Can Help Your thyroid affects almost all of your body systems. Many thyroid issues are due to an imbalance or inadequacy of minerals, many of which are difficult-to-obtain in the diet. How can you support your thyroid? Consider Keto Zone® Thyroid Zone. This supplement specifically supports your thyroid by providing a variety of minerals and nutrients that promote healthy thyroid function. These nutrients are important for whole-body health and may improve the symptoms of hypothyroidism. In fact, Keto Zone® Thyroid Zone contains natural iodine, selenium, zinc, copper, vitamins A, D, and B12, Ashwagandha extract, Guggul extract, Coleus Forskohlii, L-Tyrosine, Schizandra, Kelp, Bladderwrack, and Cayenne – important minerals and nutrients for thyroid health (4). Thyroid Zone has been designed to encourage: Optimal Thyroid Hormone Production T4 to T3 Conversion Thyroid Hormone Activation Balanced Iodine Levels Optimal Thyroid Enzymes And Function Protection of the Thyroid From Oxidative Stress Weight Loss Healthy Metabolism Balanced Energy Thyroid Zone promotes balance and health in your thyroid, and therefore, your entire body. How Hormone Zone Can Help In addition, Dr. Colbert has formulated a ground-breaking supplement that supports women’s hormones. Specifically, Keto Zone® Hormone Zone contains Diindolylmethane (DIM), Vitamin D3, and Vitamin K2. Together these nutrients support balanced hormones throughout a woman’s life while also promoting bone health, heart health, and whole-body health. Here’s a summary of each: DIINDOLYLMETHANE (DIM) FOR HORMONE SUPPORT Diindolylmethane (DIM) is an important compound produced by our bodies when we eat cruciferous vegetables. If you’ve ever heard the advice to eat more greens to lower breast cancer risk, it’s due to the resulting production of DIM. DIM alters the metabolism of estrogen in order to help our bodies balance hormones. How? First, it can block an enzyme that converts testosterone into estrogen. Next, DIM converts “bad estrogens” (there are many forms) into good estrogen metabolism. It’s the bad estrogen forms that cause most PMS (pre-mentrual syndrome) and menopause symptoms). Further, DIM encourages pathways that encourage good estrogen production. DIM is a powerful compound for balancing a woman’s hormones and reducing negative estrogen symptoms (5). VITAMIN D3 Vitamin D3 is a prohormone, or nutrient that is readily converted to its hormone form in the body. It is extremely important for a myriad of health functions, including calcium regulation, mental health, immune function, healthy bones and teeth, and metabolism. The vast majority of adults are low in vitamin D3. When it’s deficient, they may experience more infections and illness, lower bone density, cardiovascular disease, and mental illnesses and disorders like depression (6). Adding more Vitamin D3 supports women’s health! VITAMIN K2 Vitamin K2, or menaquinone, is found in animal foods and fermented foods. Most people have heard of vitamin K1 because it’s important for blood clotting, from birth onward. But the importance of vitamin K2 for bone health has only recently been discovered. What’s more, K2 is often deficient in adults. Vitamin K2 is extremely important for bone health, especially in post-menopausal women. Supplementing vitamin K2 and vitamin D together may reduce spinal fractures, hip fractures, and osteoporosis. Further, vitamin K2 supports good dental health from infancy into advanced age (7). Together, these powerful ingredients work to promote: Healthy hormone levels throughout adulthood Optimal estrogen ratios and testosterone levels Bone density and reduced risk of fractures Dental health Immune function Cardiovascular health Healthy skin Daily energy Healthy weight It’s never too late to focus on your hormone balance and health. A great step is to add a natural, hormone-balancing supplement which includes DIM, Vitamin D3, and Vitamin K2, such as Keto Zone® Hormone Zone. Can You Take Thyroid Zone & Hormone Zone Together? If you’re looking to support your thyroid health and encourage healthy hormone balance, you can certainly take Keto Zone® Thyroid Zone and Keto Zone® Hormone Zone at the same time! In fact, they work great together as their compounds synergistically support women’s health! Want Testosterone Support As Well? Of course, it may seem like we’re overlooking the men (or the testosterone needs of women). This article is about women’s thyroid and hormone health, after all. But, we’ve not forgotten testosterone. In fact, Dr. Colbert has also formulated a testosterone supplement that supports men’s health. Keto Zone® Testosterone Zone is men’s answer for healthy testosterone levels through every decade. It is formulated with all-natural, potent ingredients including Testofen, a powerful all-natural testosterone-supporting compound. And best of all, you can get all three products, Keto Zone® Thyroid Zone, Hormone Zone, and Testosterone Zone in a cost-effective, convenient combo pack: Dr. Colbert’s Hormone Health System! Bottom Line Many people benefit from all-natural thyroid and hormone support and supplementation. Is it time for you to try them? Are you experiencing negative health symptoms that could be soothed or alleviated? Dr. Colbert’s Keto Zone® Thyroid Zone and Keto Zone® Hormone Zone are great supplements with which to start. You can experience positive thyroid, hormone, whole-body health effects. In addition, try Dr. Colbert’s Hormone Health System to add testosterone to the mix! To read the original article click here.

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Hyaluranic Acid, a Naturally Occurring Compound, Awakens Stem Cells to Repair Damaged Muscle

AHA Publisher — Fri, 12 Aug 2022 07:00:51 +0000

Ottawa Hospital via Newswise – A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair. In damaged muscle, stem cells must work together with immune cells to complete the repair process, yet how these cells coordinate to ensure the efficient removal of dead tissue before making new muscle fibers has remained unknown. The scientists have now shown that a natural substance called hyaluronic acid, which is used in cosmetics and injections for osteoarthritis, is the key molecule that manages this fundamental interaction. “When muscles get damaged, it is important for immune cells to quickly enter the tissue and remove the damage before stem cells begin repair,” said Dr. Jeffrey Dilworth, senior scientist at The Ottawa Hospital and professor at the University of Ottawa and senior author on the study. “Our study shows that muscle stem cells are primed to start repair right away, but the immune cells maintain the stem cells in a resting state while they finish the cleanup job. After about 40 hours, once the cleanup job is finished, an internal alarm goes off in the muscle stem cells that allows them to wake up and start repair.” Dr. Dilworth and his team identified hyaluronic acid as the key ingredient in this internal alarm clock that tells muscle stem cells when to wake up. When muscle damage occurs, stem cells start producing and coating themselves with hyaluronic acid. Once the coating gets thick enough, it blocks the sleep signal from the immune cells and causes the muscle stem cells to wake up. Using mouse and human tissues, Dr. Dilworth and his team also discovered how muscle stem cells control the production of hyaluronic acid using epigenetic marks on the Has2 gene. “Interestingly, aging is associated with chronic inflammation, muscle weakness and a reduced ability of muscle stem cells to wake up and repair damage,” said lead author Dr. Kiran Nakka, a research associate with Dr. Dilworth who conducted this research as part of his postdoctoral studies. “If we could find a way to enhance hyaluronic acid production in the muscle stem cells of older people it might help with muscle repair.” The authors note that the regenerative effect of hyaluronic acid seems to depend on it being produced by the muscle stem cells. The team is currently examining if drugs that modify the epigenetics of muscle stem cells could be used to increase their production of hyaluronic acid. To read the original article click here.

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Top 10 Reasons to Take a Daily Multivitamin

AHA Publisher — Mon, 01 Aug 2022 07:00:29 +0000

Dr. Don Colbert – Are you one of the millions of Americans who take a daily multivitamin? Or, are you someone who thinks they are a waste of money? Beyond deciding whether or not to take one, there’s also the issue of quality. Not all multivitamin are created equal. Here are 10 reasons to consider a daily multivitamin and what sets the best multivitamin apart from others. 10 Top Reasons to Take a Daily Multivitamin 1. Current Food Supply and Crops We’d all love to believe our food supply is as healthy as ever. However, much of the soil in our country (and others) has been stripped of nutrients levels after years of conventional farming. While the push for organic farming and more sustainable methods has been great, our crops can still be lower in nutrients than we’d like. A daily multivitamin can make up for some of these deficiencies. 2. Weight Loss Plans Almost anytime you’re trying to lose weight, you reduce the amount, or types of foods you consume. And while this can be very healthy, you may miss out on key nutrients. For example, if you cut out dairy, you may not get quite enough Vitamin D3 through the foods you choose. Or, if you cut out red meats, you may lack adequate heme-iron levels. A daily multivitamin can bridge the gap so that you can choose healthy foods that help you meet your weight goals while getting in enough micronutrients. 3. Healthy Aging As we age, our cellular nutritional needs actually increase because many body systems have to work harder to maintain health despite aging tissues (1). Unfortunately, it becomes more difficult for our bodies to absorb needed nutrients. In addition, medications can further deplete our body of nutrients and/or affect absorption. A multivitamin can help us maintain adequate micronutrient intake for healthy aging. Additionally, a good multivitamin should be full of food-derived antioxidants, which fight the build-up of oxidative stress and free radicals (1). These charged molecules harm cells and expedite aging. Antioxidants in a daily multivitamin can offset deficiencies and fight oxidative stress. 4. Heart Health It’s no secret that the nutrients on your plate and in your supplements affect your heart. In fact, Vitamins B1, B2, B6, K1, Niacin (B3), CoQ10 and magnesium all play a role in cardiovascular health. What’s more, some micronutrients promote healthy cholesterol and blood pressure levels while supporting a lessened inflammation response in the body. In an age in which heart ailments are the leading cause of death of both men and women, we need all the heart-healthy nutrients we can get. Studies have found that multivitamin use may be associated with less heart ailments and better health (2, 3, 4). 5. Immune Function Many micronutrients play a role in healthy immune function. In fact, the most important micronutrients for a healthy immune system include vitamins A, C, D, E, B2, B6 and B12, folic acid, beta carotene, iron, selenium, and zinc (5). These nutrients can be found in foods and a good daily multivitamin. While you can certainly eat foods to provide many needed nutrients, most adults are found to be lacking in important immune-boosting nutrients like vitamin D. A good multivitamin can help. 6. Eye Health Micronutrients are also important for eye health. Vitamins A, C, E, Niacin (B3), and selenium support it. Lutein and Zeaxanthin protect the eyes from harmful light waves. In fact, studies have shown multivitamins containing a combination of vitamins, lutein, and zeaxanthin can reduce the risk of macular degeneration (7, 8). Macular Degeneration is an eye disease the causes vision loss and is considered the leading cause of blindness around the world (9). Additionally, researchers have found that taking a daily multivitamin may reduce the risk of cataract symptoms, another eye ailment that contributes to vision loss in older adults (10). 7. Bone Health Bone density gradually diminishes as we age. What’s more, going through menopause can put women at a higher risk of bone loss (11). Thankfully, a good multivitamin can provide micronutrients that support bone health, reduce risk of fractures, and even promote bone healing. These nutrients include calcium, magnesium, phosphorus, vitamin D, and K2 (12, 13, 14, 15). Bone health is supremely important throughout life. Make sure to get the nutrients you need for healthy bones. 8. Brain Function Beyond physical health, multivitamins may support mental health. In fact, some research shows that taking a daily multivitamin can preserve brain function and boost mental health as well. Interestingly enough, one study published by the Centre for Human Psychopharmacology at Swinburne University in Australia even found that daily supplementation with a multivitamin was able to support better memory in older men at risk for cognitive decline (16). Additionally, multivitamins may also support healthy moods and reduce depressive symptoms. One study published in Psychopharmacology found that daily multivitamin supplementation was linked to significant reductions in both anxiety and stress (17). Similarly, another study found that taking a multivitamin was effective at increasing alertness, improving mood and enhancing feelings of overall well-being (18). How can this all be linked to a daily multivitamin? Brain health, like other organs, depends on many micronutrients like antioxidants, anti-inflammatory nutrients, and healthy fatty acids (19). Since our crops, diets, and food supply often lack everything we need, a daily multivitamin can help. 9. Healthy Hair and Skin How can you support the health of your hair and skin? Many lifestyle and diet habits impact hair, skin, and nail health. The important nutrients include Vitamins B3 (Niacin), biotin, Vitamin C, Vitamins A, C, E, iron, zinc, and CoQ10 (20, 21, 22, 23, 24). In fact, adequate micronutrients can slow thinning of hair, improve the appearance of skin, and improve nail health. 10. Energy and Vitality Wouldn’t you love more energy and vitality? Focus on adequate iron, B Vitamins, and magnesium. In fact, these nutrients support energy production, better sleep, and cellular health (25). In addition, a healthy low-carb Mediterranean diet using Dr. Colbert’s Beyond Keto can improve overall health, energy, and vitality. Why Choose Dr. Colbert’s Enhanced Multivitamin? While many multivitamins on the market contain low potency of nutrients, man made chemicals, and artificial coloring and sweeteners, Dr. Colbert’s Enhanced Multivitamin is different. It contains the highest-quality active-form micronutrients ingredients, including methylcobalamin (the active form of Vitamin B12), and methyltetrahydrofolate (the active form of folic acid). These nutrients are efficiently absorbed and effectively used in the body. In fact, active forms of micronutrients are superior in many ways. Most importantly, your body does not have to try convert them to the active form. Importantly, many people cannot convert all inactive nutrients to active ones. Dr. Colbert’s Enhanced Multivitamin contains active Vitamin K2, active Vitamins B1, B2, B3, B5, B6, B7, B9 and B12 (methylcobalamin), Vitamin A, C, D, E, and K, biotin, calcium, potassium, folic Acid (methyltetrahydrofolate), and iodine. Bottom Line A great multivitamin can support your entire body, and specific areas of health listed above. But choose wisely. Dr. Colbert’s Enhanced Multivitamin stands above others with active forms of micronutrients, high-potency, and natural ingredients. To read the original article click here.

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Do Beliefs About Aging Impact Our Health & Longevity?

AHA Publisher — Wed, 20 Apr 2022 07:00:10 +0000

Dr. Caroline Leaf – In this podcast (episode #373) and blog, I talk to Dr. Becca Levy, an award-winning Yale professor of psychology and global health. We discuss the dangers of ageism, how positive and negative age stereotypes affect the health of older individuals, how to use the mind and brain more effectively as we age, age as a socially fluid construct, what happens to memory and the mind when we get older, and so much more! In her amazing new book Breaking the Age Code: How Your Beliefs About Aging Determine How Long and Well You Live, Dr. Becca examines the question: do beliefs about aging impact our health and longevity? Her research is centered around her time in Japan studying how differently older people are treated in the country, and how it may be connected to their high life expectancy. In Japan, older people are celebrated, while really old people are treated like rock stars—they embrace the aging process. This led to the question, how do our beliefs about aging shape our health and our lives? In her book, Dr. Becca “demonstrates that many health problems formerly considered to be entirely due to the aging process, such as memory loss, hearing decline, and cardiovascular events, are instead influenced by the negative age beliefs that dominate in the US and other ageist countries.” As Dr. Becca notes, ageism is like an evil octopus. It is omnipresent and goes in so many different directions, wrapping its tentacles over so many parts of our lives. In fact, the World Health Organization recently declared that ageism is one of the most widespread forms and socially sanctioned forms of prejudice in our world today, and something we often overlook or do not see. Negative messages and beliefs about aging limit opportunities, affect health, and compound existing prejudices like sexism and racism. In her research, Dr. Becca observed how beliefs about aging expressed at a younger age can impact a person’s survival. People who have more positive beliefs about getting older on average lived 7 1/2 years longer than those with a more negative perception of aging. Since we start developing perceptions about getting older from as young as 3, it is so important to examine how and why these beliefs can impact not only how we treat older people, but also how we age. Because of the mind-brain-body connection, many health outcomes are connected to our beliefs about aging, including our cardiovascular and cognitive wellbeing. One study noted how younger adults who had more negative beliefs about aging increased their risk of a cardiovascular event when they turned 60, while subjects with a more optimistic outlook on aging reduced their risk for cardiovascular issues when they reached the age of 60. Similarly, research has shown how people with more positive beliefs about aging reduce their risk for developing dementias like Alzheimer’s, even if they were born with risky genes. Our memory and brain health can actually get better as we age. The common stereotype that our mind declines as we age doesn’t match the science. There are many different types of memory that are stable and can improve as we age, including our ability to communicate and solve conflicts. Indeed, as we age, our brain connectivity and neurons keeps developing, which adds to our intelligence. A forgetful moment is not just a “senior moment” or something bad; it is a sign that our memory changes over time, which is not in and of itself a bad thing. We need to remember that age can be a socially fluid construct. There is no set way of aging, and the aging process is not just determined by our biology. As Dr. Becca notes, aging is determined by many factors; our genes only contribute around 25% to how we age. The other 75% includes environmental factors and things we can control, including our cultural and individual beliefs about aging that can impact our health and longevity. The great news is that our attitudes towards aging can be changed or improved at any time during our lifespan, which can have a positive effect on our health and lifespan. This is preventative health at its best. As we learn to shift our age beliefs to be more positive and reduce negative culture messages about aging, we can impact the course of our lives. We can become aware of and change the messages we receive and develop concerning aging on both an individual and societal level. In her book, Dr. Becca has some great tools that help us improve our perception of aging, and subsequently, our health. One of most powerful things we all can do is increase our awareness. What are our age beliefs? How do we see aging? What kind of age-related messages are we exposed to? A great way to do this what Dr. Becca calls “age-belief journaling”. For one week, write down every belief that you see or hear about aging (on social media, in conversations, on TV, at work, at school and so on) and write down if you think it is positive or negative. At the end of the week, add up the negatives and positives. What is the ratio? And with the negative portrayals, do you think they had to be so negative? Is there another way aging could have been portrayed? Actively noticing the beliefs about aging we have and are exposed to is the first step to actively changing them in ways that positively impact our health and lifespan. It is also helpful to become knowledgeable about the actual science behind aging. This gives us an arsenal to draw on to discount the negative age beliefs and stereotypes, such as “you can’t teach an old dog new tricks”. The reality is that we actually can—we can improve our cognition and learn new things at ANY age. To read the original article click here.

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Brain Function Boosted by Daily Physical Activity in Middle-Aged, Older Adults

AHA Publisher — Tue, 01 Feb 2022 08:00:53 +0000

University of California San Diego Health via Newswise – A new study by researchers at University of California San Diego School of Medicine adds to the canon of research associating physical activity with cognitive performance, this time using 90 middle-aged and older subjects who wore accelerometers while physically active and completed mobile cognitive testing from home. “The future of lifestyle interventions really needs to be remote-based,” said Raeanne Moore, PhD, associate professor in the Department of Psychiatry at UC San Diego School of Medicine and principal investigator of the study. “The pandemic has made this especially clear.” On the days their physical activity increased, the study found, the 50- to 74-year-old participants performed more effectively on an executive function task, and on the days when their physical activity decreased, so too did their cognitive performance. The findings published Jan. 31, 2022 in the journal JMIR mHealth and uHealth. “It was a very linear relationship,” Moore said. “We hypothesized that we would find this, but we couldn’t be sure because we weren’t telling people to increase their physical activity. They just did what they do every day.” First author Zvinka Zlatar, PhD, a clinical psychologist at UC San Diego School of Medicine, added: “Future interventions, in which we ask people to increase their physical activity, will help us determine if daily changes in physical activity lead to daily gains in cognition measured remotely or vice versa.” The correlation between physical activity and cognition remained when adjustments were made for various co-morbidities, such as HIV status, age, sex, education and race/ethnicity. But it held only for persons who function dependently — who rely on others to perform the tasks of daily living, such as managing household activities or paying the bills. “For them, physical activity may have a greater benefit on daily, real-world cognitive performance,” Moore said, a finding consistent with research into Alzheimer’s disease and related dementias. Though it didn’t fall within the purview of this study, Moore speculated that, because functionally independent adults likely perform more cognitively stimulating and social activities, which are known to have positive impacts on brain health, physical activity may have less of an impact on cognition. Moore and Zlatar said their work has implications for the development of novel digital health interventions to preserve brain health in aging. “We don’t know yet if there’s a cumulative, long-term effect to these small daily fluctuations in cognition,” Zlatar said. “That’s something we plan to study next – to see if performing physical activity at different intensities over time, in unsupervised settings, can produce long-term improvements in brain health and sustained behavior change.” To read the original article click here.

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One Month to a Grateful Heart

AHA Publisher — Wed, 27 Oct 2021 07:00:10 +0000

Dr. Don Colbert – Heart check: Do you have a grateful heart? While we often talk about physical heart health, it’s just as important to look at emotional and spiritual heart health. If you embody gratefulness, you are likely able to look past the everyday struggles and find peace in life’s turmoil. But if not, you may be sinking in a pit of anxiety, jealousy, or pessimism. What’s more, you might be missing an amazing opportunity to improve physical health through gratitude. Honestly, it’s not always easy to have a grateful heart. However, our God has promised to help us in the journey to a truly grateful heart, unshaken by life’s ups and downs. It’s not your burden to bear alone, but a beautiful walk with God. One Month to a Grateful Heart During November, take a cue from the upcoming Thanksgiving Holiday and put gratitude into practice every day. Here are 4 ways to strengthen your own heart with daily thanksgiving throughout the month. 1. SPEND TIME IN GOD’S WORD AND IN PRAYER. When Jesus prayed, He praised God. At the Last Supper, just hours before His crucifixion, He thanked God. This is the example we have: Give praise and be thankful. Of course, this can be easier said than done when life gets tough. But, the more you spend time with God, the Giver of all good things, the more you will see just how good He is. Try spending time with Him, even if just a few minutes, every single day. From there, the gratitude in your heart can overflow into every other part of your life. 2. ACKNOWLEDGE THE THINGS FOR WHICH YOU ARE GRATEFUL, ALL DAY EVERY DAY. Have you heard of the book One Thousand Gifts by Ann Voskamp? It is a beautiful portrayal of gratitude in a daily, ordinary life. Ann teaches that gratitude precedes God’s miracles in Scripture and throughout our own lives. In the book, Ann tells the story of how she came to the challenge of writing down 1000 things she was thankful for. She kept a notepad and pen handy, and wrote down small and big gratitudes, throughout each day. For her, it was life changing. Do you think a daily, hourly, moment-by-moment focus on gratitude could change your life? What do you have to lose? Take this challenge in November. Start small, and write just a few per day if you’d like. Keep your mind and your attitude focused on the things for which you are thankful! 3. LOOK OUTSIDE YOURSELF When we are in the middle of turmoil or feeling defeated, it’s very easy to lose sight of our own blessings. One of the best cures? Get involved with helping others! Taking the focus off ourselves and blessing others is a great way to develop a grateful heart. You can pray for others daily. You can bless others with a note, text, or encouraging call. You can give small gifts out of the blue – anything from flowers from your garden to a coffee gift card. Or, get involved in a bigger operation with an established charitable group. 4. GIVE YOURSELF LOTS OF GRACE Lastly, there’s no room for perfectionism here. Gratitude requires grace. If you slip up, feel down, miss a day of writing down your blessings, or just have a negative attitude for a day, give yourself grace. As you do, you’ll learn to take captive the negative thoughts, forgive yourself, and move on quickly. If you’re feeling sad about yourself, it’s difficult to simultaneously feel grateful. We serve a God who not only forgives us, but takes our worries and cares from us. Give yourself grace and continue to look for your blessings each day. A Grateful Heart Bolsters Physical Health Did you know a grateful heart is actually good for you, physically? It’s true. Some of the health benefits of a grateful heart include: Stronger mental health: Believe it or not, you can decrease cortisol, the stress hormone, by up to 23% by practicing gratitude (1). What’s more, healthcare practitioners have sustained lower perceived stress (decrease of 28%) and depression by keeping a gratitude journal (2). Controlling cortisol is crucially important to overall health. Healthier Hearts: In studies, gratitude is associated with better cholesterol levels, lowered blood pressure and decreased heart rate variability. This all works together to improve cardiovascular health and overall health (4, 5). Ease with Change and Healthy Habits: Some benefits of gratitude work in reverse. Researchers have found that those who practice gratitude also tend to make healthier choices. Specifically, there’s an association between those who are reportedly grateful and less use of tobacco, more exercise, and better food choices (5, 6). On the flip side, gratitude intervention shows promise when helping patients increase healthy habits. In one study, 31% of participants quit smoking and maintained abstinence after 6 months, compared to meta-analysis averages of 23% with a nicotine patch alone (7). Stronger Immune Function: Gratitude and optimism can actually improve your body’s response to inflammation. Studies have found that our bodies produce more disease-fighting cells when we are grateful and optimistic (11). In addition, anytime you reduce cortisol, you maintain a healthier balance with DHEA levels. This supports healthy immune function (8). Better Sleep and Healthy Aging: One key factor to healthy aging is brain health. One necessity for brain health is sleep. Fortunately, gratitude supports better sleep (9)! In one study, gratitude was linked to a 10 percent improvement in sleep and a 19 percent decrease in depression levels in patients with insomnia (10). Looking for More Ways to Improve Physical and Mental Health? Did you know there’s an all-natural oil that can help with stress and anxious feelings? In addition, it supports health throughout the body! Hemp oil, specifically nano-particle oils like those in Dr. Colbert’s Nano-Science Hemp Oil, promotes health from your brain to your toes. We are fortunate to be able to use natural plants in our lives to support our health. Another thing for which to be grateful! Bottom Line November is the perfect opportunity to focus on a grateful heart. Make it count! Spend time with God, truly seek out and list your blessings, help and encourage others, and give yourself grace this month! To read the original article click here.

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This Protein Boosts Mice Life Expectancy by an Average 30%

AHA Publisher — Thu, 03 Jun 2021 07:00:53 +0000

Abigail Klein Leichman via Israel21c – Life expectancy was increased by an average of 30 percent in male and female mice engineered to have high levels of a protein called SIRT6, a team of international scientists reported in the journal Nature Communications. The mice also were better able to overcome age-related diseases such as cancer and blood disorders, and remained vigorous as they aged rather than becoming frail. The study was led by Prof. Haim Cohen, director of the Sagol Healthy Human Longevity Center at Bar-Ilan University in Israel. Cohen’s research has long focused on how SIRT6 is involved in regulating biological processes such as aging, obesity and insulin resistance. The team used biochemical methods and metabolic analyses to uncover the mechanism through which SIRT6 acts as a type of “fountain of youth.” Whereas older animals generally experience a decline in energy, the bodies of mice with extra SIRT6 broke down fats and lactic acid to create sugar utilized for energy in their muscles and brain. “This discovery, combined with our previous findings, shows that SIRT6 controls the rate of healthy aging,” said Cohen. “If we can determine how to activate it in humans, we will be able to prolong life, and this could have enormous health and economic implications.” Cohen did the study with his PhD student Asael Roichman; Prof. Eyal Gottlieb from the Technion-Israel Institute of Technology; Prof. Rafael de Cabo of the National Institute on Aging at the US National Institutes of Health; and Prof. Manuel Serrani of the Institute for Research in Biomedicine in Barcelona. To read the original article click here. For more articles from Israel21c click here.

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How to Build Your Own ‘Longevity Gene’

AHA Publisher — Wed, 26 May 2021 07:00:49 +0000

Al Sears, MD – Kane Tanaka is the oldest person on the planet. At 118, she’s defying the “experts” who insist that genes determine your lifespan. This summer, when the Olympic torch travels through her hometown of Shime, Japan, Kane will carry the flame. Imagine that, a 118-year-old torch bearer! Most doctors attribute her longevity to “good genes.” But despite thousands of studies over the past 50 years, no researcher has been able to identify a single gene explaining the longevity of supercentenarians like Kane. As a regular reader, you’ll know that I believe your genes don’t determine how long, or how well, you can live. And it looks like the geneticists are finally coming around to my point of view. As a matter of fact, many of them now agree that genes only account for about 25% of your longevity.1The remaining 75% is determined by your nutrition, activity level, and lifestyle. Despite the realization that non-genetic factors are much more important, Cornell University researchers wanted to give one unique gene a closer look… A “FOX Hunt” for Longevity… The FOX03 gene plays a key role in regulating metabolism, fighting free radicals, and calming inflammation – three major pathways to aging. Researchers wanted to know how it functions. So they flooded mice brain cells with free radicals and watched FOX03 go to work. FOX03 responded by signaling brain stem cells to halt their usual journey to becoming full-fledged neurons. Now the brain needs a constant supply of new cells to keep you sharp as you age. So the obvious question: Why did FOX03 stop the assembly line? Stem cells are extremely vulnerable as they morph into brain cells. By signaling them to suspend their development, FOX03 was conserving the brain’s limited supply.2 That’s pretty impressive. But even more significant is this: There are several ways you can activate your FOX03 gene to make it twice as powerful. In a sense, you can build your own “longevity gene.” Energize FOX03 to Hunt Free Radicals Energizing FOX03 to hunt down free radicals helps preserve the vital telomeres that protect the integrity of your DNA. Here are three ways to do it: Astaxanthin – My regular readers already know that astaxanthin, nature’s most powerful antioxidant, guards your retinas and staves off macular generation. But recent studies show it nearly doubles FOXO3 activity.3,4 I recommend wild-caught food sources such as salmon, shrimp, and crawfish. But you should also supplement with up to 50 mg of astaxanthin daily. I tell my patients to look for a supplement derived from the best natural source. That’s Haematococcus pluvialis algae. Calorie restriction/fasting – There’s growing evidence FOXO3 and various forms of fasting work to accelerate apoptosis, ridding your body of the dysfunctional cells that contribute to inflammation. Calorie restriction lowers the body’s production of insulin-like growth factor 1 [IGF-1], and as IGF-1 declines FOX03 activity ramps up.5 EGCG – Consider it another reason to make green tea part of your health routine. Already highly regarded for its anti-inflammatory and heart-health benefits, there’s growing evidence the green tea extract EGCG activates the FOX03 gene as well. Most of the studies so far are on animals.6But EGCG-activated FOX03 inhibited the growth of human breast cancer cells.7 A cup of green tea contains about 100 mg of EGCG. I recommend you supplement with up to 1,500 mg of the extract daily. 1 Passarino, G., De Rango, F., & Montesanto, A. (2016). Human longevity: Genetics or Lifestyle? It takes two to tango. Immunity & Ageing, 13(1). https://doi.org/10.1186/s12979-016-0066-z 2 Study Reveals How a Longevity Gene Protects Brain Stem Cells From Stress. (2021, February 19). Retrieved April 5, 2021, from WCM Newsroom website: https://news.weill.cornell.edu/news/2021/02/study-reveals-how-a-longevity-gene-protects-brain-stem-cells-from-stress 3 Research: University of Hawaii reports Astaxanthin can activate the FOX03 “Longevity Gene” in mammals. (2017, March 28). Retrieved April 5, 2021, from John A. Burns School of Medicine website: https://jabsom.hawaii.edu/research-university-of-hawaii-reports-ability-of-astaxanthin-to-significantly-activate-fox03-longevity-gene-in-mammals/ 4 Astaxanthin compound found to switch on the FOX03 “Longevity Gene” in mice. (2017, March 28). Retrieved March 26, 2021, from ScienceDaily website: https://www.sciencedaily.com/releases/2017/03/170328092428.htm 5 Komatsu, T., Park, S., Hayashi, H., Mori, R., Yamaza, H., & Shimokawa, I. (2019). Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction. Nutrients, 11(12), 3068. https://doi.org/10.3390/nu11123068 6 Bartholome, A., Kampkötter, A., Tanner, S., Sies, H., & Klotz, L.-O. (2010). Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Archives of Biochemistry and Biophysics, 501(1), 58–64. https://doi.org/10.1016/j.abb.2010.05.024 7 Belguise, K., Guo, S., & Sonenshein, G. E. (2007). Activation of FOXO3a by the Green Tea Polyphenol Epigallocatechin-3-Gallate Induces Estrogen Receptor Expression Reversing Invasive Phenotype of Breast Cancer Cells. Cancer Research, 67(12), 5763–5770. https://doi.org/10.1158/0008-5472.can-06-4327 To read the original article click here. For more articles from Al Sears, MD click here.

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