gut bacteria Archives - Amazing Health Advances

The Best Foods and Herbs to Eliminate Intestinal Parasites

The AHA! Team — Fri, 29 Aug 2025 05:19:40 +0000

Lori Alton via NaturalHealth365 – Parasites consume nutrients from the food we eat – and can also feed on blood, resulting in a lack of vital iron and protein. In addition, they can cause malabsorption of nutrients, leading to deficiencies. Parasites lurking deep within the human body may be hidden from sight – but their effects can be far-reaching and serious. Ranging in size from tiny microorganisms to ten-foot-long segmented worms, intestinal parasites can cause inflammation in the brain, muscles, esophagus, and skin and are associated with leaky gut syndrome, irritable bowel syndrome, gastritis, acid reflux, joint pain, seasonal and food allergies – and a host of other health problems. The good news is that these noxious pests are vulnerable to certain foods and natural herbal remedies. Read on to discover what these substances are and how you can use them to rid your body of a parasitic infection. Intestinal parasites can wreak havoc on our health Parasites consume nutrients from the food we eat – and can also feed on blood, resulting in a lack of vital iron and protein. In addition, they can cause malabsorption of nutrients, leading to deficiencies. Intestinal parasites can enter the bloodstream and travel throughout the body, where they can penetrate body tissues such as the liver, lungs, and stomach – with serious consequences. For example, parasites lodged in the liver can cause cirrhosis and abscesses. There are many routes through which parasites can enter the body, including contaminated food – particularly pork, shellfish, and scavenger fish – and water. Some can also be transmitted through the bite of a mosquito or flea, through intimate contact, or even through the nose and mouth after a contaminated surface has been touched. Although anyone can get parasites, having low immunity, poor diet, and poor hygiene can all raise the risk of infection. Protozoa and helminths: A pair of health threats There are two major classes of intestinal parasites. Protozoa are single-celled microscopic organisms. Examples of infectious parasitical protozoa include Giardia intestinalis and Cryptosporidium. Because these microorganisms can reproduce inside humans, infections can be fatal if left untreated. Symptoms of protozoan disease include diarrhea, abdominal pain, nausea, dehydration, fatigue and joint pain. Helminths Helminths are multicellular worms and include roundworms, flatworms, pinworms – the most common form of helminth in the United States – tapeworms, hookworms, and whipworms. Helminths differ from protozoa in that although they can live in your lower intestine, they can’t reproduce there. However, they can still cause serious health problems. Before treating for parasites, make sure you undergo comprehensive tests, including microbiology. After you know which parasites you are fighting, you can try one or more of the following foods and herbs to eliminate them. Pumpkin seeds are an anti-parasitical snack Pumpkin seeds are tasty, crunchy, and nutritious. They also can paralyze helminths, allowing them to be easily flushed from the body, and have been traditionally used as a remedy for parasites. Some natural health experts advise blending a cup of raw pumpkin seeds with half a cup of coconut milk and half a cup of water, then eating the resultant paste – following up with a glass of water. Although pumpkin seeds can be very effective, results may not be immediate – you may need to repeat the treatment several times. Garlic: A one-two punch against parasites Garlic is packed with sulfur-containing amino acids, which help to combat parasites. A compound in garlic known as allicin also helps to kill and expel worms – but the garlic must be sliced, diced, or chopped to fully release it. The more finely garlic is chopped, the more allicin it releases. After mincing or dicing garlic, let it sit for a few minutes to allow this chemical process to occur. Alternatively, you can chew it for at least a minute. Papaya: A tropical fruit that fights parasites Along with amino acids, digestive enzymes such as papain (found in papayas) and bromelain (found in pineapples) can create an unfriendly environment for protozoa and helminths alike. The value of this traditional natural remedy for intestinal parasites was confirmed in a placebo-controlled study published in the Journal of Medicinal Foods. Sixty children were treated with a mixture of air-dried Carica papaya seeds and honey, resulting in parasite clearance rates that ranged between 71.4 percent and 100 percent. Researchers praised papaya seeds as an effective, cheap, and safe way to treat human intestinal parasites. In addition to foods such as pumpkin seeds, garlic, and papaya seeds, some common herbs have parasite-destroying properties. Just one word of caution: Always consult a holistic physician or trusted herbal medicine expert before starting a detoxification program to avoid harming the body. Let’s not forget: Oil of oregano Highly antimicrobial, oil of oregano – made from Oreganum vulgare – can be very effective against intestinal parasites. In a study published in Phytotherapy Research, adults infected with three different types of parasites were given 600 mg of oregano oil a day. After six weeks, parasites were eradicated in 72 percent of the participants; 23 percent greatly decreased their parasite load. Because researchers think that oil of oregano gets its anti-parasitical powers from carvacrol, be sure to use oil standardized to at least 65 percent carvacrol. Neem: An ancient remedy for parasites Antibacterial, antifungal, and antiviral neem has been used in India for thousands of years to reliably kill internal and external parasites. The neem tree, scientifically known as Azadirachta indica, is native to India, where it serves so many medicinal purposes that it is often referred to as “the village pharmacy.” One of neem’s assets is that it not only kills parasites but also removes the toxins they leave behind as they are dying. This detoxifying property of neem also makes it a boon to the liver, which is often compromised by parasitic infection. Wormwood, black walnut, and cloves: a potent combination Scientifically known as Artemisia annua and also called annual mugwort and sweet Annie, Wormwood has pronounced anti-protozoan effects and is particularly effective at killing parasitic larvae. In addition, it stimulates macrophages, which are key in the immune system’s defense against parasitic infestation. Wormwood is often combined with black walnut, or Juglans negra, and the essential oil of cloves. The juglone in black walnut helps to kill parasites, while the antimicrobial oil of cloves can destroy virtually all parasite eggs in the intestinal tract. Combining these three substances can interrupt the parasitic life cycle, terminating these pests for good. How diet can help you to avoid parasites,/h5> Remember: Organic acids and enzymes help to kill parasites. Eating foods rich in these substances can create a body environment that discourages parasitic infection. As a preventative, natural health experts recommend eating six tablespoons of raw, extra-virgin coconut oil, a whole clove of garlic, and one large red onion. High-quality multi-strain probiotics can help destroy parasites in both the upper and lower gastrointestinal systems. Drinking fermented beverages – such as kefir and apple cider vinegar – and eating fermented probiotic-rich foods such as miso soup, sauerkraut, and kimchi can encourage the growth of beneficial bacteria in the gut and help to ward off infection. Finally, it is essential to sharply reduce and eliminate sugar, grains – which break down to sugar in the body – and alcohol. Editor’s note: Discover the shocking truth behind your “unexplained” health problems + the best ways to detoxify your body, watch the Whole Body Detox Summit created by NaturalHealth365 Programs. Sources for this article include: NIH.gov CDC.gov NIH.gov To read the original article click here.

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Summer Brain Fog? It Could Be Your Gut — Here’s What Scripture & Science Say About It

The AHA! Team — Wed, 28 May 2025 05:14:57 +0000

Dr. Don Colbert – If you find yourself feeling mentally sluggish during the summer months—struggling with memory, focus, or motivation—you’re not alone. Many of my patients describe what they call “summer brain fog.” And while you might blame it on the heat or disrupted routines, there’s often a deeper root: your gut. In this article, I want to unpack the fascinating link between gut health and brain function, and why healing your gut might be the most effective way to sharpen your mind—especially this time of year. We’ll also look at what science has to say, and how Scripture reinforces the importance of caring for our bodies with wisdom and intentionality. The Gut-Brain Connection: More Than a Feeling The gut and brain are connected by a complex network of nerves, biochemicals, and messenger systems known as the gut-brain axis. This communicationToxic Summer: Hidden Chemicals in Sunscreen, Swimsuits, and Bug Spray — And What God Says About Stewarding Your Body highway allows your digestive system to send and receive signals to and from your brain—often influencing mood, focus, memory, and even sleep. Here’s what we know from science: The gut produces over 90% of the body’s serotonin, a neurotransmitter crucial for mood regulation. An imbalance in the gut microbiome—such as an overgrowth of bad bacteria or yeast—can trigger inflammation, which can cross the blood-brain barrier and contribute to brain fog, anxiety, and fatigue. Studies show that gut dysbiosis (imbalanced bacteria) is associated with cognitive decline and poor memory. When the gut is struggling, the brain often suffers quietly until symptoms like fatigue, poor concentration, or forgetfulness emerge. Why Summer Makes It Worse There are several seasonal habits that may quietly sabotage gut health during the summer: 1. Processed Summer Treats Ice cream, BBQ sauces loaded with sugar, soda, and artificial dyes—these common indulgences can feed harmful gut bacteria and promote systemic inflammation. 2. Travel & Disruption of Routine Whether it’s international travel or a simple road trip, your digestion can be thrown off by irregular meals, different water sources, or unfamiliar foods. 3. Alcohol & Dehydration Increased alcohol intake and reduced hydration in the heat can irritate the gut lining and impair healthy digestion. 4. Sleep Disturbance Longer days and more activity can interfere with restful sleep, which your gut (and brain) need for repair and detox. What You Can Do to Restore Clarity If you want to reclaim your mental edge this summer, healing your gut is an excellent place to start. Here are a few simple yet powerful steps: 1. Cut the Sugar and Processed Foods Sugar feeds the wrong bacteria. Swap sugary snacks for high-fiber fruits like berries, which also support digestion and reduce inflammation. 2. Rebuild with Probiotics and Fiber Adding a quality probiotic and a soluble fiber supplement helps repopulate good bacteria and keep your gut regular. I often recommend Zone Biotics Probiotic and Fiber Zone from Divine Health. 3. Consider Advanced Gut Support For those needing more comprehensive care, Biotic Zone Probiotic is an advanced formula that combines powerful probiotics and prebiotics to promote digestive balance, reduce bloating, and support brain-gut communication. 4. Support the Gut Lining L-glutamine, aloe vera, and collagen can help repair a leaky gut. You can find these in many gut repair powders or take them separately. Explore our detox and cleanse supplements for comprehensive support. 5. Hydrate Intentionally Drink filtered water consistently throughout the day. Add sea salt or electrolytes to help absorption, especially if you’re sweating more than usual. 6. Focus on Anti-Inflammatory Foods Include foods like leafy greens, turmeric, wild salmon, and extra virgin olive oil. These nourish the brain and gut while reducing inflammation. Gut-Healing Foods That Also Fuel Mental Clarity Your food choices play a pivotal role in gut health—and by extension, brain function. Here are some of the best whole foods to incorporate into your daily routine: 1. Fermented Foods Kimchi, sauerkraut, kefir, and unsweetened yogurt are rich in probiotics that help replenish good bacteria in your gut. 2. Prebiotic-Rich Foods Foods like garlic, onions, leeks, asparagus, and green bananas feed the good bacteria and support a thriving microbiome. 3. Omega-3 Rich Foods Wild-caught salmon, sardines, flaxseeds, and chia seeds help reduce inflammation and support the brain-gut connection. 4. Polyphenol-Packed Plants Blueberries, pomegranate, spinach, and dark chocolate (70%+ cacao) provide antioxidants that protect both the brain and gut lining. 5. Bone Broth Loaded with collagen and amino acids like glutamine, bone broth helps seal and heal the gut lining. 6. Clean Proteins Organic pasture-raised poultry, wild-caught fish, and grass-fed beef provide essential nutrients for cellular repair and neurotransmitter production. These foods are a foundational part of the preventative and holistic approach I recommend—and they nourish more than just your body. They create the internal environment needed for peace, energy, and mental clarity. What Scripture Reminds Us About the Body Scripture reminds us that our bodies are a gift from God, and we are called to steward them well: “Do you not know that your bodies are temples of the Holy Spirit, who is in you, whom you have received from God?” — 1 Corinthians 6:19 Caring for your body—including your gut—isn’t just about physical health. It’s about clarity, energy, and the ability to serve others and fulfill your purpose with excellence. Sometimes the greatest clarity doesn’t come from another coffee or pushing through fatigue. It comes from healing the internal systems God designed to work together in harmony. 🛒 Ready to Support Your Gut? Explore Dr. Colbert’s Top Gut Health Supplements: 👉 Zone Biotics Probiotic 👉 Fiber Zone 👉 Biotic Zone Probiotic 👉 Detox & Cleanse Collection Final Thoughts Summer brain fog isn’t something you have to live with or push through. By supporting your gut, you support your brain—and ultimately your quality of life. From a scientific perspective, gut health is one of the most powerful levers for cognitive and emotional wellness. And from a spiritual perspective, it’s a meaningful way to honor the temple God entrusted to us. Until next time, stay sharp, stay healthy, and stay grounded in grace. To your health, Dr. Don Colbert, MD To read the original article click here.

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Vitamin B: Effective Cure for Many Intestinal Patients with Chronic Fatigue

The AHA! Team — Fri, 13 Dec 2024 06:35:56 +0000

Aarhus University via EurekAlert! – A new study reveals the link between gut bacteria and the effectiveness of vitamin B1 treatment for chronic disease in patients with intestinal inflammation. Fatigue is a common and often debilitating companion for people with inflammatory bowel conditions. Now, a new Danish study provides insight into why vitamin B1 – also known as thiamine – helps some patients regain their energy, while others do not experience the same effect. The study shows, among other things, that patients’ response to vitamin B1 depends on gut bacteria, with researchers focusing particularly on a specific “good bug” that seems to play a crucial role. “We know that about half of the fatigued patients benefit from treatment with vitamin B1, but we haven’t been able to find anything that distinguishes those who had an effect from those who did not. Now we know that it’s especially the bacterium Faecalibacterium prausnitzii (FP) that is the key,” says Professor and Consultant Christian Lodberg Hvas, who is the lead author of the study. Surprising findings FP is a bacterium that many studies have identified as having beneficial properties or at least being frequently found in people with a healthy gut. The researchers were surprised to find that the presence of a single key bacterium determines whether patients with chronic fatigue experience a good effect from thiamine treatment. “We thought we were looking for a ‘fatigue microbiome,’ a composition of gut bacteria that is particularly seen in patients with chronic fatigue. But we didn’t find that. Instead, we found that the microbiome of the fatigued largely resembles the microbiome of those who are not fatigued,” explains Christian Lodberg Hvas. Still a mystery The study involved 40 patients with inflammatory bowel disease and chronic fatigue. Each patient received both vitamin B1 and a placebo in two periods of four weeks with a break in between. This allowed the researchers to see if the vitamin treatment had an effect on fatigue. At the same time, the researchers examined the patients’ gut bacteria to see if there was a correlation between specific bacteria and the effect of the treatment. Although the researchers found a clear connection between FP and the patients’ response to the treatment, it remains a mystery why this is the case. “The bacterium is largely present in people with good health and only present in low numbers in people with chronic diseases. We don’t know if it’s just a marker for health or if it’s part of the reason why healthy people are indeed healthy,” explains Christian Lodberg Hvas. “But the more studies that point to a beneficial effect of FP, the more it suggests that the bacterium is involved as a cause of health and not just as a bystander,” he adds. A cure for many with unexplained fatigue For some patients, fatigue can be explained by a lack of iron, vitamin D, or low thyroid function. These are all conditions that are easy to treat. But a large group of patients with inflammatory bowel disease remains with unexplained fatigue. “We really want to help them, and although we don’t have an explanation, we now have a cure – for those who have many FP in their gut,” says Christian Lodberg Hvas. “Therefore, we now recommend high-dose vitamin B1 treatment to all our patients where we don’t find any obvious explanation for chronic fatigue. We know that it only works for half, but it’s still a good chance, and a month’s treatment is cheap,” he adds. The clear recommendation also comes because the treatment has proven to be completely free of side effects. “However, one must accept that thiamine smells and tastes peculiar – so your hands, urine, and sweat will smell like vitamin pills with the very high dose you’re taking,” says Christian Lodberg Hvas. About the research: Study type: Exploratory analyses of biological material from a randomized clinical trial Collaborators: DTU National Food Institute External funding: Novo Nordisk Foundation Link to scientific article: https://doi.org/10.1016/j.gastha.2024.08.012 DOI 10.1016/j.gastha.2024.08.012 To read the original article click here.

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New Study Uncovers the Alzheimer’s Gut Microbiome Connection

The AHA! Team — Thu, 05 Dec 2024 06:33:48 +0000

Recent studies have uncovered a fascinating link between Alzheimer’s disease and a lower risk of developing certain cancers, particularly colorectal cancer.

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Oral-Gut Axis: How Mouth Bacteria Impact Your Overall Health

The AHA! Team — Wed, 28 Aug 2024 08:38:47 +0000

Priyanjana Pramanik, MSc. via News-Medical – A new study found that the prevalence of nicotine pouch use was low in U.S. adults despite a 641% increase in sales of the products between 2019 and 2022. A recent review in the journal Nature Reviews Microbiology explored the interactions between the oral and gut microbiomes and their collective effect on human health. Authors Jack A. Gilbert of the University of California San Diego and Erica M. Hartmann of Northwestern University found that while oral microorganisms may enter the gastrointestinal tract and contribute to gut dysbiosis, the mechanisms and broader implications of these interactions require further study. The importance of the gut microbiome The human body hosts a vast diversity of microorganisms that play a vital role in health by supporting the immune system and defending against pathogens. However, they may also contribute to chronic diseases. Dysbiosis, or disruptions in these microbial communities, is linked to metabolic and autoimmune disorders and gastrointestinal issues. The gut and oral cavity are two key areas with dense microbial populations. The oral microbiome is influenced by food and environment and has been linked to oral diseases like gingivitis and periodontitis, affecting systemic health by influencing microbial populations in the digestive and respiratory systems. The gut microbiome, shaped by genetics, diet, and lifestyle, is crucial for immune responses and infection prevention. Understanding the interactions between the gut and oral microbiomes is necessary for grasping their impact on diseases like colorectal cancer (CRC) and inflammatory bowel disease (IBD). The oral cavity is a gateway The gastrointestinal tract begins at the mouth and extends to the anus, including organs like the liver, pancreas, and gallbladder. The oral cavity, highly vascularized and home to diverse microbial communities, serves as the primary entry point for microbes into the body. It hosts over 770 bacterial species in different microenvironments, such as the buccal mucosa, tongue, and dental plaques. Key genera include Streptococcus, Veillonella, and Prevotella. The gut microbiome, primarily anaerobic and comprising species like Bacteroides and Ruminococcus, shares some taxa with the oral cavity, but distinct physical and chemical barriers usually prevent oral microbes from colonizing the gut. However, under conditions like low gastric acidity or antibiotic use, oral bacteria can migrate to the gut, potentially contributing to diseases. Understanding this oral-gut microbial transfer is crucial for exploring its role in disease and health. The mouth-gut connection The oral cavity, susceptible to conditions like dental caries, oral cancers, and periodontal diseases (gingivitis and periodontitis), plays a significant role in overall health. Periodontal diseases involve the destruction of tissues around the teeth due to an inflammatory response to plaque and microbes. Gingivitis, a reversible inflammation of the gums, can progress to periodontitis if untreated, causing deeper tissue damage and bone loss. Research suggests a strong link between oral health and gut diseases. Periodontal pathogens, such as P. gingivalis and F. nucleatum, can migrate from the mouth to the gut, contributing to conditions like IBD. These bacteria promote inflammation and disrupt the gut’s microbial balance. Studies have found higher levels of oral bacteria in the guts of individuals with IBD, indicating the mouth-gut axis’s role in these diseases. Additionally, the oral microbiome has been associated with CRC. Oral bacteria like F. nucleatum can influence tumor growth and treatment resistance in CRC. This connection underscores the importance of oral health in preventing and managing systemic diseases. Understanding these links can lead to better prevention and treatment strategies for gut diseases and cancers. Oral health and overall health Poor oral health, especially periodontitis, can significantly impact the entire body. Oral bacteria can travel through the gastrointestinal tract and bloodstream, contributing to various diseases. Periodontitis causes low-grade systemic inflammation, which can disrupt the body’s health and promote diseases like IBD and cardiovascular diseases. It increases levels of pro-inflammatory cytokines in the blood, indicating an ongoing inflammatory response. One mechanism through which oral health affects the body is through the bone marrow, where inflammation from periodontitis boosts the production of immune cells, leading to heightened inflammatory responses elsewhere. Another mechanism involves periodontal bacteria directly affecting distant organs by releasing toxins that promote inflammation and diseases like rheumatoid arthritis and atherosclerosis. Additionally, oral health impacts the gut directly. Bacteria from the mouth can colonize the gut, exacerbating conditions like IBD. Treating periodontal disease can reduce systemic inflammation and improve chronic disease symptoms, demonstrating the bidirectional relationship between oral health and systemic diseases. Addressing oral health is thus crucial for overall health and managing systemic conditions. Conclusions Changes in oral bacteria can affect gut health, leading to systemic inflammation and various diseases. The relationship between the oral cavity and gut is bidirectional, but the exact mechanisms remain unclear. More research is needed to understand how oral bacteria influence chronic diseases and to develop better models for studying these interactions. Future studies should resolve the oral-gut microbiome axis at the strain level to confirm the role of oral bacteria in chronic diseases and examine the role of translocated strains in gut microbiome-linked diseases through in vivo and in vitro models. To read the original article click here.

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Gut Flora Disruption in Infancy Linked to Autism & ADHD

The AHA! Team — Thu, 09 May 2024 20:05:19 +0000

Linköping University via News-Medical – Disturbed gut flora during the first years of life is associated with diagnoses such as autism and ADHD later in life. This is according to a study led by researchers at the University of Florida and Linköping University and published in the journal Cell. The study is the first forward-looking, or prospective, study to examine gut flora composition and a large variety of other factors in infants, in relation to the development of the children’s nervous system. The researchers have found many biological markers that seem to be associated with future neurological development disorders, such as autism spectrum disorder, ADHD, communication disorder and intellectual disability. “The remarkable aspect of the work is that these biomarkers are found at birth in cord blood or in the child’s stool at one year of age over a decade prior to the diagnosis,” says Eric W Triplett, professor at the Department of Microbiology and Cell Science at the University of Florida, USA, one of the researchers who led the study. 16,000 children born in 1997-1999, representing the general population, have been followed from birth into their twenties The study is part of the ABIS (All Babies in Southeast Sweden) study led by Johnny Ludvigsson at Linköping University. More than 16,000 children born in 1997-1999, representing the general population, have been followed from birth into their twenties. Of these, 1,197 children, corresponding to 7.3 percent, have been diagnosed with autism spectrum disorder, ADHD, communication disorder or intellectual disability. A large number of lifestyle and environmental factors have been identified through surveys conducted on several occasions during the children’s upbringing. For some of the children, the researchers have analysed substances in umbilical cord blood and bacteria in their stool at the age of one. “We can see in the study that there are clear differences in the intestinal flora already during the first year of life between those who develop autism or ADHD and those who don’t. We’ve found associations with some factors that affect gut bacteria, such as antibiotic treatment during the child’s first year, which is linked to an increased risk of these diseases,” says Johnny Ludvigsson, senior professor at the Department of Biomedical and Clinical Sciences at Linköping University, who led the study together with Eric W. Triplett. Children who had repeated ear infections during their first year of life had an increased risk of being diagnosed with a developmental neurological disorder later in life. It is probably not the infection itself that is the culprit, but the researchers suspect a link to antibiotic treatment. They found that the presence of Citrobacter bacteria or the absence of Coprococcus bacteria increased the risk of future diagnosis. One possible explanation may be that antibiotic treatment has disturbed the composition of the gut flora One possible explanation may be that antibiotic treatment has disturbed the composition of the gut flora in a way that contributes to neurodevelopmental disorders. The risk of antibiotic treatment damaging the gut flora and increasing the risk of diseases linked to the immune system, such as type 1 diabetes and childhood rheumatism, has been shown in previous studies. “Coprococcus and Akkermansia muciniphila have potential protective effects. These bacteria were correlated with important substances in the stool, such as vitamin B and precursors to neurotransmitters which play vital roles orchestrating signaling in the brain. Overall, we saw deficits in these bacteria in children who later received a developmental neurological diagnosis.” -Angelica Ahrens, Assistant Scientist in Eric Triplett’s research group at the University of Florida and first author of the study The present study also confirms that the risk of developmental neurological diagnosis in the child increases if the parents smoke. Conversely, breastfeeding has a protective effect, according to the study. In cord blood taken at the birth of children, the researchers analysed the amounts of various substances from the body’s metabolism, such as fatty acids and amino acids. They also measured some harmful substances that come from outside, such as nicotine and environmental toxins. They compared substances in the umbilical cord blood of 27 children diagnosed with autism with the same number of children without a diagnosis. Children who were later diagnosed had low levels of several important fats in the umbilical cord blood It turned out that children who were later diagnosed had low levels of several important fats in the umbilical cord blood. One of these was linolenic acid, which is needed for the formation of omega 3 fatty acids that are anti-inflammatory and have several other effects in the brain. The same group also had higher levels than the control group of a PFAS substance, a group of substances used as flame retardants and shown to negatively affect the immune system in several different ways. PFAS substances can enter the body via drinking water, food and the air we breathe. It is not certain that the relationships that the research team found in the Swedish children can be generalised to other populations, but these issues need to be studied in other groups as well. Another question is whether gut flora imbalance is a triggering factor or whether it has occurred as a result of underlying factors, such as diet or antibiotics. However, even when the researchers accounted for risk factors that might affect the gut flora, they found that the link between future diagnosis remained for many of the bacteria. This indicates that some of the differences in gut flora between children with and without future diagnosis are not explained by such risk factors. The research is at an early stage and more studies are needed, but the discovery that many biomarkers for future developmental neurological disorders can be observed at an early age opens up the possibility of developing screening protocols and preventive measures in the long term. The study has been funded with support from, among others, JDRF, Horizon Europe, Barndiabetesfonden (the Swedish Child Diabetes Foundation), Forte and the Swedish Research Council. Source: Linköping University Journal reference: Ahrens, A. P., et al. (2024). Infant microbes and metabolites point to childhood neurodevelopmental disorders. Cell. doi.org/10.1016/j.cell.2024.02.035. To read the original article click here.

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Incredible Bacterium Prevents Disease

AHA Publisher — Mon, 31 Oct 2022 07:00:19 +0000

Al Sears, MD, CNS – Researchers made a startling discovery… A never-before-recorded new gut bacterium with impressive disease-preventing properties. Researchers in Belgium spent two years examining 12,000 microbiome samples collected from all over the world. During their research, they came across something no one had ever seen before… A new “gut bug.” They named their new discovery Dysosmobacter welbionis. Dysosmobacter exists in about 70% of the population. But it’s almost nonexistent in patients with chronic diseases like diabetes, obesity, and metabolic syndrome.1,2 What makes this discovery so exciting is that Dysosmobacter welbionis produces a critical metabolite called butyrate. Butyrate, a short-chain fatty acid, is generated by beneficial bacteria that thrive in your digestive tract. Its ability to keep you healthy is stunning. In fact, butyrate has been shown to: Lower insulin resistance and improve blood sugar3 Boost mitochondrial energy in cells4 Tamp down inflammation by shielding you from leaky gut syndrome5 Stimulate your brain to grow more neurons6 Relieve Crohn’s disease and inflammatory bowel disease 7 Alleviate symptoms of depression and anxiety8 Modulate your immune response to keep it from overreacting9 And the latest research shows that butyrate exhibits “extraordinary anti-cancer activities.”10 Unfortunately, today’s high-glycemic, processed foods destroy the beneficial bacteria that create butyrate in the gut. And that sets the stage for what I call Syndrome Zero. But there is good news: Once you rebalance your gut biome, butyrate flourishes and your risk of chronic disease plummets. Here’s what I recommend… Start Your Own Gut-Flora Revival I always advise my patients to start with natural nutrients. Most doctors will never tell you this, but butter or clarified ghee made from the milk of grass-fed cows are two of the best sources of butyrate. In fact, the word butyrate comes from the Latin word butyrum, meaning butter. Upping your intake of prebiotic fiber is another smart move. Butyrate-friendly bacteria love almonds, garlic, apples, kiwi fruits, chickpeas, asparagus, Jerusalem artichokes, and avocados. Beyond nutritional changes, here are three butyrate-boosting steps for you to follow… Three Simple Steps To Protect Your Health Ban these butyrate-killers. Obviously, you want to avoid consuming an excess of processed carbs and sweets. Buy grass-fed beef to avoid ingesting the antibiotics routinely fed to most livestock and poultry. Try to buy organic veggies… And be sure to avoid artificial sweeteners since fake sugars harm beneficial flora. Add inulin and XOS. Inulin is a non-digestible fiber. Once it reaches the large intestine, it turns into a prebiotic that feeds a host of butyrate-producing microbes. Fresh chicory root is your best source of inulin. Many butyrate-producing microbes also love to dine on another plant fiber called XOS (xylooligosaccharides). This little-known prebiotic is found in bamboo shoots, corn husks, and eucalyptus wood. But who wants to eat that. I recommend supplements. When it comes to XOS, be sure to check the label. Make sure the label specifies xylooligosaccharides, and keep an eye on portion size, too. My advice is only buy supplements that offer at least a 2.8 gram portion of XOS. That’s the level at which XOS really becomes effective. But go easy at first, start with a gram a day. Then gradually increase up to five grams. Supplement with butyrate. Studies show that low dosages (below 3.5 grams daily) of butyrate supplements are the most beneficial to your digestive tract. But excessive rates (above 7 grams daily) can disrupt the intestinal barrier. Start with 500 mg a day and build up to 2 or 3 grams over a period of four or five weeks. You should always take butyrate with healthy fatty acids like omega-3 to replenish your cell membranes. To Your Good Health, Al Sears, MD, CNS References: 1 “A New Bacteria, Made in Belgium (and UCLouvain).” EurekAlert!, 9 June 2021, accessed September 2021. 2 Le Roy T, et al. “Dysosmobacter Welbionis Is a Newly Isolated Human Commensal Bacterium Preventing Diet-Induced Obesity and Metabolic Disorders in Mice.” Gut. 2021 Jun 8;gutjnl-2020-323778. doi: 10.1136/gutjnl-2020-323778. Online ahead of print. 3 Gao Z, et al. “Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice.” Diabetes. 2009. 58(7);1509–17. 4 Rose S, et al. “Butyrate Enhances Mitochondrial Function during Oxidative Stress in Cell Lines from Boys with Autism.” Translational Psychiatry. 2018. 8(1)10:1038/s41398-017-0089-z. 5 Canani R. “Potential Beneficial Effects of Butyrate in Intestinal and Extraintestinal Diseases.” World J Gastroenterol 2011. 17(12):1519. 6 “Modulating Gut Microbe Populations to Generate More Butyrate, Thus Raising BDNF Levels and Improving Cognitive Function.” Fight Aging! 2019. 7 Gevers D, et al. “The treatment-naïve microbiome in new-onset Crohn’s disease.” Cell Host Microbe. 2014 Mar 12; 15(3): 3828392. 8 Varela RB, Valvassori SS. “Sodium butyrate and mood stabilizers block ouabaininduced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats.” J Psychiatr Res. 2015 Feb;61:114-21 9 Chang PV, Hao L, et al. “The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.” Proc Natl Acad Sci USA. 2014 Feb 11;111(6):2247-52. 10 Williams E,et al. “Anti-Cancer Effects of Butyrate: Use of Micro-Array Technology to Investigate Mechanisms.” Proc Nutr Soc. 62(1):107-115. To read the original article click here.

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Gut Microbes May Lead to Therapies for Mental Illness, UTSW Researcher Reports

AHA Publisher — Fri, 16 Sep 2022 07:00:45 +0000

UT Southwestern Medical Center via Newswise – The role of the microbiome in intestinal and systemic health has garnered close attention among researchers for many years. Now evidence is mounting that this collection of microorganisms in the human gut can also impact a person’s neurological and emotional health, according to a recent perspective article in Science by a UT Southwestern researcher. Neuroscientist Jane Foster, Ph.D., Professor of Psychiatry at UT Southwestern and a leading expert on the microbiome, outlines how scientists are unraveling the relationship of the microbiome to the brain, including connections to diseases such as depression and amyotrophic lateral sclerosis (ALS). Dr. Foster, who was the first to link microbes in the guts of mice to anxiety, said animal studies have revealed certain microbes and related metabolites that increase anxiety-like behavior and brain function. Translating these findings to clinical populations could lead to novel therapies to improve symptoms and clinical outcomes. Dr. Foster joined UT Southwestern and its Center for Depression Research and Clinical Care (CDRC) in May to lead the effort to connect the dots between a person’s 39 trillion gut microbes and their propensity for brain disease. She previously served as Professor at McMaster University in Ontario and co-molecular lead of The Canadian Biomarker Integration Network in Depression (CAN-BIND). “People who are at risk for depression or diagnosed with depression are heterogeneous. So we want to use biology to understand the biomarkers that can help define the different clusters of people,” Dr. Foster said. She said UT Southwestern’s approach, which is built on the premise that clinical care and research go hand-in-hand, attracted her to join the center. “That holistic approach is necessary if we are going to find better answers for people suffering with mental illness,” Dr. Foster said. The CDRC conducts research in unipolar and bipolar depression to better understand the causes of depression, identify new treatments, and improve existing ones. “I am very pleased that we were able to recruit Dr. Foster to join our center, given our continuing goal to investigate the biosignature of mental health through a multipronged approach,” said Madhukar H. Trivedi, M.D., Professor of Psychiatry and Director of the CDRC. Drs. Foster and Trivedi previously collaborated to look for immune markers in blood samples obtained through CAN-BIND to see how inflammation might influence depression, and in stool samples collected from participants in the longitudinal Texas Resilience Against Depression study. If the sample from a patient with depression yields certain microbes that are associated with treatment success from certain antidepressants or therapies, this may drive personalized medicine for this patient. “Currently we have a host of treatment choices, yet decisions are predominantly based on behavior and self-report, and imaging and EEGs in some cases,” Dr. Foster said. “Antidepressants typically work for just around 40% of people. Other choices include cognitive behavioral therapy, deep brain stimulation, or even exercise and diet. By expanding on the individual patient’s profile, can we now improve the number of people that respond to a particular treatment?” Dr. Trivedi holds the Betty Jo Hay Distinguished Chair in Mental Health, and the Julie K. Hersh Chair for Depression Research and Clinical Care. To read the original article click here.

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Food Allergies Can Be Reversed in Mice by Targeting the Microbiome

AHA Publisher — Wed, 24 Aug 2022 07:00:45 +0000

American Chemical Society (ACS) via Newswise – CHICAGO, Aug. 21, 2022 — Although many people with dietary allergies experience mild symptoms when exposed to triggering foods, some face potentially fatal consequences. A bacterial compound called butyrate that’s made by healthy microbiomes has shown promise against allergic reactions in lab tests, but it’s nasty to take orally. Today, scientists describe a more palatable way to deliver this compound and report that their “polymeric micelles” are effective against peanut allergies in mice. The treatment could someday counteract many types of food allergies and inflammatory diseases. The researchers will present their results at the fall meeting of the American Chemical Society (ACS). ACS Fall 2022 is a hybrid meeting being held virtually and in-person Aug. 21–25, with on-demand access available Aug. 26-Sept. 9. The meeting features nearly 11,000 presentations on a wide range of science topics. Some of the bacteria in the gut microbiome produce metabolites, such as butyrate, that foster the growth of beneficial bacteria and maintain the lining of the gut. If a person’s microbiome is unhealthy and lacks these butyrate-producing bacteria, fragments of partially digested food can leak out of the gut and produce an immune reaction that results in an allergic response. One way to treat those with allergies would be to provide the missing bugs to them orally or with a fecal transplant, but that hasn’t worked well in the clinic, according to Jeffrey Hubbell, Ph.D., one of the project’s principal investigators (PIs). “So we thought, why don’t we just deliver the metabolites — like butyrate — that a healthy microbiome produces?” “But butyrate has a very bad smell, like dog poop and rancid butter, and it also tastes bad, so people wouldn’t want to swallow it,” says Shijie Cao, Ph.D., who is presenting the results at the meeting for the team, which is at the University of Chicago. And even if people could choke it down, butyrate would be digested before reaching its destination in the lower gut. To overcome these challenges, the researchers, including co-PI Cathryn Nagler, Ph.D., and Ruyi Wang, Ph.D., designed a new delivery system. They polymerized butanoyloxyethyl methacrylamide — which has a butyrate group as a side chain — with methacrylic acid or hydroxypropyl methacrylamide. The resulting polymers self-assembled into aggregates, or polymeric micelles, that tucked the butyrate side chains in their core, thus cloaking the compound’s foul smell and taste. The researchers administered these micelles to the digestive systems of mice lacking either healthy gut bacteria or a properly functioning gut lining. After digestive juices released the butyrate in the lower gut, the inert polymers were eliminated in the feces. The treatment restored the gut’s protective barrier and microbiome, in part by increasing production of peptides that kill off harmful bacteria, which made room for butyrate-producing bacteria. Most importantly, dosing allergic mice with the micelles prevented a life-threatening anaphylactic response when they were exposed to peanuts. “This type of therapy is not antigen specific,” Cao notes. “So theoretically, it can be broadly applied to any food allergies through the modulation of gut health.” Next up are trials in larger animals, followed by clinical trials. If those trials succeed and the U.S. Food and Drug Administration approves the oral treatment, the micelles could be marketed in small packets; consumers would tear open a packet and stir the contents into a glass of water or juice. In other work with the micelles, the team is analyzing data on treating inflammatory bowel diseases with the oral therapy. The team is also investigating administration via injection. The researchers have shown that this method allows the micelles and their butyrate cargo to accumulate in lymph nodes, which are part of the immune system. They found that this approach is effective in treating peanut allergies in mice, but it could also be used to suppress immune activation locally — rather than throughout the body. For example, injections could be helpful in patients who have had an organ transplant or who have a localized autoimmune and inflammatory condition, such as rheumatoid arthritis. The researchers acknowledge support and funding from their start-up company, ClostraBio, and the University of Chicago. To read the original article click here.

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