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New COVID-19 Drug Passes Phase 2 Clinical Trial

AHA Publisher — Thu, 20 Jan 2022 08:00:34 +0000

Sanford Burnham Prebys via Newswise – LA JOLLA, CALIF. – Jan 18, 2021 – In a phase 2 clinical trial conducted by Avalo Therapeutics and supported by researchers from Sanford Burnham Prebys, a significantly higher proportion of hospitalized patients with COVID-19 remained alive and free of respiratory failure for 28 days after receiving treatment with a new antibody called CERC-002. Unlike other experimental COVID therapies, CERC-002 does not target the virus itself, instead targeting the immune response associated with the virus to stop the disease from progressing before it becomes fatal. “At the beginning of the pandemic we thought vaccines were going to be all we really needed. But with variants like omicron, we’re going to have more people that progress to serious illness even with the vaccine,” says study coauthor Carl F. Ware, Ph.D., director of the Infectious and Inflammatory Diseases Center at Sanford Burnham Prebys. “We need treatments to stop the progression to severe disease and death.” The findings were published December 6 in the Journal of Clinical Investigation. COVID-19: a Continuing Crisis In the United States, over 800,000 people have died from COVID-19. A large proportion of these deaths have been among the elderly or those who are immunocompromised due to a preexisting condition. And while three quarters of the population has received at least one dose of the COVID-19 vaccine, many remain unvaccinated. “A lot of us feel safer now that we’ve gotten our shots,” Ware says, “but the threat of the pandemic has not gone away, even for vaccinated people.” Most people with COVID-19 experience few to no symptoms. However, elderly individuals, people with a concurrent health condition or those who are immunocompromised are susceptible to a condition called cytokine storm, in which their own immune molecules called cytokines flood the body in higher concentrations than usual. Rather than helping fight the virus, these extra immune molecules wreak havoc, causing patients to develop the deadly respiratory failure characteristic of severe COVID disease. “The COVID virus gets the immune system amped up by producing these molecules, which is normally how the immune system fights diseases,” says Ware. “But when there are too many cytokines and they’re not doing their job, it can lead to severe damage.” Neutralizing the Cytokine Storm The new treatment, CERC-002, is a cytokine neutralizer—an immune molecule that recognizes and deactivates a cytokine known as LIGHT, which is elevated in patients with COVID-19. Cytokine neutralization drugs are currently being tested in the clinic, but they are mainly effective in severely ill patients who are already on a ventilator or other organ support. “There is a critical need for drugs to stop milder cases from progressing to severe,” says Ware. “This treatment targets the cytokine immune response early enough to stop it in its tracks, which no other treatment does right now.” 83 COVID patients were enrolled in the study, half receiving the treatment, and half receiving a placebo. All patients were hospitalized with mild-to-moderate respiratory distress and were also receiving standard-of-care therapy during the trial. They found that 83.9% of patients who received a dose of CERC-002 on top of standard of care remained alive and free from respiratory distress for 28 days. For patients receiving placebo, the number was only 64.5%. Looking Ahead As a phase 2 clinical trial, the purpose of this study was to test whether the compound has therapeutic potential in a small number of patients. Now that the drug has proven successful at a small scale, it can be tested on a larger number of patients to ensure its benefits are consistent across the population. Additionally, because CEC-002 targets the immune response in COVID cases rather than the virus itself, the compound may have applications that extend beyond COVID. “Cytokine storm is not unique to COVID. It occurs in other infections—even in autoimmune diseases with no active infection, so this treatment may have some utility in these other diseases as well.” While there is more work to be done before CERC-002 becomes widely available, it does offer a glimmer of hope during a pandemic that seems never-ending. “We have made a lot of progress in controlling the pandemic with vaccines and other new therapies, but it’s not over yet,” says Ware. “Treatments like this may bring physicians an option to protect infected people from severe illness. To read the original article click here.

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BETTER than Laxatives: The “King of Fruit” Helps to Relieve Constipation and Greatly Improve Your Health

AHA Publisher — Mon, 08 Feb 2021 08:00:11 +0000

Lori Alton via NaturalHealth365 – When it comes to regularity, almost everybody needs a little help “moving things along” at one time or another. But for millions of Americans, the problem is not just an occasional “glitch” in routine but a frequent occurrence. According to a recent review published in Gastroenterology, 16 percent of Americans suffer from chronic constipation – with the odds rising to 33 percent for those over 60. Luckily, recent research shows that this unpleasant problem may have a pleasant solution. Multiple studies have supported the digestive benefits of mangos, including their ability to ease constipation significantly. In addition, this sweet, colorful tropical fruit fights disease and improves health in surprising ways. Warning: Constipation Can Have MULTIPLE Causes and Potentially Lethal Consequences Constipation is defined as infrequent bowel movements – typically characterized as less than three a week – accompanied by straining. Constipation is considered chronic when symptoms persist for three months. Causes can include insufficient dietary fiber, dehydration, and the use of certain medications, particularly opioids. Although the majority of cases of constipation are merely uncomfortable, the condition can, in many cases, be dangerous and even sometimes fatal. Complications can include anal fissures, fecal impactions, and even a perforated colon, which can inject bacteria into the bloodstream. As the Mayo Clinic notes, any unexplained or persistent changes in bowel habits call for a visit to your doctor. Peer-Reviewed Research Shows Common Fruit Outperforms Commercial Laxatives in Easing Constipation In a clinical study conducted by researchers at Texas A and M University and published in Molecular Nutrition and Food Research, adults with chronic constipation were given 300 mg (about two cups) of fresh mango daily. The researchers noted that mangoes “significantly improved” the frequency of bowel movements – and were more effective than a supplement that contained an equivalent amount of powdered soluble fiber. The mango consumption also lowered levels of markers of intestinal inflammation – something that pharmaceutical laxatives can’t accomplish. One of the study’s co-authors credited bioactive polyphenols in mangoes with the beneficial effects. The team also observed that daily mango consumption altered and improved the makeup of the microbiome (the all-important community of beneficial bacteria living in the digestive tract). Researchers have learned that the microbiome is strongly linked with immune system health – and that disruptions in its bacterial composition (a condition known as dysbiosis) have been linked with serious diseases, including autoimmune conditions, autism, atherosclerosis, and obesity. Mangoes may also ease constipation with their healthy amounts of dietary fiber and their content of amylases – digestive enzymes that help break down complex carbohydrates. More Good News: The “Super-Antioxidant” in Mangoes Fights Heart Disease and Cancer The mango, botanically known as Mangifera indica, has been referred to by aficionados as “the king of fruits.” Mangoes earn this royal title with their treasure trove of antioxidant polyphenols, or beneficial plant-based chemicals. These include anthocyanins and carotenoids (a group of plant pigments), along with antioxidant and anti-inflammatory flavonoids such as quercetin, kaempferol, and gallic and ellagic acids. These antioxidant “good actors” scavenge the harmful free radicals that would otherwise trigger oxidative stress, along with potentially cancer-causing mutations in DNA. But the mango has one more health-preserving trick up its sleeve: a potent compound known as mangiferin. Mangiferin, classified as a “super-antioxidant,” is believed to be more powerful than vitamin C – a major antioxidant in its own right. Researchers say mangiferin is also antiviral, anti-allergenic, anti-inflammatory, analgesic, and immune system-boosting – in other words, it contains a whole pharmacy of disease-fighting effects. In research published in Comprehensive Reviews in Food Science and Food Safety, the investigators credited mangiferin with the potential to fight atherosclerosis, heart disease, and cancer. In animal studies, mangiferin inhibited angiogenesis – the ability of tumors to grow new blood vessels – and slowed tumor growth. These Beneficial Compounds in Mangoes Protect Your Eyesight and Reduce Macular Degeneration The U.S. Centers for Disease Control and Prevention (CDC) reports that close to 2 million Americans over 40 suffer from age-related macular degeneration (ARMD) – the leading cause of vision loss in older adults. But another of the impressive benefits of mangoes is that they may help prevent it. The brilliant yellow of the mango’s pulp is a testament to the presence of lutein and zeaxanthin, a pair of carotenoids (antioxidant plant pigments) found in orange and yellow foods such as corn, pumpkin, and squash. Lutein and zeaxanthin in mangoes help protect the retina, particularly the macula – the part that converts light into brain signals. In addition to scavenging harmful free radicals, lutein and zeaxanthin absorb excess ultraviolet light and “blue” light from TVs and computer screens, thereby warding off ARMD. In one study, people with the highest levels of these carotenoids had a 41 percent lower risk of developing macular degeneration. There Is Even More Good News! “King of Fruit” Is Loaded With an Abundance of Life-Giving Vitamins, Nutrients, and Minerals At a modest 99 calories a cup, mangos are a nutritional bargain. Each fruit contains over 2.5 grams of dietary fiber, along with 67 percent of the recommended daily amount of immune system-boosting vitamin C. Mangoes also contain the essential minerals magnesium and potassium, which help regulate heartbeat and blood pressure. Many of the antioxidants in mangoes function synergistically, meaning each work together to enhance the effect of the others. Many researchers believe that taking nutrients that have been isolated from mangoes is not as effective or healthful as simply eating these succulent fruits. You can access the benefits of mangoes by adding them to smoothies, tossing them into salads, using them in marinades and jams, or eating them as a snack out of hand. Because mangoes are high in natural sugars, nutritionists advise moderation – with about two cups a day (or two smallish mangos) as the upper limit. Of course, check first with your integrative doctor before addressing constipation with mangoes. Just remember: when it comes to constipation, you don’t have to take it sitting down (metaphorically speaking, of course.) Delicious mangoes pack a nutritional wallop of polyphenols and fiber that can help ease this uncomfortable problem naturally, safely, and effectively. Sources for this article include: Healthline.com MayoClinic.org NIH.gov NIH.gov To read the original article click here. For more articles from NaturalHealth365 click here.

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