New E-Cigarette Products Contain Highly Potent Sweeteners

The AHA! Team — Wed, 09 Jul 2025 05:23:42 +0000

Eric-Sven Jordt, Ph.D. via Duke Health – As of now, neither federal nor state regulations address the increasing presence of artificial sweeteners in tobacco products. e-cigarettes tested by Duke researchers A majority of popular disposable e-cigarettes tested by Duke researchers contain a potent, unregulated artificial sweetener that may enhance the appeal to young and first-time users. The additive neotame is up to 13,000 times sweeter than table sugar and is often used in e-cigarettes that also feature fruity, candy and cool mint flavors. Clinical studies have found that candy flavors and sweeteners increase the appeal, preference, and abuse potential of e-cigarettes and other tobacco products. “The addition of a potent sweetener may increase the potential for addiction by facilitating initiation and chronic use,” said Eric-Sven Jordt, Ph.D., associate professor in the departments of Anesthesiology and Pharmacology and Cancer Biology at Duke and senior author of a study appearing June 2 in JAMA. “The presence of neotame also raises toxicity concerns,” Jordt said. “While approved by the U.S. Food and Drug Administration for use in food, it is not known whether it is safe to inhale neotame heated and vaporized by an e-cigarette.” Jordt and colleagues — including co-lead authors Hanno C. Erythropel, Ph.D., an analytical chemist at Yale School of Medicine and Sairam V. Jabba, Ph.D., senior research scientist in Duke’s Department of Anesthesiology – analyzed 55 disposable e-cigarettes marketed in 2024, including the popular brands Elfbar, Geekbar, Mr. Fog and Breeze, and products that contained no nicotine or a nicotine-mimicking substance called 6-methylnicotine. Of the 55 disposable e-cigarettes tested all contained neotame, with an average neotame content that was nearly five times higher than in a mentos mint candy. Disposable e-cigarettes containing the nicotine analog 6-methylnicotine had even higher neotame content. “Our study demonstrates that the artificial sweetener neotame is a ubiquitous ingredient in popular disposable e-cigarettes sold in the United States,” Jabba said. “Interestingly, less popular FDA-authorized ENDS products such as Vuse or those awaiting an authorization decision that were introduced before 2021 such as Juul do not contain this additive. The addition of neotame to disposable cigarettes may give these products a competitive edge. Youth and young adults strongly favor sweetened products, especially in combination with candy flavors.” As of now, neither federal nor state regulations address the increasing presence of artificial sweeteners in tobacco products. “FDA and state regulators need to rein in the spread of heavily sweetened, disposable e-cigarettes that have not been authorized for marketing by the FDA, but are nevertheless available in local stores and from online vendors,” Jordt said. “Otherwise, gains made in the reduction of e-cigarette use by youth may be reversed.” In addition to Jabba, Jordt and Erythropel, study authors include Remi A. Mellinghoff, Victor Garcia-Gallet, Peter Silinski, and Julie B. Zimmerman. Funding for the study was provided by the Yale Tobacco Center of Regulatory Science, the National Institute on Drug Abuse, part of the National Institutes of Health (U54DA036151, R01DA060884), and the Center for Tobacco Products of the FDA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the FDA. To read the original article click here.

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Harmful Metals Found in Vapors From Tank-Style Electronic Cigarettes

AHA Publisher — Mon, 30 Sep 2019 07:00:34 +0000

University of California – Riverside via EurekAlert – “Concentrations of the metals, such as lead, in the aerosols increased with more voltage,” Williams said. “Concentrations of some elements – chromium, lead, and nickel – were high enough to be a health concern. We found the concentrations of chromium, copper, lead, nickel, and zinc exceeded the proposed permissible exposure limit from the Occupational Safety and Health Administration.” RIVERSIDE, Calif. – A team of scientists at the University of California, Riverside, has found the concentration of metals in electronic cigarette aerosols – or vapor – has increased since tank-style electronic cigarettes were introduced in 2013. Electronic cigarettes, which consist of a battery, atomizing unit, and refill fluid, are now available in new tank-style designs, equipped with more powerful batteries and larger capacity reservoirs for storing more refill fluid. But the high-power batteries and atomizers used in these new styles can alter the metal concentrations that transfer into the aerosol. “These tank-style e-cigarettes operate at higher voltage and power, resulting in higher concentrations of metals, such as lead, nickel, iron, and copper, in their aerosols,” said Monique Williams, a postdoctoral researcher in the Department of Molecular, Cell, and Systems Biology, and the first author of the research paper that appears today in Scientific Reports. “Most of the metals in e-cigarette aerosols likely come from the nichrome wire, tin solder joints, brass clamps, insulating sheaths, and wicks – components of the atomizer unit.” The researchers examined six tank-style electronic cigarettes and found all the aerosols had metals that appeared to originate in the atomizers. Further, they found the model with fewest metal parts in its atomizer had the fewest metals in its aerosol. Of the 19 metals they screened, aluminum, calcium, chromium, copper, iron, lead, magnesium, nickel, silicon, tin, and zinc were from components in the atomizing units. “Concentrations of the metals, such as lead, in the aerosols increased with more voltage,” Williams said. “Concentrations of some elements – chromium, lead, and nickel – were high enough to be a health concern. We found the concentrations of chromium, copper, lead, nickel, and zinc exceeded the proposed permissible exposure limit from the Occupational Safety and Health Administration.” Chromium, lead, and nickel are known carcinogens. Prolonged exposure to chromium could cause gastrointestinal effects, nasal and lung cancer, respiratory irritation, and lung function impairment. Prolonged exposure to lead could produce vomiting, diarrhea, cardiovascular effects, and lung cancer. Nickel inhalation could cause lung disease, damage to the nasal cavity, lung irritation, lung inflammation, hyperplasia in pulmonary cells, and fibrosis. The researchers analyzed the following six tanks and their atomizers: Kangertech Protank, Aspire Nautilus tank, Kanger T3S tank, Tsunami 2.4, Smok tank, and Clone. They collected aerosols from these brands using two methods and found the total concentrations of metals varied, ranging from 43 to 3,138 micrograms per liter with the “impinger method” of collection and 226 to 6,767 micrograms per liter with the “cold trap method.” “When batteries with more power are used in these tank-style e-cigarettes, their atomizing units can heat to temperatures greater than 300 C, which could produce harmful byproducts,” said Prue Talbot, a professor of cell biology, who led the research team. “The presence of heavy metals, including some known carcinogens, in e-cigarette aerosols is concerning because with prolonged exposure they could cause adverse health effects. “Our data on tank-style e-cigarettes and the concentrations of metals they deliver may be useful to regulatory agencies, health care providers, and consumers,” she added. To read the original article click here.

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New E-Cigarette Products Contain Highly Potent Sweeteners

Harmful Metals Found in Vapors From Tank-Style Electronic Cigarettes