E-Cigarettes Archives - Amazing Health Advances

New E-Cigarette Products Contain Highly Potent Sweeteners

The AHA! Team — Wed, 09 Jul 2025 05:23:42 +0000

Eric-Sven Jordt, Ph.D. via Duke Health – As of now, neither federal nor state regulations address the increasing presence of artificial sweeteners in tobacco products. e-cigarettes tested by Duke researchers A majority of popular disposable e-cigarettes tested by Duke researchers contain a potent, unregulated artificial sweetener that may enhance the appeal to young and first-time users. The additive neotame is up to 13,000 times sweeter than table sugar and is often used in e-cigarettes that also feature fruity, candy and cool mint flavors. Clinical studies have found that candy flavors and sweeteners increase the appeal, preference, and abuse potential of e-cigarettes and other tobacco products. “The addition of a potent sweetener may increase the potential for addiction by facilitating initiation and chronic use,” said Eric-Sven Jordt, Ph.D., associate professor in the departments of Anesthesiology and Pharmacology and Cancer Biology at Duke and senior author of a study appearing June 2 in JAMA. “The presence of neotame also raises toxicity concerns,” Jordt said. “While approved by the U.S. Food and Drug Administration for use in food, it is not known whether it is safe to inhale neotame heated and vaporized by an e-cigarette.” Jordt and colleagues — including co-lead authors Hanno C. Erythropel, Ph.D., an analytical chemist at Yale School of Medicine and Sairam V. Jabba, Ph.D., senior research scientist in Duke’s Department of Anesthesiology – analyzed 55 disposable e-cigarettes marketed in 2024, including the popular brands Elfbar, Geekbar, Mr. Fog and Breeze, and products that contained no nicotine or a nicotine-mimicking substance called 6-methylnicotine. Of the 55 disposable e-cigarettes tested all contained neotame, with an average neotame content that was nearly five times higher than in a mentos mint candy. Disposable e-cigarettes containing the nicotine analog 6-methylnicotine had even higher neotame content. “Our study demonstrates that the artificial sweetener neotame is a ubiquitous ingredient in popular disposable e-cigarettes sold in the United States,” Jabba said. “Interestingly, less popular FDA-authorized ENDS products such as Vuse or those awaiting an authorization decision that were introduced before 2021 such as Juul do not contain this additive. The addition of neotame to disposable cigarettes may give these products a competitive edge. Youth and young adults strongly favor sweetened products, especially in combination with candy flavors.” As of now, neither federal nor state regulations address the increasing presence of artificial sweeteners in tobacco products. “FDA and state regulators need to rein in the spread of heavily sweetened, disposable e-cigarettes that have not been authorized for marketing by the FDA, but are nevertheless available in local stores and from online vendors,” Jordt said. “Otherwise, gains made in the reduction of e-cigarette use by youth may be reversed.” In addition to Jabba, Jordt and Erythropel, study authors include Remi A. Mellinghoff, Victor Garcia-Gallet, Peter Silinski, and Julie B. Zimmerman. Funding for the study was provided by the Yale Tobacco Center of Regulatory Science, the National Institute on Drug Abuse, part of the National Institutes of Health (U54DA036151, R01DA060884), and the Center for Tobacco Products of the FDA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the FDA. To read the original article click here.

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1 Million Adult Vapers in England Have Never Regularly Smoked

The AHA! Team — Fri, 15 Nov 2024 06:20:34 +0000

Priyanjana Pramanik, MSc. via News-Medical – This rapid increase between 2021 and 2024 was particularly among younger age groups. In a recent study published in The Lancet Public Health, researchers estimate trends in vaping among adults in the United Kingdom who have not smoked regularly. The health implications of vaping In the past, vaping or the use of e-cigarettes in England was primarily reported among current or former smokers trying to reduce or quit smoking. If vaping were only adopted by those who would otherwise smoke, the overall rate of smoking or vaping would remain constant or show signs of declining rather than increasing. The rising rate of vaping could be attributed to the widespread availability of disposable e-cigarettes in recent years, which has led to a rapid increase in vaping among regular and non-regular smokers. Although e-cigarettes may be less harmful than smoking, these devices contain toxic chemicals that the user consumes. In fact, several studies indicate that vapers are exposed to higher levels of toxicants than non-users. About the study Researchers collected data using a monthly cross-sectional survey across England, Wales, and Scotland to ensure a nationally representative sample. Approximately 2,450 individuals participated in the survey each month between 2016 and early 2024. The vaping status of adults who reported never regularly smoking was evaluated using questions about their current e-cigarette use, daily or non-daily e-cigarette use, as well as as the type of device and strength of nicotine used. Study participants also provided sociodemographic data such as gender, age, and social class, as well as lifestyle information such as alcohol consumption. Statistical models were used to calculate trends in the prevalence of smoking after adjusting for alcohol consumption and sociodemographic characteristics. These trends were then assessed according to age, with the prevalence of vaping compared before and after the increased availability of disposable e-cigarettes. Study findings The analysis included 94,107 unique never-regular smokers, as well as younger individuals who had never smoked. Vaping among never-regular smokers was stable at approximately 0.5% until 2021. From 2021 onwards, vaping increased rapidly to 3.5% in April 2024. This increased prevalence of vaping was primarily attributed to younger adults under the age of 24, 14.4% of whom vaped, as compared to those over the age of 48, less than 1% of whom vaped. Although age differences were significant, trends were similar across social class and gender. Alcohol consumption was positively correlated with vaping prevalence, with heavy drinkers more likely to vape at a rate of 22.1%. Comparatively, only 3% of low-risk drinkers and 1.3% of non-drinkers vaped. Throughout the analysis period, non-daily vaping was less common than daily vaping, but the prevalence of daily vaping was four times greater than that of non-daily vaping. Researchers also found clear indications that disposable e-cigarettes are implicated in these trends. In the post-disposable period, users were more likely to report longer vaping durations, with a reduced prevalence of short-term use. Since disposable devices have become more common, vapers are increasingly younger, heavier drinkers, and more likely to be female. There is also a pronounced shift towards disposable e-cigarettes and devices with higher nicotine strengths. More purchases were also reported from convenience stores or supermarkets, and fewer from vape shops. Conclusions The study findings demonstrate the significant rise in vaping rates in England over the past three years, specifically among those who are not regular smokers, as well as younger adults and heavier drinkers. In 2021, one in 200 never-regular smokers reported vaping. By April 2024, this rate increased to one in 28. Disposable e-cigarettes, which appear to appeal to younger adults and women, may encourage the use of higher nicotine strengths. The health impacts of these behavioral shifts may be significant, particularly among individuals who would not typically engage in vaping, which increases their exposure to toxins they would have otherwise avoided. Addressing these issues is associated with various challenges as policymakers seek to reduce vaping among non-smokers while ensuring that e-cigarettes are available and remain attractive to smokers who would like to quit. Stricter regulations on the appearance, pricing, and marketing of these products may support these public health efforts to reduce the appeal of vaping. Journal reference: Jackson, S.E., Shahab, L., Tattan-Birch, H., & Brown, J. (2024). Vaping among adults in England who have never regularly smoked: a population-based study, 2016–24. The Lancet Public Health. doi:10.1016/S2468-2667(24)00183-X To read the original article click here.

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Some E-Cigarette Chemicals Mimic Nicotine, Possibly Bypassing Regulation

The AHA! Team — Fri, 11 Oct 2024 08:21:24 +0000

Duke Health – In what appears to be an effort to bypass public health regulations covering vaping products, some tobacco companies have begun replacing nicotine in e-cigarettes with related chemicals that have similar properties but unknown health effects, Duke Health researchers report. In a research letter appearing Aug. 7 in JAMA, study authors at Duke and Yale University also found that the quantity of these chemicals, known as nicotine analogs, are not accurately disclosed on the packaging. “Vaping products containing nicotine are subject to federal laws that prohibit sales to people under the age of 21,” said study co-author Sairam V. Jabba, D.V.M., Ph.D., a senior research scientist at Duke University School of Medicine. Nicotine analogs are currently not subject to the FDA process “Nicotine analogs are currently not subject to the FDA process and have not been studied for their health effects,” Jabba said. “Our analysis of some of these analog-containing vaping products sold in the U.S. found significant and concerning inaccuracies in the ingredients these products claim to contain and what they actually contain. Further, it’s possible manufacturers are attempting to avoid FDA tobacco regulation.” One chemical, known as 6-methyl nicotine, has been shown in rodent experiments to be far more potent than nicotine in targeting the brain’s nicotine receptors and more toxic than nicotine. Another, called nicotinamide, is marketed as targeting the same brain receptors as nicotine, despite evidence it does not bind to these receptors. The nicotine analogs were included in flavored e-cigarettes, which prior research has indicated are preferred by youths and those who vape for the first time. Jabba and colleagues, including co-senior author Sven Eric Jordt, Ph.D., analyzed an e-cigarette product sold under the brand name Spree Bar, which comes in at least nine flavors and is listed as containing 5 percent 6-methyl nicotine. Study results showed the actual amount of the chemical was about 88% less than labeled. The e-cigarettes also included an artificial sweetener that is up to 13,000 times sweeter than table sugar, and an artificial coolant that mimics menthol’s effects. A second brand of e-cigarettes — marketed as Nixotine, Nixodine, Nixamide and Nic-Safe – contained a nicotine analog called nicotinamide, also at levels lower than the labels indicated, and combined with undisclosed amounts of 6-methyl nicotine. This brand did not include sweeteners or coolants. These products appear to be designed to circumvent the laws and regulations “These products appear to be designed to circumvent the laws and regulations in place to protect people — especially children — from the harmful effects of smoking and tobacco use,” Jordt said. “We do not know what these chemicals do when they are heated and inhaled. These are questions that should be answered before we allow products on the market.” In addition to Jordt and Jabba, study authors include Hanno C. Erythropel, Peter Silinski, Paul T. Anastas, Suchitra Krishnan-Sarin and Julie B. Zimmerman. Yale’s Tobacco Center of Regulatory Science received funding support for the study from the National Institute on Drug Abuse, which is part of the National Institutes of Health (U54DA036151), and the Center for Tobacco Products of the FDA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the FDA. To read the original article click here.

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FDA Bans Juul E-Cigarettes Tied to Teen Vaping Surge

AHA Publisher — Mon, 27 Jun 2022 07:00:15 +0000

Matthew Perrone via CBN News – WASHINGTON (AP) — Federal health officials on Thursday ordered Juul to pull its electronic cigarettes from the U.S. market, the latest blow to the embattled company widely blamed for sparking a national surge in teen vaping. The action is part of a sweeping effort by the Food and Drug Administration to bring scientific scrutiny to the multibillion-dollar vaping industry after years of regulatory delays. The FDA said Juul must stop selling its vaping device and its tobacco and menthol-flavored cartridges. Those already on the market must be removed. Consumers aren’t restricted from having or using Juul’s products, the agency said. To stay on the market, companies must show that their e-cigarettes benefit public health. In practice, that means proving that adult smokers who use them are likely to quit or reduce their smoking, while teens are unlikely to get hooked on them. The FDA noted that some of the biggest sellers like Juul may have played a “disproportionate″ role in the rise in teen vaping. The agency said Thursday that Juul’s application didn’t have enough evidence to show that marketing its products “would be appropriate for the protection of the public health.” A Juul representative did not immediately respond to a request for comment from The Associated Press. In a statement, the FDA said Juul’s application left regulators with significant questions and didn’t include enough information to evaluate any potential risks. The agency said the company’s research included “insufficient and conflicting data” about things like potentially harmful chemicals leaching from Juul’s cartridges. “Without the data needed to determine relevant health risks, the FDA is issuing these marketing denial orders.” Michele Mital, acting director of the FDA’s tobacco center, said in the statement. The agency has granted some e-cigarette applications. Since last fall, the agency has given its OK to tobacco-flavored e-cigarettes from R.J. Reynolds, Logic, and other companies. But industry players and anti-tobacco advocates have complained that those products account for just a tiny percent of the $6 billion vaping market in the U.S. Regulators repeatedly delayed making decisions on devices from market leaders, including Juul, which remains the best-selling vaping brand although sales have dipped. Last year, the agency rejected applications for more than a million other e-cigarettes and related products, mainly due to their potential appeal to underage teens. The American Lung Association called Thursday’s decision “long overdue and most welcome,” and cited Juul for stoking youth vaping. E-cigarettes first appeared in the U.S. more than a decade ago with the promise of providing smokers with a less harmful alternative. The devices heat a nicotine solution into a vapor that’s inhaled, bypassing many of the toxic chemicals produced by burning tobacco. But studies have reached conflicting results about whether they truly help smokers quit. And efforts by the FDA to rule on vaping products and their claims were repeatedly slowed by industry lobbying and competing political interests. The vaping market grew to include hundreds of companies selling an array of devices and nicotine solutions in various flavors and strengths. The vaping issue took on new urgency in 2018 when Juul’s high-nicotine, fruity-flavored cartridges quickly became a nationwide craze among middle and high school students. The company faces a slew of federal and state investigations into its early marketing practices, which included distributing free Juul products at concerts and parties hosted by young influencers. In 2019, the company was pressured into halting all advertising and eliminating its fruit and dessert flavors. The next year, the FDA limited flavors in small vaping devices to just tobacco and menthol. Separately, Congress raised the purchase age for all tobacco and vaping products to 21. But the question of whether e-cigarettes should remain on the market at all remained. The FDA has been working under a court order to render its decisions; anti-tobacco groups successfully sued the agency to speed up its review. FDA regulators warned companies for years they would have to submit rigorous, long-term data showing a clear benefit for smokers who switch to vaping. But all but the largest e-cigarette manufacturers have resisted conducting that kind of expensive, time-consuming research. While Juul remains a top seller, a recent federal survey shows that teens have been shifting away from the company. Last year’s survey showed Juul was the fourth most popular e-cigarette among high schoolers who regularly vape. The most popular brand was a disposable e-cigarette called Puff Bar which comes in flavors like pink lemonade, strawberry, and mango. That company’s disposable e-cigarettes had been able to skirt regulation because they use synthetic nicotine, which until recently was outside the FDA’s jurisdiction. Congress recently closed that loophole. Overall, the survey showed a drop of nearly 40% in the teen vaping rate as many kids were forced to learn from home during the pandemic. Still, federal officials cautioned about interpreting the results given they were collected online for the first time, instead of in classrooms. The brainchild of two Stanford University students, Juul launched in 2015 and within two years rocketed to the top of the vaping market. Juul, which is partially owned by tobacco giant Altria, still accounts for nearly 50% of the U.S. e-cigarette market. It once controlled more than 75%. On Tuesday, the FDA also laid out plans to establish a maximum nicotine level for certain tobacco products to reduce their addictiveness. In that announcement, the agency also noted that it has invested in a multimedia public education campaign aimed at warning young people about the potential risks of e-cigarette use. ___ AP Health Writer Tom Murphy contributed to this report. Copyright 2022 by The Associated Press. All rights reserved. To read the original article click here.

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