depression risk Archives - Amazing Health Advances

Inflammation May Be the Link Between Chronic Pain and Depression

The AHA! Team — Mon, 02 Jun 2025 05:18:17 +0000

Yale School of Medicine via Newswise – A new study published in Science Advances shows that a person’s risk of depression increases alongside the number of places in the body in which they experience pain. Chronic pain—or pain that lasts at least three months—is closely intertwined with depression. Individuals living with pain’s persistent symptoms may be up to four times more likely to experience depression, research shows. Almost 30% of people worldwide suffer from a chronic pain condition such as low back pain and migraines, and one in three of these patients also report co-existing pain conditions. A new study published in Science Advances Now, a new study published in Science Advances shows that a person’s risk of depression increases alongside the number of places in the body in which they experience pain. Furthermore, inflammatory markers such as C-reactive protein (a protein produced by the liver in response to inflammation) help explain the association between pain and depression. This finding suggests that the mechanisms underlying chronic pain and depression may be driven by systemic inflammation, the researchers say. “Pain isn’t only physical,” says Dustin Scheinost, PhD, associate professor of radiology and biomedical imaging at Yale School of Medicine (YSM), and the study’s principal investigator. “Our study adds to the evidence that physical conditions can have mental health consequences.” Inflammatory markers may explain depression risk The Yale team analyzed data from the UK Biobank—a long-term study in the United Kingdom that has collected extensive health information from more than 400,000 individuals over 14 years. UK Biobank participants reported whether they were experiencing pain that interfered with daily life and identified the sites and duration of their pain. The categories for pain sites included head, face, neck, back, stomach, hip, knee, and general pain. The dataset also included if and when the participants were diagnosed with depression. The researchers analyzed data from participants with both chronic and acute (lasting less than three months) pain. They found that both types of pain from all body sites were associated with depression, and that chronic pain was more strongly associated than acute pain. Furthermore, having chronic pain in multiple parts of the body was linked to a greater risk of depression than having pain at a single site. The UK Biobank also included assessments of participants’ blood. The Yale researchers used these data to look for inflammatory markers, such as C-reactive proteins, platelets, and white blood cells. They found that several of these inflammatory markers helped explain the relationship between pain and depression—and C-reactive proteins in particular were the strongest variable. “This gives us some preliminary evidence about the inflammatory mechanisms underlying the association between pain and depression,” says Rongtao Jiang, PhD, postdoctoral associate at YSM and the study’s first author. Illuminating the brain-body connection The study adds to growing evidence highlighting the significance of the brain-body connection, the authors say. “We often think of brain health or mental health as separate from cardiac health or liver health, for instance,” says Scheinost. “But all of these body systems influence each other.” Further research into the underlying drivers of pain and depression could help scientists develop new intervention strategies, he adds. Most of the participants studied were of European ancestry. In future studies, Jiang says he is interested in studying whether these findings also apply to individuals of other ethnicities. Scheinost’s team is also studying the association between chronic pain and opioid use disorder. “This is another disorder that goes hand-in-hand with the experience of chronic pain,” Scheinost says. To read the original article click here.

The post Inflammation May Be the Link Between Chronic Pain and Depression appeared first on Amazing Health Advances.

The Wrong Kind of Food Linked to Increased Depression Risk

The AHA! Team — Mon, 23 Sep 2024 08:06:35 +0000

Patrick Tims via NaturalHealth365 – Technology and social isolation are frequently cited as major factors in the rising depression epidemic both in the United States and around the world. While many people do feel increasingly disconnected from their communities, the surge in depression cannot be solely attributed to these tech-driven issues. Recent research published in Clinical Nutrition points to another significant factor: the consumption of ultra-processed foods. With an estimated 280 million people globally experiencing depression, it’s clear that multiple factors contribute to this widespread issue. Research reveals link between ultra-processed foods and depression Recent research highlights a significant connection between the consumption of ultra-processed foods and an increased risk of depression. While this study focused on Brazilian residents, it’s worth noting that Brazilians actually consume fewer ultra-processed foods on average than people in the United States, the United Kingdom, and other developed nations. The study, part of the “NutriNet Brasil” initiative, aimed to investigate chronic diseases and dietary patterns among Brazilians aged 18 and older. Participants completed online questionnaires on their health and dietary habits, initially enrolling in the winter of 2020. The researchers used Nova24h, an innovative online dietary recall tool to assess dietary intake. This technology categorizes foods based on their level of processing and monitors consumption patterns at six and twelve-month intervals. How processed foods might be affecting your mood A Patient Health Questionnaire was employed at the 14-month mark to evaluate symptoms of depression. Participants without a previous depression diagnosis who scored in the depressive range were assessed further with additional questionnaires every six months. This ongoing analysis aimed to track changes in depression symptoms over time. The data analysis uncovered a strong link between the consumption of highly processed foods and the onset of depression. Even after adjusting for factors like diet quality, lifestyle, and demographics, the study found that increased consumption of highly processed foods was associated with a higher risk of developing depression. Specifically, the risk increased by 42% for those consuming higher levels of processed foods compared to those with the lowest intake. Additionally, for every 10% increase in highly processed food consumption, there was a corresponding 10% rise in depression risk. Simple tips to cut down on processed foods and boost your well-being Transitioning to a healthier diet begins with mindful grocery shopping. Here are some practical tips to help you reduce your intake of processed foods and enhance your well-being: Plan your meals: Create a weekly meal plan that includes a variety of whole foods such as organic fruits, vegetables, lean proteins, and whole grains. This helps ensure you’re not relying on processed foods for convenience. Make a shopping list: Before heading to the store, prepare a list of nutritious groceries based on your meal plan. Stick to this list to avoid the temptation of picking up processed snacks or convenience foods. Read labels carefully: When buying packaged foods, check the ingredient list for artificial additives, preservatives, and high levels of sugar or sodium. Opt for products with fewer ingredients and recognizable names. Cook at home: Prepare meals from scratch as much as possible. Home-cooked meals allow you to control the ingredients and avoid hidden additives found in processed foods. Incorporate fresh produce: Focus on buying fresh, organic fruits and vegetables. Choose a variety of colors and types to ensure you’re getting a wide range of nutrients. Opt for lean proteins: Choose lean protein sources such as pasture raised (organic) chicken, wild-caught fish, and organic beans. These options are less processed and provide essential nutrients without added fats or preservatives. Stay hydrated: Drink plenty of clean (filtered) water throughout the day. Sometimes, cravings for processed foods can be mistaken for thirst. Find healthy substitutes: Replace processed snacks with healthier alternatives like fresh fruit, nuts, or homemade popcorn. Experiment with recipes to find satisfying, nutritious options. Grow your own produce: If possible, start a small organic garden at home. Growing your own vegetables and herbs can be a rewarding way to ensure you have access to fresh, unprocessed ingredients. Explore local markets: Shop at local farmers’ markets or organic stores. These venues often offer fresh, seasonal produce and can be a great way to support local agriculture. By following these tips, you’ll reduce your intake of processed foods and boost your mental and physical health, leading to a happier and healthier you. Sources for this article include: Clinicalnutritionjournal.com Psypost.org WHO.int To read the original article click here.

The post The Wrong Kind of Food Linked to Increased Depression Risk appeared first on Amazing Health Advances.

Researchers Identify Biomarker for Depression, Antidepressant Response

AHA Publisher — Wed, 05 Jan 2022 08:00:45 +0000

University of Illinois Chicago via Newswise – Researchers are one step closer to developing a blood test that provides a simple biochemical hallmark for depression and reveals the efficacy of drug therapy in individual patients. Published in a new proof of concept study, researchers led by Mark Rasenick, University of Illinois Chicago distinguished professor of physiology and biophysics and psychiatry, have identified a biomarker in human platelets that tracks the extent of depression. The research builds off of previous studies by several investigators that have shown in humans and animal models that depression is consistent with decreased adenylyl cyclase — a small molecule inside the cell that is made in response to neurotransmitters such as serotonin and epinephrine. “When you are depressed, adenylyl cyclase is low. The reason adenylyl cyclase is attenuated is that the intermediary protein that allows the neurotransmitter to make the adenylyl cyclase, Gs alpha, is stuck in a cholesterol-rich matrix of the membrane — a lipid raft – where they don’t work very well,” Rasenick said. The new study, “A Novel Peripheral Biomarker for Depression and Antidepressant Response,” published in Molecular Psychiatry, has identified the cellular biomarker for translocation of Gs alpha from lipid rafts. The biomarker can be identified through a blood test. “What we have developed is a test that can not only indicate the presence of depression but it can also indicate therapeutic response with a single biomarker, and that is something that has not existed to date,” said Rasenick, who is also a research career scientist at Jesse Brown VA Medical Center. The researchers hypothesize they will be able to use this blood test to determine if antidepressant therapies are working, perhaps as soon as one week after beginning treatment. Previous research has shown that when patients showed improvement in their depression symptoms, the Gs alpha was out of the lipid raft. However, in patients who took antidepressants but showed no improvement in their symptoms, the Gs alpha was still stuck in the raft — meaning simply having antidepressants in the bloodstream was not good enough to improve symptoms. A blood test may be able to show whether or not the Gs alpha was out of the lipid raft after one week. “Because platelets turn over in one week, you would see a change in people who were going to get better. You’d be able to see the biomarker that should presage successful treatment,” Rasenick said. Currently, patients and their physicians have to wait several weeks, sometimes months, to determine if antidepressants are working, and when it is determined they aren’t working, different therapies are tried. “About 30% of people don’t get better — their depression doesn’t resolve. Perhaps, failure begets failure and both doctors and patients make the assumption that nothing is going to work,” Rasenick said. “Most depression is diagnosed in primary care doctor’s offices where they don’t have sophisticated screening. With this test, a doctor could say, ‘Gee, they look like they are depressed, but their blood doesn’t tell us they are. So, maybe we need to re-examine this.’” To read the original article click here.

The post Researchers Identify Biomarker for Depression, Antidepressant Response appeared first on Amazing Health Advances.