declining vision Archives - Amazing Health Advances

New Drug Shows Promise in Restoring Vision for People with Nerve Damage

The AHA! Team — Fri, 04 Apr 2025 05:24:11 +0000

University of Colorado Anschutz Medical Campus via EurekAlert! – Research from the University of Colorado Anschutz Medical Campus reveals drug could potentially help repair vision in those with multiple sclerosis (MS) and other neurological conditions. Researchers at the University of Colorado Anschutz Medical Campus have found a promising drug candidate that could help restore vision in individuals with multiple sclerosis (MS) and other neurological conditions that damage neurons. The study was published this week in the journal Nature Communications. The drug, LL-341070, enhances the brain’s ability to repair damaged myelin— the protective sheath around nerve fibers. Damage to myelin is a hallmark of diseases like MS, as well as a natural consequence of aging, often resulting in vision loss, loss of motor skills, and cognitive decline. The research, focused on vision, demonstrated that while the brain has some ability to repair itself when myelin is damaged, the process can be slow and inefficient. Researchers observed that LL-341070 significantly accelerated the repair process and improved brain function related to vision in mice, even after severe damage. “This research brings us closer to a world where the brain has the capacity to heal itself” “This research brings us closer to a world where the brain has the capacity to heal itself” said Ethan Hughes, PhD, co-lead author and associate professor in the Department of Cell and Developmental Biology at the CU School of Medicine. “By harnessing this potential, we hope to help people with diseases like MS by potentially reversing some of the damage, offering people the opportunity to regain their vision and cognitive function.” Researchers discovered that the treatment makes the repair process is much more effective following serious damage, highlighting the importance of intervention with severe injury. Even partial repair of myelin was found to significantly improve vision-related brain functions. “We’ve known for years that myelin plays a crucial role in brain function” “We’ve known for years that myelin plays a crucial role in brain function,” said Daniel Denman, PhD, co-lead author of the study and assistant professor in the Department of Physiology and Biophysics at the CU School of Medicine. “This study highlights the role of cortical myelin in visual function. The drug could be a game-changer because it accelerates the brain’s natural repair mechanisms.” The researchers plan to test the drug in other areas of the brain and refine the treatment, hoping to make it even more effective and eventually accessible to patients. “This discovery is just the beginning,” Hughes said. “We are optimistic that LL-341070 and similar therapies could one day provide real, tangible benefits to patients by improving overall brain function and quality of life.” About the University of Colorado Anschutz Medical Campus The University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education and patient care. The campus encompasses the University of Colorado health professional schools, more than 60 centers and institutes and two nationally ranked independent hospitals – UCHealth University of Colorado Hospital and Children’s Hospital Colorado – which see more than two million adult and pediatric patient visits yearly. Innovative, interconnected and highly collaborative, the CU Anschutz Medical Campus delivers life-changing treatments, patient care and professional training and conducts world-renowned research fueled by $910 million in annual research funding, including $757 million in sponsored awards and $153 million in philanthropic gifts. Journal Nature Communications To read the original article click here.

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LASIK: What You Need to Know

The AHA! Team — Mon, 28 Oct 2024 05:04:15 +0000

Kourtney H. Houser, MD via Duke Health – Chances are, you know someone who has had LASIK surgery, or you may have considered the procedure yourself. Despite the allure of ditching daily eyewear, the decision to undergo this elective surgery is one most people understandably deliberate on for quite a while. Here, Duke corneal specialist Kourtney Houser. MD, explains what you need to know if you are considering LASIK surgery. Is LASIK as quick, easy, and painless as it’s sometimes described? Make no mistake — LASIK is surgery, and anyone who implies otherwise is not forthcoming. The surgeon creates a flap in the cornea, and a laser is used to reshape the underlying cornea. The surgery takes less than ten minutes, and patients feel pressure but no pain. However, that does not mean it is a simple procedure that just anyone can perform. Like any surgery, the experience of the surgeon is the most important factor in achieving the best results. What factors are important when considering LASIK? In addition to the surgeon’s experience, several elements are crucial to success with LASIK surgery. It starts with a thorough preoperative exam by a qualified surgeon and staff to ensure you are a good candidate. The quality of the surgical tools, such as the laser used, is also very important. We believe that having dedicated, on-site laser machines in a controlled operating room environment, where temperature and humidity are constantly monitored, contributes to better outcomes in our patients. We also have two different excimer laser platforms so that we can customize the procedure to each patient’s eye measurements and ensure the best vision possible. What complications are possible, and how common are they? Any eye procedure has a risk of vision loss, infection, or scarring, but thankfully this is very rare with LASIK. We actually think that the infection risk is less than that with contact lens wear over a patient’s lifetime, based on some reviews. Other risks include needing a second procedure, worsened dry eye, and development of pain or discomfort in the eyes, but most of these can be avoided by appropriate and in-depth pre-operative screening. Our rate of complications is extremely low, with the majority of them occurring less than 1% of the time. Our rates of enhancement (the need for additional laser adjustments) are under 2%. Who is not a good candidate for LASIK? Good question. There are people who are not candidates for LASIK surgery. In fact, I generally turn down roughly 20% of the prospective patients who come in for an evaluation. Some of the more common reasons include high refractive errors (nearsightedness or farsightedness), dry eyes, thin or abnormally shaped corneas, cataracts, and retinal problems from diabetes. The good news is that if you do not qualify for LASIK, Duke offers an array of alternative surgical procedures, such as PRK, phakic intraocular lenses, and cataract surgery with presbyopia- or astigmatism-correcting intraocular lenses. How long do improvements last? Improvements typically last a lifetime, though there can be some slight regression with time depending on your prescription. Also, most patients will develop a need for reading glasses as they reach their 40s and 50s–and while this doesn’t signify the LASIK “not working” anymore, it does usually require patients to wear glasses for some near tasks. What’s the bottom line when considering LASIK? LASIK is not for everybody, but those who are good candidates can experience a life-changing experience–independence from glasses or contact lenses and the freedom to see without correction for many years. As with any surgery, people should do their homework beforehand and choose a surgeon and facility in which they have confidence. To read the original article click here.

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Improving Vision with At-Home Brain Exercises

The AHA! Team — Fri, 18 Oct 2024 08:08:57 +0000

John Jeffay via Israel21c – RevitalVision offers a unique intervention for people with eyesight challenges, treating the brain where images are processed. Doctors told Amit Azulay again and again that she’d never be able to drive because of medical conditions affecting her eyesight. She proved them wrong — using a unique piece of software developed by a startup in Israel that has been clinically proven to improve vision. Despite suffering nystagmus (involuntary eye movements) and albinism, her eyesight became good enough to apply for a license (see her delighted response to the news here). Amit, aged 25, is one of many patients who say the online training exercises have literally changed their lives. RevitalVision offers a unique intervention for people with eyesight challenges. It doesn’t treat the eye. It treats the brain. The eye is the hardware, providing the best optical signal it can. But in many cases, the brain struggles to process that signal. That could be because of medical conditions including diabetes, glaucoma or AMD (age-related macular degeneration). It could be a cataract patient whose hardware has been upgraded (cloudy lenses replaced with clear ones) but whose software (the brain) hasn’t caught up. Or somebody who’s had laser surgery but now has blurry vision resulting from reduced contrast sensitivity and still has to wear glasses. Or somebody with “lazy eye” (amblyopia) whose brain sidelines signals from the eye that doesn’t work as well as the other. Or somebody who’s borderline for wearing glasses and would prefer not to. RevitalVision addresses all these problems, and more, with a structured program that trains the brain to better make sense of the blurry signals it receives. Screams of joy RevitalVision’s program typically involves three half-hour, at-home computer sessions per week for two or three months. Patients are trained via a dedicated app. The result, says Yair Yahav, the company’s CEO, is a measurable improvement in vision of 20% to 25%, equivalent to an extra two or more lines on a standard eye chart or, in many cases, the difference between a driving license and no license. “Some patients come to our premises in Modi’in [central Israel], where we have a team of optometrists,” he tells ISRAEL21c. “About once a week I hear screams of joy from a patient in another room who now has good enough vision to qualify for a driving license. We have people who are literally crying. “They’ve been told their whole life that there’s no way, forget it, you’ll never be able to drive. “Then they come to us and if they’re missing just one or two lines [on the eye chart], that’s the average, we tell them they have an 85% to 90% chance of success.” One patient testimonial is from a woman who couldn’t read the label on her medicine, or see well enough to sign a check. She now can. Another, a graduate student with congenital nystagmus, always had to sit at the front of the class to read the board. Now she can sit anywhere. “It’s really lifechanging for many, many people,” says Yahav. Image processing He explains the science behind what they do. “The quality of the image we see depends both on image capturing and image processing,” he says. “We don’t treat the lens of the eye; we treat the brain by enhancing its ability to process visual information, which results in significant vision improvement.” The brain training is based on a “Gabor patch,” which looks like a grid of blurry black and white stripes on a gray background. It was invented by Dennis Gabor, who was born in Hungary, fled the Holocaust, invented holography, and was awarded the Nobel Prize for physics in 1971. His seemingly simple image perfectly matches the shape of the receptive fields of neurons, or nerve cells, in the part of the brain that processes visual information. Repeatedly stimulating those neurons improves their performance, just like physical exercise at the gym builds muscle, says Yahav. Shoring up weaknesses RevitalVision uses an algorithm to understand exactly where the weaknesses lie for each patient. In a typical on-screen exercise, the patient sees three images pop up, two of a Gabor patch and one of a blank. They have to click, using their computer’s mouse, to indicate which is which. The exercises get harder and harder, with the Gabor patch appearing less clear or further toward the edge of the patient’s field of vision. All the time, the algorithm is assessing responses and adjusting the images it displays accordingly. “Our software maps the patient’s cortical deficits, neurons that do not respond well. Then the algorithm tailors specific stimulation to match those deficits,” says Yahav. “Once the patient is consistently answering correctly, the software knows that’s the exact threshold, the maximum vision of the patient in this exercise, and moves on to the next one. “We are training the neurons to be more responsive and restoring the basic mechanism of visual processing in the brain,” he says. FDA approved Yahav says RevitalVision has “the only regulated product approved by the FDA with clinical claims to improve vision for a variety of eye diseases and impairments.” Some products approved to treat amblyopia, he says, are not for those over the age of nine. RevitalVision builds on pre-Internet technology developed in Israel, which it acquired from another company. This technology was launched commercially two years ago as a web-based product available by direct purchase or through an eyecare specialist. So far, the company’s product has treated 15,000 patients. “We’ve raised $7 million so far and we’re raising another $6 million. Now we are scaling up,” says Yahav. The company received a grant from the Israel Innovation Authority during its product development stage, and is conducting trials at Shamir Medical Center associated with Tel Aviv University. It currently employs six people in Israel, six in India and one in the UK. The potential market is so huge that the biggest challenge right now is to spread the word, says Yahav. For more information, click here. To read the original article click here.

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Morning Exposure to Deep Red Light Improves Declining Eyesight

AHA Publisher — Fri, 03 Dec 2021 08:00:11 +0000

University College London via Newswise – Just three minutes of exposure to deep red light once a week, when delivered in the morning, can significantly improve declining eyesight, finds a pioneering new study by UCL researchers. Published in Scientific Reports, the study builds on the team’s previous work*, which showed daily three-minute exposure to longwave deep red light ‘switched on’ energy producing mitochondria cells in the human retina, helping boost naturally declining vision. For this latest study, scientists wanted to establish what effect a single three-minute exposure would have, while also using much lower energy levels than their previous studies. Furthermore, building on separate UCL research in flies** that found mitochondria display ‘shifting workloads’ depending on the time of day, the team compared morning exposure to afternoon exposure. In summary, researchers found there was, on average, a 17% improvement in participants’ colour contrast vision when exposed to three minutes of 670 nanometre (long wavelength) deep red light in the morning and the effects of this single exposure lasted for at least a week. However, when the same test was conducted in the afternoon, no improvement was seen. Scientists say the benefits of deep red light, highlighted by the findings, mark a breakthrough for eye health and should lead to affordable home-based eye therapies, helping the millions of people globally with naturally declining vision. Lead author, Professor Glen Jeffery (UCL Institute of Ophthalmology), said: “We demonstrate that one single exposure to long wave deep red light in the morning can significantly improve declining vision, which is a major health and wellbeing issue, affecting millions of people globally. “This simple intervention applied at the population level would significantly impact on quality of life as people age and would likely result in reduced social costs that arise from problems associated with reduced vision.” Naturally Declining Vision and Mitochondria In humans around 40 years old, cells in the eye’s retina begin to age, and the pace of this ageing is caused, in part, when the cell’s mitochondria, whose role is to produce energy (known as ATP) and boost cell function, also start to decline. Mitochondrial density is greatest in the retina’s photoreceptor cells, which have high energy demands. As a result, the retina ages faster than other organs, with a 70% ATP reduction over life, causing a significant decline in photoreceptor function as they lack the energy to perform their normal role. In studying the effects of deep red light in humans, researchers built on their previous findings in mice, bumblebees and fruit flies, which all found significant improvements in the function of the retina’s photoreceptors when their eyes were exposed to 670 nanometre (long wavelength) deep red light. “Mitochondria have specific sensitivities to long wavelength light influencing their performance: longer wavelengths spanning 650 to 900nm improve mitochondrial performance to increase energy production,” said Professor Jeffery. Morning and Afternoon Studies The retina’s photoreceptor population is formed of cones, which mediate colour vision, and rods, which adapt vision in low/dim light. This study focused on cones*** and observed colour contrast sensitivity, along the protan axis (measuring red-green contrast) and the tritan axis (blue-yellow). All the participants were aged between 34 and 70, had no ocular disease, completed a questionnaire regarding eye health prior to testing, and had normal colour vision (cone function). This was assessed using a ‘Chroma Test’: identifying coloured letters that had very low contrast and appeared increasingly blurred, a process called colour contrast. Using a provided LED device all 20 participants (13 female and 7 male) were exposed to three minutes of 670nm deep red light in the morning between 8am and 9am. Their colour vision was then tested again three hours post exposure and 10 of the participants were also tested one week post exposure. On average there was a ‘significant’ 17% improvement in colour vision, which lasted a week in tested participants; in some older participants there was a 20% improvement, also lasting a week. A few months on from the first test (ensuring any positive effects of the deep red light had been ‘washed out’) six (three female, three male) of the 20 participants, carried out the same test in the afternoon, between 12pm to 1pm. When participants then had their colour vision tested again, it showed zero improvement. Professor Jeffery said: “Using a simple LED device once a week, recharges the energy system that has declined in the retina cells, rather like re-charging a battery. “And morning exposure is absolutely key to achieving improvements in declining vision: as we have previously seen in flies, mitochondria have shifting work patterns and do not respond in the same way to light in the afternoon – this study confirms this.” For this study the light energy emitted by the LED torch was just 8mW/cm2, rather than 40mW/cm2, which they had previously used. This has the effect of dimming the light but does not affect the wavelength. While both energy levels are perfectly safe for the human eye, reducing the energy further is an additional benefit. Home-Based Affordable Eye Therapies With a paucity of affordable deep red-light eye-therapies available, Professor Jeffery has been working for no commercial gain with Planet Lighting UK, a small company in Wales and others, with the aim of producing 670nm infra-red eye ware at an affordable cost, in contrast to some other LED devices designed to improve vision available in the US for over $20,000. “The technology is simple and very safe; the energy delivered by 670nm long wave light is not that much greater than that found in natural environmental light,” Professor Jeffery said. “Given its simplicity, I am confident an easy-to-use device can be made available at an affordable cost to the general public. “In the near future, a once a week three-minute exposure to deep red light could be done while making a coffee, or on the commute listening to a podcast, and such a simple addition could transform eye care and vision around the world.” To read the original article click here.

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