Hyaluranic Acid, a Naturally Occurring Compound, Awakens Stem Cells to Repair Damaged Muscle

AHA Publisher — Fri, 12 Aug 2022 07:00:51 +0000

Ottawa Hospital via Newswise – A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair. In damaged muscle, stem cells must work together with immune cells to complete the repair process, yet how these cells coordinate to ensure the efficient removal of dead tissue before making new muscle fibers has remained unknown. The scientists have now shown that a natural substance called hyaluronic acid, which is used in cosmetics and injections for osteoarthritis, is the key molecule that manages this fundamental interaction. “When muscles get damaged, it is important for immune cells to quickly enter the tissue and remove the damage before stem cells begin repair,” said Dr. Jeffrey Dilworth, senior scientist at The Ottawa Hospital and professor at the University of Ottawa and senior author on the study. “Our study shows that muscle stem cells are primed to start repair right away, but the immune cells maintain the stem cells in a resting state while they finish the cleanup job. After about 40 hours, once the cleanup job is finished, an internal alarm goes off in the muscle stem cells that allows them to wake up and start repair.” Dr. Dilworth and his team identified hyaluronic acid as the key ingredient in this internal alarm clock that tells muscle stem cells when to wake up. When muscle damage occurs, stem cells start producing and coating themselves with hyaluronic acid. Once the coating gets thick enough, it blocks the sleep signal from the immune cells and causes the muscle stem cells to wake up. Using mouse and human tissues, Dr. Dilworth and his team also discovered how muscle stem cells control the production of hyaluronic acid using epigenetic marks on the Has2 gene. “Interestingly, aging is associated with chronic inflammation, muscle weakness and a reduced ability of muscle stem cells to wake up and repair damage,” said lead author Dr. Kiran Nakka, a research associate with Dr. Dilworth who conducted this research as part of his postdoctoral studies. “If we could find a way to enhance hyaluronic acid production in the muscle stem cells of older people it might help with muscle repair.” The authors note that the regenerative effect of hyaluronic acid seems to depend on it being produced by the muscle stem cells. The team is currently examining if drugs that modify the epigenetics of muscle stem cells could be used to increase their production of hyaluronic acid. To read the original article click here.

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5 Surprisingly Simple Tricks to Eradicate Acid Reflux

AHA Publisher — Mon, 15 Mar 2021 07:00:44 +0000

Dr. Don Colbert – Are you one of the millions of people suffering from acid reflux? Statistics show that around 50% of Americans will suffer the symptoms of this unfortunate condition! That means the likelihood of you or your family being affected is really high. That’s why we’ve compiled a list of 5 all-natural remedies for acid reflux. But first… What Is Acid Reflux? Acid reflux is a result of stomach acid that has made it’s way up into the esophagus. This part of the body is not designed to have contact with the powerful acid of the stomach and prolonged exposure can lead to damage of the tissue of the esophagus. Interestingly, acid reflux is not always caused by too much stomach acid, but can also result from the body not producing enough stomach acid and/or digestive enzymes. Poor dietary choices, over eating, quickly eating, or eating in a stressed state can all contribute to acid reflux. These activities can cause an excess of acid production which may then lead to acid finding its way into the esophagus. Symptoms Of Acid Reflux Acid reflux can cause a myriad of symptoms including heartburn, bloating, nausea, and indigestion. Symptoms can be triggered by eating fried foods, alcohol, coffee, chocolate, spicy food, onions, garlic, citrus, soda, and tomatoes. The chances are that you or a loved one will be dealing with acid reflux at some point in your life. Many people use antacids or other medications to help alleviate the symptoms but these treatments can often have unwanted side effects and don’t always actually treat the underlying cause of the condition. So before you pay for expensive and often counterproductive medications first try these 5 easy and natural acid reflux remedies: Chew Your Food By eating mindfully and chewing each bite of food at least 30 times, not only is the act of masticating mechanically breaking down the food, but this also allows the enzymes of the saliva to begin to digest your food before swallowing. Plus, this gives the stomach adequate time to gauge the proper amount of acid that needs to be produced. Be sure to eat in a relaxed state without too much distraction. When we are relaxed, the nervous system to comes in to parasympathetic dominance which is considered the “rest and digest” state. This will allow your body to utilize adequate resources for the digestion and assimilation of your meal. Apple Cider Vinegar Mix 1-2 tablespoons of apple cider vinegar in 6-8 oz of filtered or spring water. Drink this mixture 10-30 minutes before your meal to help create an environment in the stomach conducive to healthy digestion and balanced stomach acid production. The vinegar will help curb overproduction of acid or will stimulate acid in the case of underproduction. Ginger Ginger root can be used as a delicious appetizer to help prepare your stomach for digestion by stimulating the production of stomach acid, enzymes, and bile. Take a small slice of ginger root and marinate it in a bit of lime juice. Top it off with a dash of mineral rich celtic, himalayan, or aztec sea salt. The salt contains chloride which will help stimulate production of stomach acid (hydrochloric acid). Allow the ginger to marinate in this mixture for 1-2 hours. Consume the marinated ginger 10 to 30 minutes before your meal for best results. Probiotics The balance of bacteria in our digestive tract is critical to the efficiency of our digestion. By adding a small amount of fermented food such a sauerkraut, kimchi, grass-fed yogurt or kefir, raw grass-fed cheese, or kombucha, you introduce a high number of beneficial bacteria, yeasts, and enzymes that help regulate digestion and balance stomach acid production. Additionally, you can supplement probiotics in a capsule or powder form. Digestive Enzymes When the pancreas is not producing adequate digestive enzymes or if the pancreatic ducts are congested and the enzymes can not make their way to the stomach then the food you eat is not broken down entirely and can irritate the stomach causing acid reflux. Raw living foods have naturally occurring enzymes that are wiped out by the cooking of food. To get around this issue you can use a high quality digestive enzyme supplement before meals can help supplement the digestive process allowing your food to digest easier and prevent the overproduction of stomach acid. It is important to only use digestive enzymes intermittently because the goal is to boost your body’s own innate ability to produce enzymes so you are not overly reliant on a supplement. Digest Like The Best! These 5 simple tricks can support your body’s balanced production of stomach acid and dramatically reduce the likelihood of experiencing acid reflux. These all natural and effective remedies produce results without turning to Dr. Don Colbert has formulated a highly efficacious supplement called Fermented Green Supremefood. This collection of fermented grasses and vegetables comes packed with beneficial probiotics, enzymes, and fiber which all help to regulate digestion and alleviate acid reflux. References http://articles.mercola.com/home-remedies-heartburn-acid-reflux-ulcer.aspx http://www.globalhealingcenter.com/natural-health/home-remedies-for-acid-reflux/ https://draxe.com/acid-reflux-symptoms/ http://lifespa.com/cool-your-digestion/# To read the original article click here. For more articles from Dr. Colbert click here.

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Hyaluranic Acid, a Naturally Occurring Compound, Awakens Stem Cells to Repair Damaged Muscle

5 Surprisingly Simple Tricks to Eradicate Acid Reflux