Regular Exercise May Help Prevent Fatty Liver Disease Through Bile Acid Metabolism

The AHA! Team — Wed, 23 Jul 2025 05:30:05 +0000

American Physiological Society (APS) via Newswise – Aerobic exercise and a high capacity for exercise may protect against metabolic dysfunction-associated steatotic liver disease (MASLD), also known as fatty liver disease, by increasing the conversion of cholesterol into bile acids, according to a new study published in Function. The paper has been selected as an APSselect article for July by the American Physiological Society (APS). MASLD is a chronic condition in which excessive fat is stored in the liver. It is tied to high cholesterol, Type 2 diabetes, obesity and insulin resistance. It can also lead to liver disease and increases the risk of heart disease. While exercise is known to prevent and treat fatty liver, researchers don’t yet understand exactly how this happens. This new study offers insights: Researchers propose that exercise prevents or reduces fatty liver, in part, by improving bile acid metabolism. The most prominent way cholesterol is removed from the body is by its conversion to bile acids, which aid the digestion of fat and trigger signals that improve how the body uses sugar and fat. By stimulating bile acid metabolism, exercise increases the disposal of cholesterol and activates signals that improve how the body processes food. In the study, rats bred to have genetically high- or low-exercise capacity were provided a high-fat diet, which normally causes fatty liver. This design was chosen because exercise capacity has been independently linked to lower risk for fatty liver disease in people. In addition, genetically identical mice were fed a high-fat diet, and half were allowed access to voluntary running wheels to simulate daily exercise in humans. A separate group of mice that lacked the ability to make bile acids were studied to test whether bile acid metabolism is necessary for the protective effects of exercise. Key findings included: High-exercise capacity rats had higher liver bile acid production, more bile acids in their feces, and lower blood levels of bile acids compared to the low-exercise capacity group. Daily exercise also increased bile acid synthesis, fecal bile acid loss and protected against fatty liver in the genetically identical mice. This demonstrates that daily exercise provides the same benefit as high exercise capacity due to genetic differences. Mice with an impaired ability to produce bile acids experienced no benefit of exercise in preventing fatty liver. Aerobic exercise increased bile acid production, and this process was required to prevent fatty liver. “Importantly, our results identify bile acid synthesis as a key mediator between aerobic capacity, exercise and hepatic energy metabolism that may also be linked to whole-body metabolism and long-term risk for Type 2 diabetes and MASLD,” the researchers wrote. “[B]ile acid synthesis plays a critical role in aerobic capacity and exercise ability in combating MASLD.” Read the full article, “Aerobic Capacity and Exercise Mediate Protection Against Hepatic Steatosis via Enhanced Bile Acid Metabolism.” It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. Read this month’s selected research articles.   To read the original article click here.

The post Regular Exercise May Help Prevent Fatty Liver Disease Through Bile Acid Metabolism appeared first on Amazing Health Advances.

Let Artichokes Be Your “Armor” – How This Intriguing Food Protects Against Serious Diseases

AHA Publisher — Wed, 07 Jul 2021 07:00:03 +0000

Lori Alton via NaturalHealth365 – While artichokes feature a nutty, mild flavor when properly prepared, their interlocking leaves and armor-plated appearance convey the perception that they are the “tough customers” of the food world. And, when it comes to defending your health, it turns out that artichokes really do live up to their intimidating appearance. These odd-looking members of the thistle family, botanically known as Cynara cardunculus var. scolymus, contain a roster of antioxidant compounds that help combat serious conditions such as heart disease, liver disease, and cancer. In fact, a scientific review supported the ability of artichoke extract to lower blood levels of unhealthy cholesterol and fats – thereby alleviating two risk factors for heart disease. Let’s take a closer look at this tough-but-tender delicacy. Artichoke Extract Improves Heart Health in MULTIPLE Ways In a recent systematic analysis published in Critical Reviews in Food and Science Nutrition, the authors examined nine random controlled trials involving a total of 702 participants to evaluate the effects of artichoke extract on heart health. They concluded that artichoke extract did lower triglycerides and harmful LDL cholesterol – without decreasing levels of beneficial HDL cholesterol. (Additional studies have shown that regular consumption of artichokes or artichoke extract may even increase HDL). The secret could lie with artichokes’ extraordinarily high content of antioxidants, particularly luteolin. This compound not only allows the body to process cholesterol more effectively – but prevents its formation in the first place. Artichokes also contribute to cardiovascular health with their generous amounts of vitamin K (a single medium-sized artichoke contains about 25 percent of the recommended daily intake). This important nutrient helps fight atherosclerosis by keeping calcium out of the blood vessels and in the bones. In addition to possessing cholesterol-lowering effects, artichokes may help reduce high blood pressure. One study of 98 hypertensive men shows modest decreases in BP from daily consumption of an artichoke extract. Not only are artichokes a good source of potassium – which also helps to lower blood pressure – but scientists report that they promote the activity of enzymes that widen and relax blood vessels. But Wait, That’s Not All! Here Is How Artichokes Support Liver Health and Improve Digestion Like their close relative, milk thistle, artichokes contain high levels of an antioxidant compound known as silymarin. Credited with the ability to both protect the liver and promote the regeneration of liver tissue, silymarin is advised by integrative doctors to treat non-alcoholic fatty liver disease or NAFLD. For example, in one clinical study, 600 mg of artichoke extract a day led to improved liver function for NAFLD patients. The benefits of artichokes don’t stop there. An artichoke constituent known as cyanin stimulates bile production, speeding up digestion and the breakdown of fats. In fact, an integrative doctor may recommend artichokes or artichoke extract to treat flatulence, bloating, nausea, heartburn, and irritable bowel syndrome. In one older – but still influential – study, 96 percent of patients with irritable bowel syndrome rated artichoke extract as “better than or … equal to” their previously prescribed medications in easing IBS symptoms. The researchers characterized the extract as both well-tolerated and safe and called for further study. Discover the Compounds That Earned Artichokes the Title of “Cancer-Fighting Nutrient” While human studies on artichokes and cancer are limited, early laboratory and animal research seems to support their value as a cancer-fighting nutrient. A list of the antioxidants contained in artichokes reads like a “Who’s Who” of healthful substances – and includes rutin, quercetin, silymarin, gallic acid, and cyanin. These compounds help prevent the oxidative stress that can trigger the development of cancer. And, in a cell study published in the International Journal of Environmental Research and Public Health, the scientists noted that chlorogenic acid, cynaropricin, and caffeolquinic acids in artichoke leaf extract had “marked” effects on the vitality of colon cancer cells. (In some cases, they were able to induce apoptosis, the pre-programmed death of cancer cells). Thus, the team credited artichoke leaf extract with potential chemotherapeutic effects. In addition, consumption of dietary fiber has been linked in studies with lowered risk of certain types of cancer. One cooked medium-sized artichoke features a generous 6.8 grams of soluble and insoluble fiber. Artichokes Supply a Wealth of Top-Shelf Nutrients Artichokes can be prepared by boiling, roasting, steaming, or even breading and stuffing. Serve the tender hearts in salads, atop pizzas, or in dips and spreads – but first, spoon out the “choke” (the spiny, bristly material at the top of the heart) and toss it. At a modest 60 calories apiece, artichokes provide a lot of nutritional “bang for the buck.” These tasty thistles are also a good source of plant-based protein – with a medium cooked artichoke containing 3.5 grams – and provide healthy amounts of antioxidant vitamin C, B vitamins, and the bone-building minerals phosphorus, magnesium, and calcium. Artichoke extracts are also available, with typical amounts ranging from 300 to 640 mg three times a day. However, check first with your integrative physician before supplementing, and make sure to select a high-quality supplement from a reputable vendor. Artichokes have long been a part of the heart-healthy Mediterranean diet. But there’s no reason not to make them a regular part of yours (if you haven’t already). Sources for this article include: NIH.gov Healthline.com NIH.gov NIH.gov To read the original article click here. For more articles from NaturalHealth365 click here.

The post Let Artichokes Be Your “Armor” – How This Intriguing Food Protects Against Serious Diseases appeared first on Amazing Health Advances.

combatting liver disease Archives - Amazing Health Advances

Regular Exercise May Help Prevent Fatty Liver Disease Through Bile Acid Metabolism

Let Artichokes Be Your “Armor” – How This Intriguing Food Protects Against Serious Diseases