cerebral palsy Archives - Amazing Health Advances https://amazinghealthadvances.net/tag/cerebral-palsy/ Your hub for fresh-picked health and wellness info Wed, 13 Nov 2024 05:13:28 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.1 https://amazinghealthadvances.net/wp-content/uploads/2019/08/AHA_Gradient_Bowl-150x150.jpg cerebral palsy Archives - Amazing Health Advances https://amazinghealthadvances.net/tag/cerebral-palsy/ 32 32 The Value of Saving Umbilical Cord Blood https://amazinghealthadvances.net/the-value-of-saving-umbilical-cord-blood-8343/#utm_source=rss&utm_medium=rss&utm_campaign=the-value-of-saving-umbilical-cord-blood-8343 https://amazinghealthadvances.net/the-value-of-saving-umbilical-cord-blood-8343/#respond Wed, 06 Nov 2024 06:06:28 +0000 https://amazinghealthadvances.net/?p=16524 Duke Health – Jessica M. Sun, MD, a pediatric hematologist/oncologist at Duke Children’s, explains why you might want to save your child’s umbilical cord blood. What is umbilical cord blood? Umbilical cord blood is a baby’s blood left in the placenta (also called the afterbirth) after the baby is born and the umbilical cord is cut. Historically, umbilical cord blood was discarded with the placenta as medical waste. Over the past few decades, cord blood has been shown to contain stem cells and early precursor cells that can be used for life-saving stem cell transplantation for children and adults in need of a stem cell transplant. Cord blood is more tolerant of a new host and can be used without full matching, providing increased access to transplantation for patients who cannot find a matched donor. How is umbilical cord blood used in medicine? Hematopoietic stem cell transplantation can be an effective therapy for children and adults with certain cancers, immune deficiencies, bone marrow failure syndromes, and some genetic diseases including inborn errors of metabolism and hemoglobinopathies. Traditionally, stem cells used for transplantation were obtained from bone marrow or blood. More recently, cord blood has become an alternative source of stem cells for transplantation. A major limitation to stem cell transplantation therapy is the ability to find a suitable donor. Only 20 to 25% of patients in need of a transplant have relative who is a “match” and can serve as their donor. Of those without a related donor, only 10 to 50% of patients (depending on their race and ethnicity) will find a matched unrelated bone marrow donor through the National Marrow Donor Program and other donor registries. Cord blood transplantation does not require as strict matching as bone marrow, so many people who cannot find a matched bone marrow donor can find a suitable cord blood donor. It is estimated that more than 4,000 cord blood transplants are being performed each year around the world. Cord blood and cells derived from birthing tissues are also being studied as a source of stem cells for other purposes, including regenerative therapies for tissues damaged by injury or disease. Duke researchers are currently studying whether an infusion of cord blood can help a child with cerebral palsy, children born with hydrocephalus, and babies with birth asphyxia. We are also studying whether a cell manufactured from cord blood can help repair the lining of nerve cells in the brains of children with leukodystrophies and adults with primary progressive multiple sclerosis. However, these applications remain unproven and are currently the subject of ongoing research. How is umbilical cord blood collected and stored? Umbilical cord blood can be collected without risk to the mother or infant donor. Cord blood can be collected from the placenta, either during the third stage of labor or within 10 to 15 minutes after delivery of the placenta, by sterilely puncturing one of the umbilical veins with a needle and allowing the cord blood to drain into a sterile bag containing an anticoagulant to prevent clotting. After collection from the placenta, some of the red blood cells are usually removed and the volume of the cord blood collection is reduced. For long-term storage, cells undergo specialized freezing procedures and are stored in special freezers under liquid nitrogen. Maximal storage time, or expiration date, is unknown, but cells are likely to remain usable for decades. Cord blood units from public banks have been successfully transplanted after 18 years in storage. What are the options for cord blood storage? There are two main types of cord blood banks, public and private. In general, public banks are nonprofit entities supported by federal or private funding. After the mother consents, public banks collect cord blood from healthy full-term pregnancies at no cost to the donor’s family. In giving consent, the infant’s mother acknowledges that the donation is voluntary and gives up all rights to the cord blood for the public good. The mother also agrees to allow her medical records and the baby’s newborn records to be reviewed, gives a detailed family medical history, and allows a sample of her own blood to be taken for infectious disease testing. Units passing screening tests designed to eliminate risks of transmitting genetic or infectious diseases are typed, placed in the search registry, and are available to any suitable patient in need of transplantation. Units that do not meet criteria for public banking may be discarded or used for research purposes. Private cord blood banks are generally for-profit companies that store “directed donations” intended for future use by the child or a family member. Using a kit provided by the bank, the cord blood is collected by the physician, midwife, or nurse delivering the baby and shipped back to the company’s banking facility. The parents of the infant are charged an initial fee for collection and processing of the cord blood and then an annual fee for storage. Varying degrees of testing is performed on the units, and minimal standards are used to determine whether a unit is eligible for processing and banking. The majority of private collections are undertaken as an investment in the unknown potential for cord blood to be used to treat serious illnesses in the future. Most obstetricians and pediatricians feel that routine cord blood storage in healthy babies is unnecessary. In this regard, it is important to note that a child’s own cord blood would not be used for transplantation of a child with leukemia or other cancers, in part due to concern for contamination with cancerous cells, and it would not be used to treat a genetic condition because the cord blood would contain the same genetic problem. Currently, directed donation of umbilical cord blood for another family member is recommended when a first-degree relative has a high risk pediatric cancer that can be treated with transplantation therapy, a hemoglobinopathy or other transfusion-dependent blood disorder, a congenital immune deficiency, or an inborn error of metabolism. How can I donate my child’s umbilical cord blood? It is always a good idea to discuss options for cord blood banking with your obstetric provider or pediatrician. To privately store your baby’s cord blood for possible future use by the child or a family member, you may contact one of the many private cord blood banks to arrange collection, shipment, and payment. Additional information about cord blood banking, including a list of private banks, can be found through the Parent’s Guide to Cord Blood Foundation. To donate your baby’s cord blood for public use, first check whether the hospital at which you plan to deliver works with a cord blood bank to collect cord blood for public donation. In North Carolina, public collections are available at Duke, UNC, Womack Army Medical Center, and Rex Hospitals. If your hospital does not participate in public cord blood banking, there are a few public cord blood banks, including the Carolinas Cord Blood Bank at Duke, that offer a free kit program so that public donations may be collected at other hospitals. Interested parents should contact the bank (919-668-2071) at least six weeks before the baby’s due date to learn more about the program. Currently, public donations are limited to mothers who have a healthy pregnancy, are 18 years or older, and are pregnant with a single baby. More information about public cord blood donation is available through the National Marrow Donor Program. To read the original article click here.

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]]> https://amazinghealthadvances.net/the-value-of-saving-umbilical-cord-blood-8343/feed/ 0 Newly Identified Lipid in Breast Milk Might Reduce Cerebral Palsy in Infants https://amazinghealthadvances.net/newly-identified-lipid-in-breast-milk-might-reduce-cerebral-palsy-in-infants-8266/#utm_source=rss&utm_medium=rss&utm_campaign=newly-identified-lipid-in-breast-milk-might-reduce-cerebral-palsy-in-infants-8266 https://amazinghealthadvances.net/newly-identified-lipid-in-breast-milk-might-reduce-cerebral-palsy-in-infants-8266/#respond Tue, 10 Sep 2024 08:15:57 +0000 https://amazinghealthadvances.net/?p=16223 Duke Health – In animal studies, the fat molecule encourages stem cells to generate new cells that produce the brain’s white matter About 60,000 babies are born before 32 weeks’ gestation in the United States every year, and 10% of them will develop cerebral palsy resulting from infections that damage nerve fibers deep in the brain called white matter. 60,000 babies are born before 32 weeks’ gestation in the United States every year While it’s known that the white matter loss will lead to neurological deficits, there is currently no treatment to help these infants avoid the outcome. In experiments using neonatal mice, researchers at Duke Health have identified a fatty molecule in breast milk that triggers a process in which stem cells in the brain produce cells that create new white matter, reversing the injury. The study appears Aug. 3 in the journal Cell Stem Cell. Eric Benner, M.D., Ph.D., is the study’s corresponding author and is a distinguished assistant professor in the Department of Pediatrics at Duke University School of Medicine. Benner said further study in a clinical trial is needed, but the finding is promising. “Developing therapies for children — especially such medically fragile children — is very difficult to do because there are justifiably strict safety concerns,” Benner said. “The fact that this molecule is already found in something that is safe for premature babies – breast milk – is extremely encouraging. There are many types of fats in breast milk “It’s been known that fats in breast milk benefit a child’s brain development, but there are many types of fats in breast milk,” Benner said. “This work has identified a lipid molecule in breast milk that promotes white matter development. Now, we can begin to develop a therapy that isolates and delivers this lipid in a way that is safe for the unique challenges of these infants.” Benner is a neonatologist at Duke University and one of the co-founders of Tellus Therapeutics, a Duke spinout company developed with the help of the Duke University Office for Translation & Commercialization to bring this therapy from the bench into the neonatal intensive care unit. The fatty molecule identified in the study will be administered intravenously to patients in an upcoming clinical trial. This is significant because many of the infants who are part of this vulnerable population also have gastrointestinal issues and cannot safely be given milk or medication by mouth. The lipid molecule enters the brain and binds with stem cells there, encouraging the stem cells to become or produce a type of cell called oligodendrocytes. The oligodendrocytes are like a hub that allow for the production of white matter in the central nervous system. This newly produced white matter in pre-term infants prevents the neurological damage that would otherwise impact the child’s ability to move – the hallmarks of cerebral palsy. “The timing of brain injury is extremely difficult to predict, thus a treatment that could be safely given to all preterm babies at risk would be revolutionary,” said Agnes Chao, M.D., a former fellow in the Division of Neonatology and first author of the paper. The timing of brain injury is extremely difficult to predict “As a neonatologist, I’m so excited that I may be able to offer a treatment to families with babies that are affected by preterm brain injury who would otherwise have no other options,” Chao said. In addition to Benner and Chao, study authors include Pavle Matak, Kelly Pegram, James Powers, Collin Hutson, Rebecca Jo, Laura Dubois, J. Will Thompson, P. Brian Smith, Jason R. Gibson, Noelle E. Younge, Blaire Rikard, Simon G. Gregory, Ronald N. Goldberg, Mari L Shinohara, Estefany Y. Reyes, Chunlei Liu. The study was funded by the National Institutes of Health (1R01NS114578, T32HD094671, K12HD043494, T32HD043728, R01AG070826, R01MH127104, P41EB015897, 1UL1-TR002553), Jean and George Brumley Jr. Neonatal Perinatal Research Institute, with additional support from the Duke Scholars Award from the School of Medicine, Duke University Center for In Vivo Microscopy, and the National Center for Advancing Translational Sciences. To read the original article click here.

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