Scientists Uncover Cell Responsible for Repairing Liver Tissue

The AHA! Team — Mon, 06 May 2024 18:05:40 +0000

University College London via News-Medical – A type of cell responsible for repairing damaged liver tissue has been uncovered for the first time by a team of scientists, including Professor Rajiv Jalan (UCL Liver & Digestive Health). The study, published in Nature, showed how these new-found cells migrate to the site of damage, providing new insights into the way the liver heals itself. The authors say the findings could spur the development of new therapies that harness the liver’s unique capacity to regenerate. During acute liver failure, the organ’s ability to repair and regenerate is often overwhelmed, with patients requiring an emergency liver transplant to regain liver function. Scientists from the University of Edinburgh studied human liver tissue from patients with acute liver failure for signs of cell proliferation and regeneration following the rapid loss of liver function. They found that a significant proportion of cells retained the ability to multiply. There were, however, still substantial areas of damage in the patients’ livers, suggesting that processes other than cell proliferation are critical during regeneration. The research team profiled the genes within every liver cell in both healthy and regenerating human liver tissue to better understand the regeneration process, using a technique called single-cell RNA sequencing. The findings uncovered a previously undetected population of wound-healing liver cells that emerge during human liver regeneration to aid recovery. Working with University of Glasgow scientists at the Cancer Research UK Scotland Institute, the team used special imaging techniques in mice to view the wound-healing cells in action. Researchers from the UCL Institute for Liver & Digestive Health and the Royal Free Hospital then provided important clinical validation of the novel mechanism of liver repair in humans. “We investigated whether the ‘liver repair’ mechanisms that the team from Edinburgh and Glasgow discovered in animal models also occurred in humans, and found that the mechanisms were present in patients with severe acute indeterminate hepatitis. This provides evidence that the observations made in the study are likely to be clinically relevant for the treatment of liver diseases in humans.” -Professor Rajiv Jalan, UCL Liver & Digestive Health During liver regeneration, so-called leader cells appear at the edge of the healthy tissue, dragging the tissue together to close the wound – similarly to how skin heals after a cut. Imaging also revealed that the population of healing liver cells appears before cell proliferation begins. Widespread infection is a major concern following acute liver failure. Bacteria from the gut can escape into the liver when the liver is damaged. This can lead to sepsis if the liver is unable to clear the infection. The liver may prioritise the healing of wounds before cell proliferation to restore the gut-liver barrier and prevent the spread of bacteria, experts say. Professor Neil Henderson, principal investigator of the study from the University of Edinburgh’s Centre for Inflammation Research, said: “Cutting-edge technologies have allowed us to study human liver regeneration in high definition for the first time, facilitating the identification of a cell type that is critical for liver repair. “We hope that our findings will accelerate the discovery of much-needed new treatments for patients with liver disease.” The research team also included scientists from the Universities of Birmingham, Cambridge and Texas, and the United States Acute Liver Failure Study Group network. This work was funded by Wellcome. Journal reference: Matchett, K. P., et al. (2024). Multimodal decoding of human liver regeneration. Nature. doi.org/10.1038/s41586-024-07376-2. To read the original article click here.

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Repair Your Gut with This Biomolecule

AHA Publisher — Wed, 22 Jul 2020 07:00:18 +0000

Monash University via EurekAlert– In a world first, Monash University researchers have identified a key biomolecule that enhances the repair of your gut lining by prompting stem cells to regenerate damaged tissue. A strong cellular lining is essential for a healthy gut as it provides a barrier to the billions of microbes and harmful toxins present in our intestinal tract. This barrier is often damaged by infection and inflammation, which causes many painful symptoms. The study, published in Cell Stem Cell and led by Professor Helen Abud and Dr Thierry Jardé from Monash Biomedicine Discovery Institute, investigated the environment that surrounds gut stem cells and used “mini gut” organoid methodology where tiny replicas of gut tissue were grown in a dish. The study defined key cells that reside in close proximity to stem cells in the gut that produce the biomolecule Neuregulin-1 that acts directly on stem cells to kick-start the repair process. “Our really important discovery is that supplementation with additional Neuregulin-1 accelerates repair of the gut lining by activation of key growth pathways,” Professor Abud said. “Our findings open new avenues for the development of Neuregulin 1-based therapies for enhancing intestinal repair and supporting rapid restoration of the critical gut function.” Gastrointestinal disease, such as Crohn’s disease and ulcerative colitis, is a major health issue worldwide and results in severe damage to the epithelial cell layer lining the gut. Under these conditions, the intestine has a limited capacity to repair efficiently to restore its main absorptive function and is associated with symptoms including diarrhoea, dehydration, loss of weight and malnutrition. Developing ways to support intestinal tissue repair will dramatically improve patient recovery. “It was very exciting to observe that Neuregulin 1 can not only drive cells to divide but enhances stem cell properties which supercharges these cells into a repair program,” Dr Jardé said. “This shortens the period of damage. The gut lining is injured during common chemotherapy treatment for cancer and we were also able to show recovery is significantly improved with application of Neuregulin-1 following chemotherapy. To read the original article click here.

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Scientists Uncover Cell Responsible for Repairing Liver Tissue

Repair Your Gut with This Biomolecule