Study Expands Link Between Childhood Stress and Chronic MS Symptoms

The AHA! Team — Fri, 30 Aug 2024 08:46:29 +0000

Duke Health – DURHAM, N.C. – Childhood stress may predict pain, fatigue, and mental illness in adults with multiple sclerosis, according to a study led by a Duke Health researcher. The findings, appeared online in the journal PLOS ONE, support efforts to integrate trauma-informed care and screenings for stressors into clinical practice. Childhood stress and adversity has been linked to numerous adult health outcomes This could help providers better conceptualize patient backgrounds and potential disease trajectories to create personalized approaches to patient care. “Since the original Adverse Childhood Experiences (ACEs) study in the late 90’s, childhood stress and adversity has been linked to numerous adult health outcomes, including many of the leading causes of mortality in the U.S.,” said lead author Carri Polick, Ph.D., a clinical associate in the Duke University School of Nursing. “This is, in part, due to the physiological stress response and how it sets the tone for how people experience stress and cope over their lifetime.” Researchers analyzed data from 719 adults with MS who responded to an online self-report survey deployed by the National MS Society. Researchers analyzed data from 719 adults with MS Stressors were categorized into emotional stressors, physical stressors, and environmental stressors. They were then analyzed with hierarchical modeling to show accumulation while retaining insight into specific types of stressors. This study is unique in that it moves beyond stressors that are traditionally measured, such as abuse and neglect, to capture environmental factors such as housing instability, discrimination, and the impact of living in an unsafe neighborhood. This is also the first study to include nuanced stressor data like duration and severity of exposures within the context of clinical symptoms of MS. The study found childhood emotional and physical stressors were significantly associated with the presence and severity of both fatigue and pain in adulthood. Environmental, emotional, and physical stressors were significantly associated with mental health challenges including depression, anxiety, PTSD, and other psychiatric disorders. Environmental, emotional, and physical stressors were significantly associated with mental health challenges “From a preventative perspective, teasing out which stressors are potentially most impactful during childhood is important to help inform intervention and policy efforts to decrease the stress experience and promote healthy trajectories from childhood into adulthood,” Polick said. Additional authors of the study include Robert Ploutz-Snyder, Tiffany Braley, Cathleen Connell, and Sarah Stoddard. The study received funding support from the National Institutes of Health (T32NR016914). To read the original article click here.

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NEW Study Reveals SURPRISING Cause of Multiple Sclerosis

AHA Publisher — Mon, 31 Jan 2022 08:00:27 +0000

Sara Middleton via NaturalHealth365 – According to the National Multiple Sclerosis Society, multiple sclerosis (MS) is a chronic inflammatory disease in which a person’s immune system mistakenly attacks their central nervous system, including the brain, spinal cord, and optic nerves. It can lead to a wide range of signs and symptoms, from numbness and weakness in the limbs to blurry vision to bowel and bladder problems. There are still so many unknowns about MS, which affects about 2.6 to 2.8 million people worldwide. But recent research from Harvard University points to an unexpected potential cause: the Epstein-Barr virus (EBV). New Harvard Study Sheds Light on Potential Cause of MS: A Common Herpes Virus Led by researchers at the Harvard T.H. Chan School of Public Health, a study recently found a “high prevalence of Epstein-Barr virus associated with multiple sclerosis.” Senior author Alberto Ascherio said in an article published by Harvard that the “hypothesis that EBV causes MS has been investigated by our group and others for several years, but this is the first study providing compelling evidence of causality.” The evidence came from an analysis of serum samples taken from 10 million U.S. soldiers over 20 years. Of this cohort, around 1,000 were diagnosed with MS during their period of service. After establishing the soldiers’ EBV status at the time of their first serum sample and tracking their medical histories, the Harvard researchers determined that the risk of MS was 32 times greater after infection with EBV. Interestingly, this increased risk of MS “was not increased after infection with other viruses.” What’s more, the authors found that the serum levels of a biomarker of nerve damage typical in MS patients increased only after EBV infection. Based on these findings, the authors conclude that their data indicate EBV is “the leading cause of MS.” Right now, there is no way to prevent or treat EBV infection, Ascherio says to Harvard, but suggests that specific drugs or vaccines against EBV may help “prevent or cure” MS. Never Heard of the Epstein-Barr Virus Before? Here Are Three Things to Know Epstein-Barr isn’t a virus we hear about very often in the media, even though it is pervasive. To help you understand more about this virus, here are three things you might not know about Epstein-Barr: Epstein-Barr virus (EBV) is a member of the herpes virus family that spreads easily, primarily via bodily fluids such as saliva, semen, and blood. A person can become infected with EBV by sharing food, drinks, utensils, and toothbrushes with someone who already has it. It really is extremely common. According to Science Daily, around 90 percent of all people will be infected with EBV at some point in their lifetime, but usually with no adverse effects. Most people who contract EBV will not go on to develop MS. Other diseases or illnesses already associated with EBV infection include infectious mononucleosis (“mono”) and certain types of cancer, including Hodgkin lymphoma. Signs and symptoms of an acute EBV infection, which usually occurs in childhood, are similar to those seen in other viral infections, including fever, fatigue, swollen lymph nodes, enlarged spleen and liver, and a skin rash. But while acute infections are often easy to recognize, chronic, low-grade infections are much more difficult to identify. If you suspect that EBV may be wreaking havoc in your body, seeking out an integrative physician may be your best bet, as they tend to be more familiar with how EBV infections work. They understand that after exposure, EBV lies dormant in your body, even after the initial symptoms subside. As long as your immune system is robust and you are healthy, your body’s specialized immune cells will keep the virus dormant. But when your immune system becomes compromised, EBV can come out of hiding and become reactivated. Keeping your immune function strong is a critical part of tackling EBV infections. So, make your health a top priority. After all, it’s a great foundation for a good life. Sources for this article include: MayoClinic.org Harvard.edu Science.org NationalMSsociety.org CDC.gov Cancerresearchuk.org Cell.com Sciencedaily.com NIH.gov

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Study Expands Link Between Childhood Stress and Chronic MS Symptoms

NEW Study Reveals SURPRISING Cause of Multiple Sclerosis