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Bali Secret Grows New Brain Cells

The AHA! Team — Mon, 10 Feb 2025 06:32:15 +0000

Al Sears, MD, CNS – When I was in Bali, I learned that elephants – which are well known for their long and impressive memories – go to great lengths to seek out gotu kola leaves. It’s one of their favorite foods. Could this plant be the reason why elephants never forget? Who knows? What we do know is that research proves gotu kola can enhance your brain power. Let me explain… For decades, scientists believed that the adult human brain couldn’t grow new brain cells. They thought we were born with all the brain cells we’ll ever have – and that when they were gone, they were gone for good. They thought we were born with all the brain cells we’ll ever have However, a breakthrough study by researchers at Princeton University proved the opposite. That study, published in the prestigious Journal of Science, revealed the continuous growth of new brain cells in adult macaque monkeys. Then, a follow-up study published in the journal Cell found that humans also produce new neurons. And that – even in old age – your brain still produces around 700 new neurons a day.[i] In other words, despite what “medical experts” may tell you, your memory and cognitive performance don’t have to decline. In fact, they can actually improve as you age. And one of the best ways to boost your brain performance is with gotu kola, or Centella asiatica. Research shows it can revitalize your brain and nervous system and help you feel sharp and alert as it recharges your memory. Research shows it can revitalize your brain and nervous system In a number of studies, gotu kola enhanced memory performance, problem-solving abilities, intelligence, and mental energy.[ii] A landmark study published in the Journal of Pharmacy and Pharmacology found that gotu kola stimulates the growth of brain cells…[iii] While additional studies proved that gotu kola: [iv],[v],[vi],[vii] Improves cognitive function – even in cognitively impaired older adults Doubles how quickly and accurately you process information Increases problem-solving skills up to 45% Improves reading skills up to 29% Significantly boosts your attention span Increases concentration Further studies also give us lots of evidence that gotu kola is a powerful antioxidant and brain protector, as well as a nerve growth factor. Studies show it may also help stop plaque formation in Alzheimer’s disease and prevent dopamine neurotoxicity in Parkinson’s.[viii],[ix] I’ve recommended gotu kola for years as a way to treat stroke victims suffering from stroke-related dementia. A recent study backs up what I learned from traditional healers… According to this study from Indonesia, where gotu kola is used commonly in both traditional and mainstream medicine, concluded that therapy with an extract of the herb at 750 mg per day for six weeks was “effective in improving cognitive impairment after stroke.” The extract is called TTFCA, which stands for triterpenic fraction of Centella asiatica. This contains gotu kola’s most potent components. And it has shown special strength in improving memory.[x] Other studies have shown gotu kola is highly effective at preventing strokes in the first place – by promoting healthy veins and combatting high blood pressure. TTFCA improves the dilatation of blood vessels, which decreases blood pressure and improves blood flow throughout your body – from the largest veins to the tiniest of capillaries.[xi] When choosing a gotu kola supplement, look for one with more of the active components. Choose one that is standardized to the asiaticosides or asiatic acid. 3 Ways You Can Improve Your Memory with Gotu Kola I recommend my patients use gotu kola in three ways. As an extract. Take 10 to 20 ml per day. As a supplement. When choosing a gotu kola supplement, look for one with more of the active components. Select one that is standardized to the asiaticosides or asiatic acid. I recommend taking 300 mg a day. As a dried herb. One of my favorite ways to use gotu kola is by making a cup of tea. Here’s how: Measure 1 to 2 teaspoons (about 6 to 8 grams) of dried gotu kola into a cup. Cover with boiling water and allow to steep for 15 minutes. Strain, then sweeten with organic honey. Enjoy three cups a day. [i] Spalding K, et al. “Dynamics of hippocampal neurogenesis in adult humans.” Cell. 2013 Jun 6; 153(6):1219–1227. [ii] Prakash A, Kumar A. “Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism.” Neurol Sci. 2013 Aug;34(8):1403-9. [iii] Soumyanath A, et al. “Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.” J Pharmacy Pharmacol. 2005;57(9):1221–1229. [iv] Shinomol GK, et al. “Exploring the role of ‘Brahmi’ (Bacopa monnieri and Centella asiatica) in brain function and therapy.” Recent Pat Endocr Metab Immune Drug Discov. 2011;5(1):51-57. [v] Xu Y, et al. “Gotu kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.” J Alzheimers Dis. 2008 Apr;13(3):341-9. [vi] Tiwari S, et al. “Effect of Centella asiatica on mild cognitive impairment (MCI) and other common age-related clinical problems.” Dig J Nanomater Bio. 2008;3:215–220. [vii] Wattanathorn J, et al. “Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.” J Ethnopharmacol. 2008;116(2):325-332. [viii] Orhan I. “Centella asiatica (L.) Urban: From traditional medicine to modern medicine with neuroprotective potential.” eCAM. 2012;2012:946259. [ix] Xu Y, et al. “Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide.” J Alzheimers Dis. 2008 Apr; 13(3):341-9. [x] Farhana KM, Malueka RG, et al. “Effectiveness of gotu kola extract 750 mg and 1000 mg compared with folic acid 3 mg in improving vascular cognitive impairment after stroke.” eCAM. 2016: 2795915. [xi] Incandela L, et al. “Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy.” Angiology. 2001 Oct.;52 Suppl 2:S9-13. To read the original article click here.

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Brain Cell Grafts in Monkeys Jump-Start Human Trial for New Parkinson’s Treatment

The AHA! Team — Mon, 28 Oct 2024 05:21:55 +0000

University of Wisconsin–Madison via Newswise – People with Parkinson’s disease are receiving a new treatment in a clinical trial started after University of Wisconsin–Madison scientists demonstrated the safety and feasibility of the therapeutic delivery method in a study of non-human primates. People with Parkinson’s disease are receiving a new treatment in a clinical trial started after University of Wisconsin–Madison scientists demonstrated the safety and feasibility of the therapeutic delivery method in a study of non-human primates. Parkinson’s disease damages neurons in the brain that produce dopamine, a brain chemical that transmits signals between nerve cells. The disrupted signals make it progressively harder to coordinate even simple movements and cause rigidity, slowness and tremors that are the disease’s hallmark symptoms. Patients are typically treated with drugs like L-DOPA to increase dopamine production. Although the drugs help many patients, they present complications and lose their effectiveness over time. Parkinson’s disease damages neurons in the brain that produce dopamine Researchers at the Wisconsin National Primate Research Center successfully grafted brain cells called dopaminergic neuronal progenitor cells into the brains of cynomolgus macaque monkeys. California-based Aspen Neuroscience provided the cells, grown from multiple lines of human induced pluripotent stem cells, along with key pieces of the equipment for delivering them to specific parts of the brain. “By the time of diagnosis, it is common for people with Parkinson’s to have lost the majority of dopaminergic neurons, leading to progressive loss of motor and neurological function,” explains Edward Wirth III, an expert in cell therapies, study co-author and Aspen’s chief medical officer. “To replace these lost cells, we must target a very specific area of the brain with a high degree of surgical precision. Utilizing the latest advances in intraoperative MRI guided techniques, the patient’s new cells are transplanted, a few microliters at a time, to the exact area where they are most needed.” Working with potential cell therapies in pursuing treatments for Parkinson’s disease is a particular specialty of the team at Marina Emborg’s lab and their primate center colleagues. “Using autologous cells, a patient’s own cells, avoids the need to use immunosuppression to keep the patient’s body from rejecting or attacking the graft,” says Emborg, a UW–Madison professor of medical physics. “Aspen has developed the technological methods for manufacturing, for quality control, that makes it feasible at scale to make autologous cells and get them to the patients.” The researchers’ results in non-human primates, which supported Aspen’s successful Investigational New Drug application to the Food and Drug Administration to begin human trials, were published today in the Journal of Neurosurgery. “This study was an important step in our work to bring the promise of a cell-replacement therapy to people with Parkinson’s disease” “This study was an important step in our work to bring the promise of a cell-replacement therapy to people with Parkinson’s disease,” says Andrés Bratt-Leal, study co-author, Aspen Neuroscience co-founder and senior vice-president of research and development. “The results were instrumental in opening our first-in-human trial and informing how we deliver patients’ own cells to them in the study.” The UW–Madison scientists, led by Parkinson’s researcher Emborg, took up the Aspen-funded work fresh off their own success (published in 2021) reversing Parkinson’s symptoms in monkeys by grafting neurons grown from the monkeys’ own cells, called an autologous transplant. The 2021 study, using cells grown by UW–Madison stem cell researcher Su-Chun Zhang, added new dopamine-producing neurons to each animal’s brain through injections guided in real time by MRI to an area of the brain called the putamen. Dopamine production increased dramatically, as did the monkeys’ motor skills. At the same time, symptoms of depression and anxiety were reduced. The new study was designed to test the delivery of Aspen’s human cells. Wirth and Aspen scientists worked with Emborg’s team to bridge the monkey-to-human application. While Emborg’s previous study administered cells to the putamen through the top of the skull, the Aspen study examined cell administration through the back of the skull — an angle that could allow surgeons to reach their target with fewer insertions of the apparatus that delivers the new cells into the brain. “The core idea is to decrease the risk of infection, the trauma, the surgical time the patient spends under anesthesia,” Emborg says. “The fewer tracks you have to follow through the brain, the better for all of that.” Six monkeys received grafts of the human neurons Six monkeys received grafts of the human neurons through two paths in each side, or hemisphere, of their brains, with more cells deposited on one side of the brain than the other. A control group of three animals underwent the procedure without the cell delivery. “In tissue samples taken seven and 30 days after the procedures, we found the grafted cells persisted in five of the animals,” Emborg says. The researchers confirmed the presence of Aspen’s human neurons in the monkeys’ brains, finding more cells in the hemispheres that were injected with a higher dose, more cells in the 30-day tissue samples compared to the seven-day samples and the presence of a protein produced by young neurons working to integrate with neighboring cells — all signs the cells grafts were successful. It was a true collaboration, according to Emborg — between the Aspen scientists, her lab and the Wisconsin National Primate Research Center veterinarians and staff — to validate the company’s procedures and equipment before study co-author Paul Larson, a neurosurgeon at Banner – University Medical Center Tucson and professor of neurosurgery at the University of Arizona College of Medicine – Tucson, began Aspen’s first-in-human trial with people with Parkinson’s in April. The work done to refine the logistics, surgical equipment and techniques in the animal procedures will inform the way patients in the human trial receive and recover from the new therapy, providing hope for those struggling with a debilitating disease. “Our results were all so exciting,” Emborg says. “And then, when I saw they had been able to begin with a human patient this spring, I just had tears in my eyes.” To read the original article click here.

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Roasted Beet Salad Recipe

AHA Publisher — Thu, 12 Nov 2020 08:00:02 +0000

Dr. Josh Axe, DC, DMN, CNS – Beets are some of the healthiest vegetables around, and that’s why I incorporate this roasted beet salad recipe into my meal rotation. Did you know that the benefits of beets include being high in antioxidants, reducing disease-causing inflammation, detoxing the blood and even reduce high blood pressure? But perhaps the most surprising fact about beets is how few people know what to do with them. Whether you’re someone who routinely skips beets when purchasing produce or have already embraced them into your diet, you will love this roasted beet salad. While it takes an hour from start to finish, there’s very little hands-on time required — and this roasted beet and goat cheese salad just might turn you into a beet fanatic! Key Ingredients This roasted beet salad with goat cheese recipe is chock-full of healthy ingredients — including the dressing. Here are the main players that make this beet goat cheese salad shine: Beets: Beets are incredibly nutrient-dense, which is why they’re the star of this show. High in fiber, folate, manganese, potassium, vitamin C, magnesium, iron, copper and more, beets have been studied for their ability to relieve inflammation, promote heart health, aid detoxification, boost brain function, support digestion, enhance athletic performance and even aid weight loss. Goat Cheese: A great supporting actor in this beet and goat cheese salad is, of course, the goat cheese. It’s a great healthy fat source that also provides a host of protein, probiotics and calcium, making it a healthier choice than many varieties of cow cheese. Pear: Pear nutrition provides a good amount of fiber and vitamin C, and like beets, pears are good for the heart, weight, digestive system, bones and immunity. Honey: Along with heart-healthy olive oil and balsamic vinegar, honey helps make up the base of the salad dressing in this roasted beet salad recipe. Honey, particularly raw honey, is a true superfood that benefits just about every part and every function of the body. Of course, the almonds, onions and orange juice/zest only add to the nutrition of this beet and goat cheese salad. How to Make a Roasted Beet Salad Let’s start by preheating the oven to and wrapping up the beets in thick aluminum foil. Make it easier to pull them out later by placing the wrapped beets on a baking pan. When the oven is nice and toasty, slide the beets in and let the oven work its magic for the next hour or so. Once the beets are tender, pull them out. Give them some time to cool off, then peel and cube them. Look at that color! While the beets are returning to a temperature at which you can handle them without scalding yourself, whisk together your dressing, with the orange juice, honey, vinegar, orange zest, mustard and oil. Then add in some nutritious onion, pear and cubed beets. You’re almost there! Divvy up the salad among four plates (or take an extra helping). Top each portion with goat cheese and heart-healthy almonds. Now that is a salad! I love how fancy this salad looks but also how easy it is to whip up for lunch or a light dinner. It’s a great way to introduce a new veggie to your family’s menu. You could even add grilled chicken or fish to make this more hearty. Roasted Beet Salad Recipe DESCRIPTION Whether you’re someone who routinely skips beets or already eat them, you will love this roasted beet salad. INGREDIENTS 3 medium beets with tops trimmed to 1” ¼ cup fresh orange juice 2 teaspoons honey 2 teaspoons balsamic vinegar 1 teaspoon grated orange zest 1 teaspoon Dijon mustard ½ teaspoon extra virgin olive oil 1 pear, cored and sliced ½ cup thinly sliced onion ¼ cup crumbled goat cheese 2 tablespoons sliced almonds, toasted salt and pepper INSTRUCTIONS Preheat oven to 400 degrees Fahrenheit. Wrap beets tightly in heavy-duty foil. Roast beets until tender, 50 to 60 minutes. Cool, peel and cut into cubes. In a large bowl, whisk together orange juice, honey, vinegar, orange zest, mustard and olive oil. Season with salt and pepper to taste. Add pear, onion and roasted beets and toss to coat. Divide salad evenly among 4 plates and serve topped with cheese and almonds. NUTRITION Serving Size: 1 salad Calories: 165 Sugar: 14.2g Sodium: 124mg Fat: 7.3g Saturated Fat: 3.7g Unsaturated Fat: 3.6g Trans Fat: 0g Carbohydrates: 20.3g Fiber: 3.8g Protein: 6.4g Cholesterol: 15mg To read the original article click here. For more articles from Dr. Axe click here.

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