Researchers Develop New Method to Regenerate Bone and Heal Severe Fractures

AHA Publisher — Wed, 20 Jan 2021 08:00:37 +0000

Lund University via News-Medical Net – Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone. The study, published in the research journal Science Advances, was conducted on rats, but the researchers think that the method in various combinations will soon be commonplace in clinical settings. “The drugs and materials we used in the study for the regeneration of bone are already approved. We simply packaged them in a new combination. Therefore, there are no real obstacles to already using the method in clinical studies for certain major bone defects that are difficult to resolve in patients. But we want to introduce the technique in a controlled form via clinical studies and have recently been granted ethical approval.” (Deepak Raina, Study Lead Author, Orthopedics Researcher, Lund University) Bones in the human body have a fantastic ability to repair injury, but some defects are so large or complicated that the healing process is delayed or absent. This may be due to the bone having been subjected to a major trauma in connection with a traffic accident for example, or a tumor or infection causing a major bone defect. These cases are currently treated through bone transplantation, usually with bone taken from the patient’s own pelvis. “In cases involving severe open fractures in the lower leg, over 5 per cent of all fractures fail to heal. With our method, we will be able to avoid taking bone from the pelvis, which is a major gain for the patient.” There is a need for new solutions and several research teams, both in Europe and in the USA, are working on improving the bone healing process. So far, the injectable cocktail successfully mixed by the Swedish and German researchers consists of three different components: an artificial ceramic material developed in Lund, a bioactive bone protein (rhBMP-2) and a drug, bisphosphonate, that combats bone resorption. “The bone protein we use has had negative effects in previous studies due to a secondary premature bone resorption, among other things.We have successfully mitigated this effect with the bisphosphonate and, by packaging the drug in a slowly resorbing bone substitute, we can control the speed of release. In the current study with the combination, we achieved a six-fold reduction in the amount of protein compared to previous efforts, while still inducing bone formation. The result was that even fractures with an extensive bone defect could heal without complications. We believe this finding will be of great clinical use in the future”, says Deepak Raina. To read the original article click here.

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Holy Fruit Turns on Healing Stem Cells

AHA Publisher — Tue, 01 Sep 2020 07:00:12 +0000

Al Sears, MD, CNS – New research has found a way to dramatically increase the number of stem cells circulating in the blood using the “holy fruit of the Himalayas,” or seaberry. This bright orange fruit has been used for thousands of years to treat inflammation and infections, boost immunity, and slow the aging process. Modern research explains why it works. In the study, 12 healthy adults had their blood drawn before and after eating either seaberry extract or a placebo. Data on stem cell activity was analyzed following each blood draw.1 Within two hours of eating the berry, researchers found that: Progenitor stem cells capable of cardiovascular maintenance and repair increased 24%. Endothelial stem cells increased by 33%. These multipotent stem cells found in bone marrow, have the ability to develop into multiple specialized cells. Increasing the number of circulating stem cells in your body has been proven to potentially repair: Acute myocardial infarction2 Stroke3 Bone fracture4 Muscle injury5 Spinal cord injury6 Inner ear damage7 Boost Your Stem Cells Easily at Home First take seaberry extract daily. To get the results researchers saw in the study, take 500 mg daily. It’s available as a softgel, powder and juice. Look for certified organic, non-GMO products. Second, try fasting for two days every six months. A study from the University of Southern California shows that this kind of fasting causes stem cells to awake from their normal dormant state and start regenerating. This practice destroyed damaged and older cells, and caused new cells to be born, effectively renewing the immune system.8 Finally, workout intensely. A study in the European Heart Journal showed that vigorous exercise in mice activated 60% of their cardiac stem cells.9 In a human study, researchers proved that strenuous exercise leads to high levels of stem cells in bone, liver and other organs.10 To Your Good Health, Al Sears, MD, CNS 1. Drapeau C, et al. “Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects.” Clin Interv Aging. 2019:14:253-263. 2. Luo Y, et al. “Short-term intermittent administration of CXCR4 antagonist AMD3100 facilitates myocardial repair in experimental myocardial infarction.” Acta Biochim Biophys Sin (Shanghai). 2013;45(7):561-569. 3. Wang L, et al. “Mobilization of endogenous bone marrow derived endothelial progenitor cells and therapeutic potential of parathyroid hormone after ischemic stroke in mice.” PLoS One. 2014;9(2):e87284. 4. Toupadakis CA, et al. “Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model.” Cytotherapy. 2013;15(9):1136-1147. 5. Stratos I, et al. “Granulocyte-colony stimulating factor enhances muscle proliferation and strength following skeletal muscle injury in rats.” J Appl Physiol. 2007;103(5):1857-1863. 6. Urdziková L, et al. “Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat.” Cytotherapy. 2011;13(9):1090-1104. 7. Elbana AM. “Role of endogenous bone marrow stem cells mobilization in repair of damaged inner ear in rats.” Int J Stem Cells. 2015;8(2):146-154. 8. Cheng CW, et al. “Prolonged fasting reduces igf-1/pka to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.” Cell Stem Cell. 14(6):810-823. 9. Gariani K, et al. “Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.” Hepatology. 2016;63(4):1190-1204. 10. Valero MC, et al. “Eccentric Exercise facilitates mesenchymal stem cell appearance in skeletal muscle.” PLOS One. 2012;7(1):e29760. This article has been modified. To read the original article click here. For more articles by Al Sears MD click here.

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bone fracture Archives - Amazing Health Advances

Researchers Develop New Method to Regenerate Bone and Heal Severe Fractures

Holy Fruit Turns on Healing Stem Cells