beating cancer Archives - Amazing Health Advances

Chemotherapy May Fuel Cancer Regrowth: New Research Reveals Disturbing Findings

The AHA! Team — Fri, 18 Jul 2025 05:27:38 +0000

Lori Alton via NaturalHealth365 – According to current statistics, about one million people a year (in the U.S. alone) undergo chemotherapy in an attempt to beat cancer. Yet this toxic treatment has a poor success rate in treating most kinds of cancer, and its benefits can be short-lived. Making the picture even grimmer is the fact that cancer recurrence after chemotherapy is frequently deadly. Now, from the front lines of cancer research comes the disturbing news that one particular type of chemotherapy can actually lead to cancer regrowth and recurrence. One approach to treating cancer creates a breeding ground for cancer stem cells Chemotherapy-induced senescence, often touted as a new weapon in cancer therapy, involves “putting cancer cells to sleep.” The protocol is intended to place cancer cells in a state of arrested growth, where they are alive but not dividing. While senescence is supposed to prevent further cancerous growth, new research shows that it can serve as a sort of “nursery” and safe harbor for cancer stem cells – the most dangerous and treatment-resistant type of cancer cells. A pair of recent studies reveal the consequences of therapy-induced senescence. In an explosive article published in Frontiers in Oncology, Markus Schosserer, Ph.D., wrote that there is ample evidence that senescent cancer cells can produce inflammatory molecules that promote a rich environment for cancer regrowth. In a breakthrough German study published in Nature, the team presented startling conclusions: senescence not only helps cancer cells avoid death but actually transforms them into cancer stem cells. This is very bad news, as stem cells – which can break from a tumor and metastasize throughout the body – are also the most resistant to treatment. Cancer cells can “outmaneuver” induced senescence In the German study, researchers examined human lymphoma cells treated with drugs to induce senescence and discovered they were developing “stemness.” In other words, the lymphoma cells started to express genes vital for maintaining stem cell function. When the team “released” the cancer cells from senescence, they discovered an alarming outcome. The cells began to multiply again – and more rapidly than those that had not become senescent. Although senescence is supposed to be irreversible, the team found evidence that cancer cells can escape it on their own – without the help of the genetic manipulation they used. Testament to this unfortunate possibility is that the scientists found more previously senescent stem cells in tumor patients after lymphoma recurred than had existed in the same individuals when they received their initial treatment. This demonstrated to the scientists that at least some cells had “figured out” how to outwit senescence. Noted professor of experimental oncology Dr. Jan Paul Medema commented, ‘There is compelling evidence … that … when cancer cells escape from senescence, they have an enhanced ability to drive tumor growth.’ Study leader Dr. Clemens A. Schmitt reported that switching off a specific cell signaling pathway could work to neutralize stemness in the previously senescent cells. However, there is no doubt that the study findings pose a definite setback for a formerly promising protocol. In addition, other studies have emerged showing that chemotherapy can do more harm than good. Chemotherapy for breast cancer can spread cancer cells A common protocol for breast cancer patients is to surgically remove tumors after chemo has been administered. The theory is that the chemo will help shrink the tumor while preventing the spread of cancer throughout the body. However, the treatment may accomplish the opposite effect. The toxic chemo drugs may actually switch on a repair mechanism – creating more blood vessel pathways and permitting tumors to grow back even stronger. In a study at the Albert Einstein College of Medicine, researchers found that chemotherapy triggered the circulation of more cancer cells throughout the lungs and the body. Chemotherapy features toxic side effects The American Cancer Society acknowledges that chemotherapy damages healthy cells – and reports that chemotherapy side effects include vomiting, diarrhea, anemia, hair loss, fertility problems, chronic fatigue, and infections. Neutropenia, the most serious side effect, involves the depletion of white blood cells needed to fight diseases and infections. Weight changes and mood changes – with depression, memory loss, and inability to concentrate – may also occur. Normal cells damaged by chemotherapy Normal cells most likely to be damaged by chemotherapy are cells in hair follicles, blood-forming cells in the bone marrow, cells in the mouth and digestive tract, and cells in the reproductive system. Experts report that in some situations – for example, the early stages of colorectal cancer – chemotherapy has been shown to provide some benefit, granting extra years of life. But on the whole, chemotherapy yields disappointing results and may even exacerbate cancer cell growth – as shown in this pair of startling studies. Editor’s note: Discover the many natural ways to stop cancer cell growth, own the Stop Cancer Docu-Class created by NaturalHealth365 Programs. Sources for this article include: NIH.gov Medicalnewstoday.com Sciencedaily.com Cancer.org To read the original article click here.

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Curcumin Stops Cancer Cell Growth, New Research Confirms

The AHA! Team — Mon, 30 Jun 2025 05:24:05 +0000

Lori Alton via NaturalHealth365 – With its spiky purple flowers and dull green leaves, milk thistle may appear to be nothing more than an ordinary weed growing wild in vacant lots and fields. Turmeric, a kitchen spice from India and Southeast Asia, has long been treasured by natural healers for its ability to fight inflammation, regulate blood sugar, and combat infections. But turmeric benefits extend even beyond these traditional uses. Ongoing research suggests that its active ingredient – a plant pigment known as curcumin – could be a valuable weapon in the fight against cancer. Many studies have supported turmeric’s anticancer effects, including its ability to reduce the number and size of tumors. However, studies also revealed a dramatic and encouraging “twist:” turmeric can potentially target several particularly aggressive and lethal forms of cancer while leaving noncancerous cells unharmed. For instance, recent research has shown that curcumin may help fight colorectal cancer by influencing how cancer cells clean out damaged parts (autophagy) and self-destruct when unhealthy (apoptosis), offering new hope in combating this common and deadly disease. An international team of scientists concludes that curcumin inhibits an enzyme involved in carcinogenesis Researchers at the University of California, San Diego School of Medicine, Peking University, and Zhejiang University collaborated on a study published in the Proceedings of the National Academy of Sciences. The researchers used multiple models to show that turmeric can powerfully inhibit a specific enzyme called DYRK2 (or dual-specificity tyrosine-regulated kinase 2). The team used cutting-edge X-ray crystallography to obtain 3D images – in which curcumin could be seen binding to the enzyme at the atomic level. This is significant because binding to and inhibiting DYRK2 impairs the activity of proteasomes – protein complexes involved in cancer development. The team noted that inhibiting proteasome activity in cancer cells interfered with proliferation, reducing tumors, slower cancer growth, and an overall lessening of the cancer burden. Curcumin targets the “Achilles heel” of lethal cancers Some cancers – including triple-negative breast cancer and multiple myeloma – are classified by scientists as “proteasome-addicted,” meaning they are dependent on proteasome complexes. Impairing the activity of the proteasome inhibits tumor development, leading scientists to theorize that this dependency may well be the “Achilles’ heel” of these aggressive, hard-to-treat cancers. Pharmaceutical proteasome inhibitors have already been developed and approved, but there is a catch: these medications damage noncancerous cells. In response, resourceful researchers have been focusing on inhibiting proteasome activity by identifying and manipulating proteasome regulators. This is where the power of turmeric comes into play. By depleting DYRK2, curcumin suppresses proteasome activity – with very little damage to healthy cells in the area. Curcumin strengthens the cancer-fighting effects of pharmaceutical proteasome inhibitors – meaning that smaller dosages – and fewer side effects – may be possible. When used with carfilzomib – an FDA-approved proteasome inhibitor used to treat multiple myeloma – curcumin increased apoptosis (cancer cell death) – while causing minimal harm to healthy cells. Curcumin uses multiple pathways to target cancer If curcumin’s only cancer-fighting abilities were impairing the DYRK2 enzyme and inhibiting proteasome activity, it would still be a promising area for study in cancer prevention and treatment. However, curcumin has an impressive variety of cancer-fighting pathways. Curcumin helps inhibit angiogenesis, the growth and development of new blood vessels to nourish and support tumors. It also “switches off” genes that promote tumor development while helping the immune system identify and destroy malignant cells. In addition, curcumin can help to protect your DNA from potentially cancer-causing mutations caused by radiation and environmental toxins. It also suppresses the production of MMPs or matrix metalloproteinases. These enzymes attack the extracellular matrix and facilitate the invasion of cancer cells. Finally, by reducing the production of adhesion molecules that cling to cell walls, curcumin stops cancer cells from settling in place – effectively “throwing a monkey wrench” into the ability of cancer cells to metastasize. Additional research supports curcumin’s effectiveness. In one study, curcumin supplementation caused a 36 percent reduction in the size of lung tumors. In another, it caused a 40 percent decrease in the development of colon tumors. And – in one particularly promising clinical study – curcumin cut the growth rate of prostate-specific androgen (a marker of tumor progression) in half. How can I take curcumin? Study co-author Sourav Banerjee, Ph.D., a postdoctoral scholar at UCSD School of Medicine, remarked on curcumin’s “chemical drawbacks,” noting that orally administered curcumin is broken down and eliminated by the human body very quickly. Dr. Banerjee says, “It (curcumin) needs to be modified to enter the bloodstream and stay in the body long enough to target the cancer.” This is why experts say that adding turmeric to food may not provide enough bioavailable curcumin to obtain therapeutic results. The best option currently is to seek a high-quality, high-potency organic curcumin extract standardized to contain at least 95 percent curcuminoids. Note: Do not attempt to treat cancer or any other serious medical condition with turmeric or curcumin without the guidance of a qualified doctor. Before supplementing with curcumin, get the go-ahead from your trusted holistic healthcare provider. Simply put, as scientists continue to discover curcumin’s multiple effects against cancer, this amazing flavonoid seems destined to play a major role in natural cancer therapies and cancer prevention. Sources for this article include: NIH.gov To read the original article click here.

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Green Warriors: 14 Overlooked Plants Revolutionizing Cancer Treatment & Prevention

The AHA! Team — Wed, 30 Oct 2024 05:36:04 +0000

Patrick Tims via NaturalHealth365 – The plants around us are more than mere greenery. Traditional healers have recognized the powerful medicinal properties of various herbs and botanicals for centuries. Now, modern science is catching up, revealing the profound potential of these natural remedies in combating one of our most difficult health challenges: cancer. A new study published in Pharmaceuticals in April 2024 sheds light on how specific medicinal plants may help prevent and even treat various types of cancer. From familiar herbs to exotic species, researchers have identified plant-based compounds with promising anti-tumorigenic properties. Cultivating health: Medicinal plants with cancer-fighting potential While not all these plants can be easily grown at home, understanding their benefits can inform your choices in herbal supplements and traditional remedies. Here are some of the medicinal plants highlighted in the study for their potential to combat abnormal cell growth: 1. Hibiscus Hibiscus, a flowering plant, contains chemical components, including phenolic compounds. The dried extract of hibiscus is packed with phenols and saponins that inhibit the growth of prostate cancer cells. Hibiscus also contains anthocyanin, which helps decrease the growth of cervical cancer cells. Aside from treating cancer, the plant also helps treat severe illness, neurological problems, and diabetes. 2. Moringa oleifera This plant’s leaves, flowers, and pods are consumed raw or cooked. Moringa oleifera leaves contain minerals, vitamins, and essential amino acids. The plant’s chlorogenic acid, quinic acid, niacin, and other components help prevent the formation and spread of cancerous tumors. 3. Kalanchoe blossfeldiana Kalanchoes are colorful houseplants that make stunning additions to dinner tables while also playing an important role in improving human health. Kalanchoe extract has cytotoxic potential that prevents the spread of ovarian cancer. The flower’s extract stops the cancer cell cycle with an exceptionally potent ability to treat metastatic lung cancer. 4. Silybum marianum L. This tree plant is commonly used as an herbal remedy in other parts of the world. Derived from milk thistle, Silybum marianum L. is loaded with polyphenolic compounds and more that prevent the formation of cancerous tumors. The plant’s components are potent against prostate cancer. 5. Curcuma longa This perennial plant hails from the same family as ginger. Curcuma longa is chock-full of several hundreds of active components you’ve undoubtedly tasted in curcumin. Curcumin triggers apoptosis, meaning the death of cancer cells. Moreover, curcumin decreases the growth of tumor cells. 6. Withania somnifera This immunological superstar, also called Indian ginseng, hails from the rugged mountainous terrain of Punjab. The plant’s derivative, Withaferin-A, helps defeat breast cancer. This economical plant is also effective in the fight against a wide variety of oral cancers. 7. Glycyrrhiza glabra Also known as licorice, glycyrrhiza glabra is commonly used by those who practice Ayurvedic medicine. This herbaceous plant contains hundreds of compounds, some of which prevent the expansion of carcinogenesis through cell cycle stimulation and additional processes. Glycyrrhiza glabra is especially effective in the battle against breast cancer. 8. Nerium oleander As a member of the Apocynaceae family, Nerium oleander is an ornamental plant with surprising medicinal utility. The plant has anticancer, anti-diabetes, and anti-inflammatory capabilities. The plant’s extract is particularly potent in preventing the expansion of cancer cells, thwarting the growth of nearly all tested forms of carcinomas. 9. Catharanthus roseus Also known as Madagascar periwinkle, Catharanthus roseus contains chemical constituents ranging from alkaloids to flavonoids. The plant also contains many other compounds that make it quite the potent cancer-prevention powerhouse. To be more specific, the plant helps inhibit the spread of an inflammatory enzyme dubbed “sPLA2,” which is a common biomarker for breast cancer. 10. Arum palaestinum This lovely flowering plant is laden with flavonols, C-glycosides, alkaloids, and more. Though often used for ornamental purposes in home gardens, the plant also provides utility for treating chronic illness, diabetes, stomach issues, and cancer. The use of Arum palaestenium to treat hepatocellular carcinoma reveals the plant prevents cancerous cells from proliferating. 11. Soursop This tropical plant is used to treat cancer and other illnesses. Soursop has bioactive substances, including phenolic compounds, alkaloids, and acetogenins, with inherent antioxidant properties that help in the battle against cancer. 12. Burdock Burdock, a nearly ubiquitous plant, has medicinal components within its leaves, roots, and seeds. The plant contains B vitamins, minerals, amino acids, lignans, sterols, and phenols. Burdock’s natural lignan lappaol F is a formidable cancer-fighting agent that thwarts the growth of cancerous tumor cells through the cessation of cell cycles. In particular, burdock is valuable for its inherent ability to inhibit the advancement of tumors including cancerous pancreatic tumors. Moreover, burdock has excelled in the battle against cancer cells that have resisted multiple drugs. 13. Stinging Nettle Nettle is a medicinal plant that tastes surprisingly good. Add some homegrown nettles to your salad or soup, and you’ll receive an infusion of vitamins C, B, and A, along with beta-carotene, protein, magnesium, potassium, and iron that help fight cancer. This medicinal plant’s anticancer qualities have proven effective against three cancer cell lines, including breast cancer. 14. Dandelion Commonly used for medicinal purposes by various cultures, dandelion is loaded with vitamins D, A, B, and C. Moreover, dandelion’s zinc, manganese, magnesium and iron are also beneficial. Data from Korean researchers reveals dandelion flavonoids and phenols help thwart the growth of cancer. Dandelion extract has proven especially helpful in combating the spread of breast cancer. Tap into nature’s medicine cabinet by including these plants in your diet The medicinal plants highlighted in this study offer intriguing possibilities for enhancing health and reducing cancer risk. While not all of these plants are common garden varieties or suitable for home cultivation, there are ways to incorporate their benefits into your life: Explore traditional herbal remedies: Many plants studied, such as Curcuma longa (turmeric) and Moringa oleifera, have long histories in traditional medicine. Consider incorporating these into your diet or exploring herbal supplements under the guidance of a healthcare professional. Embrace culinary herbs: Some cancer-fighting plants, like Curcuma longa (turmeric), can be easily included in your cooking. These add both flavor and potential health benefits to your meals. Seek out specialized products: For plants like Annona muricata (soursop) or Catharanthus roseus (Madagascar periwinkle), look for teas, extracts, or supplements from reputable sources. Grow what you can: While not all medicinal plants are suitable for home gardens, some, like Hibiscus, can be grown in pots or gardens, adding beauty and potential health benefits to your space. Remember, while these plants show promise in cancer research, they’re not a substitute for professional medical care. Always consult with a holistic healthcare provider before making significant changes to your diet or starting new supplements, especially if you have existing health conditions or are undergoing cancer treatment. Sources for this article include: MDPI.com Planet-today.com To read the original article click here.

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Licorice, an Effective Breast Cancer Fighter?

The AHA! Team — Fri, 07 Jun 2024 08:45:08 +0000

Dr. Veronique Desaulniers via NaturalHealth365 – Licorice has been proven in numerous studies to stop cancer in its tracks, especially when it comes to breast cancer tumors. But this humble yet powerful herb has also gotten a bad rap for its association with heart arrhythmias, drops in potassium levels, and even heart attacks in some individuals. What is the real deal about licorice? Is it a healer or a health threat? Keep reading for the true facts that every cancer patient needs to know. Licorice: Don’t overdo it, and stay away from the candy! Let’s cut right to the chase and first talk about what all the fuss is about. The FDA and others warn that you can overdose on too much licorice – and for some individuals, this is absolutely true. According to the FDA: “…black licorice contains the compound glycyrrhizin, which is the sweetening compound derived from licorice root. Glycyrrhizin can cause potassium levels in the body to fall. When that happens, some people experience abnormal heart rhythms, as well as high blood pressure, edema (swelling), lethargy, and congestive heart failure.” Researchers at the University of Massachusetts add that too much licorice may have an effect on adrenal hormones and can lead to a condition called pseudoaldosteronism. For these reasons, most experts recommend that healthy individuals interested in using the vast healing power of licorice utilize deglycyrrhizinated licorice, or DGL, where the glycyrrhizin has been removed (although glycyrrhizin itself is considered to be one of the healing substances in the root). Many also recommend not using any licorice product or supplement for more than four weeks at a time. Of course, if you experience any of the symptoms mentioned above, stop using it right away. I would add that if you are on any kind of cancer-healing protocol, stay away from the candy version. This is not a healthy way to utilize the healing effects of this powerful herb. The “candy” version often contains more sugar than the actual herbal extract, and science has confirmed that cancer feeds on sugar. In addition, many commercially processed licorice candies are created using ammonium chloride. Although no tests have been done as yet to determine this chemical’s carcinogenic effects, the U.S. Centers for Disease Control have found that chronic exposure to ammonium chloride can lead to acute respiratory problems. What are the powerful cancer-killing properties? Interestingly, the University of Massachusetts researchers and others in Western medicine recommend that individuals with hormone-sensitive cancers (such as breast, ovarian, uterine, and prostate cancer) avoid using licorice altogether. However, this advice is in direct contrast to recent studies that have found specific tumor-reducing, immune-boosting, and hormone-regulating factors within the root. Researchers at the University Sains School of Medical Sciences in Kelantan, Malaysia, discovered eight different bioactive immunomodulators within herbs such as licorice, curcumin, apricot, ginseng, and a host of others. Of these eight, four of them can be found in licorice, including: Ajoene, an anti-fungal Arctigenin, a lignan with anti-cancer effects β-carotene, a powerful anti-oxidant; and Glabridin acid can also prevents DNA damage caused by oxidation. Other studies have found similar connections between the properties of licorice and breast cancer healing and prevention: Researchers at Rutgers University were able to isolate a particular polyphenol molecule, ß-hydroxy-DHP (BHP), extracted from licorice root. This molecule has the ability to kill breast and prostate cancer tumor cells while leaving healthy cells unaffected. The Chinese have long used licorice root as a hormone balancer and for complications associated with menopause. A study conducted by Nanjing Medical University in Nanjing, China, looked specifically at the Dimethyl Sulfoxide (DMSO) content found in licorice root and its effect on estrogen-positive breast cancer. The researchers found that licorice extract had an effect on estrogen levels that was breast cancer-preventative in a dose-dependent manner: the DMSO stunted cancer cell proliferation in high doses yet had the opposite effect at low doses. Other studies have found that licorice root helps to positively balance testosterone metabolism, decrease serotonin re-uptake, and reduce cortisol levels, all three of which are important to breast cancer prevention and healing. Finally, licorice has proven to be a powerful immune system regulator. Isoliquiritigenin and Naringenin found in the root can promote T cell growth. Glycyrrhizin and other flavonoids found in licorice can help reduce inflammation in the body overall. Consider licorice as part of your breast cancer healing toolbox There are so many powerful herbs found in nature that contain powerful cancer-healing properties. With over 400 compounds in one small root, licorice can definitely be considered among them. Ancient cultures from India to Greece knew this; licorice has been used all over the world for thousands of years as a hormone-balancer, immune system booster, aid for oral health, digestive aid, and more. Now, modern science is discovering the exact mechanisms that make it a true healer. If you are considering using this herbal wonder as part of your breast cancer healing protocol, be sure to do so with the help of a qualified healthcare provider. In addition, certain tests, such as the Research Genetics Cancer Center (RGCC) Test, may be able to pinpoint if licorice supplementation is right for your breast cancer journey. Editor’s note: Discover the best ways to stop cancer cell growth naturally, own the Stop Cancer Docu-Class created by NaturalHealth365 Programs. Sources for this article include: NIH.gov Sciencedirect.com Lifeextension.com NIH.gov NIH.gov NIH.gov NIH.gov NIH.gov NIH.gov NIH.gov Rgcc-group.com To read the original article click here.

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Controlling the Immune System’s Brakes to Treat Cancer, Autoimmune Disorders

AHA Publisher — Sun, 03 Nov 2019 07:00:36 +0000

St. Jude Children’s Research Hospital via EurekAlert – The findings may also influence cancer treatment by supercharging immunotherapy–in which the patient’s own immune system is activated to target a tumor. Immunologists at St. Jude Children’s Research Hospital have discovered key biological switches that control regulatory T cells–specialized white blood cells that keep the immune system in check. A paper detailing this work was published today in Immunity. “Understanding the mechanisms that govern regulatory T cells opens up an array of options for drug development,” said corresponding author Hongbo Chi, Ph.D., of the St. Jude Department of Immunology. “By boosting or suppressing the activity at the right time, you could develop treatments for cancer or autoimmune disorders.” In their studies, the researchers traced the molecular machinery controlling a biological switch called mTORC1 that activates regulatory T cells. Until this work, that machinery had been a mystery. The immunologists’ studies revealed that two central mTORC1 regulators are enzymes called Rag and Rheb. The enzymes’ crucial role in activating the protective regulatory T cells was revealed when the scientists discovered that mice lacking Rag or Rheb developed lethal autoimmune disease. Regulatory T cells are critical to preventing the immune system from attacking the body’s own tissues in autoimmune diseases such as lupus and rheumatoid arthritis. The discovery of the roles of Rag and Rheb is important because drugs that activate those enzymes could prove useful as treatments for autoimmune diseases. The drugs would enhance the regulatory T cells’ function as immune safety brakes. The findings may also influence cancer treatment by supercharging immunotherapy–in which the patient’s own immune system is activated to target a tumor. A significant barrier to such therapies has been the immune-damping activity of regulatory T cells. Drugs that inhibit Rag or Rheb could aid immunotherapies against cancers by suppressing the regulatory T cells. The researchers found that amino acids play a major role in activating mTORC1 in regulatory T cells, functions that were mediated by Rag and Rheb. Amino acids are the building blocks of proteins, which means that “nutrient-sensing” by the immune system, for example of the food a person eats, could influence that individual’s immune response–not only to cancers, but also to organ transplants and infections. To read the original article click here.

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Deep-Learning Tech Reveals Personal ID of Cancer Cells

AHA Publisher — Tue, 29 Oct 2019 07:00:36 +0000

Brian Blum via Israel21c – Technion’s computerized pathologist decodes cancer signatures to improve personalized medicine. Just as every handwritten signature is unique, so is every cancerous tumor. Researchers at the Technion-Israel Institute of Technology have now used artificial intelligence and big datato decode the unique signatures of certain cancer cells. (The original scan (left) and the areas where information was extracted (in red and green, right) using the technology developed at the Technion. Photo courtesy of Technion Spokesperson Department) The resulting technology – dubbed a “computerized pathologist” –could significantly boost development of personalized cancer treatments. The researchers worked with digital images from breast-cancer biopsy samples. The new technology, described earlier this summer in the medical journal JAMA, extracts molecular information from the cell shape (morphology) and its environment. “Pathologists we spoke to said it was an impossible task,” explained doctoral student Gil Shamai, who worked with Prof. Ron Kimmel of the Technion’s Faculty of Computer Science and fellow doctoral student Ron Slossberg. “A human pathologist cannot infer the tumor features from its shape because of the sheer number of variables. The good news is that artificial intelligence technologies, and especially deep learning, are capable of doing so. The computer, unlike even the most skilled pathologist, can characterize the cancer with a complex analysis of its morphology.” With the help of image processing and AI tools, the researchers predicted the molecular profile of cancerous cells just by looking at the tissue as it appears on standard biopsy scans. “We succeeded in identifying the ‘signature’ that the cancer leaves in the tissue,” Shamai added. The team had to write its own software code to compare the biopsies it was analyzing with samples of more than 20,000 scans from 5,356 breast cancer patients. Such deep learning systems “require a huge amount of information and obtaining the kind of information required is not easy.” The researchers were then able to map estrogen and progesterone receptors along with other molecular biomarkers. The study focused on breast cancer, but the technology will be relevant to all cancers. “This is a feasibility study,” said Kimmel. “In the first phase, we believe it will be a tool to help doctors make decisions and will later be developed as a real clinical tool.” The research was supported by the Ministry of Science and Technology, the National Science Foundation, the Lorry Lokey Interdisciplinary Center for Life Sciences and Engineering, and Schmidt Futures. Dr. Yoav Binenbaum of Tel Aviv Medical Center and Prof. Ziv Gil of Rambam Medical Center also participated in developing the technology. To read the original article click here. For more articles from Israel21c click here.

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Exercise Can Now Be Prescribed Like Medicine for People With and Beyond Cancer

AHA Publisher — Sat, 26 Oct 2019 07:00:41 +0000

Penn State College of Medicine via News Wise – It’s well known that exercise is good for preventing and treating many forms of heart disease, but less commonly known are the benefits of physical activity for people living with and beyond cancer. Newswise — It’s well known that exercise is good for preventing and treating many forms of heart disease, but less commonly known are the benefits of physical activity for people living with and beyond cancer. A new initiative called Moving Through Cancer — led by Kathryn Schmitz, professor of public health sciences at Penn State College of Medicine, and an international team of health practitioners and researchers — is hoping to change that. In a paper published today (Oct. 16) in CA: A Cancer Journal for Clinicians, Schmitz and her fellow researchers outline new exercise recommendations for people living with and beyond cancer. “With more than 43 million cancer survivors worldwide, we have a growing need to address the unique health issues facing people living with and beyond cancer and better understand how exercise may help prevent and control cancer,” said Schmitz, who is also a member of the Penn State Cancer Institute. “This esteemed, multidisciplinary group of leaders on the forefront of exercise oncology aimed to translate the latest scientific evidence into practical recommendations for clinicians and the public and to create global impact through a unified voice.” According to the researchers, exercise is important for cancer prevention and can lower the risk of developing colon, breast, endometrial, kidney, bladder, esophagus and stomach cancers. Exercise during and after cancer treatment can help improve fatigue, anxiety, depression, physical function, and quality of life, and can also help improve survival after a breast, colon or prostate cancer diagnosis. Depending on the patient’s activity levels and abilities, the researchers generally recommend 30 minutes of moderately intense aerobic exercise three times a week and 20 to 30 minutes of resistance exercise twice a week. But, Schmitz said health care professionals can also customize exercise prescriptions to individual patients. “Through our research, we’ve reached a point where we can give specific FITT exercise prescriptions — which means frequency, intensity, time and type — for specific outcomes like quality of life, fatigue, pain and others,” Schmitz said. “For example, if we’re seeing a head and neck cancer patient with a specific set of symptoms, we could give them an exercise prescription personalized to them.” The recommendations are one result of a roundtable of experts formed by Schmitz and the American College of Sports Medicine (ACSM) to review the latest scientific evidence and offer recommendations about the benefits of exercise for prevention, treatment, recovery and improved survival for people living with and beyond cancer. Related Articles: How Not to Die from Cancer Only Minutes to a Balanced Microbiome Schmitz said the recommendations will help with one of the premier goals of Moving Through Cancer: raising public awareness about the benefits of exercise for people living with and beyond cancer by 2029. “Currently, an average person on the street will know that exercise is good for preventing and treating heart disease, but not for melanoma,” Schmitz said. “We want to change that. When researchers in the 1950s built an evidence base for exercise and heart disease, there was a shift in public knowledge about that connection. It’s now time for the same thing to happen with exercise and cancer.” Schmitz said the second piece of the initiative is resources and programs to help get people with and beyond cancer moving. The Moving Through Cancer website has an exercise program registry that can help patients, families, health care providers and others find programs near them. The final piece is policy, Schmitz said, which could be used to increase the likelihood that health care professionals will talk to their patients about exercise and that patients will be adequately referred as they move through cancer. Two additional papers were published today (Oct. 16) as part of the initiative in the ACSM research journal Medicine & Science in Sports & Exercise. The papers — titled “American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control” and “Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable” — detail specific outcomes and guidance. Schmitz said that combined, all three papers are a call to action for health care professionals and policy makers to help guide awareness and practice of exercise as medicine for people living with and beyond cancer. “This is the center of my professional heart,” Schmitz said. “My mission for a decade now has been that I want exercise to be as ubiquitous in cancer care as it is in cardiac disease care, only better. The new recommendations and guidance are a tool that can help make that a reality.” Partner organizations that participated in the roundtable include: ACSM, American Cancer Society, the National Cancer Institute — part of the National Institutes of Health, American Academy of Physical Medicine and Rehabilitation, American College of Lifestyle Medicine, American Physical Therapy Association, American Society of Clinical Oncology, Canadian Society of Exercise Physiology, Centers for Disease Control and Prevention, Commission on Accreditation for Rehabilitation Facilities, German Union for Health Exercise, Exercise and Sport Science Australia, Macmillan Cancer Support, National Comprehensive Cancer Network, Royal Dutch Society for Physical Therapy, Society of Surgical Oncology and Sunflower Wellness. To read the original article click here.

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Creatine Powers T Cells’ fight Against Cancer

AHA Publisher — Thu, 24 Oct 2019 07:00:50 +0000

University of California – Los Angeles Health Sciences via EurekAlert – Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research. The study, conducted in mice and published in the Journal of Experimental Medicine, is the first to show that creatine uptake is critical to the anti-tumor activities of CD8 T cells, also known as killer T cells, the foot soldiers of the immune system. The researchers also found that creatine supplementation can improve the efficacy of existing immunotherapies. “Because oral creatine supplements have been broadly utilized by bodybuilders and athletes for the past three decades, existing data suggest they are likely safe when taken at appropriate doses,” said Lili Yang, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and the study’s senior author. “This could provide a clear and expedient path forward for the use of creatine supplementation to enhance existing cancer immunotherapies.” The findings of the paper stem from the Yang lab’s research into the metabolic needs of tumor-infiltrating lymphocytes, immune cells that travel into tumors to fight cancer. Examining these cells, the team observed that killer T cells taken from inside of tumors possessed a large number of creatine transporter molecules, which sit on cells’ surfaces and control creatine uptake into cells. “As biologists, we are always asking ‘why?'” said Yang, who is also an assistant professor of microbiology, immunology and molecular genetics and a member of the UCLA Jonsson Comprehensive Cancer Center. “We could see that these tumor-battling T cells had increased their capacity to take in creatine, likely for a good reason, so we designed experiments to determine what happens when they can’t get it.” The lab genetically engineered mouse models so that their killer T cells were deficient in a gene called CrT, or Slc6a8, which is responsible for producing creatine transporter molecules. They found that mice whose killer T cells could not take in creatine were less capable of fighting tumors. The team then tried validating their hypothesis from the opposite angle, giving non-engineered mice a daily dose of creatine comparable to the safe dose recommended to athletes and bodybuilders. This creatine boost — which was given to some mice via injection and others as an oral supplement — made both groups better equipped to suppress both skin and colon cancer tumor growth. Related Articles: Memory T Cells Shelter in Bone Marrow, Boosting Immunity in Mice with Restricted Diets Anxiety Disorders Linked to Disturbances in the Cells’ Powerhouses “Taken together, these findings suggest that killer T cells really need creatine to fight cancer,” Yang said. “Without it, they simply can’t do their jobs effectively.” Creatine is naturally occurring in humans and other vertebrates; it is primarily produced in the liver and kidneys. Most humans take in additional creatine through their diets, with meat and fish as major sources. In addition to these natural sources, creatine supplements are widely popular among athletes and bodybuilders looking to gain muscle mass and improve performance. The popularity of creatine supplements stems from the knowledge that cells with high-energy demands, like those found in muscle and brain tissue, use creatine to store excess energy for when they most need it. These new findings add killer T cells to the list of creatine-dependent cells, all of which utilize two distinct sources of power, much like hybrid cars. The first power source is a metabolic process that is similar to a fuel engine, converting nutrients like glucose, amino acids and lipids into ATP, the energy currency of cells. The secondary power source is creatine, which — like a hybrid car’s battery — absorbs excess energy (in this case, ATP) and stores it to be released when fuel is in short supply to keep the cells working until more fuel can be burned. “This creatine-powered hybrid engine system enables killer T cells to make the most of their available energy supply in an environment where they have to compete with fast-growing tumor cells for nutrients,” Yang said. Next, the team tried combining creatine supplementation with PD-1/PD-L1 blockade therapy, a form of cancer immunotherapy that prevents T cell exhaustion and has been approved to treat a broad range of cancers including melanoma, lymphoma, colon, lung, liver, kidney and cervical. They found that creatine supplementation and anti-PD-1 blockade therapy worked synergistically, tipping the metabolic scales in T cells’ favor and enabling them to avoid exhaustion and fight cancer effectively for an extended period. Four out of five mice that received this combination therapy were found to have completely eradicated their colon cancer tumors and remained tumor-free for over three months. Furthermore, when they were given a second round of tumor cells, all these “cancer survivor” mice were protected from tumor recurrence and remained tumor-free for an additional six months. As a next step, the team is repeating these experiments using special mouse models that harbor human tumor grafts and human immune cells. If they are able to replicate these effects in human cells, the team will work to determine the proper dose, timing and method to give people creatine supplements to enhance existing immunotherapies. Because the strategy has proven effective in mouse models of both melanoma and colon cancer, the team expects the findings could apply to a range of cancers. The experimental combination therapy described above was used in preclinical tests only and has not been tested in humans or approved by the Food and Drug Administration as safe and effective for use in humans. This newly identified therapeutic strategy is covered by a patent application filed by the UCLA Technology Development Group on behalf of the Regents of the University of California, with Yang and Stefano Di Biase as co-inventors. The researchers recommend that people consult a doctor before incorporating a new supplement such as creatine into their routine as supplements can carry risks of drug interactions and other harmful side effects. There is concern that long-term use of creatine at high doses could damage the liver, kidneys or heart. To read the original article click here.

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Yale Scientists Help Immune System Find Hidden Cancer Cells

AHA Publisher — Sat, 19 Oct 2019 07:00:46 +0000

Yale University via EurekAlert – Cancer cells are masters at avoiding detection, but a new system developed by Yale scientists can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss, the researchers report Oct. 14 in the journal Nature Immunology. The new system reduced or eliminated melanoma and triple-negative breast and pancreatic tumors in mice, even those located far from the primary tumor source, the researchers report. “This is an entirely new form of immunotherapy,” said Sidi Chen, assistant professor of genetics and senior author of the study. Immunotherapy has revolutionized the treatment of cancer but existing therapies don’t work on all patients or not at all against some cancers. Existing therapies sometimes fail to recognize all molecular disguises of cancer cells, rendering them less effective. To address those shortcomings, Chen’s lab developed a new system that weds viral gene therapy and CRISPR gene-editing technology. Instead of finding and editing pieces of DNA and inserting new genes, the new system — called Multiplexed Activation of Endogenous Genes as Immunotherapy (MAEGI) — launches a massive hunt of tens of thousands of cancer-related genes and then acts like a GPS to mark their location and amplify the signals. MAEGI marks the tumor cells for immune destruction, which turns a cold tumor (lacking immune cells) into a hot tumor (with immune cells). It is the molecular equivalent of dressing tumor cells in orange jump suits, allowing the immune system police to quickly find and eradicate the deadly cells, Chen said. “And once those cells are identified, the immune system immediately recognizes them if they show up in the future,” Chen said. The new system in theory should be effective against many cancer types, including those currently resistant to immunotherapy, he said. Upcoming studies will optimize the system for simpler manufacturing and prepare for clinical trials in cancer patients. To read the original article click here.

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