Study Links Common Antidepressants to Weight Gain

The AHA! Team — Mon, 16 Dec 2024 06:09:50 +0000

News Staff via NaturalHealth365 – Depression and anxiety affect more Americans than ever before, with millions of people taking antidepressants, anti-anxiety medication, and various hybrid courses of therapy every day. While these medications may work for some people (temporarily), they are not without unwanted side effects, including weight gain, reduced positive feelings and suicidal thoughts! While gaining weight over the course of antidepressant treatment is relatively common, the amount of weight gain varies between the first-line medications used in most doctors’ offices. Researchers set out to quantify the expected weight gain associated with antidepressant use and compare the differences among major prescriptions. Although depression and anxiety are widespread in today’s society, numerous treatment options exist, many of which are holistic and do not involve medication. This article will examine a recent study on antidepressant-related weight gain and its findings and explore alternative approaches to managing depression and anxiety beyond prescription medications. What’s fueling the rise in depression? There is no shortage of stressors in the world today to be depressed about; a combination of unstable geopolitics, inflation, and any number of personal issues can weigh heavily on a person’s mental health. Our society is so breakneck that we are expected to work ourselves to the bone while not displaying weakness, and this can easily lead to burnout and depression. There are other factors at play, however – the unnatural and highly processed diets that we almost all partake in are key factors in depression development. There is a profound link between bodily inflammatory states and the development of depression in all age groups. It is reasonable to look at the world around us and assume that mental health crises abound because of the state of everything, but one of the biggest contributors could be living right within your body. Researchers explore the impact of antidepressants on weight gain Antidepressants like SSRIs (selective serotonin reuptake inhibitors) work by preventing the reabsorption (or reuptake) of serotonin, a neurotransmitter, back into neurons. This allows serotonin to remain available longer in the brain, improving mood regulation. While the exact mechanism of how this alleviates anxiety and depression isn’t fully understood, the ability of SSRIs to enhance serotonin signaling has shown enough efficacy in treating these conditions to warrant their widespread medical use. In addition to a variety of other side effects, some mild, some less so, weight gain is a well-known side effect of most antidepressants. The researchers of the study above assessed the health records of over 180,000 mental health patients over 24 months in the United States. They examined the baseline weight and BMI of each individual at the time their course of antidepressants began, at the midpoint of 12 months, and the end. The main antidepressants, often referred to as ‘first-line’ medications, include bupropion (Wellbutrin), escitalopram (Lexapro), paroxetine (Paxil), duloxetine (Cymbalta), sertraline (Zoloft), citalopram (Celexa), and venlafaxine (Effexor). Each of these medications has its own profile of potential side effects, but some may also provide additional benefits for comorbid mental health conditions alongside depression. As a result, the choice of medication is tailored to the individual’s specific needs and circumstances. The analysis of over 180,000 patients showed a clear line of weight gain in an overwhelming majority. Of those examined, Zoloft and Lexapro showed the most significant weight gain. The difference between each medication was not extremely high, and bupropion showed the least weight gain. The researchers, however, did admit that they could not control for medication adherence – their data indicated only that the patients were prescribed these medications for the 24 months of the observation, but there was no way to know if they were taking them regularly or not. Tips to combat depression naturally Research increasingly supports the idea that what we eat can significantly impact our mood and mental well-being. A groundbreaking study published in the journal Nutritional Neuroscience found that adherence to a Mediterranean-style diet supplemented with fish oil was associated with lower rates of depression and improved overall mental health. We, at NaturalHealth365, consistently advocate for a natural diet rich in organic, whole foods as a powerful tool to combat many chronic health issues. While depression is a complex condition that may not always respond solely to dietary changes, adopting a whole-food diet can play a crucial role in supporting mental health. In addition, we know that the pharmaceutical industry would like all of us believe that depression or anxiety is best treated by taking their drugs. Conversely, we would like to see more doctors giving out lifestyle advice to their patients to improve the quality of their physical, mental and emotional wellbeing. For example, consistent daily exercise offers multiple benefits for mental health. It helps regulate blood sugar levels, which in turn reduces systemic inflammation. Additionally, exercise has been shown to boost mood and alleviate symptoms of depression and anxiety. Quality sleep is crucial for overall health, with mental well-being particularly vulnerable to sleep disturbances. Many modern health issues can be significantly improved through a combination of regular exercise, proper nutrition, and adequate sleep. Bottom line: do everything you can to improve the quality of your sleep, starting tonight. Remember, addressing sleep, exercise, and diet is fundamental to managing any health condition, including mental health disorders. By focusing on these areas, you’re taking proactive steps toward better mental and physical well-being. Sources for this article include: Acpjournals.org Medicalnewstoday.com NIH.gov To read the original article click here.

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Researchers Identify Biomarker for Depression, Antidepressant Response

AHA Publisher — Wed, 05 Jan 2022 08:00:45 +0000

University of Illinois Chicago via Newswise – Researchers are one step closer to developing a blood test that provides a simple biochemical hallmark for depression and reveals the efficacy of drug therapy in individual patients. Published in a new proof of concept study, researchers led by Mark Rasenick, University of Illinois Chicago distinguished professor of physiology and biophysics and psychiatry, have identified a biomarker in human platelets that tracks the extent of depression. The research builds off of previous studies by several investigators that have shown in humans and animal models that depression is consistent with decreased adenylyl cyclase — a small molecule inside the cell that is made in response to neurotransmitters such as serotonin and epinephrine. “When you are depressed, adenylyl cyclase is low. The reason adenylyl cyclase is attenuated is that the intermediary protein that allows the neurotransmitter to make the adenylyl cyclase, Gs alpha, is stuck in a cholesterol-rich matrix of the membrane — a lipid raft – where they don’t work very well,” Rasenick said. The new study, “A Novel Peripheral Biomarker for Depression and Antidepressant Response,” published in Molecular Psychiatry, has identified the cellular biomarker for translocation of Gs alpha from lipid rafts. The biomarker can be identified through a blood test. “What we have developed is a test that can not only indicate the presence of depression but it can also indicate therapeutic response with a single biomarker, and that is something that has not existed to date,” said Rasenick, who is also a research career scientist at Jesse Brown VA Medical Center. The researchers hypothesize they will be able to use this blood test to determine if antidepressant therapies are working, perhaps as soon as one week after beginning treatment. Previous research has shown that when patients showed improvement in their depression symptoms, the Gs alpha was out of the lipid raft. However, in patients who took antidepressants but showed no improvement in their symptoms, the Gs alpha was still stuck in the raft — meaning simply having antidepressants in the bloodstream was not good enough to improve symptoms. A blood test may be able to show whether or not the Gs alpha was out of the lipid raft after one week. “Because platelets turn over in one week, you would see a change in people who were going to get better. You’d be able to see the biomarker that should presage successful treatment,” Rasenick said. Currently, patients and their physicians have to wait several weeks, sometimes months, to determine if antidepressants are working, and when it is determined they aren’t working, different therapies are tried. “About 30% of people don’t get better — their depression doesn’t resolve. Perhaps, failure begets failure and both doctors and patients make the assumption that nothing is going to work,” Rasenick said. “Most depression is diagnosed in primary care doctor’s offices where they don’t have sophisticated screening. With this test, a doctor could say, ‘Gee, they look like they are depressed, but their blood doesn’t tell us they are. So, maybe we need to re-examine this.’” To read the original article click here.

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Study Links Common Antidepressants to Weight Gain

Researchers Identify Biomarker for Depression, Antidepressant Response