antibiotics Archives - Amazing Health Advances

Antibiotics Destroy Memories?

The AHA! Team — Thu, 05 Dec 2024 06:09:34 +0000

Al Sears, MD, CNS – A study by epidemiologists at Harvard Medical School reveals a crucial link between your gut’s reaction to antibiotics – especially when taken during midlife and older – and a dramatic decline in cognitive ability as you age. Even in my earliest days of practicing medicine, I was never a big fan of prescribing antibiotics – except, of course, in cases of extreme or life-threatening infections. Because even back then, I was concerned about the damage these drugs could cause to your gut. That’s because trillions of microscopic bacteria – some that protect against certain diseases and some that can cause disease – live in your microbiome and exist in a delicate balance with each other. The problem is that antibiotics can’t distinguish between so-called “good” bacteria and the “bad” ones causing the infection. These drugs kill everything they touch. You see, this microbiome of bacteria and other microbes is essential to almost every aspect of your health – from your immune system and how much energy you have to the absorption of nutrients and even your vulnerability to depression. Now a study by epidemiologists at Harvard Medical School reveals a crucial link between your gut’s reaction to antibiotics – especially when taken during midlife and older – and a dramatic decline in cognitive ability as you age. This makes sense because your gut microflora acts like a biochemical telegraph system that sends messages along your vagus nerve directly to your brain. Don’t get me wrong. I’m not against antibiotics, per se. Since the rollout of penicillin in the 1940s, and the other antibiotics that followed, these drugs have saved hundreds of millions of lives in the fight against diseases like tuberculosis, pneumonia, and diphtheria. I am against their overuse. And now there’s one more reason to stop overusing these drugs… Studying the data of more than 14,000 women from the Nurses’ Health Study project, Harvard scientists found that taking antibiotics for two months or more during midlife was “significantly” linked to poorer cognition, learning, and memory scores , as well as reduced psychomotor speed and attention.1 The researchers noted that the decline in brain power was the equivalent of losing about three or four years of normal aging. The message of the study is loud and clear – keep your antibiotic use to a bare minimum. There are still too many doctors who hand these dangerous drugs out like candies whenever a patient appears with a sore throat, cough, or a urinary tract infection. According to the Centers for Disease Control and Prevention, around 1 in 3 antibiotic prescriptions are unnecessary.2 But the problem isn’t just confined to prescription antibiotics. Antibiotics are pumped into industrialized cattle and poultry to fight bacterial infections that spread through cramped feedlots and battery chicken farms. They are also sprayed onto fruit trees and industrial vegetable farms to prevent and treat infection. During spraying, the wind can carry them further afield into the water supply. 3 Simple Steps To Protect Yourself From Antibiotics Protecting yourself from the damage of antibiotics requires a three-pronged strategy… Avoid Cheap Meats: Cattle and poultry pumped full of antibiotics are now awash in our food supply. Make sure the meat you purchase is always grass-fed, pastured, and antibiotic free. Unless you know the source of the meat and the practices of the ranch or farm, the safest foods are USDA-certified organic foods. If your grocer doesn’t carry them, let them know you’ll shop elsewhere. Bulk up Your Immune System: A strong immune system is essential, not just for fighting infections – but also for fighting the effects of antibiotic use. Two of my favorite immune system boosters are: Anamu. Studies show this South American herb contains a powerful compound called dibenzyl trisulphide, which is a potent stimulator of your body’s “T helper cells.” Their job is to give other immune cells an extra boost.3 Anamu capsules are available at most health food stores. I suggest taking 500 to 1,000 mg per day in divided doses. Astragalus. This herb has been used in Traditional Chinese Medicine for millennia to strengthen the body’s immune defenses. Astragalus is called an “adaptogen,” meaning it helps protect the body against physical and mental stresses. I recommend 500 mg of the concentrated extract three times a day. Replace Big Pharma Meds with Natural Antibiotics: Nature has given us hundreds, if not thousands, of herbal alternatives. A few good ones are: Garlic. Research has found that garlic can be an effective treatment against many forms of bacteria, including Salmonella and E. coli. Garlic has also been shown to be effective against drug-resistant tuberculosis bacteria. Honey. Multiple studies reveal honey to be a powerhouse natural antibiotic, with the ability to inhibit more than 60 kinds of bad bacteria.4 The best is raw honey and always avoid pasteurized honey products. Curcumin. This is the main ingredient in the spice turmeric, and it’s one of the cornerstones of ancient Ayurvedic medicine. Thousands of studies prove curcumin beats a long list of modern drugs, including antibiotics. A recent study found curcumin killed 100% of the MRSA superbug within 2 hours.5 To Your Good Health, Al Sears, MD, CNS References: 1. Mehta RS, et al. “Association of midlife antibiotic use with subsequent cognitive function in women.” March 2022. Plos One. 17(3):e0264649. 2. “1 in 3 antibiotic prescriptions unnecessary: New CDC data show large percentage of antibiotics misused in outpatient settings.” CDC. May 3, 2016. Available at: https://www.cdc.gov/media/releases/2016/p0503-unnecessary-prescriptions.html 3. Williams LA, et al. “A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu).” West Indian Med J. 2007 Jan;56(1):17-21. 4. Mandal MD, Mandal S. “Honey: its medicinal property and antibacterial activity.” Asian Pac J Trop Biomed. 2011 Apr;1(2):154-60. 5. Poonam Tyagi, et al. Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane. PLoS One. 2015;10(3):e0121313. To read the original article click here.

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Expiring Medications Could Pose Challenge on Long Space Missions

The AHA! Team — Fri, 18 Oct 2024 08:11:11 +0000

Duke Health – Medications used by astronauts on the International Space Station might not be good enough for a three-year journey to Mars. A new study led by Duke Health shows that over half of the medicines stocked in space — staples such as pain relievers, antibiotics, allergy medicines, and sleep aids — would expire before astronauts could return to Earth. Astronauts could end up relying on ineffective or even harmful drugs, according to the study appearing July 3 in npj Microgravity, a Nature journal. “It doesn’t necessarily mean the medicines won’t work, but in the same way you shouldn’t take expired medications you have lying around at home, space exploration agencies will need to plan on expired medications being less effective,” said senior study author Daniel Buckland, M.D., Ph.D., an assistant professor of emergency medicine at Duke University School of Medicine and an aerospace medicine researcher. Expired medications can lose their strength by a little – or a lot. The actual stability and potency of medications in space compared to Earth remain largely unknown. The harsh space environment, including radiation, could reduce the effectiveness of medications. Buckland and co-author Thomas E. Diaz, a pharmacy resident at The Johns Hopkins Hospital, noted that expired medications could pose a challenge as space agencies plan for long-duration missions to Mars and beyond. Diaz used a Freedom of Information Act Request to obtain information about the space station formulary, assuming NASA would use similar medications for a Mars mission. Using a database of international drug expiration dates, the researchers determined that 54 of the 91 medications had a shelf-life of 36 months or less. Using the most optimistic estimates, about 60% of these medications would expire before a Mars mission concludes. Under more conservative assumptions, the figure jumps to 98%. The study did not assume accelerated degradation but focused on the inability to resupply a Mars mission with newer medicines. This lack of resupply affects not only medications but also other critical supplies, such as food. Increasing the number of medications brought on board could also help compensate for lowered efficacy of expired meds, authors said. “Those responsible for the health of space flight crews will have to find ways to extend the expiration of medications to complete a Mars mission duration of three years, select medications with longer shelf-lives, or accept the elevated risk associated with administering expired medication,” Diaz said. “Prior experience and research show astronauts do get ill on the International Space Station, but there is real-time communication with the ground and a well-stocked pharmacy that is regularly resupplied, which prevents small injuries or minor illnesses from turning into issues that affect the mission,” Buckland said. Additional authors include Emma Ives and Diana I. Lazare. The study received no external funding. To read the original article click here.

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Overgrowth of Nerve Cells Appears to Cause Lingering Symptoms After Recurrent UTIs

The AHA! Team — Mon, 05 Aug 2024 08:13:54 +0000

Duke Health – DURHAM, N.C. – A perplexing problem for people with recurring urinary tract infections (UTIs) is persistent pain, even after antibiotics have successfully cleared the bacteria. Now Duke Health researchers have identified the likely cause – an overgrowth of nerve cells in the bladder. The finding, appeared March 1 in the journal Science Immunology, provides a potential new approach to managing symptoms of recurring UTIs that would more effectively target the problem and reduce unnecessary antibiotic usage. “Urinary tract infections account for almost 25% of infections in women,” said senior author Soman Abraham, Ph.D., professor in the departments of Pathology, Molecular Genetics and Microbiology, Integrative Immunobiology, and Cell Biology at Duke University School of Medicine. Urinary tract infections account for almost 25% of infections in women “Many are recurrent UTIs, with patients frequently complaining of chronic pelvic pain and urinary frequency, even after a round of antibiotics,” Abraham said. “Our study, for the first time, describes an underlying cause and identifies a potential new treatment strategy.” Abraham and colleagues collected bladder biopsies from recurrent UTI patients who were experiencing pain despite no culturable bacteria in their urine. Using biopsies from people without UTIs as a comparison, they found evidence that sensory nerves were highly activated in the UTI patients, explaining the persistent sense of pain and urinary frequency. Further studies in mice revealed the underlying events, with unique conditions in the bladder that prompt activated nerves in the lining to bloom and grow with each infection. “Typically, during every bout of UTI, epithelial cells laden with bacteria are sloughed off, and significant destruction of nearby nerve tissue occurs,” said Byron Hayes, lead author of the study and previously a postdoctoral fellow in Duke’s Department of Pathology. “These events trigger a rapid repair program in the damaged bladder involving massive regrowth of destroyed nerve cells.” This immune response, including repair activities, is led by mast cells – which are immune cells that fight infection and allergens. Mast cells release chemicals called nerve growth factor, which drive overgrowth and increase sensitivity of nerves. The result is pain and urgency. The researchers were able to address these symptoms by treating study mice with molecules that suppress production of the mast-cell generated nerve growth factor. “This work helps illuminate a puzzling clinical condition that drives medical costs and affects the quality of life of millions of people, primarily women,” Abraham said. “Understanding the crosstalk between mast cells and nerves is an essential step toward effective treatments for people suffering repeat urinary tract infections.” In addition to Abraham and Hayes, study authors include Hae Woong Choi, Abhay PS Rathore,Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Andrea Mencarelli, Pradeep Bist, Lai Guan Ng, Changming Shi, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes Jr, and Ru-Rong Ji. The study received funding support from the National Institutes of Health (K12-DK100024, R01-DK121969, R01-DK121032, R01-GM144606), the National Research Foundation of Korea (2020R1C1C1003257), and a Korea University grant. To read the original article click here.

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Improve Your Gut Health With These 9 Simple Strategies

The AHA! Team — Fri, 12 Jul 2024 18:26:46 +0000

Dena Schmidt via NaturalHealth365 – News about the importance of gut health and probiotics linked to overall health has been circulating quite a bit lately. In fact, even conventionally trained doctors are waking up to the importance of maintaining a healthy gut. Of course, it’s understandable because digestive health is the key to every aspect of our physical, mental, and emotional well-being. Ultimately, if we ignore our digestion, we’ll eventually pay the unwanted price of poor health. Thankfully, there are several positive steps we can take to support a healthy gut microbiome. In doing so, we will absorb nutrients better, help keep the immune system strong, and enjoy a much better mental/emotional outlook on life. Transform your gut health with 9 essential steps for optimal wellness 1. Digestive enzymes Digestive enzymes assist in breaking down food, reducing inflammation, and regulating immune responses that could otherwise damage tissues. Taking high-quality enzyme supplements with meals can help to address deficits, support digestive health, and optimize nutrition. If you can’t afford this option, at the very least, everyone would benefit from chewing food more to help with digestion. If you’re unsure about your supplement options – consult a trusted holistic healthcare provider or health coach with experience in nutritional counseling. 2. Eat more raw fruits and vegetables Assuming your digestive system can tolerate this, you should be eating more organic fruits and vegetables. By the way, when you these kind of foods (more), you will help to create an ideal balance of digestive enzymes in the gut. While all fruits and veggies contain enzymes, those with the most beneficial effects include spinach, apples, pineapples, carrots, avocados, grapefruits, and tomatoes. If you’re not used to eating this way – start off with smaller amounts and work your way up in volume. 3. Probiotics for better gut health Naturally occurring gut bacteria, such as Bifidobacteria and Lactobacillus, play crucial roles in maintaining our health. These beneficial bacteria enhance the functioning of the intestinal barrier, making it more effective at preventing harmful substances from entering the bloodstream. They help suppress a range of pathogens, including viruses, yeasts, and molds, thereby reducing the risk of infections and illnesses. Friendly gut bacteria also significantly strengthen the immune system. By interacting with the gut-associated lymphoid tissue (GALT), they help modulate immune responses and promote a balanced immune system, which is essential for defending against diseases while preventing excessive inflammatory reactions. 4. Add fiber to your diet – daily Fiber is essential for healthy digestion and proper intestinal function. In addition to promoting regular bowel movements, fiber supports a healthy gut microbiome and enhances your body’s detoxification pathways. Including a variety of fiber-rich foods in your daily diet can help maintain digestive health, balance gut bacteria, and assist in the removal of toxins from your body. Aim to incorporate both soluble and insoluble fiber sources, such as organic fruits, vegetables, whole grains, and legumes, to ensure comprehensive support for your digestive system. 5. Get physical – but don’t overdo it Regular, moderate exercise improves circulation and helps to move toxins out of the body. It also assists with regular bowel movements and oxygenating the blood and cells. No doubt, walking is the best form of aerobic exercise and offers all the benefits of lower blood pressure, greater heart health, and a wonderful sense of reduced stress in your life – at the end of every walk. (20 – 60 minutes/day is best, and if you’re new to exercise, increase your efforts slowly each week) 6. Drink clean, pure water every day Drinking plenty of fresh, clean (purified) water throughout the day will keep every cell in your body healthy and strong. Staying well-hydrated helps rid the body of toxins and improves cellular performance. Note: if you or someone you love is feeling constipated – this is a major health tip: drink more water! Generally speaking, drinking half your body weight in ounces of water is a good place to start. For example, if your body weight is 120 pounds – drink about 60 ounces/day. (At first, this will seem impossible – but, eventually, it’s easy) 7. Eat fermented foods Fermented foods allow you to naturally incorporate key enzymes and probiotics into your diet. Just a small quantity per day can go a long way toward improving your health. Some examples of healthy fermented foods include pickled vegetables, raw sauerkraut, miso soup, tempeh, yogurt, kefir, and kombucha. 8. Chew your food 25 times per mouthful or more This simple step allows you to assist your digestive system in doing its job and improving gut health along the way. The less work your digestive system has to do in terms of breaking food down, the more efficient it can be. There are also the added mental and emotional benefits of chewing your food. In fact, here’s a challenge for you: If you chew your food 50-100 times (for every mouthful of food), you will notice a greater sense of calm than ever before. 9. Be warned: Antibiotics can destroy your gut health Antibiotics have been connected with permanent changes in the microflora of people through generations of families, promoting the transmission of deadly organisms and difficulty in recolonization by beneficial bacteria. Do not overuse antibiotics; if possible, don’t use them at all. Instead, favor natural ways to treat infection and boost the immune system. For instance, garlic, oregano oil, and vitamin C can help neutralize toxins, unfriendly bacteria, and viruses. Bottom line: Gut health status is strongly linked to immune system strength, the ability to absorb (or not) nutrients from the food we eat, and many other essential bodily functions, such as cellular repair and detoxification. These nine steps outlined in this special report will give you a great place to start if you’re looking to improve the quality of your life. Enjoy! Sources for this article include: NIH.gov NYTimes.com LifeExtension.com ChrisKresser.com To read the original article click here.

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New Antibiotic Approach Proves Promising Against Lyme Bacterium

The AHA! Team — Fri, 31 May 2024 05:32:44 +0000

Duke Health – A technique that has demonstrated success against cancer tumors could also be lethal to bacteria and other pathogens DURHAM, N.C. – Using a technique that has shown promise in targeting cancer tumors, a Duke Health team has found a way to deploy a molecular warhead that can annihilate the bacterium that causes Lyme disease. Tested in cell cultures using the Borrelia burgdoferi bacterium, the approach holds the potential to target not only bacteria, but also fungi such as yeast and viruses. The findings appear in the journal Cell Chemical Biology. Duke Health team has found a way to deploy a molecular warhead that can annihilate the bacterium that causes Lyme disease “This transport mechanism gets internalized in the bacterium and brings in a molecule that causes what we’ve described as a berserker reaction – a programmed death response,” said lead author Timothy Haystead, Ph.D., professor in Duke’s Department of Pharmacology and Cancer Biology. “It wipes out the bacteria — sterilizes the culture with a single dose of light. And then when you look at what occurs with electron microscopy, you see the collapse of the chromosome.” Haystead and colleagues used a molecular facilitator called high-temperature protein G (HtpG), which is involved in protecting cells that are undergoing heat stress. This family of proteins has been the focus of drug development programs for possible cancer therapies. Studies of this protein as an antimicrobial have also been encouraging, but the Duke team’s work appears to be the first to tether an HtpG inhibitor to a drug that enhances sensitivity to light. The researchers found that the HtpG inhibitor, armed with the photosensitive drug, was rapidly absorbed into the cells of the Lyme bacteria. When hit with light, the bacteria’s cells went into disarray and ultimately collapsed, killing them. “Our findings point to a new, alternate antibiotic development strategy, whereby one can exploit a potentially vast number of previously unexplored druggable areas within bacteria to deliver cellular toxins,” Haystead said. In addition to Haystead, study authors include Dave L. Carlson, Mark Kowalewski, Khaldon Bodoor, Adam D. Lietzan, Philip Hughes, David Gooden, David L. Loiselle, David Alcorta, Zoey Dingman, Elizabeth A. Mueller, Irnov Irnov, Shannon Modla, Tim Chaya, Jeffrey Caplan, Monica Embers, Jennifer C. Miller, Christine Jacobs-Wagner, Matthew R. Redinbo, and Neil Spector (deceased). The study received funding support from the Steven and Alexander Cohen foundation and Bay Area Lyme Foundation. To read the original article click here.

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5-Steps to Relieve Tinnitus

The AHA! Team — Mon, 27 May 2024 08:03:23 +0000

Al Sears, MD, CNS – My patient T.K. was a wreck. He looked like he hadn’t slept in a week. I asked him what was going on. “It’s nothing you can fix, doc,” he said. “I’ve been to three specialists, and they all told me the same thing… “I’ve got tinnitus, and I just have to live with it.” Luckily, I was able to help him. Tinnitus is an aggravating, nerve-racking, and unseen condition. The constant ringing in your ears robs you of sleep, makes you miserable as it drowns out your hearing, and, over time, makes you more prone to illness. Tinnitus also shatters your focus and concentration. Sadly, up to 25% of the U.S. population suffers from the condition.1 And that number skyrockets to up to 90% of people who are hearing-impaired. And standard medicine can’t do a darn thing to fix it. There’s no drug that cures tinnitus. But there are plenty of Big Pharma pills that can CAUSE it… The most common are analgesic drugs. These pain relievers are available by prescription and over the counter. Examples of analgesic painkillers include nonsteroidal anti-inflammatories like Advil, Aleve, and Motrin; the acetaminophen in Tylenol, Excedrin, and NyQuil; and old-fashioned aspirin. But it’s not just painkillers that damage your ears. Blood pressure medications like ACE inhibitors, beta-blockers, cancer drugs, and certain antibiotics can cause or worsen tinnitus. Anti-anxiety medications and antidepressants – Big Medicine’s “solution” to treat the symptoms – are known to actually increase the ringing in the ears.2 Another preventable cause of tinnitus is aspartame, the most common artificial sweetener on the market. Aspartame, which has been deemed safe by the FDA, is known as an “excitatory neurotransmitter.” It increases electrical activity in the brain, specifically in the auditory cortex. Use my 5-step protocol to relieve tinnitus For years, I’ve treated patients with a simple five-step protocol. Ditch your ear-damaging pain relievers. Taking an NSAID for the occasional aches and pain typically isn’t a problem. But if you find yourself reaching for one of these pills regularly, consider replacing it with a natural alternative… Tulsi (holy basil): This powerful adaptogen reduces inflammation. It also contains ursolic acid, which inhibits the production of the inflammatory COX-2 enzyme. I recommend taking 150 mg three times a day. Indian Frankincense — Indian Frankincense, also known as Boswellia, “significantly increases” both pain threshold and pain tolerance. Researchers even recommend it as a treatment for osteoarthritis.3 I suggest 400 mg three times a day. White Willow Bark. This plant contains salicin, the same compound found in aspirin. Studies show it relieves arthritis pain as well as lower back pain.4 I recommend 240 mg per day. Lower blood pressure with my favorite supplement. Studies show boosting CoQ10 can drop blood pressure an amazing 11 to 17 mmHg in systolic pressure and 8 to 10 mmHg in diastolic pressure.5 I recommend taking 100 mg daily until your blood pressure is controlled. At that point, you can drop to 60 mg. And make sure you take the ubiquinol form of CoQ10 – it’s the most potent. Protect your ears with omega-3. The Blue Mountain Hearing Study followed almost 3,000 people for eight years. The researchers found those with the highest intake of omega-3 had a 42% lower risk of hearing loss.6 I recommend taking 1,000 mg of the omega-3 fatty acid DHA each day. Look for a formula made from calamari oil. It has one of the highest concentrations of DHA available. Turn down the noise with ginkgo biloba. Over 40 clinical studies show ginkgo eases tinnitus. For example, one study had tinnitus patients take ginkgo or a placebo. After 12 weeks, the ginkgo group had reduced ringing.7 Take 80 mg three times a day. But make sure your ginkgo contains at least 24% “flavone glycosides” and 6% “terpene lactones.” Try this for trauma-related tinnitus. If your tinnitus was caused by exposure to loud noises, I recommend you use the brain-booster vinpocetine for relief. It’s widely used in Europe and Japan, but doctors in the Americas don’t know much about it. In one study, tinnitus disappeared in half of those who took it within one week of trauma. But even if you don’t take it right away, it can lessen the severity. Despite the time lapse since the trauma, 66% saw a significant decrease. I recommend 20 mg a day.8 To Your Good Health, Al Sears, MD, CNS References: 1. Bhatt J, et al. “Tinnitus epidemiology: prevalence, severity, exposures and treatment patterns in the United States.” JAMA Otolaryngol Head Neck Surg. 2016 Oct 1; 142(10): 959–965. 2. Tang Z and Trussell L. “Serotonergic modulation of sensory representation in a central multisensory circuit is pathway specific.” Cell Rep. 2017;20(8):1844-1854. 3. Yu G, et al. “Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis.” BMC Complement Ther Med. 2020:20(1). 4. Chrubasik S., et al. “Treatment of low back pain exacerbations with willow bark extract: A randomized double-blind study.” Am J Med. 2000. 5. Rosenfeldt FL, et al. “Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.” J Hum Hypertens. 2007;21(4):297-306. 6. Gopinath B, et al. “Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss.” Am J Clin Nutr. 2010; 92( 2): 416-421 7. Morgenstern C. et al., “The efficacy of Ginkgo special extract EGb 761 in patients with tinnitus.” Int J Clin Pharmacol Ther. 2002; 40(5): 188-97. 8. Konopka W, et al. “Treatment results of acoustic trauma.” Otolaryngol Pol. 1997;51 Suppl 25:281-4. To read the original article click here.

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Gut Flora Disruption in Infancy Linked to Autism & ADHD

The AHA! Team — Thu, 09 May 2024 20:05:19 +0000

Linköping University via News-Medical – Disturbed gut flora during the first years of life is associated with diagnoses such as autism and ADHD later in life. This is according to a study led by researchers at the University of Florida and Linköping University and published in the journal Cell. The study is the first forward-looking, or prospective, study to examine gut flora composition and a large variety of other factors in infants, in relation to the development of the children’s nervous system. The researchers have found many biological markers that seem to be associated with future neurological development disorders, such as autism spectrum disorder, ADHD, communication disorder and intellectual disability. “The remarkable aspect of the work is that these biomarkers are found at birth in cord blood or in the child’s stool at one year of age over a decade prior to the diagnosis,” says Eric W Triplett, professor at the Department of Microbiology and Cell Science at the University of Florida, USA, one of the researchers who led the study. 16,000 children born in 1997-1999, representing the general population, have been followed from birth into their twenties The study is part of the ABIS (All Babies in Southeast Sweden) study led by Johnny Ludvigsson at Linköping University. More than 16,000 children born in 1997-1999, representing the general population, have been followed from birth into their twenties. Of these, 1,197 children, corresponding to 7.3 percent, have been diagnosed with autism spectrum disorder, ADHD, communication disorder or intellectual disability. A large number of lifestyle and environmental factors have been identified through surveys conducted on several occasions during the children’s upbringing. For some of the children, the researchers have analysed substances in umbilical cord blood and bacteria in their stool at the age of one. “We can see in the study that there are clear differences in the intestinal flora already during the first year of life between those who develop autism or ADHD and those who don’t. We’ve found associations with some factors that affect gut bacteria, such as antibiotic treatment during the child’s first year, which is linked to an increased risk of these diseases,” says Johnny Ludvigsson, senior professor at the Department of Biomedical and Clinical Sciences at Linköping University, who led the study together with Eric W. Triplett. Children who had repeated ear infections during their first year of life had an increased risk of being diagnosed with a developmental neurological disorder later in life. It is probably not the infection itself that is the culprit, but the researchers suspect a link to antibiotic treatment. They found that the presence of Citrobacter bacteria or the absence of Coprococcus bacteria increased the risk of future diagnosis. One possible explanation may be that antibiotic treatment has disturbed the composition of the gut flora One possible explanation may be that antibiotic treatment has disturbed the composition of the gut flora in a way that contributes to neurodevelopmental disorders. The risk of antibiotic treatment damaging the gut flora and increasing the risk of diseases linked to the immune system, such as type 1 diabetes and childhood rheumatism, has been shown in previous studies. “Coprococcus and Akkermansia muciniphila have potential protective effects. These bacteria were correlated with important substances in the stool, such as vitamin B and precursors to neurotransmitters which play vital roles orchestrating signaling in the brain. Overall, we saw deficits in these bacteria in children who later received a developmental neurological diagnosis.” -Angelica Ahrens, Assistant Scientist in Eric Triplett’s research group at the University of Florida and first author of the study The present study also confirms that the risk of developmental neurological diagnosis in the child increases if the parents smoke. Conversely, breastfeeding has a protective effect, according to the study. In cord blood taken at the birth of children, the researchers analysed the amounts of various substances from the body’s metabolism, such as fatty acids and amino acids. They also measured some harmful substances that come from outside, such as nicotine and environmental toxins. They compared substances in the umbilical cord blood of 27 children diagnosed with autism with the same number of children without a diagnosis. Children who were later diagnosed had low levels of several important fats in the umbilical cord blood It turned out that children who were later diagnosed had low levels of several important fats in the umbilical cord blood. One of these was linolenic acid, which is needed for the formation of omega 3 fatty acids that are anti-inflammatory and have several other effects in the brain. The same group also had higher levels than the control group of a PFAS substance, a group of substances used as flame retardants and shown to negatively affect the immune system in several different ways. PFAS substances can enter the body via drinking water, food and the air we breathe. It is not certain that the relationships that the research team found in the Swedish children can be generalised to other populations, but these issues need to be studied in other groups as well. Another question is whether gut flora imbalance is a triggering factor or whether it has occurred as a result of underlying factors, such as diet or antibiotics. However, even when the researchers accounted for risk factors that might affect the gut flora, they found that the link between future diagnosis remained for many of the bacteria. This indicates that some of the differences in gut flora between children with and without future diagnosis are not explained by such risk factors. The research is at an early stage and more studies are needed, but the discovery that many biomarkers for future developmental neurological disorders can be observed at an early age opens up the possibility of developing screening protocols and preventive measures in the long term. The study has been funded with support from, among others, JDRF, Horizon Europe, Barndiabetesfonden (the Swedish Child Diabetes Foundation), Forte and the Swedish Research Council. Source: Linköping University Journal reference: Ahrens, A. P., et al. (2024). Infant microbes and metabolites point to childhood neurodevelopmental disorders. Cell. doi.org/10.1016/j.cell.2024.02.035. To read the original article click here.

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A Major Clinical Trial Shows How to Reduce the Risk of Stomach Bleeding Occasionally Caused by Regular Aspirin Use

AHA Publisher — Mon, 07 Nov 2022 08:00:23 +0000

University of Nottingham via Newswise – A new study, led by experts at the University of Nottingham found that the risk of stomach bleeding caused by using aspirin long-term, can be reduced with a short course of antibiotics, potentially improving the safety of aspirin when used to prevent heart attacks, strokes and possibly some cancers. The results of the .HEAT (Helicobacter pylori Eradication Aspirin) trial, which was led by Professor Chris Hawkey from the University of Nottingham’s School of Medicine and Nottingham Digestive Diseases Centre, and funded by the National Institute for Health and Care Research Health Technology Assessment programme, are published in The Lancet. Aspirin in low doses is a very useful preventative drug in people at high risk of strokes or heart attacks. However, on rare occasions, it can provoke internal ulcer bleeding. By thinning the blood, aspirin makes ulcers in the stomach bleed. These ulcers may be caused by a particular type of bacteria, helicobacter pylori. The STAR (Simple Trials for Academic Research) team from the University of Nottingham investigated whether a short course of antibiotics to remove these bacteria would reduce the risk of bleeding in aspirin users. The .HEAT (Helicobacter pylori Eradication Aspirin) Trial was a very large trial conducted in 1,208 UK general practices. It was a real-life study which used clinical data routinely stored in GP and hospital records, instead of bringing patients back for follow up trial visits. The team wrote to 188,875 patients who were taking aspirin and 30,166 volunteered and took part in the study. Those who tested positive for H. pylori were randomised to receive antibiotics or placebos (dummy tablets) and were followed for up to 7 years. Over the first two and a half years, those who had antibiotic treatment were less likely to be admitted to hospital because of ulcer bleeding than those who had dummy tablets (6 versus 17). Protection occurred rapidly: with those who received placebos (dummy treatment), the first hospitalisation for ulcer bleeding occurred after 6 days, compared to 525 days following antibiotic treatment. Over a longer time period, protection appeared to wane. However, the overall rate of hospitalisation for ulcer bleeding was lower than expected and this in line with other evidence that ulcer disease is on the decline. Risks for people already on aspirin are low. Risks are higher when people first start aspirin, when searching for H. pylori and treating it is probably worthwhile. Professor Chris Hawkey said: “Aspirin has many benefits in terms of reducing the risk of heart attacks and strokes in people at increased risk. There is also evidence that it is able to slow down certain cancers. The .HEAT trial is the largest UK-based study of its kind, and we are pleased that the findings have shown that ulcer bleeding can be significantly reduced following a one-week course of antibiotics. The long-term implications of the results are encouraging in terms of safe prescribing” The results of the trial will be presented at the UEG (United European Gastroenterology) scientific meeting in Vienna where it has won a 10,000 Euro top abstract prize. The STAR team intend to use the prize to sponsor a competition to support a collaboration with a research team that would like to take advantage of STAR methodology. To read the original article click here.

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Big Chickens Create Big Problems: Antibiotics Are Only One of Them

AHA Publisher — Wed, 03 Aug 2022 07:00:26 +0000

Patrick Tims via NaturalHealth365 – Chicken is the average person’s meat of choice, yet most people don’t think about how this commercially produced food makes its way to the dinner table. This tasty meat is beginning to pose some serious health concerns for reasons that will surprise some readers. In particular, medical professionals, nutritionists, and health experts are questioning whether the antibiotics provided to chickens might be harmful to human health. The question is whether the antibiotics and sustenance used to make chickens large and supposedly “healthy” are a net negative. The little-known truth is that antibiotics are only one of many potential health-related issues tied to industrial chicken processing operations. So let’s take a look at the truth about the meat industry. Antibiotics Pumped into Chickens Have Detrimental Effects Though the average person might not care that the massive chickens living at animal farms are loaded up with antibiotics, those who study human health and biology for a living are beginning to question whether the use of such antibiotics is prudent. Antibiotics are given to chickens at industrial facilities to ward off infection amidst overcrowded living conditions. Antibiotics also help fatten birds without spending on additional feed that would take a chunk out of the enterprise’s bottom line. As a result, chickens have ballooned from their average weight of a couple of pounds back in the 1920s to over half a dozen pounds. It merely takes two months for a chicken to reach six pounds, yet it took nearly twice as long for the chickens of “yesteryear” to hit 2.5 pounds on the scale. Though the industry’s leaders don’t like to admit it, the truth is an investigation conducted by Reuters in 2014 found the United States Food and Drug Administration (FDA) passed guidance that restricted antibiotics, yet companies ramped up the use of antibiotics all the more. Even one of Kentucky Fried Chicken’s suppliers, Koch Foods, was nabbed red-handed using antibiotics. Bigger Isn’t Always Better There is a good argument to be made that increasing the size of chickens is a positive as it generates more sustenance. Though today’s chickens are larger than those of a couple of decades ago, they need about 7% less food per pound for optimal growth. In addition, larger chickens tend to have more health problems, including leg issues, as they carry additional weight. However, farmers have started to breed chickens for optimal leg strength. The question is whether the industry’s leaders are succeeding in establishing the delicate balance between chickens living with a modicum of dignity and optimizing their value. The modern chicken farming industry is economically efficient, providing customers affordable meat without a lengthy wait. As a result, chicken has become the country’s most popular type of meat and also one of the country’s most economically efficient meals. Antibiotics Will Be Used for the Foreseeable Future If factory farmers were to eliminate antibiotics altogether, an additional 175,000 tons of feed would be required to support the country’s turkey population. Furthermore, if antibiotics were not included in animal feed, that sustenance would prove significantly less efficient, and animals wouldn’t make proper use of the available nutrients. As a result, it is safe to say antibiotics will likely continue playing a role in factory farming. If you’re looking for a healthier alternative, find a local (organic) farmer to supply your food needs. These local farmers tend to avoid the use of toxic drugs, provide a healthier environment for their animals and do not feed their animals genetically manipulated food. Sources for this article include: ChildrensHealthDefense.org To read the original article click here.

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