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How Milk Thistle Extract can Support Liver Health and Healing

The AHA! Team — Fri, 27 Jun 2025 05:29:03 +0000

Lori Alton via NaturalHealth365 – With its spiky purple flowers and dull green leaves, milk thistle may appear to be nothing more than an ordinary weed growing wild in vacant lots and fields. Yet, this unimpressive-looking plant is truly a shining star when it comes to avoiding disease and promoting healing. Milk thistle, scientifically known as Silybum marianum, is prized by natural healers for its ability to eliminate liver ailments, including nonalcoholic fatty liver disease, which is currently reaching epidemic proportions in the United States. But supporting liver health is not milk thistle’s only gift. Discover how this extraordinary herb can help you. Milk thistle protects against toxic effects from cancer treatment, arrests tumors The active ingredient in milk thistle, an antioxidant flavonoid called silymarin, reduces the inflammation and oxidative damage that can trigger cancer. It also helps preserve glutathione, the body’s premier inflammation-fighting antioxidant. Scientists have known for some time that milk thistle may act against cancer. In a review conducted at the University of Minnesota, researchers cited “strong evidence” for silymarin’s liver-protective and anti-cancer effects. Significantly, they credited silymarin with combating cancer by inhibiting the binding of toxins to cell membrane receptors. In a new study published in The International Journal of Oncology, researchers found that silibinin, a form of silymarin, suppressed chemoresistance, the condition in which cancer fails to respond to the effects of drugs. The team noted that silibinin also prevented further malignancy, protected against potentially cancer-causing DNA mutations, and inhibited tumor growth. In other research, researchers found that silymarin also helps prevent liver damage from chemotherapy and protects the skin and mucosal lining from damage from radiation therapy. Milk thistle is a potent antifungal agent Overgrowth of Candida albicans, a common fungus, can cause symptoms of fatigue, “brain fog,” digestive problems, and skin rashes. And, a growing problem of drug resistance in pharmaceutical antifungals – which parallels the current epidemic of antibiotic resistance – can make Candida difficult to treat. Researchers have found that silymarin can penetrate the cell membrane of the Candida microbe, stopping the pathogen’s growth and spread and helping to clear the overgrowth. Silymarin is also effective in blocking and inhibiting biofilms, layered communities of pathogenic microorganisms that are stubbornly resistant to treatment. Silymarin helps to regulate glucose levels For the past thousand years, herbalists and Ayurvedic healers have advised milk thistle to support healthy blood sugar levels, and modern research confirms the value of this ancient remedy. In one recent study, a 90-day course of a combination of milk thistle, boswellia, and nettles slashed hemoglobin A1c levels – a measure of blood sugar over several months – by a substantial 19 percent. The herbal combination also drastically reduced blood sugar levels – from an average of 150 to 180 mg/dL to an average of 124 mg/dL – and triglyceride levels. In addition, a recently published cell study shows that silymarin protects the retina from diabetic damage, a common consequence of the disease. The Big NEWS: Milk thistle supports a healthy liver Milk thistle’s main claim to fame is its ability to improve liver enzymes, rebuild liver cells, and alleviate liver ailments. In addition to easing hepatitis and cirrhosis, milk thistle shows promise in dealing with nonalcoholic fatty liver disease and halting the progression to steatohepatitis, a more serious form of the condition. Research has supported milk thistle’s beneficial effects on liver disease, with one study showing that hepatitis patients treated with silymarin returned to work sooner and experienced less depression and anxiety than those in the control group. In addition, milk thistle helps detoxify the liver and protect against injury from heavy metals and drugs. In a review published in Phytotherapy Research, the team credited silymarin with reducing liver injury caused by a variety of toxins, drugs, and heavy metals, including acetaminophen, carbon tetrachloride, radiation, alcohol, iron overload, and Amanita phalloides, a type of poisonous mushroom. As an added bonus: milk thistle’s protective effects also extend to the stomach. The herb has been shown to suppress gastric inflammation and protect against ulcers caused by non-steroidal anti-inflammatory drugs. Surprising fact: Milk thistle has antidepressant properties Yet another surprising benefit of milk thistle is its ability to function as a natural mood elevator. Animal studies support its ability to reduce anxiety and depression caused by traumatic brain injury, which it appears to do by reducing the activity of microglial cells caused by a disturbance in the neural circuits between the limbic system and the cortex of the brain. In one study, silymarin performed as well as the pharmaceutical drugs fluoxetine (Prozac) and diazepam (Valium) in supporting mood. Researchers noted that silymarin reversed stress-induced changes to the hippocampus and cerebral cortex while boosting levels of the neurotransmitters serotonin and dopamine. Because of silymarin’s ability to reduce inflammation and neurodegeneration, researchers are even exploring its potential to prevent and treat Alzheimer’s disease. How should I take milk thistle? Experts recommend temporary short-term amounts of 150 mg, taken one to three times a day, for detoxification. A holistic healthcare provider may recommend 50 to 150 mg a day for liver support, maintenance, and longer-term use. Use a formulation standardized to 70 to 80 percent silymarin for best results. As always, consult your holistic doctor to determine if milk thistle is right for you and to determine the proper amount. Although it is generally considered safe and well tolerated, high amounts can cause mild digestive upset. Note: if you are allergic to any member of the aster family – such as daisies, ragweed, marigolds, or chrysanthemums – don’t take milk thistle. Milk thistle has long been revered for its ability to cleanse and detoxify the liver. However, recent research confirming its ability to ward off other diseases demonstrates that this herb is valuable and versatile. Editor’s note: To support healthy liver function, I highly recommend LuvByNature LiverLuv – which is gluten free, non-GMO and delicious. Sources for this article include: NIH.gov NIH.gov To read the original article click here.

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9 Signs of Narcissistic Personality Disorder

The AHA! Team — Fri, 16 May 2025 05:08:42 +0000

Larissa Biggers via Duke Health – Narcissism vs. Narcissistic Personality Disorder Having narcissistic tendencies — like bragging or making yourself the center of attention — are normal when they occur occasionally. Narcissistic personality disorder (NPD) is different. Symptoms are more severe, occur across different situations and environments, and make relationships with others challenging, if not impossible. Here, Zachary Rosenthal PhD, a clinical psychologist at Duke Health, answers questions about NPD and what you can do if you suspect that you or a loved one has the condition. Dr. Zach Rosenthal discusses the symptoms of NPD, how it is diagnosed, and the individualized approach he takes for treating the disorder. What are the symptoms of narcissistic personality disorder? Use the acronym “SPECIAL ME” to remember the nine signs of NPD. SPECIAL ME Sense of self-importance Preoccupation with power, beauty, or success Entitled Can only be around people who are important or special Interpersonally exploitative for their own gain Arrogant Lack empathy Must be admired Envious of others or believe that others are envious of them How is NPD diagnosed? Trained mental health professionals conduct a structured interview to learn more about an individual’s typical behavior patterns. If someone consistently displays at least five of the SPECIAL ME traits, they meet the diagnostic criteria for the condition. Is NPD genetic? No, there is no gene for NPD, and people are not born with it. Like other mental health conditions, environment is a major factor. Children who are encouraged to believe they are extraordinary and always deserve the best — sometimes at the expense of others — could later develop NPD. In these children, traits like confidence are rewarded, while qualities like empathy are not. Are narcissists bad people? Narcissists are not bad people; it’s their behavior that’s problematic. They have been conditioned to believe that they are special and deserve to be treated better than others and approach the world accordingly. Can I have a relationship with someone with NPD? It depends. If your romantic partner, family member, or boss has NPD, they can make your life challenging. Because they put themselves first, you may feel belittled, and your mental health could suffer. Coping strategies include setting personal boundaries and gently walking away if they are breached. However, this is not always easy to do. Calling your partner a narcissist won’t help either. Instead, you should focus on your well-being and decide what you are willing to tolerate. Can people recover from NPD? Yes, but changing a learned behavior takes time and effort. People with NPD do not generally seek help on their own, and if they do, it is often because of a co-existing problem, like anxiety. Because there is no proven medication or therapy to treat NPD, providers take an individualized approach. Getting to know the patient and establishing a trusting relationship are key components of treatment. If a person is willing to change and their therapist can help them bridge the gap between their current and desired behaviors, there is hope for recovery. To read the original article click here.

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6 Sun Poisoning Natural Remedies (Plus How It’s Different from Sunburn)

The AHA! Team — Fri, 02 May 2025 05:19:39 +0000

Annie Price via Dr. Axe – Unfortunately, most people experience sunburn at some point in their lives, but not everyone has had a case of sun poisoning. Have you? For those of you who haven’t, you’re probably wondering, “What does sun poisoning look like?” Bumps that appear in clusters where the skin was exposed to sun are a telltale sign, and it only takes a matter of minutes for sun poisoning to be visible on the body. Then again, you can also be in the sun for hours, end up with a bad sunburn but not have sun poisoning. Severe Sunburn vs. Sun Poisoning Sun poisoning is often the term used for a severe case of sunburn, but a severe sunburn and true poisoning are two totally different things. Why do some people experience “poisoning” from the sun while others never do? Sun poisoning is actually a type of sun allergy, and up to 20 percent of the population may have a sun allergy and can therefore experience sun poisoning. How can you differentiate between a really bad sunburn and actual sun poisoning? In this article, you’ll learn the answer to this question and much more — including the best natural treatment options for sun poisoning. What Is Sun Poisoning? (Types, Symptoms) What is the difference between sun poisoning and sunburn? You can have a sunburn and sun poisoning at the same time, but it’s also possible to have sun poisoning without sunburn. A sunburn is red, painful skin that feels warm when you touch it. It’s the result of exposure to ultraviolet (UV) rays, most often from the sun, but it can also be from artificial sources, like sun lamps. Sun poisoning also occurs after exposure to UV rays, but unlike a sunburn, it’s actually your skin having an allergic reaction to the rays. People who experience an allergy to the sun have their immune systems go into overdrive as a result of their skin being exposed to and changed by the sun. Sun Poisoning Symptoms What does a sun poisoning rash look like? A sun poisoning rash often includes small bumps where the body was exposed to the sun. These bumps can be in dense clusters. What does sun poison feel like? It’s often itchy and can also be painful. Signs of sun poisoning caused by an allergy include: Skin redness Itching or pain Tiny bumps that may merge into raised patches Scaling, crusting or bleeding Sun poisoning blisters or hives Visible sun poisoning symptoms Visible sun poisoning symptoms often appear on the “V” of the neck, the backs of the hands, as well as the the outside surfaces of the arms and the lower legs. Sun poisoning on lips as well as sun poisoning on feet are possible but less common. Most of the time, skin symptoms are located on areas of the body exposed to sunlight, but rarely the bumps or hives may even appear on skin covered by clothing. “Sun poisoning” is sometimes used to describe a severe sunburn with symptoms like: Skin redness and blistering Pain and tingling Swelling Headache Fever and chills Nausea Dizziness Dehydration Types of Sun Allergies How long does it take for sun poisoning to go away? The duration of the reaction depends upon the type of sun allergy. Types of sun allergies include: Polymorphous light eruption (PMLE) Polymorphous light eruption or polymorphic light eruption is a rash caused by sun exposure in individuals who have developed a sensitivity to sunlight. A PMLE rash usually goes away in two to three days without additional sun exposure. Actinic prurigo (hereditary PMLE) This is an inherited form of PMLE seen in people with Native American ancestry, including the Native American populations of North, South and Central America. Actinic prurigo or hereditary PMLE symptoms are more intense than those of classic PMLE. Symptoms also typically start sooner during childhood or adolescence. Like PMLE, actinic prurigo can be worse in warmer/sunnier months in temperate climates. In tropical climates, symptoms can be experienced year-round. Photoallergic eruption This allergic skin reaction is triggered by the effect of sunlight on a chemical that has been applied to the skin. The “chemical” is often an ingredient in sunscreen, fragrances, cosmetics or antibiotic ointments. It also can be from an ingested drug, such as a prescription medication. The duration of a photoallergic eruption is unpredictable, but typically symptoms will go away after the problem chemical is identified and no longer used externally or internally. Solar urticaria This sun allergy results in hives on sun-exposed skin. Solar urticaria is considered a rare skin condition that most often affects young women. Individual hives usually go away within 30 minutes to two hours, but they often return when skin is exposed to sunlight again. Causes and Risk Factors According to the Mayo Clinic, certain medications, chemicals and medical conditions can make the skin more sensitive to the sun. It isn’t clear why some people have a sun allergy and others don’t. Inherited traits may play a role. Causes and risk factors can include: Heredity (a sun allergy can be inherited) Certain medications, such as antibiotics A chemical coming in contact with the skin Having light skin — since people with light skin are generally considered the most sun-sensitive, which makes them more likely to experience a phototoxic reaction like sun poisoning Signs and symptoms of sun poisoning usually show up within minutes to hours following exposure to the sun. Diagnosis While a severe sunburn can cause skin redness, inflammation, blistering and shedding, sun poisoning usually involves small, itchy bumps on the skin. Typically, a severe sunburn is the result of excessive time spent in the sun without protection, but it only takes minutes to experience sun poisoning. Your doctor will likely make a diagnosis based on your symptoms, a basic exam of your skin, your medical history and family history (especially Native American ancestry). Phototesting can also help to diagnosis sun poisoning. This testing involves exposing a small patch of skin to ultraviolet light. Sometimes your doctor may also perform additional testing, such as a blood test or skin biopsy. Conventional Treatment What will a doctor do for sun poisoning? If it’s a mild case, treatment may not be necessary. Conventional sun poisoning treatment for more severe cases can include steroid pills or creams. Phototherapy is another form of conventional treatment in which the skin is intentionally exposed to a special lamp that produces ultraviolet rays to gradually get the skin used to sunlight. In a temperate climate, this is often done a few times a week over the course of several weeks in the springtime to lessen the chances of negative sun reactions in the sunnier summer months. The malaria drug called hydroxychloroquine (Plaquenil) is also used for some sun allergies. Recommendations for home treatment of mild sun poisoning are similar to mild sunburn treatment and can include: Using a cool compress on the area Applying aloe vera gel Hydrating with water and electrolyte drinks Not scratching Staying out of the sun Conventional painkillers, like ibuprofen or naproxen, to decrease pain and swelling Natural Sun Poisoning Treatment 1. Stay out of the sun According to Mayo Clinic, “For mild symptoms, you may need to simply avoid the sun for a few days.” Ideally, you may have avoided problematic sun exposure to avoid the poisoning in the first place, but it’s good to know that staying out of the sun for a few days can be enough to have symptoms fade away. 2. Protect your skin What if you have an allergic reaction to the sun but can’t avoid being outdoors for the next few days? Make sure to use a natural broad-spectrum sunscreen. 3. Try phototherapy (with real sunlight) Instead of artificial ultraviolet light, some doctors may suggest and help you use controlled exposure to natural sunlight to improve your sun allergy. When done correctly, repeated controlled exposure to the sun’s rays can lead to desensitization to the sun. Repeated sun exposure has been known to lead to a “hardening” or natural decrease in the skin’s sensitivity to sunlight. According to the Cleveland Clinic, “Sun reactions are more common in the spring and early summer, when people start to go out in the sun more often. With continued sun exposure over the summer months, skin can sometimes become resistant, lessening the likelihood of an allergic reaction.” 4. Eliminate possible external and internal causes Are you currently taking a medication or supplement that may be leading to your increased sun sensitivity? Look into the possibility that something you are ingesting may be leading to your overreaction to the sun’s rays. St. John’s wort, for example, is a natural remedy known for increasing sun sensitivity. Conventional medications, such as acne treatments, allergy medications, antibiotics, antidepressants and non-steroidal anti-inflammatory drugs (NSAIDs), are known to increase sun sensitivity. The same thing goes for products you use topically, including perfumes, lotions, exfoliants and even sunblocks. Something you’re applying to your body may contain a synthetic or natural ingredient that is increasing your sun sensitivity. You may see an elimination of your symptoms once you stop using an offending topical or oral product. 5. Use natural moisturizers Just like with a sunburn, it’s important to keep the problem area moisturized to reduce symptoms. It’s also a great idea to use a natural remedy that is anti-inflammatory and cooling, such as pure aloe vera gel. Coconut oil is another great natural moisturizer you may have on hand already. 6. Be cautious with citrus fruits As you are healing (and if you want to prevent symptoms in the future), be mindful of your citrus fruit consumption if you’re going to spend time in the sun. Eating and drinking a lot of citrus fruits and juices, like orange and grapefruit, can make sunburn and sun poisoning more likely. Why? Citrus fruits have been shown to contain compounds that cause the skin to be more sensitive to light. If you’ve consumed a lot of citrus and you’re going to be in the sun, it’s even more important that you cover up with clothing and use sunscreen. How to Prevent Sun Poisoning Similar to how you can help prevent sunburn, you can help prevent sun poisoning by taking sun-safety precautions, such as: Wearing protective clothing and hats Wearing a broad-spectrum sunscreen on exposed areas of the body Reapplying sunscreen at least every two hours and after you’ve been sweating or in water Limiting your sun exposure between the hours of 10 a.m. and 4 p.m. when the sun is at its strongest Using sun protection even on cloudy or cool days, especially around water, sand and snow, which can intensify the sun’s rays Making sure you are not taking any medications (such as antibiotics or diuretics) or supplements that can make your skin more sensitive to sunlight Checking topical products, since many skin care ingredients can also increase sun sensitivity … read product labels carefully for warnings of increased sun sensitivity Seek care from your primary health care provider or a dermatologist Seek care from your primary health care provider or a dermatologist if you have a rash on large areas of your body, including parts that are covered by clothing or an itchy rash that does not improve with treatment. Also seek medical attention if you have abnormal bleeding under the skin in sun-exposed areas. Immediate emergency care is warranted if you have signs of a life-threatening allergic reaction, which can include but are not limited to skin hives, swelling around the lips or eyes, difficulty breathing, or trouble swallowing. Final Thoughts A severe sunburn is often referred to as sun poisoning, but true sun poisoning is actually an allergic reaction to ultraviolet rays from the sun. Common symptoms of sun poisoning include small red bumps on areas of the skin exposed to the sun. Spending excessive time in the sun without sun protection can result in a bad sunburn but not necessarily sun poisoning. At the same time, poisoning can occur...

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New App Offers Relief for Parents Mourning the Loss of a Child

The AHA! Team — Mon, 10 Feb 2025 06:10:12 +0000

Uppsala University via News-Medical – A new study shows that an app can help parents who are mourning the loss of a child. Parents who used the app for three months reported reduced symptoms of prolonged grief and post-traumatic stress, and also had fewer negative thoughts. Some parents thought the app should be offered early in the mourning process. This is demonstrated in a new study from Uppsala University, published in the scholarly journal Cognitive Behaviour Therapy. In the acute grief following a death, it is natural for family members to think it feels unreal and difficult to accept that the person who has died will not be coming back. For most people, the intense grief diminishes over time. They can accept the grief, live positively and manage to look ahead. However, some people become stuck in acute grief, a condition known as ‘prolonged grief’. They may preserve the child’s room as it was or visit the grave very frequently, even several years after the loss. It becomes a kind of ritual and a duty that they cannot escape. We have investigated whether the app can alleviate symptoms of prolonged grief and of depression and post-traumatic stress as well. In the study, we also investigate whether destructive patterns such as rumination and avoidance can be improved in this way.” Josefin Sveen, Professor of Clinical Psychology and first author of the study There are several apps based on cognitive behavioural therapy for coping with various mental health problems. A common feature of these apps is that they help the user to normalise thoughts, behaviours and feelings that are natural in the various situations they address. Based on previous self-help app In her previous research on the app PTSD Coach, a self-help app for people suffering from PTSD, Sveen discovered that parents whose child has died lack help in managing their grief. She therefore began to develop the new app in the hope that this could help them. Initially, she thought of parents whose child had died of cancer. Later, this group was expanded to include children dying from other causes. The study involved 248 parents (80 per cent of them mothers). All had lost a child in the last 10 years. Almost half of the children had died of cancer and the average age at the time of death was 11. Participation was entirely voluntary. The participants were contacted by letter and via social media hosted by the Swedish Childhood Cancer Fund and Spädbarnsfonden (the Swedish Infant Death Foundation), which also co-financed the study. Half of the participants received access to the app, the other half had to wait three months before being allowed to use it. “Grief meter’ The app has four components. Firstly, learning about grief and prolonged grief, and learning to accept grief. Secondly, help in finding support in your surroundings, for example, from friends, relations or colleagues, and easily accessible contact details to support organisations. Thirdly, practical exercises and strategies, including relaxation and help in writing about your grief and your feelings. One exercise involves writing a letter to the child who has died. It can also involve visiting physical places that you have previously avoided, or looking at photos of the child. The fourth component is a ‘grief meter’ in which the user can rate their own grief and register how strong or weak the feeling of grief has been at different points during the day. “Many participants thought this was particularly useful. Being able to see that their grief changed from day to day, that there are certain times when it is worst, and that they can feel quite all right in between,” Sveen says. She continues: “I am glad we have succeeded in producing an app that parents feel helps them. The feedback we received from them was that they appreciated the variety of functions offered by the app – as they described it, it was helpful to have several types of support in just one place. The self-assessments that they made of their health also show that their prolonged grief symptoms declined thanks to the app. Some parents thought that in future, the app should be offered early in the process of mourning.” Next step young people The study shows that the app can be a first step in providing information about grief and strategies for managing the challenges that grief brings. The next steps will be, firstly, to follow up the study in a year’s time, and secondly, to conduct a similar study with an app for young people who have lost a parent and/or a sister or brother. Source: Uppsala University Journal reference: Sveen, J., et al. (2024). My grief app for prolonged grief in bereaved parents: a randomised waitlist-controlled trial. Cognitive Behaviour Therapy. doi.org/10.1080/16506073.2024.2429068. To read the original article click here.

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Seeking Stress Relief: 20 Natural Stress Relievers to Boost Your Health

The AHA! Team — Mon, 27 Jan 2025 06:49:02 +0000

Jillian Levy, CHHC via Dr. Axe – Stress: We all deal with it, yet we know how much better off we’d be — both physically and mentally — if we could only get it under control and find stress relievers that really work. While stress can be a positive, motivating factor at times (such as when you’re under pressure to perform well at work or to ace an important exam), more and more research shows that chronic stress impacts the body in ways similar to a poor diet, lack of sleep or sedentary lifestyle. Would you believe that 75 percent to 90 percent of all doctors office visits are related to conditions caused by stress? It’s true. How exactly does stress negatively affect our health in so many ways? It mostly boils down to changes in our hormones, which then cascade to an increase in inflammation and various other problems. Uncontrolled stress experienced over a long period of time is considered “chronic stress,” dangerous and capable of increasing someone’s risk for heart disease, diabetes, weight gain or obesity, mental disorders, autoimmune diseases, digestive disorders, and even cancer. Let’s face it, the stress we face today isn’t going anywhere, which is exactly why it’s more important than ever to find natural ways to relieve stress that work well for us. Thankfully there are natural stress relievers that can help. If you adhere to the following stress relief practices, you’re likely to better manage your stress on a daily basis. Best of all, there are stress relievers out there for just about everyone. Higher stress levels today In many parts of the world, more people today report experiencing negative experiences — which includes physical pain, worry, sadness, stress and anger — on a daily basis than at any recent point in history. What is causing everyone to feel so stressed and burnt out? Some of the top reasons people feel stressed and mentally unwell include: Worries over finances and the economy Health and healthcare-related concerns Disapproval of government performance and worries over politics Anxiety over current events, including natural and societal events such as mass shootings, climate crisis, racial tensions and terrorism Stress due to social media and technology use Feelings of loneliness and depression We know that stress can negatively affect nearly all parts of the body, including the musculoskeletal system, respiratory system, cardiovascular system, endocrine system, gastrointestinal system, nervous system, and both female and male reproductive systems. Here are some of the ways ongoing stress can lead to discomfort and disease: Causes tension headaches and migraines Makes it harder to sleep and causes fatigue (even adrenal fatigue) Triggers digestive issues, such as stomach pain or IBS Can lead to overeating and weight gain or sporadic eating patterns and skipping meals Makes it more likely that people favor sedentary activities and don’t exercise Can lead to social isolation, loneliness and poor relationships Can increase obesity, heart disease, Alzheimer’s disease, diabetes and asthma What is chronic stress? Chronic stress is considered the type of stress that interferes with your ability to function normally over an extended period, such as more than six months. Obviously people of all ages can experience chronic stress, but it’s thought that younger and middle-aged adults between the ages of 15 and 49 are most likely to deal with debilitating chronic stress. “Generation Z” is considered to be the most stressed-out age group in many industrialized nations, due to factors like violence, political turmoil, poor finances and poor health, while “millennials” report the highest rates of anxiety, loneliness and depression. Do people always know that they are dealing with chronic stress? Not necessarily. It’s not always easy for people to make a connection between stress in their lives and symptoms such as pain and brain fog. People also tend to struggle with identifying exactly what’s causing them to worry or feel angry, overwhelmed or depressed. When chronically stressed, you release more “stress hormones” such as adrenaline and cortisol, a steroid hormone in the broader class of steroids called glucocorticoids that is secreted by the adrenal glands. When levels of stress hormones remain elevated over time, they impact many bodily functions. That’s why finding natural stress relievers is so important both mentally and physically. Natural stress relievers 1. Exercise and yoga One of the best stress relievers available to us is exercise, a natural remedy for anxiety because it releases powerful endorphin chemicals in the brain, which act like the body’s built-in painkillers and mood-lifters. Research has suggested the negative effects of stress on the body seem to be exaggerated in people who are inactive, a phenomenon called “stress-induced/exercise deficient” phenotype. Because we react to stress by experiencing changes in our neuro-endocrine systems, regular exercise is protective because it regulates various metabolic and psychological processes in the body, including reinforcing our natural circadian rhythms, sleep/wake cycles, moods and blood sugar levels. Exercise has been shown to help improve insulin sensitivity, can help someone become more aware of her hunger levels, may improve confidence/self-esteem, and can lead to better mental processing and a lower risk for depression. Can’t sleep? Well, exercise can help with that too, which is very important considering quality sleep is needed to regulate hormones and help the body recover. Yoga has been shown to have similar benefits, reinforcing the “mind-body connection,” improving how people (especially women) feel about their bodies, helping with sleep and controlling anxiety. A review of more than 35 clinical trials that tested the effects of regular yoga on stress levels and health found that, overall, yoga offered significant improvements in various physical and psychological health markers for the majority of people. Looking for an even more impactful way to feel the benefits of exercise? Do so while listening to uplifting music. Research findings have indicated that music listening positively impacts the psycho-biological stress system, helps activate the parasympathetic nervous system, improves recovery time, and has benefits for hormonal balance and brain functioning overall. Another terrific way to relieve stress is through forest bathing. To forest bathe, you immerse yourself in naturally beautiful and health-boosting forest surroundings by using your various senses of sight, hearing, smell, etc. It’s meant to be a very peaceful and positive experience that has been shown by science to provide various health benefits. A study found that the tree’s compounds can decrease stress hormone levels in both men and women. 2. Meditation/devotional prayer Meditation and healing prayer are both proven stress relievers that help people deal with worry, anxiety and finding peace of mind. Best of all, they can both be practiced conveniently anytime of day, in your own home and with no therapist, practitioner or program needed, making them no-brainers. Meditation and prayer have been used for literally thousands of years to improve well-being and connection to others, and today they’re actually backed up by science as well. Natural stress relief meditation and mindfulness-based stress reduction are types of simple mental techniques that are practiced for as little as 10–15 minutes once or twice a day in order to bring about more “mindfulness” and reduce stress or anxiety. Various other forms of meditation have been shown to lower physiological responses to stress, improve mental alertness, and help people overcome various emotional and physical problems, such as: anxiety depression poor mental health that affects quality of life attention problems substance use eating habits sleep pain weight gain 3. Acupuncture Acupuncture has increasingly been used to treat many stress-related conditions, including psychiatric disorders, autoimmune or immunological-related diseases, infertility, anxiety, and depression. In fact, researchers have found that acupuncture treatments result in changes in the cardiovascular and immune systems, increasing protective T-cell proliferation and helping with cellular immuno-responses. Studies have shown that acupuncture is one of the best stress relievers for patients recovering from heart disease because it helps regulate the nervous system, therefore having positive effects on blood pressure levels, circulation, hormones and other factors. 4. Nutrient-dense diet A steady supply of nutrients like essential vitamins, trace minerals, healthy fats, electrolytes, amino acids and antioxidants all help your brain handle stress better, therefore benefiting your entire body. It’s also a great weight loss tip for women and men. Some of the most nutrient-dense foods for natural stress relief include: Foods high in B vitamins (which the body uses to convert nutrients to energy) — raw or cultured dairy products, cage-free eggs, grass-fed beef, wild-caught fish, poultry, brewer’s yeast, and green leafy vegetables. Foods high in calcium and magnesium — as relaxing minerals and electrolytes, calcium and magnesium are important for relaxing muscles, relieving headaches and helping you sleep. Try unsweetened organic yogurt, wild-caught salmon, beans/legumes, leafy green veggies, cruciferous veggies like broccoli, avocados and nuts. High-protein foods — foods with protein provide amino acids that are needed for proper neurotransmitter functions. Healthy fats and omega-3 fatty acids — cold-water, wild-caught fish like salmon or sardines can reduce inflammation and help stabilize moods, plus omega-3s are great for the brain, development and heart health. Other healthy fats that support brain health include nuts/seeds, avocado, olive oil and coconut oil. These brain foods and mood-boosting foods work as natural stress relievers. On the other hand, foods to avoid in order to keep stress levels down (aka bad mood foods) include: Packaged or sugary foods — processed, refined foods or those with added sugar can give you blood sugar highs and lows throughout the day, increasing anxiety and causing cravings and fatigue. Too much alcohol or caffeine — both alcohol and caffeine can cause or worsen anxiety, make you dehydrated, interfere with sleep to leave you tired, and make you unable to cope with stress well. Refined vegetable oils — imbalances in polyunsaturated fatty acids, meaning getting much more omega-6s than omega-3s from your diet, are tied to metabolic damage, inflammation and even poor gut health, which can affect mental processes. 5. Challenging thoughts with cognitive behavioral therapy Cognitive behavioral therapy (CBT) is a type of therapeutic practice that has been proven to lower anxiety, stress and multiple disorders — including addiction, eating disorders, insomnia and depression. Knowing that at least 50 percent of the time experiencing a mental disorder is due mostly to chronic, untreated stress reactions, therapists use CBT to train all types of people to better react to situations that are stressful. CBT focuses on challenging and changing your thoughts first and foremost, since the way you perceive an event (not the actual event itself) means everything in terms of how your body reacts. Once you can identify the root thought pattern that is causing harmful behaviors, you can work on changing how you think about events and therefore react to them. The idea behind CBT is this: If you can reframe the way you think about events in your life — for example, instead of panicking over a job change you choose to embrace it, prepare as best you can and seize the opportunity to start fresh — you can literally reduce the stress you wind up feeling from the event. CBT is useful for training us to avoid internal causes of stress, such as “all-or-nothing” thinking, jumping to conclusions, pessimism, having unrealistic expectations for ourselves, always expecting the worst-case scenario, and feeling guilt or shame over events that are out of our control. 6. Spending more time in nature and being social Making time for connecting with the people around you (like practicing fika), spending time outside, and doing things you love with family, friends and your spouse are all stress relievers that are good for your health in many ways. Social connection is tied to longevity, since it helps people feel like they’re a part of something larger than themselves and helps give them perspective. Being outdoors has some similar effects, reminding people that they’re one piece of a much larger universe, lifting their moods and making it easier to get good sleep. For many American workers, their work stress accelerates because they don’t take their full vacations or are always on call. Instead, take your deserved...

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Anxiety Natural Remedies: 15+ Ways to Relax & Find Calm

The AHA! Team — Mon, 09 Dec 2024 06:12:13 +0000

Dr. Josh Axe, DC, DNM, CN via Dr. Axe – Anxiety is a normal response to stress or a dangerous situation. It’s often referred to as the “fight or flight” response. Anxiety can be a disabling condition that’s accompanied by long-term stress and a decline in overall health. It contributes to many chronic diseases, even when treated with conventional medications. That’s why we need to use natural remedies for anxiety and other mood disorders that address the root of the problem instead of putting a Band-Aid on your anxiety symptoms. In fact, anxiety can affect people of all ages, with an estimated 31.1 percent of adults in U.S. experiencing symptoms at some point in their lives. In addition, 40 percent to 67 percent of people with anxiety experience signs of depression, which makes it an even more serious and difficult condition to treat properly, and the lifetime prevalence is estimated to be between 4.3 percent and 5.9 percent.. Research shows that people with anxiety have difficulty successfully achieving short- or long-term remission, with remission rates remaining as low as 38 percent after five years. The good news is that there are many natural remedies for anxiety that are safe and don’t cause adverse side effects like so many anti-anxiety medications. By eating a clean and well-balanced diet that contains important nutrients like B vitamins, magnesium and omega-3s, and using essential oils for anxiety, you may notice an immediate difference in your mood, energy levels and sleep patterns. Plus, there are many supplements and lifestyle changes that serve as natural remedies for anxiety as well. What Is Anxiety? Anxiety is a normal response to stress or a dangerous situation. It’s often referred to as the “fight or flight” response. It’s also the most prevalent mental health condition. Anxiety becomes problematic when it is constant or in reaction to inappropriate circumstances, which over time can negatively affect your day-to-day life. In fact, there are a number of anxiety disorders, including generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder and panic disorder. Anxiety is also a big part of phobias and other issues, such as autophobia (the fear of being alone) and the Sunday scaries. Causes and Risk Factors Causes of anxiety include: stress traumatic life experiences thyroid problems dysfunctional serotonin excessive alcohol caffeine or sugar intake hormone imbalance In addition, research shows that risk factors for anxiety disorders include being female, experiencing stressful life events in childhood and adulthood, having a family history of mental health disorders, having limited economic resources, and being shy in childhood. Signs and Symptoms Although anxiety is characterized by excessive worrying and tension, other physical and psychological symptoms of anxiety can include: muscle tension chest tightness heart palpitations high blood pressure insomnia digestive problems panic attacks irritability difficulty concentrating restlessness sweating anxiousness inability to socialize Natural Remedies for Anxiety Diet 1. Eat a Clean and Well-Balanced Diet Several studies show that there is a connection between the diet choices and psychology, physiology and behavior. Dietary choices impact a person from the moment he or she is born to adult life. Consuming too many or too little calories can increase anxiety symptoms and other psychological or emotional disorders. Also, poor diet can lead to many anxiety symptoms, including moodiness, fatigue and abnormal blood sugar levels that cause nervousness and the jitters. A poor diet can also lead to weight gain, and this can impact your body image and bring on feelings of worthlessness and self-doubt. Eating anti-inflammatory foods can be a natural remedy for anxiety because they are important for neurotransmitters synthesizing and balancing your mood and stress response. In addition, it’s also important to eat healthy fats, unrefined carbohydrates and lean protein. To improve anxiety symptoms, make sure to add vitamin B foods, magnesium-rich foods, foods high in calcium and omega-3 foods — some of the best mood-boosting foods — to your diet too, including: wild-caught fish (like salmon, mackerel, tuna, white fish and herring) grass-fed beef organic chicken nutritional yeast eggs yogurt or kefir leafy greens (like spinach, kale, chard and collard greens) fresh vegetables (like celery, bok choy, broccoli, beets and artichokes) fresh fruits (like blueberries, pineapple, banana and figs) sea vegetables healthy fats (like avocado, coconut oil and olive oil) beans (such as black beans, adzuki beans, chickpeas and fava beans) legumes (like lentils and peas) nuts (such as walnuts, almonds and cashews) seeds (including flaxseeds, chia seeds, hemp seeds and pumpkin seeds) unrefined grains (like farro, quinoa and barley) 2. Avoid Sugary and Processed Foods Research shows that consuming foods that have a high glycemic index can contribute to anxiety and depression. Sugar and refined carbohydrates can give you blood sugar highs and lows throughout the day, increasing anxiety, nervousness and fatigue. These foods can cause mood swings and alter your energy levels, making it more difficult to get your anxiety symptoms under control. They also contribute to inflammation and alter your brain structure and neurotransmitter function. To maintain normal blood sugar levels and improve your anxiety symptoms, stay away from refined foods, including baked goods (like pastries and cookies), sweetened beverages, fast foods, fried foods, processed meat and refined grains (which can be found in cereals and packaged breads). One specific dietary option that covers many of these bases and may actually influence anxiety is the keto diet. Preliminary research in animals has found that following this high-fat, low-carb diet may result in a lowered risk for anxiety. 3. Limit Caffeine and Alcohol Too much caffeine or alcohol can increase anxiety symptoms like moodiness, nervousness and the jitters. A study published by the British Journal of Psychiatry found that abstinence from alcohol is associated with a lower risk of anxiety. To reduce anxiety, avoid alcohol completely, or limit your alcohol intake to one to three drinks per week — but no more than two at a time. Research also shows that consuming too much caffeine can induce anxiety symptoms, and people with panic disorder and social anxiety seem to be particularly sensitive to the effects of caffeine. Limit coffee or black tea to no more than one cup per day. Supplements 4. Ashwagandha Ashwagandha is an adaptogen herb that is often used as a natural remedy for anxiety because it helps stabilize the body’s response to stress. In a systematic review that assessed data on the effectiveness of ashwagandha as a treatment for anxiety, researchers found that most studies concluded with significant improvement in anxiety symptoms with ashwagandha therapy. However, ashwagandha is not only a stress reliever. It also protects the brain from degeneration, and it works to improve anxiety symptoms by destroying free radicals that cause damage to the brain and body. Research shows that ashwagandha helps improve focus, reduce fatigue and fight anxiety without the side effects of most anti-anxiety medications. 5. Kava Root Research shows that kava root can be used to treat anxiety because it’s a nonaddictive and non-hypnotic anxiolytic. Kava is used to improve mood, ease anxiety and boost sociability. It’s also used in homeopathy. It works by stimulating dopamine receptors and inducing euphoria. In fact, a randomized, controlled trial conducted in Australia found that kava can be considered a first-line therapy for generalized anxiety disorder, and it’s shown to be safe for people undergoing treatment. A meta-analysis reported by Cochrane that involved seven trials suggests that there are significant effects from kava treatment for anxiety with few side effects, which are all considered mild. Take kava under the guidance of your health care provider, as it can interact with certain medications. Also, do not consume alcohol if you are using kava, and be aware of the most common side effects, including headache, drowsiness and diarrhea. 6. 5-HTP (5-hydroxytryptophan) Supplementing with 5-HTP, which is synthesized from tryptophan (an essential amino acids that acts as a mood regulator), can help treat a number of issues that are associated with anxiety, including trouble sleeping, moodiness and headaches. 5-HTP increases serotonin, which is a calming neurotransmitter that transmits signals between the nerve cells and alters brain functions that regulate your mood and sleep patterns. Studies show that 5-HTP therapy is associated with a significant reduction in anxiety due to its calming effects. However, it’s important that you do not take 5-HTP with any prescription anti-anxiety or antidepressant medications. 7. GABA (Gamma aminobutyric acid) GABA is an amino acid that is responsible for decreasing anxiety in the nervous system, and it also helps relax your muscles. It’s used for a number of conditions in addition to relieving anxiety, including reducing PMS, relieving insomnia, stabilizing blood pressure, treating ADHD, burning fat and relieving pain. GABA is also an inhibitory neurotransmitter that can cause a sedative effect, helps regulate nerve cells and calms anxiety. Anti-anxiety drugs, like Xanax and Valium, work to increase the amount of GABA in the brain. There are GABA supplements available in your local health food or vitamin store. Another option is to use valerian root, which naturally increases your brain’s GABA level and helps calm anxiety. 8. Magnesium Magnesium plays many important roles in the body, and magnesium deficiency is one of the leading deficiencies in adults. If you’re struggling with anxiety, you may want to try taking a magnesium supplement. Magnesium helps relax your muscles and calm the nervous system. Also, it’s vital for GABA function and regulating certain hormones that are crucial for calming the brain and promoting relaxation. Magnesium is commonly used to combat anxiety, poor digestion, muscle spasms and trouble sleeping. Look for magnesium in citrate, chelate and chloride, which are forms that the body absorbs better. However, be aware that too much magnesium can cause diarrhea, so be careful with the dose. Because of this, start with smaller amounts of magnesium, and work your way up to a dose that’s effective for you. 9. Vitamin B Complex B vitamins help combat stress and stabilize your mood. Vitamin B6, in particular, serves as a natural remedy for anxiety because it works to boost mood, balance blood sugar levels and maintain a healthy nervous system. In fact, symptoms of a vitamin B6 deficiency include anxiety, irritability, depression, changes in mood, muscle pains and fatigue. In addition, vitamin B12 is also important for fighting chronic stress, mood disorders and depression. It helps improve your concentration and energy levels and allows your nervous system to function properly. Other supplements that show potential as natural remedies for anxiety include: Melatonin L-Theanine Lemon Balm Essential Oils 10. Lavender Oil Lavender oil has been shown to reduce anxiety and help relax the body. A multi-center, double-blind, randomized study conducted in Germany found that Silexan, an oral lavender oil capsule, was just as effective as benzodiazepine, anti-anxiety medication that usually induces sedation and had a high potential for drug abuse. Research also shows that using lavender oil topically or inhaling lavender can help induce calmness and relieve symptoms of anxiety, like nervousness, headaches and muscle pain. Put three drops of lavender oil in your palm, and rub it onto your neck, wrists and temples. You can also diffuse lavender oil at home or at work, inhale it directly from the bottle for immediate relief, or add five to 10 drops to warm bath water to fight anxiety naturally. 11. Roman Chamomile Roman chamomile essential oil is used to calm nerves and reduce anxiety because of its mild sedative and relaxation-promoting properties. Inhaling it works as an emotional trigger because the fragrance travels directly to the brain to help fight anxiety symptoms. A study published in Alternative Therapies in Health and Medicine found that when chamomile oil is taken orally, it causes a significant reduction of anxiety and depression symptoms when compared to a placebo. Diffuse five drops of Roman chamomile oil at home or at work, inhale it directly from the bottle, or apply it topically to the neck, chest and wrists. Roman chamomile is also gentle enough for children to use as a natural remedy for anxiety. Lifestyle 12. Physical Activity Regular physical activity helps improve sleep quality, reduce inflammation,...

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Does a Beet a Day Keep Heart Disease Away?

The AHA! Team — Mon, 11 Nov 2024 06:45:17 +0000

Penn State via EurekAlert! – Beetroot juice promotes healthy circulation in postmenopausal women, according to a new study led by Penn State researchers UNIVERSITY PARK, Pa. — After women go through menopause, their risk of heart disease increases dramatically. To improve and support heart and blood vessel health among postmenopausal women, researchers at Penn State studied whether beetroot juice can improve how blood vessels function. Results published today (June 10) in Frontiers in Nutrition indicated that daily consumption of beetroot juice by postmenopausal women may improve blood vessel function enough to reduce future heart disease risk. Beetroot juice contains high levels of nitrate, which the body converts to nitric oxide. Nitric oxide helps blood vessels expand, making it easier for blood to flow through the circulatory system. The ability of nitric oxide to widen blood vessels is known to be particularly helpful during periods of limited blood flow and oxygen delivery, such as during a heart attack, according to the researchers. David Proctor, professor of kinesiology and physiology at Penn State, and Jocelyn Delgado Spicuzza, who earned her doctorate in integrative and biomedical physiology from Penn State in May, led an interdisciplinary team of researchers who tested how nitrate-rich beetroot juice impacted blood vessel health in 24 postmenopausal women in their 50s and 60s. “After menopause, women no longer produce estrogen, which helps maintain nitric oxide in the body,” said Delgado Spicuzza, first author of the research and current SAFE-T center research project manager. “This loss of nitric oxide production contributes to the substantial increase in heart disease risk for postmenopausal women. Foods that are rich in nitrate — especially beets — are being investigated as a natural, non-pharmaceutical way to protect the heart and blood vessels.” Nitrate is an approved food additive for some animal-based food products, such as processed meats. However, nitrate food additives and preservatives are strictly regulated due to their potential to cause cancer, according to Delgado Spicuzza. In contrast, plants like beets, spinach and lettuce naturally accumulate nitrate from the soil. These plant-based sources of nitrate have cardiovascular benefits because the human body can convert nitrates from plants to nitric oxide, which it cannot do with nitrate added to meats. In this study, participants had their vascular function tested at the Penn State Clinical Research Center and then consumed two 2.3-ounce bottles of beetroot juice as an initial dose, followed by one bottle every morning for a week. All participants consumed concentrated beetroot juice, with each serving providing as much nitrate as three large beets. A few weeks later, the participants drank beetroot juice with the nitrate removed. Neither the researchers nor the participants knew which juice was being consumed at the time of testing. A day after their last dose, participants returned for testing of their vascular function. The researchers compared how well blood vessels expanded for each woman when they were and were not consuming the nitrate-rich beetroot juice. The researchers used an ultrasound sensor to monitor how blood flowed through the brachial artery — which is in the upper arm and supplies blood to the hands — during a stress test in which blood flow was restricted in each participant’s forearm for five minutes. When the restriction was removed, researchers measured how blood flow changed in the brachial artery again. The results showed that consumption of nitrate-rich beetroot juice each day improved blood flow compared to when the participants drank nitrate-free beetroot juice. The researchers said that this level of improved blood-vessel function — if it could be maintained over the postmenopausal years — could significantly reduce the risk of heart disease. They said that long-term health benefits of beetroot juice have not been studied at this point, but the long-term benefits of nitrate-rich vegetables have been confirmed. Women may need to consume beetroot juice daily “Women may need to consume beetroot juice daily — or even more often — to experience all of the potential cardiovascular benefits,” Proctor said. “Still, this research shows that beetroot juice can be very useful in protecting blood vessel health of mid-life women during a period of accelerating heart disease risk.” This study included women considered early postmenopausal, or one to six years post-menopause, and late postmenopausal, six or more years post-menopause. Late postmenopausal women saw the same benefits as the early postmenopausal group. Delgado Spicuzza said the research team was particularly excited to find that beetroot juice improved blood vessel health for women who had gone through menopause years earlier. Some treatments for protecting cardiovascular health in postmenopausal women — like hormone therapy — are only safe during the first several years post-menopause. After that, hormone therapy can increase the risk of cancers and stroke. “Some clinicians are already recommending beetroot juice to men and women with high blood pressure,” Delgado Spicuzza said. “By providing a safe and effective way to improve blood vessel function, beets could help maintain cardiovascular health in postmenopausal women. When you consider that most women are postmenopausal for at least a third of their lives, you can begin to understand the potential significance of these results.” Some clinicians are already recommending beetroot juice to men and women with high blood pressure Delgado Spicuzza won the Mid-Atlantic American College of Sports Medicine 2023 Doctoral Student Investigator Award for her presentation on this research in fall of 2023. She said it is gratifying to see this research resonate with other researchers and especially with the women in the study, who seemed to embrace the potential of beetroot juice. “Several of the participants said that they intended to continue consuming beetroot juice after the study concluded,” she said. “There seems to be a real desire on the part of postmenopausal women to support their cardiovascular health without taking additional medications. In part, I believe beets can be a complimentary food to improve blood vessel health in millions of women as they age.” Jigar Gosalia, graduate student in kinesiology at Penn State; Mary Jane De Souza, distinguished professor of kinesiology and physiology at Penn State; Kristina Petersen, associate professor of nutritional sciences at Penn State; Michael Flanagan, doctor of family medicine at Penn State Health; Liezhou Zhong, postdoctoral research fellow in the School of Medical and Health Science at Edith Cowan University in Australia; Catherine Bondonno, senior research fellow in the School of Medical and Health Science at Edith Cowan University in Australia; Elmira Alipour, clinical research coordinator at Atrium Health Carolinas Medical Center; Daniel Kim-Shapiro, professor of physics and Harbert Family Distinguished Chair for Excellence in Teaching and Scholarship at Wake Forest University; and Yasina Somani, assistant professor of exercise physiology at the University of Leeds in the United Kingdom, all contributed to this research. The researchers said they are grateful to Cyndi Flanagan and Christa Oelhaf, nurses in the Clinical Research Center, for their contributions to this research. This research was funded by the National Institutes of Health and the Huck Endowment for Nutritional Research in Family and Community Medicine at Penn State College of Medicine and University Park. Journal Frontiers in Nutrition DOI 10.3389/fnut.2024.1359671 To read the original article click here.

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The Value of Saving Umbilical Cord Blood

The AHA! Team — Wed, 06 Nov 2024 06:06:28 +0000

Duke Health – Jessica M. Sun, MD, a pediatric hematologist/oncologist at Duke Children’s, explains why you might want to save your child’s umbilical cord blood. What is umbilical cord blood? Umbilical cord blood is a baby’s blood left in the placenta (also called the afterbirth) after the baby is born and the umbilical cord is cut. Historically, umbilical cord blood was discarded with the placenta as medical waste. Over the past few decades, cord blood has been shown to contain stem cells and early precursor cells that can be used for life-saving stem cell transplantation for children and adults in need of a stem cell transplant. Cord blood is more tolerant of a new host and can be used without full matching, providing increased access to transplantation for patients who cannot find a matched donor. How is umbilical cord blood used in medicine? Hematopoietic stem cell transplantation can be an effective therapy for children and adults with certain cancers, immune deficiencies, bone marrow failure syndromes, and some genetic diseases including inborn errors of metabolism and hemoglobinopathies. Traditionally, stem cells used for transplantation were obtained from bone marrow or blood. More recently, cord blood has become an alternative source of stem cells for transplantation. A major limitation to stem cell transplantation therapy is the ability to find a suitable donor. Only 20 to 25% of patients in need of a transplant have relative who is a “match” and can serve as their donor. Of those without a related donor, only 10 to 50% of patients (depending on their race and ethnicity) will find a matched unrelated bone marrow donor through the National Marrow Donor Program and other donor registries. Cord blood transplantation does not require as strict matching as bone marrow, so many people who cannot find a matched bone marrow donor can find a suitable cord blood donor. It is estimated that more than 4,000 cord blood transplants are being performed each year around the world. Cord blood and cells derived from birthing tissues are also being studied as a source of stem cells for other purposes, including regenerative therapies for tissues damaged by injury or disease. Duke researchers are currently studying whether an infusion of cord blood can help a child with cerebral palsy, children born with hydrocephalus, and babies with birth asphyxia. We are also studying whether a cell manufactured from cord blood can help repair the lining of nerve cells in the brains of children with leukodystrophies and adults with primary progressive multiple sclerosis. However, these applications remain unproven and are currently the subject of ongoing research. How is umbilical cord blood collected and stored? Umbilical cord blood can be collected without risk to the mother or infant donor. Cord blood can be collected from the placenta, either during the third stage of labor or within 10 to 15 minutes after delivery of the placenta, by sterilely puncturing one of the umbilical veins with a needle and allowing the cord blood to drain into a sterile bag containing an anticoagulant to prevent clotting. After collection from the placenta, some of the red blood cells are usually removed and the volume of the cord blood collection is reduced. For long-term storage, cells undergo specialized freezing procedures and are stored in special freezers under liquid nitrogen. Maximal storage time, or expiration date, is unknown, but cells are likely to remain usable for decades. Cord blood units from public banks have been successfully transplanted after 18 years in storage. What are the options for cord blood storage? There are two main types of cord blood banks, public and private. In general, public banks are nonprofit entities supported by federal or private funding. After the mother consents, public banks collect cord blood from healthy full-term pregnancies at no cost to the donor’s family. In giving consent, the infant’s mother acknowledges that the donation is voluntary and gives up all rights to the cord blood for the public good. The mother also agrees to allow her medical records and the baby’s newborn records to be reviewed, gives a detailed family medical history, and allows a sample of her own blood to be taken for infectious disease testing. Units passing screening tests designed to eliminate risks of transmitting genetic or infectious diseases are typed, placed in the search registry, and are available to any suitable patient in need of transplantation. Units that do not meet criteria for public banking may be discarded or used for research purposes. Private cord blood banks are generally for-profit companies that store “directed donations” intended for future use by the child or a family member. Using a kit provided by the bank, the cord blood is collected by the physician, midwife, or nurse delivering the baby and shipped back to the company’s banking facility. The parents of the infant are charged an initial fee for collection and processing of the cord blood and then an annual fee for storage. Varying degrees of testing is performed on the units, and minimal standards are used to determine whether a unit is eligible for processing and banking. The majority of private collections are undertaken as an investment in the unknown potential for cord blood to be used to treat serious illnesses in the future. Most obstetricians and pediatricians feel that routine cord blood storage in healthy babies is unnecessary. In this regard, it is important to note that a child’s own cord blood would not be used for transplantation of a child with leukemia or other cancers, in part due to concern for contamination with cancerous cells, and it would not be used to treat a genetic condition because the cord blood would contain the same genetic problem. Currently, directed donation of umbilical cord blood for another family member is recommended when a first-degree relative has a high risk pediatric cancer that can be treated with transplantation therapy, a hemoglobinopathy or other transfusion-dependent blood disorder, a congenital immune deficiency, or an inborn error of metabolism. How can I donate my child’s umbilical cord blood? It is always a good idea to discuss options for cord blood banking with your obstetric provider or pediatrician. To privately store your baby’s cord blood for possible future use by the child or a family member, you may contact one of the many private cord blood banks to arrange collection, shipment, and payment. Additional information about cord blood banking, including a list of private banks, can be found through the Parent’s Guide to Cord Blood Foundation. To donate your baby’s cord blood for public use, first check whether the hospital at which you plan to deliver works with a cord blood bank to collect cord blood for public donation. In North Carolina, public collections are available at Duke, UNC, Womack Army Medical Center, and Rex Hospitals. If your hospital does not participate in public cord blood banking, there are a few public cord blood banks, including the Carolinas Cord Blood Bank at Duke, that offer a free kit program so that public donations may be collected at other hospitals. Interested parents should contact the bank (919-668-2071) at least six weeks before the baby’s due date to learn more about the program. Currently, public donations are limited to mothers who have a healthy pregnancy, are 18 years or older, and are pregnant with a single baby. More information about public cord blood donation is available through the National Marrow Donor Program. To read the original article click here.

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Dad’s Quest to Aid Son Leads to Stroke-Recovery Technology

The AHA! Team — Wed, 09 Oct 2024 08:31:39 +0000

John Jeffay via Israel21c – BRAIN.Q helmet’s tailored, low-intensity, low-frequency electromagnetic stimulation aims to enhance and accelerate the brain’s recovery after stroke. Yaron Segal has, like many thousands of enterprising Israelis, identified a problem. And like so many in a country driven by technological innovation, he’s established a startup to find a solution. But he’s not so interested in the payday “exit” that attracts most entrepreneurs in the Startup Nation. His ultimate goal is to find a treatment for his son Lear, born 23 years ago born with familial dysautonomia, a rare and progressive genetic neurological disorder. Segal is not an obvious candidate for the job. He trained as a physicist, specializing in climate, satellites, and three-dimensional models of the atmosphere. But when Lear was diagnosed at the age of three months, Segal decided that he would devote his energy, passion and intellect to finding an effective treatment. Remarkable discoveries He isn’t there yet, but in the long – and often frustrating – process of trying, he has made some remarkable discoveries about the brain’s ability to repair itself, and has developed a treatment that has the potential to help stroke patients live more independent lives. Segal is confident that the same technology will, at some point in the future, also benefit people living with depression, PTSD, ADHD, spinal cord injuries, traumatic brain injuries and other brain-related conditions … and familial dysautonomia. His noninvasive, cloud-based “brainwave helmet” activates a low-intensity electromagnetic field around the patient’s head. In clinical trials with stroke patients, it was demonstrated the treatment significantly improved outcomes in the treated group compared to the control group. It is believed that the investigational technology device encourages the growth of new links between brain cells – links that can get broken by a trauma, or in the case of familial dysautonomia, never existed in the first place. BRAIN.Q, the startup Segal cofounded in 2016, now has 25 staff in Israel and the USA and has attracted $50 million in funding. The crazy guy Segal was, as he puts it, “the crazy guy” who became convinced that the adult brain was capable, with encouragement, of repairing itself. Not completely, but significantly. His theory flew in the face of received medical wisdom. “Neuroplasticity” is the brain’s ability to change and adapt throughout a person’s life and reorganize its structure, functions and connections in response to new experiences, learning or environmental changes. But that couldn’t happen fully in damaged parts of the brain where there is no neural activity – until Segal’s breakthrough. He started experimenting in 2010, funded by friends and family, and within two years he’d shown that mice and rats could, with an early form of his treatment, learn to walk and function again after suffering a brain injury or a broken spinal cord. A potential investor showed the raw data from Segal’s experiment to an expert, who simply refused to accept it was possible. The dismissive response, Segal recalls, was: “I don’t believe it happened. You cannot revive links between cells.” Segal was disappointed but not dismayed. The next step was to test his breakthrough on humans. Faster recovery In a clinical trial conducted in India, stroke patients received the BRAIN.Q therapy using an earlier version of the device for 45 minutes a day, for two months. “The data points to faster recovery of the treated group, indicating that BRAIN.Q’s treatment may not only improve the overall recovery after stroke, but also shorten the recovery period. We hope to test this hypothesis in our ongoing clinical trial,” says Segal. “Some recovered dramatically in the first month, some in the second, depending on how injured the brain was. “People regained everyday function so that they didn’t need help with eating or changing clothes or bathing. “After two months of treatment someone who couldn’t move their legs and was in a wheelchair could walk. Sometimes with a stick, but they could walk.” Tools to fix the problem Stroke is a leading cause of adult disability worldwide. BRAIN.Q’s treatment reduces disability and enhances the potential for recovery. “We are affecting the brain directly, but in a non-invasive manner,” says Segal. “We are affecting the ability of the brain to regenerate connections between cells. “I don’t want to push the brain to do something that it can’t do by itself. I want to harness its natural pattern of waves,” he explains. “You can take a tow truck and drive your broken car all around the city. But I want to take it to the mechanic who will use simple tools and fix the problem.” How did he feel when he saw how the first patients had recovered? “I wanted to cry,” he says. He goes on to relate the story of a woman in Israel who suffered a spinal cord injury in a car crash and has regained control of her legs and bowels, thanks to BRAIN.Q. And there are many more examples. BRAIN.Q, based at the Hebrew University’s Givat Ram campus in Jerusalem, is now conducting trials of the investigational device at patients’ homes after they’ve been discharged from the hospital. “In the beginning I was the CEO because there was nobody else in the company,” says Segal. “Then I became the chief technical officer and now I’m chief of innovation because I think this is where I’m doing the best work I can do.” Can he help his son? Although his son Lear’s diagnosis set him on this journey, Segal eventually honed in on treating strokes because, in neurological terms, they are less complex than familial dysautonomia (also known as Riley-Day syndrome). Familial dysautonomia, particularly prevalent among individuals of Ashkenazi Jewish descent, affects the autonomic nervous system that controls involuntary bodily functions such as breathing, swallowing, digestion, tear production and muscle stability. Lear doesn’t have natural tears, can’t drink liquids, has to eat condensed food, and needs to be held while attempting to walk. In addition, he had spinal fusion surgery at the age of 10. “The most serious situation is when he is in crisis, meaning that whenever he has stress, his autonomic nervous system tries to balance his blood pressure, temperature and chemical balance, and fails. His body goes into ‘panic’ conditions, very similar to those when a normal person is bitten by a snake — he starts to vomit, his blood pressure skyrockets, his temperature increases,” Segal says. “The only way to help him is using medication that brings his autonomic nervous system to a halt, causing it to reset and resume normal operation.” Segal is hopeful that, in time, BRAIN.Q will find a way to re-grow neural links in people with this condition. Meanwhile, he is gratified that the technology can aid stroke patients. For more information, click here. To read the original article click here.

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